{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:09:03Z","timestamp":1789776543616,"version":"4.0.1"},"reference-count":132,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.redox.2024.103248","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T07:17:59Z","timestamp":1718781479000},"page":"103248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics"],"prefix":"10.1016","volume":"75","author":[{"given":"Rebecca L.","family":"Koch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Stanton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"McClatchy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Churchill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darian N.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallory E.","family":"Johns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylah R.","family":"Chase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L.","family":"Thiesfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Flynt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-4817","authenticated-orcid":false,"given":"Robert","family":"Pazdro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.redox.2024.103248_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mam.2008.08.003","article-title":"Glutathione in liver diseases and hepatotoxicity","volume":"30","author":"Yuan","year":"2009","journal-title":"Mol. Aspect. Med."},{"issue":"14","key":"10.1016\/j.redox.2024.103248_bib2","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.2174\/13816128113199990476","article-title":"Nonalcoholic fatty liver disease and cardiovascular disease","volume":"20","author":"Hyogo","year":"2014","journal-title":"Curr. Pharmaceut. Des."},{"issue":"5","key":"10.1016\/j.redox.2024.103248_bib3","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3390\/nu5051544","article-title":"Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease","volume":"5","author":"Gaggini","year":"2013","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.redox.2024.103248_bib4","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3390\/ijms17091379","article-title":"Micronutrient antioxidants and nonalcoholic fatty liver disease","volume":"17","author":"Guanliang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.redox.2024.103248_bib5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2174\/1389450116666150427155342","article-title":"Antioxidant mechanisms in nonalcoholic fatty liver disease","volume":"16","author":"Liu","year":"2015","journal-title":"Curr. Drug Targets"},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-017-0652-3","article-title":"Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study","volume":"17","author":"Honda","year":"2017","journal-title":"BMC Gastroenterol."},{"issue":"20","key":"10.1016\/j.redox.2024.103248_bib7","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.3390\/ijms20205037","article-title":"Development and progression of non-alcoholic fatty liver disease: the role of advanced glycation end products","volume":"20","author":"Fernando","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s12072-015-9689-y","article-title":"Genetic and epigenetic mechanisms of NASH","volume":"10","author":"Eslam","year":"2016","journal-title":"Hepatol Int"},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3350\/cmh.2016.0109","article-title":"Genetic predisposition in nonalcoholic fatty liver disease","volume":"23","author":"Sookoian","year":"2017","journal-title":"Clin. Mol. Hepatol."},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib10","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41588-022-01078-z","article-title":"A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation","volume":"54","author":"Vujkovic","year":"2022","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.redox.2024.103248_bib11","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1038\/s41588-023-01497-6","article-title":"Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease","volume":"55","author":"Chen","year":"2023","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jhep.2020.04.003","article-title":"Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort(\u2606)","volume":"73","author":"Anstee","year":"2020","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.redox.2024.103248_bib13","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1053\/j.gastro.2009.01.050","article-title":"Heritability of nonalcoholic fatty liver disease","volume":"136","author":"Schwimmer","year":"2009","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.redox.2024.103248_bib14","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1111\/j.1572-0241.2001.04667.x","article-title":"Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease","volume":"96","author":"Willner","year":"2001","journal-title":"Am. J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/hep.22726","article-title":"Ethnic differences in hepatic steatosis: an insulin resistance paradox?","volume":"49","author":"Guerrero","year":"2009","journal-title":"Hepatology (Baltimore, Md"},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038322","article-title":"Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese","volume":"7","author":"Kawaguchi","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001324","article-title":"Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits","volume":"7","author":"Speliotes","year":"2011","journal-title":"PLoS Genet."},{"issue":"12","key":"10.1016\/j.redox.2024.103248_bib18","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2024.103248_bib19","doi-asserted-by":"crossref","first-page":"9284","DOI":"10.1038\/srep09284","article-title":"Association between patatin-like phospholipase domain containing 3 gene (PNPLA3) polymorphisms and nonalcoholic fatty liver disease: a HuGE review and meta-analysis","volume":"5","author":"Xu","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib20","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/hep.23759","article-title":"The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease","volume":"52","author":"Rotman","year":"2010","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.redox.2024.103248_bib21","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1194\/jlr.P900013-JLR200","article-title":"A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity","volume":"50","author":"Sookoian","year":"2009","journal-title":"J. Lipid Res."},{"issue":"19","key":"10.1016\/j.redox.2024.103248_bib22","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.1073\/pnas.1901974116","article-title":"Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis","volume":"116","author":"BasuRay","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2024.103248_bib23","article-title":"Genetic risk factors associated with NAFLD","volume":"6","author":"Kim","year":"2020","journal-title":"Hepatoma Res"},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib24","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/hep4.1192","article-title":"Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease","volume":"2","author":"Dongiovanni","year":"2018","journal-title":"Hepatol Commun"},{"issue":"5","key":"10.1016\/j.redox.2024.103248_bib25","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2016.01.032","article-title":"The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent","volume":"150","author":"Mancina","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2024.103248_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49882","article-title":"Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease","volume":"8","author":"Helsley","year":"2019","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13104-020-4891-y","article-title":"Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease","volume":"13","author":"Mohammadi","year":"2020","journal-title":"BMC Res. Notes"},{"issue":"31","key":"10.1016\/j.redox.2024.103248_bib28","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1073\/pnas.1410741111","article-title":"Comparative proteomic study reveals 17\u03b2-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease","volume":"111","author":"Su","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000346195","article-title":"Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity","volume":"75","author":"Gorden","year":"2013","journal-title":"Hum. Hered."},{"issue":"12","key":"10.1016\/j.redox.2024.103248_bib30","first-page":"1481","article-title":"Lyplal1 is dispensable for normal fat deposition in mice","volume":"10","author":"Watson","year":"2017","journal-title":"Dis Model Mech"},{"issue":"12","key":"10.1016\/j.redox.2024.103248_bib31","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1093\/hmg\/ddy124","article-title":"NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects","volume":"27","author":"Sliz","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib32","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/hep.29751","article-title":"Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride","volume":"67","author":"Stender","year":"2018","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib33","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jhep.2011.05.029","article-title":"The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies","volume":"56","author":"Al-Serri","year":"2012","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.redox.2024.103248_bib34","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1194\/jlr.P900013-JLR200","article-title":"A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity","volume":"50","author":"Sookoian","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.redox.2024.103248_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.777075","article-title":"Human genetics to identify therapeutic targets for NAFLD: challenges and opportunities","volume":"12","author":"Du","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.redox.2024.103248_bib36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.redox.2024.103248_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6889533","article-title":"The role and mechanism of oxidative stress and nuclear receptors in the development of NAFLD","volume":"2021","author":"Hong","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib38","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib39","first-page":"8","article-title":"Glutathione","volume":"13","author":"Pizzorno","year":"2014","journal-title":"Integr. Med."},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.taap.2004.10.004","article-title":"Role of glutathione transport processes in kidney function","volume":"204","author":"Lash","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.redox.2024.103248_bib41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.fct.2013.07.008","article-title":"Glutathione defense mechanism in liver injury: insights from animal models","volume":"60","author":"Chen","year":"2013","journal-title":"Food Chem. Toxicol. : an international journal published for the British Industrial Biological Research Association"},{"issue":"4","key":"10.1016\/j.redox.2024.103248_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s12276-017-0013-x","article-title":"Glutathione disulfide sensitizes hepatocytes to TNF\u03b1-mediated cytotoxicity via IKK-\u03b2 S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease","volume":"50","author":"Dou","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"7","key":"10.1016\/j.redox.2024.103248_bib43","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2362.2008.01963.x","article-title":"Severe liver steatosis correlates with nitrosative and oxidative stress in rats","volume":"38","author":"Grattagliano","year":"2008","journal-title":"Eur. J. Clin. Invest."},{"issue":"572","key":"10.1016\/j.redox.2024.103248_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz2841","article-title":"Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome","volume":"12","author":"Rom","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5005\/jp-journals-10018-1159","article-title":"Reduced glutathione suppresses oxidative stress in nonalcoholic fatty liver disease","volume":"6","author":"Irie","year":"2016","journal-title":"Euroasian J. Hepato-Gastroenterol."},{"key":"10.1016\/j.redox.2024.103248_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102093","article-title":"Quantitative trait mapping in Diversity Outbred mice identifies novel genomic regions associated with the hepatic glutathione redox system","volume":"46","author":"Gould","year":"2021","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.redox.2024.103248_bib47","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.metabol.2015.11.008","article-title":"Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"65","author":"Brown","year":"2016","journal-title":"Metab. Clin. Exp."},{"issue":"12","key":"10.1016\/j.redox.2024.103248_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115922","article-title":"Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology","volume":"9","author":"Liang","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.redox.2024.103248_bib49","first-page":"409","article-title":"Evaluation of nonalcoholic fatty liver disease in C57bl\/6J mice by using MRI and histopathologic analyses","volume":"65","author":"Ryu","year":"2015","journal-title":"Comp. Med."},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group","volume":"24","author":"Bedossa","year":"1996","journal-title":"J. Hepatol."},{"issue":"9","key":"10.1016\/j.redox.2024.103248_bib51","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1111\/j.1478-3231.2010.02314.x","article-title":"Diagnosis of different liver fibrosis characteristics by blood tests in non-alcoholic fatty liver disease, Liver international","volume":"30","author":"Cal\u00e8s","year":"2010","journal-title":"official journal of the International Association for the Study of the Liver"},{"issue":"4","key":"10.1016\/j.redox.2024.103248_bib52","first-page":"445","article-title":"Evaluation of liver fibrosis: \"Something old, something new\u2026\"","volume":"29","author":"Almpanis","year":"2016","journal-title":"Ann. Gastroenterol."},{"issue":"9","key":"10.1016\/j.redox.2024.103248_bib53","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1572-0241.1999.01377.x","article-title":"Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions","volume":"94","author":"Brunt","year":"1999","journal-title":"Am. J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib54","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib55","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/hep.22724","article-title":"Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network","volume":"49","author":"Brunt","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103248_bib56","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.freeradbiomed.2021.07.035","article-title":"Genetic mapping of renal glutathione suggests a novel regulatory locus on the murine X chromosome and overlap with hepatic glutathione regulation","volume":"174","author":"Gould","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib57","first-page":"263","article-title":"The mouse universal genotyping array","volume":"6","author":"Morgan","year":"2016","journal-title":"From Substrains to Subspecies, G3"},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib58","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1534\/genetics.118.301595","article-title":"R\/qtl2: software for mapping quantitative trait loci with high dimensional data and multi-parent populations","volume":"211","author":"Broman","year":"2019","journal-title":"Genetics"},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib59","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/ng.2876","article-title":"Advantages and pitfalls in the application of mixed-model association methods","volume":"46","author":"Yang","year":"2014","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib60","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/genetics\/159.1.371","article-title":"A statistical framework for quantitative trait mapping","volume":"159","author":"Sen","year":"2001","journal-title":"Genetics"},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib61","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/genetics\/138.3.963","article-title":"Empirical threshold values for quantitative trait mapping","volume":"138","author":"Churchill","year":"1994","journal-title":"Genetics"},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib62","first-page":"15","article-title":"That BLUP is a good thing: the estimation of random effects","volume":"6","author":"Robinson","year":"1991","journal-title":"Stat. Sci."},{"issue":"5\u20136","key":"10.1016\/j.redox.2024.103248_bib63","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00335-014-9508-0","article-title":"Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene, Mammalian genome","volume":"25","author":"Recla","year":"2014","journal-title":"official journal of the International Mammalian Genome Society"},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib64","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3892\/etm.2016.2968","article-title":"Assessment of the redox status in patients with metabolic syndrome and type 2 diabetes reveals great variations","volume":"11","author":"Spanidis","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"D1","key":"10.1016\/j.redox.2024.103248_bib65","doi-asserted-by":"crossref","first-page":"D723","DOI":"10.1093\/nar\/gkw1040","article-title":"Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse","volume":"45","author":"Blake","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.redox.2024.103248_bib66","doi-asserted-by":"crossref","first-page":"D746","DOI":"10.1093\/nar\/gkv1045","article-title":"Expression Atlas update--an integrated database of gene and protein expression in humans, animals and plants","volume":"44","author":"Petryszak","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.redox.2024.103248_bib67","doi-asserted-by":"crossref","first-page":"D730","DOI":"10.1093\/nar\/gkw1073","article-title":"The mouse gene expression database (GXD): 2017 update","volume":"45","author":"Finger","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.redox.2024.103248_bib68","doi-asserted-by":"crossref","first-page":"D190","DOI":"10.1093\/nar\/gkw1107","article-title":"InterPro in 2017-beyond protein family and domain annotations","volume":"45","author":"Finn","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib69","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"issue":"D1","key":"10.1016\/j.redox.2024.103248_bib70","doi-asserted-by":"crossref","first-page":"D331","DOI":"10.1093\/nar\/gkw1108","article-title":"Expansion of the gene ontology knowledgebase and resources","volume":"45","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib71","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41588-020-0622-5","article-title":"Exploring and visualizing large-scale genetic associations by using PheWeb","volume":"52","author":"Gagliano Taliun","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2024.103248_bib72","series-title":"Database 2011","article-title":"Ensembl BioMarts: a hub for data retrieval across taxonomic space","author":"Kinsella","year":"2011"},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib73","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ydbio.2006.12.014","article-title":"N-cadherin mediates cortical organization in the mouse brain","volume":"304","author":"Kadowaki","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.redox.2024.103248_bib74","doi-asserted-by":"crossref","first-page":"38","DOI":"10.20517\/2394-5079.2018.51","article-title":"Fat and hepatocellular carcinoma","volume":"4","author":"Balsano","year":"2018","journal-title":"Hepatoma Res"},{"key":"10.1016\/j.redox.2024.103248_bib75","unstructured":"D.H. Vroon, Z. Israili, Aminotransferases, Clinical Methods: the History, Physical, and Laboratory Examinations, Butterworths, Boston."},{"issue":"8","key":"10.1016\/j.redox.2024.103248_bib76","doi-asserted-by":"crossref","first-page":"547","DOI":"10.5483\/BMBRep.2010.43.8.547","article-title":"Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT","volume":"43","author":"Kim","year":"2010","journal-title":"BMB Rep"},{"key":"10.1016\/j.redox.2024.103248_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154140","article-title":"Epigenetic silencing of microRNA-125b-5p promotes liver fibrosis in nonalcoholic fatty liver disease via integrin \u03b18-mediated activation of RhoA signaling pathway","volume":"104","author":"Cai","year":"2020","journal-title":"Metabolism"},{"issue":"31","key":"10.1016\/j.redox.2024.103248_bib78","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.3748\/wjg.v25.i31.4300","article-title":"Methionine adenosyltransferases in liver cancer","volume":"25","author":"Murray","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.redox.2024.103248_bib79","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1053\/jhep.2003.50137","article-title":"Reduced hepatic tumor incidence in cyclin G1-deficient mice","volume":"37","author":"Jensen","year":"2003","journal-title":"Hepatology (Baltimore, Md"},{"issue":"21","key":"10.1016\/j.redox.2024.103248_bib80","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1128\/MCB.01472-09","article-title":"Loss of Par-1a\/MARK3\/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis","volume":"30","author":"Lennerz","year":"2010","journal-title":"Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.redox.2024.103248_bib81","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1128\/MCB.25.5.1869-1878.2005","article-title":"Role for Akt3\/protein kinase Bgamma in attainment of normal brain size","volume":"25","author":"Easton","year":"2005","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib82","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1128\/MCB.05806-11","article-title":"Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity","volume":"32","author":"Wan","year":"2012","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib83","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41575-019-0212-0","article-title":"Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology","volume":"17","author":"Eslam","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2024.103248_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155248","article-title":"Recent guidelines for non-alcoholic fatty liver disease (NAFLD)\/fatty liver disease (FLD): are they already outdated and in need of supplementation?","volume":"136","author":"Valenzuela-Vallejo","year":"2022","journal-title":"Metabolism"},{"issue":"11","key":"10.1016\/j.redox.2024.103248_bib85","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib86","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3748\/wjg.v20.i2.475","article-title":"Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"20","author":"Sumida","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib87","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1534\/genetics.111.132597","article-title":"High-resolution genetic mapping using the mouse diversity outbred population","volume":"190","author":"Svenson","year":"2012","journal-title":"Genetics"},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib88","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1038\/s41598-019-40153-0","article-title":"Systems genetics of hepatic metabolome reveals octopamine as a target for non-alcoholic fatty liver disease treatment","volume":"9","author":"Brial","year":"2019","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.redox.2024.103248_bib89","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/hep.20618","article-title":"Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration","volume":"41","author":"Mohammed","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103248_bib90","article-title":"Cadherins associate with distinct stem cell-related transcription factors to coordinate the maintenance of stemness in triple-negative breast cancer","volume":"2017","author":"Yang","year":"2017","journal-title":"Stem Cell. Int."},{"issue":"10","key":"10.1016\/j.redox.2024.103248_bib91","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3390\/cells8101118","article-title":"The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges","volume":"8","author":"Loh","year":"2019","journal-title":"Cells"},{"issue":"53","key":"10.1016\/j.redox.2024.103248_bib92","article-title":"Endothelial-to-Mesenchymal transition, vascular inflammation, and atherosclerosis","volume":"7","author":"Chen","year":"2020","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib93","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3892\/br.2016.578","article-title":"Epithelial-mesenchymal transition in liver fibrosis","volume":"4","author":"Zhao","year":"2016","journal-title":"Biomed Rep"},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib94","doi-asserted-by":"crossref","first-page":"C1200","DOI":"10.1152\/ajpcell.00062.2020","article-title":"New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease","volume":"318","author":"Sun","year":"2020","journal-title":"Am. J. Physiol.: Cell Physiol."},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib95","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bbrc.2016.10.084","article-title":"The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration","volume":"482","author":"Lauschke","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib96","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1002\/hep.23915","article-title":"miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice","volume":"52","author":"Meng","year":"2010","journal-title":"J. Hepatol."},{"issue":"16","key":"10.1016\/j.redox.2024.103248_bib97","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140134","article-title":"Effects of tesamorelin on hepatic transcriptomic signatures in HIV-associated NAFLD","volume":"5","author":"Fourman","year":"2020","journal-title":"JCI Insight"},{"issue":"12","key":"10.1016\/j.redox.2024.103248_bib98","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/hep4.1439","article-title":"A pilot genome-wide analysis study identifies loci associated with response to obeticholic acid in patients with NASH","volume":"3","author":"Gawrieh","year":"2019","journal-title":"Hepatol Commun"},{"issue":"S1","key":"10.1016\/j.redox.2024.103248_bib99","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2019.33.1_supplement.795.18","article-title":"Regulation of the hedgehog pathway by the ketogenic diet with radiation exposure","volume":"33","author":"Sharma","year":"2019","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"4","key":"10.1016\/j.redox.2024.103248_bib100","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1053\/j.gastro.2009.06.051","article-title":"Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease","volume":"137","author":"Syn","year":"2009","journal-title":"Gastroenterology"},{"issue":"7503","key":"10.1016\/j.redox.2024.103248_bib101","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.redox.2024.103248_bib102","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/pmic.201200210","article-title":"Proteomic and bioinformatic analysis of membrane proteome in type 2 diabetic mouse liver","volume":"13","author":"Kim","year":"2013","journal-title":"Proteomics"},{"key":"10.1016\/j.redox.2024.103248_bib103","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baw100","article-title":"The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins","volume":"2016","author":"Rouillard","year":"2016","journal-title":"Database"},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib104","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1293\/tox.2017-0038","article-title":"Increased hepatic inflammation in a normal-weight mouse after long-term high-fat diet feeding","volume":"31","author":"Toita","year":"2018","journal-title":"J. Toxicol. Pathol."},{"issue":"10","key":"10.1016\/j.redox.2024.103248_bib105","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1046\/j.1440-1746.2002.02846.x","article-title":"Fatty liver in non-alcoholic non-overweight Japanese adults: incidence and clinical characteristics","volume":"17","author":"Omagari","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2024.103248_bib106","doi-asserted-by":"crossref","first-page":"g4596","DOI":"10.1136\/bmj.g4596","article-title":"Non-alcoholic fatty liver disease","volume":"349","author":"Sattar","year":"2014","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.redox.2024.103248_bib107","doi-asserted-by":"crossref","first-page":"597","DOI":"10.4103\/2230-8210.163172","article-title":"Profile of liver enzymes in non-alcoholic fatty liver disease in patients with impaired glucose tolerance and newly detected untreated type 2 diabetes","volume":"19","author":"Sanyal","year":"2015","journal-title":"Indian J Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.redox.2024.103248_bib108","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/oby.22527","article-title":"Genome-wide association study identifies loci for liver enzyme concentrations in Mexican Americans: the GUARDIAN Consortium","volume":"27","author":"Young","year":"2019","journal-title":"Obesity"},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib109","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/oby.2011.236","article-title":"Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology","volume":"20","author":"Gutierrez-Aguilar","year":"2012","journal-title":"Obesity"},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib110","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/gepi.22392","article-title":"Genome-wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals","volume":"45","author":"Gao","year":"2021","journal-title":"Genet. Epidemiol."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib111","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2353\/ajpath.2009.080703","article-title":"High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model","volume":"175","author":"VanSaun","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib112","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/path.4829","article-title":"Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances","volume":"241","author":"Lau","year":"2017","journal-title":"J. Pathol."},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib113","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3390\/cancers3021480","article-title":"Role of methionine adenosyltransferase genes in hepatocarcinogenesis","volume":"3","author":"Ramani","year":"2011","journal-title":"Cancers"},{"issue":"42","key":"10.1016\/j.redox.2024.103248_bib114","doi-asserted-by":"crossref","first-page":"15552","DOI":"10.1073\/pnas.0603781103","article-title":"Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling","volume":"103","author":"Baba","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"26","key":"10.1016\/j.redox.2024.103248_bib115","doi-asserted-by":"crossref","first-page":"E3706","DOI":"10.1073\/pnas.1607592113","article-title":"Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity","volume":"113","author":"Siggs","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.redox.2024.103248_bib116","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.immuni.2012.02.019","article-title":"Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development","volume":"36","author":"Park","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2024.103248_bib117","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3491269","article-title":"TNIP1 in autoimmune diseases: regulation of toll-like receptor signaling","volume":"2018","author":"Shamilov","year":"2018","journal-title":"J Immunol Res"},{"issue":"6","key":"10.1016\/j.redox.2024.103248_bib118","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s10038-018-0440-0","article-title":"Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population","volume":"63","author":"Oka","year":"2018","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.redox.2024.103248_bib119","article-title":"Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease","author":"Xiang","year":"2021","journal-title":"Genes & Diseases"},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib120","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nm.4453","article-title":"The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat. Med."},{"issue":"31","key":"10.1016\/j.redox.2024.103248_bib121","doi-asserted-by":"crossref","first-page":"27953","DOI":"10.1074\/jbc.M203845200","article-title":"Metallochaperone Atox1 transfers copper to the NH2-terminal domain of the Wilson's disease protein and regulates its catalytic activity","volume":"277","author":"Walker","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.redox.2024.103248_bib122","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00335-002-2172-9","article-title":"Tissue localization of the copper chaperone ATOX1 and its potential role in disease","volume":"13","author":"Moore","year":"2002","journal-title":"Mamm. Genome : official journal of the International Mammalian Genome Society"},{"issue":"12","key":"10.1016\/j.redox.2024.103248_bib123","doi-asserted-by":"crossref","first-page":"6848","DOI":"10.1073\/pnas.111058498","article-title":"The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis","volume":"98","author":"Hamza","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib124","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/ame2.12036","article-title":"Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice","volume":"1","author":"Abu-Toamih Atamni","year":"2018","journal-title":"Animal Model Exp Med"},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib125","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00335-003-2308-6","article-title":"A large-sample QTL study in mice: II. Body composition","volume":"15","author":"Rocha","year":"2004","journal-title":"Mamm. Genome"},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib126","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/genetics\/150.1.369","article-title":"Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth","volume":"150","author":"Brockmann","year":"1998","journal-title":"Genetics"},{"issue":"12","key":"10.1016\/j.redox.2024.103248_bib127","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1101\/gr.149900","article-title":"Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA\/2 mice","volume":"10","author":"Brockmann","year":"2000","journal-title":"Genome Res."},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib128","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/genetics\/152.2.699","article-title":"Identification of quantitative trait loci influencing traits related to energy balance in selection and inbred lines of mice","volume":"152","author":"Moody","year":"1999","journal-title":"Genetics"},{"issue":"9","key":"10.1016\/j.redox.2024.103248_bib129","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1194\/jlr.M700222-JLR200","article-title":"Searching for genetic factors of fatty liver in SMXA-5 mice by quantitative trait loci analysis under a high-fat diet","volume":"48","author":"Kumazawa","year":"2007","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.redox.2024.103248_bib130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S0016672306007944","article-title":"Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice","volume":"87","author":"Yi","year":"2006","journal-title":"Genet. Res."},{"issue":"2","key":"10.1016\/j.redox.2024.103248_bib131","doi-asserted-by":"crossref","first-page":"a001560","DOI":"10.1101\/mcs.a001560","article-title":"AIFM1 mutation presenting with fatal encephalomyopathy and mitochondrial disease in an infant","volume":"3","author":"Morton","year":"2017","journal-title":"Cold Spring Harb Mol Case Stud"},{"issue":"3","key":"10.1016\/j.redox.2024.103248_bib132","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3892\/or.2017.5387","article-title":"Biology and function of glypican-3 as a candidate for early cancerous transformation of hepatocytes in hepatocellular carcinoma","volume":"37","author":"Montalbano","year":"2017","journal-title":"Oncol. Rep."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172400226X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172400226X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T15:44:36Z","timestamp":1724082276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221323172400226X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":132,"alternative-id":["S221323172400226X"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2024.103248","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2024.103248","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103248"}}