{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:59:00Z","timestamp":1792119540638,"version":"4.4.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010971","name":"Yunnan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"MOST","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.redox.2024.103239","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T23:38:31Z","timestamp":1718408311000},"page":"103239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKC\u03b1 S-nitrosation"],"prefix":"10.1016","volume":"75","author":[{"given":"Ling-Yan","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijin","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Sen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Xiu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2955-0693","authenticated-orcid":false,"given":"Yong-Gang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.redox.2024.103239_bib1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0896-6273(00)80110-5","article-title":"Under siege: the brain on opiates","volume":"16","author":"Nestler","year":"1996","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.redox.2024.103239_bib2","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41593-018-0144-y","article-title":"Complex formation between the vasopressin 1b receptor, beta-arrestin-2, and the mu-opioid receptor underlies morphine tolerance","volume":"21","author":"Koshimizu","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/10298420290023954","article-title":"The neurobiology of opiate tolerance, dependence and sensitization: mechanisms of NMDA receptor-dependent synaptic plasticity","volume":"4","author":"Trujillo","year":"2002","journal-title":"Neurotox. Res."},{"issue":"6813","key":"10.1016\/j.redox.2024.103239_bib4","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/35047086","article-title":"Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence","volume":"408","author":"Bohn","year":"2000","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.redox.2024.103239_bib5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0092-8674(02)00613-X","article-title":"Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization","volume":"108","author":"He","year":"2002","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.cell.2005.06.010","article-title":"Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia","volume":"122","author":"Guan","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.redox.2024.103239_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101560","article-title":"Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation","volume":"34","author":"Liu","year":"2020","journal-title":"Redox Biol."},{"issue":"24","key":"10.1016\/j.redox.2024.103239_bib8","doi-asserted-by":"crossref","first-page":"E3441","DOI":"10.1073\/pnas.1602070113","article-title":"Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation","volume":"113","author":"Grace","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"10.1016\/j.redox.2024.103239_bib9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.tins.2020.03.011","article-title":"Post-translational modifications of opioid receptors","volume":"43","author":"Lemos Duarte","year":"2020","journal-title":"Trends Neurosci."},{"issue":"38","key":"10.1016\/j.redox.2024.103239_bib10","doi-asserted-by":"crossref","first-page":"10960","DOI":"10.1021\/bi700443j","article-title":"N-Glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway","volume":"46","author":"Li","year":"2007","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.redox.2024.103239_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/BJ20111050","article-title":"A common single nucleotide polymorphism A118G of the mu opioid receptor alters its N-glycosylation and protein stability","volume":"441","author":"Huang","year":"2012","journal-title":"Biochem. J."},{"issue":"23","key":"10.1016\/j.redox.2024.103239_bib12","doi-asserted-by":"crossref","first-page":"15780","DOI":"10.1074\/jbc.M602267200","article-title":"Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human delta opioid receptor","volume":"281","author":"Petaja-Repo","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib13","first-page":"985","article-title":"Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides","volume":"50","author":"Merkouris","year":"1996","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.redox.2024.103239_bib14","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41467-018-08162-1","article-title":"Phosphorylation-deficient G-protein-biased mu-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects","volume":"10","author":"Kliewer","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2024.103239_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34989","article-title":"Cellular tolerance at the micro-opioid receptor is phosphorylation dependent","volume":"7","author":"Arttamangkul","year":"2018","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1124\/mol.119.117358","article-title":"Separation of acute desensitization and long-term tolerance of micro-opioid receptors is determined by the degree of C-terminal phosphorylation","volume":"96","author":"Arttamangkul","year":"2019","journal-title":"Mol. Pharmacol."},{"issue":"39","key":"10.1016\/j.redox.2024.103239_bib17","doi-asserted-by":"crossref","first-page":"13890","DOI":"10.1523\/JNEUROSCI.2304-11.2011","article-title":"Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A mu-opioid receptor knock-in mice","volume":"31","author":"Grecksch","year":"2011","journal-title":"J. Neurosci."},{"issue":"36","key":"10.1016\/j.redox.2024.103239_bib18","doi-asserted-by":"crossref","first-page":"31731","DOI":"10.1074\/jbc.M111.248310","article-title":"Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation","volume":"286","author":"Groer","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.redox.2024.103239_bib19","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1074\/jbc.M007151200","article-title":"Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome","volume":"276","author":"Petaja-Repo","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"18","key":"10.1016\/j.redox.2024.103239_bib20","doi-asserted-by":"crossref","first-page":"13727","DOI":"10.1074\/jbc.275.18.13727","article-title":"Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor","volume":"275","author":"Petaja-Repo","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.redox.2024.103239_bib21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nrm1569","article-title":"Protein S-nitrosylation: purview and parameters","volume":"6","author":"Hess","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6827","key":"10.1016\/j.redox.2024.103239_bib22","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/35068596","article-title":"A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans","volume":"410","author":"Liu","year":"2001","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib23","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0092-8674(04)00131-X","article-title":"Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock","volume":"116","author":"Liu","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.redox.2024.103239_bib24","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.freeradbiomed.2021.07.002","article-title":"Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration","volume":"172","author":"Nakamura","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib25","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.neuron.2013.05.005","article-title":"Aberrant protein s-nitrosylation in neurodegenerative diseases","volume":"78","author":"Nakamura","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.redox.2024.103239_bib26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.nbd.2015.03.017","article-title":"Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases","volume":"84","author":"Nakamura","year":"2015","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.redox.2024.103239_bib27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41392-023-01439-y","article-title":"Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2024.103239_bib28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.freeradbiomed.2022.07.016","article-title":"GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson's disease","volume":"189","author":"Jiao","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2024.103239_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102172","article-title":"GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation","volume":"47","author":"Liu","year":"2021","journal-title":"Redox Biol."},{"issue":"40","key":"10.1016\/j.redox.2024.103239_bib30","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1523\/JNEUROSCI.0681-17.2017","article-title":"Increased GSNOR expression during aging impairs cognitive function and decreases S-Nitrosation of CaMKIIalpha","volume":"37","author":"Zhang","year":"2017","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.redox.2024.103239_bib31","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2014.05.010","article-title":"Development and applications of CRISPR-Cas9 for genome engineering","volume":"157","author":"Hsu","year":"2014","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib32","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3390\/cells9040958","article-title":"PC12 cell line: cell types, coating of culture vessels, differentiation and other culture conditions","volume":"9","author":"Wiatrak","year":"2020","journal-title":"Cells"},{"issue":"86","key":"10.1016\/j.redox.2024.103239_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/stke.2001.86.pl1","article-title":"The biotin switch method for the detection of S-nitrosylated proteins","volume":"2001","author":"Jaffrey","year":"2001","journal-title":"Sci. STKE : Signal Transduct. Knowl. Environ."},{"key":"10.1016\/j.redox.2024.103239_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/B978-0-12-407865-9.00019-4","article-title":"Protein s-nitrosylation measurement","volume":"522","author":"Qin","year":"2013","journal-title":"Methods Enzymol."},{"issue":"7","key":"10.1016\/j.redox.2024.103239_bib35","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1080\/15548627.2017.1320467","article-title":"Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia","volume":"13","author":"Li","year":"2017","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.redox.2024.103239_bib36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.freeradbiomed.2010.05.001","article-title":"Detection of protein S-nitrosation using irreversible biotinylation procedures (IBP)","volume":"49","author":"Huang","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.redox.2024.103239_bib37","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1080\/15548627.2015.1082020","article-title":"Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA\/alpha-synuclein aggregation","volume":"11","author":"Su","year":"2015","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.redox.2024.103239_bib38","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4161\/auto.25468","article-title":"Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin","volume":"9","author":"Feng","year":"2013","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.redox.2024.103239_bib39","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1080\/15548627.2017.1332549","article-title":"Atg 5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine","volume":"13","author":"Su","year":"2017","journal-title":"Autophagy"},{"issue":"23","key":"10.1016\/j.redox.2024.103239_bib40","doi-asserted-by":"crossref","first-page":"13656","DOI":"10.1073\/pnas.2232594100","article-title":"Essential role for RGS9 in opiate action","volume":"100","author":"Zachariou","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.redox.2024.103239_bib41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nn1636","article-title":"An essential role for DeltaFosB in the nucleus accumbens in morphine action","volume":"9","author":"Zachariou","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"7","key":"10.1016\/j.redox.2024.103239_bib42","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/npp.2017.4","article-title":"RGS9-2 Modulates responses to oxycodone in pain-free and chronic pain states","volume":"42","author":"Gaspari","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tins.2008.01.003","article-title":"Cortical excitation and chronic pain","volume":"31","author":"Zhuo","year":"2008","journal-title":"Trends Neurosci."},{"issue":"11","key":"10.1016\/j.redox.2024.103239_bib44","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/EJA.0000000000000509","article-title":"Clinical concentrations of morphine are cytotoxic on proliferating human fibroblasts in vitro","volume":"33","author":"Aguirre","year":"2016","journal-title":"Eur. J. Anaesthesiol."},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib45","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s00414-023-02961-y","article-title":"Insights in opiates toxicity: impairment of human vascular mesenchymal stromal cells","volume":"137","author":"Mazzotti","year":"2023","journal-title":"Int. J. Leg. Med."},{"issue":"2","key":"10.1016\/j.redox.2024.103239_bib46","first-page":"857","article-title":"Induction of apoptosis by morphine in human tumor cell lines in vitro","volume":"27","author":"Hatsukari","year":"2007","journal-title":"Anticancer Res."},{"issue":"6","key":"10.1016\/j.redox.2024.103239_bib47","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0028-3908(02)00030-8","article-title":"Morphine induces apoptosis of human microglia and neurons","volume":"42","author":"Hu","year":"2002","journal-title":"Neuropharmacology"},{"issue":"17","key":"10.1016\/j.redox.2024.103239_bib48","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1523\/JNEUROSCI.22-17-07650.2002","article-title":"Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism","volume":"22","author":"Mao","year":"2002","journal-title":"J. Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.redox.2024.103239_bib49","first-page":"S53","article-title":"The ratio of oxidized\/reduced glutathione as an index of oxidative stress in various experimental models of shock syndrome","volume":"48","author":"Nemeth","year":"1989","journal-title":"Biomed. Biochim. Acta"},{"issue":"3","key":"10.1016\/j.redox.2024.103239_bib50","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s10571-020-00957-5","article-title":"Morphine and fentanyl repeated administration induces different levels of NLRP3-dependent pyroptosis in the dorsal raphe nucleus of male rats via cell-specific activation of TLR4 and opioid receptors","volume":"42","author":"Carranza-Aguilar","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.redox.2024.103239_bib51","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1021\/bi201785u","article-title":"Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase","volume":"51","author":"Green","year":"2012","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.redox.2024.103239_bib52","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(02)00666-9","article-title":"Opioid tolerance-in search of the holy grail","volume":"108","author":"Kieffer","year":"2002","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.redox.2024.103239_bib53","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/01.RES.84.5.587","article-title":"Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning","volume":"84","author":"Ping","year":"1999","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.redox.2024.103239_bib54","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/FJC.0b013e3181fef9cb","article-title":"S-nitrosylation inhibits protein kinase C-mediated contraction in mouse aorta","volume":"57","author":"Choi","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"7","key":"10.1016\/j.redox.2024.103239_bib55","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1134\/S0006297923070064","article-title":"S-Glutathionylation and S-Nitrosylation as modulators of redox-dependent processes in cancer cell","volume":"88","author":"Kalinina","year":"2023","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.redox.2024.103239_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101769","article-title":"Oral nitrite treatment increases S-nitrosylation of vascular protein kinase C and attenuates the responses to angiotensin II","volume":"38","author":"Pinheiro","year":"2021","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.redox.2024.103239_bib57","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1432-1033.1996.0747h.x","article-title":"Replacement of Ser657 of protein kinase C-alpha by alanine leads to premature down regulation after phorbol-ester-induced translocation to the membrane","volume":"240","author":"Gysin","year":"1996","journal-title":"Eur. J. Biochem."},{"issue":"13","key":"10.1016\/j.redox.2024.103239_bib58","doi-asserted-by":"crossref","first-page":"9194","DOI":"10.1016\/S0021-9258(18)98335-3","article-title":"Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976","volume":"268","author":"Martiny-Baron","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.redox.2024.103239_bib59","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1097\/j.pain.0000000000000547","article-title":"Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammation","volume":"157","author":"Gu","year":"2016","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.redox.2024.103239_bib60","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.pain.2004.09.019","article-title":"Opioids in chronic non-cancer pain: systematic review of efficacy and safety","volume":"112","author":"Kalso","year":"2004","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib61","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.neuron.2011.02.001","article-title":"The doctor's dilemma: opiate analgesics and chronic pain","volume":"69","author":"Fields","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.redox.2024.103239_bib62","article-title":"Molecular mechanisms of morphine tolerance and dependence; novel insights and future perspectives","author":"Badshah","year":"2023","journal-title":"Mol. Cell. Biochem."},{"issue":"9","key":"10.1016\/j.redox.2024.103239_bib63","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1007\/s12035-021-02448-0","article-title":"Molecular mechanism of neuroprotective effect of melatonin on morphine addiction and analgesic tolerance: an update","volume":"58","author":"Su","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"9","key":"10.1016\/j.redox.2024.103239_bib64","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1073\/pnas.0914733107","article-title":"Morphine peripheral analgesia depends on activation of the PI3Kgamma\/AKT\/nNOS\/NO\/KATP signaling pathway","volume":"107","author":"Cunha","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"11","key":"10.1016\/j.redox.2024.103239_bib65","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1073\/pnas.90.11.5162","article-title":"Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor","volume":"90","author":"Kolesnikov","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib66","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0893-133X(95)00084-Q","article-title":"Perspectives on the N-methyl-D-aspartate\/nitric oxide cascade and opioid tolerance","volume":"13","author":"Pasternak","year":"1995","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.redox.2024.103239_bib67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0304-3940(96)12481-2","article-title":"Effect of spinal infusion of L-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat","volume":"207","author":"Dunbar","year":"1996","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.redox.2024.103239_bib68","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0143-4179(96)90067-0","article-title":"Effect of nitric oxide synthase inhibition on tolerance to the analgesic action of D-Pen 2, D-Pen 5 enkephalin and morphine in the mouse","volume":"30","author":"Bhargava","year":"1996","journal-title":"Neuropeptides"},{"issue":"15","key":"10.1016\/j.redox.2024.103239_bib69","doi-asserted-by":"crossref","first-page":"8220","DOI":"10.1073\/pnas.94.15.8220","article-title":"Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: evidence for opposing NO actions on morphine analgesia and tolerance","volume":"94","author":"Kolesnikov","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.redox.2024.103239_bib70","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/10409238.2017.1304353","article-title":"The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy","volume":"52","author":"Barnett","year":"2017","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/j.redox.2024.103239_bib71","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/PL00004974","article-title":"Modulation of immunoreactive protein kinase C-alpha and beta isoforms and G proteins by acute and chronic treatments with morphine and other opiate drugs in rat brain","volume":"355","author":"Ventayol","year":"1997","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"1","key":"10.1016\/j.redox.2024.103239_bib72","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1471-4159.1995.64010247.x","article-title":"Loss of protein kinase C-alpha beta in brain of heroin addicts and morphine-dependent rats","volume":"64","author":"Busquets","year":"1995","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.redox.2024.103239_bib73","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.bjp.0702555","article-title":"Parallel modulation of receptor for activated C kinase 1 and protein kinase C-alpha and beta isoforms in brains of morphine-treated rats","volume":"127","author":"Escriba","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.redox.2024.103239_bib74","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1097\/ALN.0b013e3182390788","article-title":"Isozyme-specific effects of protein kinase C in pain modulation","volume":"115","author":"Zhao","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.redox.2024.103239_bib75","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2008.04.036","article-title":"Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice","volume":"1217","author":"Gabra","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.redox.2024.103239_bib76","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuroscience.2023.05.026","article-title":"The dopaminergic system in the ventral tegmental area contributes to morphine analgesia and tolerance","volume":"527","author":"Wang","year":"2023","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.redox.2024.103239_bib77","first-page":"223","article-title":"Deciphering neural circuits mediating sound-induced analgesia","volume":"44","author":"Zhou","year":"2023","journal-title":"Zool. Res."},{"issue":"6","key":"10.1016\/j.redox.2024.103239_bib78","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1124\/pharmrev.121.000506","article-title":"Oxycodone: a current perspective on its pharmacology, abuse, and pharmacotherapeutic developments","volume":"75","author":"Barrett","year":"2023","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.redox.2024.103239_bib79","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41386-021-01153-9","article-title":"The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex","volume":"47","author":"Ceceli","year":"2022","journal-title":"Neuropsychopharmacology"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T11:43:42Z","timestamp":1724067822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231724002179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":79,"alternative-id":["S2213231724002179"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2024.103239","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKC\u03b1 S-nitrosation","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2024.103239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103239"}}