{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:49:55Z","timestamp":1793681395943,"version":"4.5.1"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["2024-0466-01"],"award-info":[{"award-number":["2024-0466-01"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["2023-0914-01"],"award-info":[{"award-number":["2023-0914-01"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2024-00339483"],"award-info":[{"award-number":["RS-2024-00339483"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.redox.2024.103269","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T06:28:54Z","timestamp":1721111334000},"page":"103269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Oxidative stress and the multifaceted roles of ATM in maintaining cellular redox homeostasis"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-935X","authenticated-orcid":false,"given":"Ji-Hoon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2024.103269_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.pa.36.040196.000503","article-title":"Oxidative stress in neurodegenerative diseases","volume":"36","author":"Simonian","year":"1996","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.redox.2024.103269_bib2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/antiox10030399","article-title":"Cellular oxidative stress","volume":"10","author":"Dossena","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2024.103269_bib3","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.3390\/ijms20102407","article-title":"Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases","volume":"20","author":"Collin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2024.103269_bib4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s12038-012-9218-2","article-title":"DNA damage by reactive species: mechanisms, mutation and repair","volume":"37","author":"Jena","year":"2012","journal-title":"J. Biosci."},{"key":"10.1016\/j.redox.2024.103269_bib5","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bbrc.2016.11.088","article-title":"The role of mitochondria in metabolism and cell death","volume":"482","author":"Vakifahmetoglu-Norberg","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2024.103269_bib6","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.redox.2024.103269_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.redox.2024.103269_bib8","doi-asserted-by":"crossref","first-page":"13908","DOI":"10.1074\/jbc.274.20.13908","article-title":"Mechanisms of protection of catalase by NADPH. Kinetics and stoichiometry","volume":"274","author":"Kirkman","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2024.103269_bib9","doi-asserted-by":"crossref","first-page":"1315S","DOI":"10.1093\/ajcn\/62.6.1315S","article-title":"Vitamins E and C, beta-carotene, and other carotenoids as antioxidants","volume":"62","author":"Sies","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.redox.2024.103269_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2013.03.022","article-title":"Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence","volume":"66","author":"Niki","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2024.103269_bib11","first-page":"1849","article-title":"Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice","volume":"61","author":"Kamsler","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2024.103269_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1568-7864(01)00007-6","article-title":"ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage","volume":"1","author":"Barzilai","year":"2002","journal-title":"DNA Repair"},{"key":"10.1016\/j.redox.2024.103269_bib13","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.redox.2024.103269_bib14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2024.103269_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tibs.2011.10.002","article-title":"The ATM protein kinase and cellular redox signaling: beyond the DNA damage response","volume":"37","author":"Ditch","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.redox.2024.103269_bib16","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1038\/sj.onc.1210872","article-title":"Activation and regulation of ATM kinase activity in response to DNA double-strand breaks","volume":"26","author":"Lee","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2024.103269_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-021-00394-2","article-title":"Cellular functions of the protein kinase ATM and their relevance to human disease","author":"Lee","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2024.103269_bib18","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev-biochem-060614-034335","article-title":"Mechanisms of ATM activation","volume":"84","author":"Paull","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.redox.2024.103269_bib19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1108297","article-title":"ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex","volume":"308","author":"Lee","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.redox.2024.103269_bib20","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1093\/emboj\/cdg541","article-title":"Requirement of the MRN complex for ATM activation by DNA damage","volume":"22","author":"Uziel","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2024.103269_bib21","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.redox.2024.103269_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aan5598","article-title":"ATM directs DNA damage responses and proteostasis via genetically separable pathways","volume":"11","author":"Lee","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.redox.2024.103269_bib23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.redox.2024.103269_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaq0702","article-title":"Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity","volume":"11","author":"Zhang","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.redox.2024.103269_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0165-7992(90)90137-9","article-title":"Superoxide dismutase activity and chromosome damage in cultured chromosome instability syndrome cells","volume":"244","author":"Lee","year":"1990","journal-title":"Mutat. Res."},{"key":"10.1016\/j.redox.2024.103269_bib26","first-page":"538","article-title":"Deficiency in the catalase activity of xeroderma pigmentosum cell and simian virus 40-transformed human cell extracts","volume":"46","author":"Vuillaume","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2024.103269_bib27","doi-asserted-by":"crossref","first-page":"34277","DOI":"10.1074\/jbc.274.48.34277","article-title":"Localization of a portion of extranuclear ATM to peroxisomes","volume":"274","author":"Watters","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2024.103269_bib28","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/labinvest.3700354","article-title":"ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes","volume":"85","author":"Liu","year":"2005","journal-title":"Lab. Invest."},{"key":"10.1016\/j.redox.2024.103269_bib29","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nature02989","article-title":"Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells","volume":"431","author":"Ito","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.redox.2024.103269_bib30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/ana.1005","article-title":"Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia","volume":"49","author":"Quick","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.redox.2024.103269_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aan5598","article-title":"ATM directs DNA damage responses and proteostasis via genetically separable pathways","volume":"11","author":"Lee","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.redox.2024.103269_bib32","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1083\/jcb.201806197","article-title":"ATM is activated by ATP depletion and modulates mitochondrial function through NRF1","volume":"218","author":"Chow","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.redox.2024.103269_bib33","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1365-2249.1999.01000.x","article-title":"Anti-oxidative capacity in patients with ataxia telangiectasia","volume":"117","author":"Reichenbach","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.redox.2024.103269_bib34","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1089\/15230860260196254","article-title":"Elevated oxidative stress in patients with ataxia telangiectasia","volume":"4","author":"Reichenbach","year":"2002","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2024.103269_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pharmthera.2015.11.003","article-title":"Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases","volume":"157","author":"Buendia","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.redox.2024.103269_bib36","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1073\/pnas.0700898104","article-title":"A genomic screen for activators of the antioxidant response element","volume":"104","author":"Liu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2024.103269_bib37","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1089\/ars.2010.3222","article-title":"Discovery of the negative regulator of Nrf2, Keap1: a historical overview","volume":"13","author":"Itoh","year":"2010","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2024.103269_bib38","first-page":"994","article-title":"Oxidative stress as a therapeutic perspective for ATM-deficient chronic lymphocytic leukemia patients","volume":"100","author":"Navrkalova","year":"2015","journal-title":"Haematologica"},{"key":"10.1016\/j.redox.2024.103269_bib39","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1084\/jem.20121337","article-title":"BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival","volume":"210","author":"Gorrini","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.redox.2024.103269_bib40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","article-title":"Activation of Nrf2\/HO-1 signaling: an important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress","volume":"34","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.redox.2024.103269_bib41","article-title":"Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress","author":"Cirotti","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.redox.2024.103269_bib42","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103111","article-title":"ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress","volume":"39","author":"Guo","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2024.103269_bib43","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1093\/hmg\/ddm166","article-title":"Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells","volume":"16","author":"Ambrose","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.redox.2024.103269_bib44","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2011-08-373639","article-title":"Mitochondrial dysfunction in ataxia-telangiectasia","volume":"119","author":"Valentin-Vega","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.redox.2024.103269_bib45","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/hmg\/ddh189","article-title":"Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice","volume":"13","author":"Schubert","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.redox.2024.103269_bib46","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1172\/JCI31604","article-title":"Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis","volume":"117","author":"Eaton","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.redox.2024.103269_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113402","article-title":"ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress","volume":"42","author":"Liu","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2024.103269_bib48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1182\/blood-2008-04-151639","article-title":"Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation","volume":"114","author":"Zhang","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.redox.2024.103269_bib49","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1073\/pnas.1418139112","article-title":"NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease","volume":"112","author":"Weyemi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.redox.2024.103269_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700933","article-title":"Structures of closed and open conformations of dimeric human ATM","volume":"3","author":"Bareti\u0107","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.redox.2024.103269_bib51","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41594-021-00654-x","article-title":"Molecular basis of human ATM kinase inhibition","volume":"28","author":"Stakyte","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.redox.2024.103269_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74218","article-title":"Structure of the human ATM kinase and mechanism of Nbs1 binding","volume":"11","author":"Warren","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.redox.2024.103269_bib53","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41422-019-0205-0","article-title":"Structural insights into the activation of ATM kinase","volume":"29","author":"Xiao","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2024.103269_bib54","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1080\/15384101.2016.1158362","article-title":"Structure of the human dimeric ATM kinase","volume":"15","author":"Lau","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.redox.2024.103269_bib55","article-title":"Structure of the intact ATM\/Tel1 kinase","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2024.103269_bib56","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.str.2019.10.013","article-title":"Near-complete structure and model of Tel1ATM from chaetomium thermophilum reveals a robust autoinhibited ATP state","volume":"28","author":"Jansma","year":"2020","journal-title":"Structure"},{"key":"10.1016\/j.redox.2024.103269_bib57","doi-asserted-by":"crossref","first-page":"13436","DOI":"10.1074\/jbc.M115.708263","article-title":"The dimeric architecture of checkpoint kinases Mec1ATR and Tel1ATM reveal a common structural organization","volume":"291","author":"Sawicka","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2024.103269_bib58","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41422-019-0176-1","article-title":"Structural basis of allosteric regulation of Tel1\/ATM kinase","volume":"29","author":"Xin","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2024.103269_bib59","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.str.2019.10.012","article-title":"Cryo-EM structure of nucleotide-bound Tel1ATM unravels the molecular basis of inhibition and structural rationale for disease-associated mutations","volume":"28","author":"Yates","year":"2020","journal-title":"Structure"},{"key":"10.1016\/j.redox.2024.103269_bib60","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.redox.2024.103269_bib61","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1091496","article-title":"Direct activation of the ATM protein kinase by the Mre11\/Rad50\/Nbs1 complex","volume":"304","author":"Lee","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.redox.2024.103269_bib62","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1108297","article-title":"ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex","volume":"308","author":"Lee","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.redox.2024.103269_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi8291","article-title":"Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress","volume":"9","author":"Howes","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.redox.2024.103269_bib64","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1128\/MCB.01382-07","article-title":"DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity","volume":"27","author":"Sun","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.redox.2024.103269_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101674","article-title":"Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement","author":"Nolfi-Donegan","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2024.103269_bib66","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.redox.2024.103269_bib67","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0959-4388(96)80100-0","article-title":"Mitochondria, free radicals, and neurodegeneration","volume":"6","author":"Beal","year":"1996","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.redox.2024.103269_bib68","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.redox.2024.103269_bib69","doi-asserted-by":"crossref","first-page":"rs3","DOI":"10.1126\/scisignal.2001034","article-title":"ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage","volume":"3","author":"Bensimon","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.redox.2024.103269_bib70","doi-asserted-by":"crossref","first-page":"9915","DOI":"10.1073\/pnas.96.17.9915","article-title":"Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs","volume":"96","author":"Barlow","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.redox.2024.103269_bib71","doi-asserted-by":"crossref","first-page":"14396","DOI":"10.1074\/jbc.M808116200","article-title":"Oxidative stress is linked to ERK1\/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes","volume":"284","author":"Kim","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2024.103269_bib72","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/mt.2012.203","article-title":"Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia","volume":"21","author":"D'Souza","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.redox.2024.103269_bib73","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1158\/0008-5472.CAN-04-0442","article-title":"Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice","volume":"64","author":"Reliene","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2024.103269_bib74","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.molcel.2021.01.019","article-title":"Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency","volume":"81","author":"Lee","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2024.103269_bib75","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6745840","article-title":"Comparison of selected parameters of redox homeostasis in patients with ataxia-telangiectasia and nijmegen breakage syndrome","volume":"2017","author":"Pietrucha","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2024.103269_bib76","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-5793(00)01422-8","article-title":"Protective roles for ATM in cellular response to oxidative stress","volume":"472","author":"Takao","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.redox.2024.103269_bib77","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1179\/135100003125001206","article-title":"Oxidative stress in ataxia telangiectasia","volume":"8","author":"Watters","year":"2003","journal-title":"Redox Rep."},{"key":"10.1016\/j.redox.2024.103269_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2024.103647","article-title":"A-T neurodegeneration and DNA damage-induced transcriptional stress","volume":"135","author":"Paull","year":"2024","journal-title":"DNA Repair"},{"key":"10.1016\/j.redox.2024.103269_bib79","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ajmg.1320420524","article-title":"Heterogeneity in ataxia-telangiectasia: classical phenotype associated with intermediate cellular radiosensitivity","volume":"42","author":"Chessa","year":"1992","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.redox.2024.103269_bib80","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1086\/301755","article-title":"Genotype-phenotype relationships in ataxia-telangiectasia and variants","volume":"62","author":"Gilad","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.redox.2024.103269_bib81","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<141::AID-AJMG4>3.0.CO;2-W","article-title":"Ataxia-telangiectasia without immunodeficiency: novel point mutations within and adjacent to the phosphatidylinositol 3-kinase-like domain","volume":"75","author":"Toyoshima","year":"1998","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.redox.2024.103269_bib82","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.tcb.2022.04.010","article-title":"DNA single-strand break repair and human genetic disease","volume":"32","author":"Caldecott","year":"2022","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.redox.2024.103269_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113896","article-title":"Regulation of transcription patterns, poly(ADP-ribose), and RNA-DNA hybrids by the ATM protein kinase","volume":"43","author":"Woolley","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2024.103269_bib84","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1093\/nar\/gkaa140","article-title":"Atm deficiency in the DNA polymerase \u03b2 null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation","volume":"48","author":"Kim","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2024.103269_bib85","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1212\/01.wnl.0000311277.71046.a0","article-title":"Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families","volume":"71","author":"Hara","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.redox.2024.103269_bib86","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1750-1172-7-67","article-title":"Missense mutations in ITPR1 cause autosomal dominant congenital nonprogressive spinocerebellar ataxia","volume":"7","author":"Huang","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.redox.2024.103269_bib87","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/1570159X15666170529104000","article-title":"Calcium signaling, PKC gamma, IP3R1 and CAR8 link spinocerebellar ataxias and purkinje cell dendritic development","volume":"16","author":"Shimobayashi","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.redox.2024.103269_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000487","article-title":"CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait","volume":"5","author":"T\u00fcrkmen","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.redox.2024.103269_bib89","doi-asserted-by":"crossref","first-page":"9256","DOI":"10.1128\/MCB.01125-06","article-title":"ATM and ATR pathways signal alternative splicing of Drosophila TAF1 pre-mRNA in response to DNA damage","volume":"26","author":"Katzenberger","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.redox.2024.103269_bib90","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2009.03.010","article-title":"DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation","volume":"137","author":"Mu\u00f1oz","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.redox.2024.103269_bib91","doi-asserted-by":"crossref","first-page":"24171","DOI":"10.1074\/jbc.M401049200","article-title":"UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation","volume":"279","author":"Nicholls","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2024.103269_bib92","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090219","article-title":"R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias","volume":"9","author":"Yeo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2024.103269_bib93","article-title":"RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana","volume":"7","author":"Su","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2024.103269_bib94","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.freeradbiomed.2004.01.003","article-title":"Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice","volume":"36","author":"Browne","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2024.103269_bib95","doi-asserted-by":"crossref","first-page":"11453","DOI":"10.1523\/JNEUROSCI.23-36-11453.2003","article-title":"Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice","volume":"23","author":"Chen","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.redox.2024.103269_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107916","article-title":"The mechanism of action of N-acetylcysteine (NAC): the emerging role of H2S and sulfane sulfur species","volume":"228","author":"Pedre","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.redox.2024.103269_bib97","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/10715762.2018.1468564","article-title":"N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why","volume":"52","author":"Aldini","year":"2018","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.redox.2024.103269_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102497","article-title":"Knockin\u2019 on Heaven's door: interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells","volume":"57","author":"Kalyanaraman","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2024.103269_bib99","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.4049\/jimmunol.178.8.4757","article-title":"Regulation of oxidative stress responses by ataxia-telangiectasia mutated is required for T cell proliferation","volume":"178","author":"Bagley","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.redox.2024.103269_bib100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058239","article-title":"ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells","volume":"8","author":"Alagoz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2024.103269_bib101","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cmet.2016.09.004","article-title":"NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair","volume":"24","author":"Fang","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.redox.2024.103269_bib102","doi-asserted-by":"crossref","first-page":"7471","DOI":"10.1073\/pnas.1820245116","article-title":"Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis","volume":"116","author":"Weyemi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.redox.2024.103269_bib103","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/s41467-018-03948-9","article-title":"Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis","volume":"9","author":"Weyemi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2024.103269_bib104","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature14512","article-title":"The core spliceosome as target and effector of non-canonical ATM signalling","volume":"523","author":"Tresini","year":"2015","journal-title":"Nature"},{"issue":"Suppl","key":"10.1016\/j.redox.2024.103269_bib105","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.redox.2024.103269_bib106","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg6363","article-title":"Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration","volume":"7","author":"Kwak","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.redox.2024.103269_bib107","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41586-022-05545-9","article-title":"R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response","volume":"613","author":"Crossley","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.redox.2024.103269_bib108","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1101\/gad.301325.117","article-title":"Genome integrity and disease prevention in the nervous system","volume":"31","author":"McKinnon","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.redox.2024.103269_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113622","article-title":"ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia","volume":"43","author":"Lai","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2024.103269_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101972","article-title":"Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia","volume":"24","author":"Yeo","year":"2021","journal-title":"iScience"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:03:03Z","timestamp":1778853783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231724002477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":110,"alternative-id":["S2213231724002477"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2024.103269","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress and the multifaceted roles of ATM in maintaining cellular redox homeostasis","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2024.103269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103269"}}