{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:55:21Z","timestamp":1790690121602,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["N-227205"],"award-info":[{"award-number":["N-227205"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016981","name":"Pharmaceutical Society of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016981","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.redox.2024.103314","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T02:26:40Z","timestamp":1723861600000},"page":"103314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation"],"prefix":"10.1016","volume":"76","author":[{"given":"Hiroki","family":"Yanagisawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-5337","authenticated-orcid":false,"given":"Isamu","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisei","family":"Nagasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gai","family":"Kanazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Tuan Giam","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kitagishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Iwakiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Otagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2024.103314_bib1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jhep.2004.09.012","article-title":"The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies","volume":"42","author":"Adams","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib2","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.redox.2024.103314_bib3","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/hep.26986","article-title":"Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S","volume":"59","author":"Wong","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2024.103314_bib4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S1470-2045(22)00078-X","article-title":"Clinical characteristics, surveillance, treatment allocation, and outcomes of non-alcoholic fatty liver disease-related hepatocellular carcinoma: a systematic review and meta-analysis","volume":"23","author":"Tan","year":"2022","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.redox.2024.103314_bib5","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1080\/13543784.2020.1839888","article-title":"The nonalcoholic steatohepatitis (NASH) drug development graveyard: established hurdles and planning for future success","volume":"29","author":"Drenth","year":"2020","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.redox.2024.103314_bib6","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa2036205","article-title":"A randomized, controlled trial of the pan-PPAR agonist lanifibranor in NASH","volume":"385","author":"Francque","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.redox.2024.103314_bib7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/med.21991","article-title":"FXR agonists for MASH therapy: lessons and perspectives from obeticholic acid","volume":"44","author":"Wang","year":"2024","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.redox.2024.103314_bib8","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jhep.2023.07.014","article-title":"Results from a new efficacy and safety analysis of the REGENERATE trial of obeticholic acid for treatment of pre-cirrhotic fibrosis due to non-alcoholic steatohepatitis","volume":"79","author":"Sanyal","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/13543784.2020.1668374","article-title":"GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)","volume":"29","author":"Alkhouri","year":"2020","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.redox.2024.103314_bib10","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/hep.31108","article-title":"Cenicriviroc treatment for adults with nonalcoholic steatohepatitis and fibrosis: final analysis of the phase 2b CENTAUR study","volume":"72","author":"Ratziu","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2024.103314_bib11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cgh.2023.04.003","article-title":"Cenicriviroc lacked efficacy to treat liver fibrosis in nonalcoholic steatohepatitis: AURORA phase III randomized study","volume":"22","author":"Anstee","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.redox.2024.103314_bib13","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/j.cgh.2023.03.041","article-title":"Clinical trial landscape in NASH","volume":"21","author":"Harrison","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41575-023-00796-x","article-title":"Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach","volume":"20","author":"Brennan","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib15","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1089\/ars.2021.0048","article-title":"The aging liver: redox biology and liver regeneration","volume":"35","author":"Bellanti","year":"2021","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2024.103314_bib16","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jhep.2021.05.041","article-title":"Loss of hepatocyte identity following aberrant YAP activation: a key mechanism in alcoholic hepatitis","volume":"75","author":"Bou Saleh","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib17","article-title":"The impact of steatosis on liver regeneration","volume":"41","author":"Allaire","year":"2018","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"key":"10.1016\/j.redox.2024.103314_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/hep.510310108","article-title":"Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway","volume":"31","author":"Selzner","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2024.103314_bib19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/liv.12089","article-title":"The impact of hepatic steatosis on liver regeneration after partial hepatectomy","volume":"33","author":"Kele","year":"2013","journal-title":"Liver Int."},{"key":"10.1016\/j.redox.2024.103314_bib20","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.jhep.2022.06.019","article-title":"Augmenter of liver regeneration: mitochondrial function and steatohepatitis","volume":"77","author":"Verma","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11030555","article-title":"Heme oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders","volume":"11","author":"Ryter","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2024.103314_bib22","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1089\/ars.2021.0080","article-title":"The protective role of the heme catabolic pathway in hepatic disorders","volume":"35","author":"V\u00edtek","year":"2021","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2024.103314_bib23","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","article-title":"The therapeutic potential of carbon monoxide","volume":"9","author":"Motterlini","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.redox.2024.103314_bib24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1471-4906(03)00181-9","article-title":"Heme oxygenase-1: unleashing the protective properties of heme","volume":"24","author":"Otterbein","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.redox.2024.103314_bib25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1476-511X-9-124","article-title":"Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice","volume":"9","author":"Nan","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.redox.2024.103314_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117678","article-title":"Heme oxygenase-1 alleviated non-alcoholic fatty liver disease via suppressing ROS-dependent endoplasmic reticulum stress","volume":"253","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.redox.2024.103314_bib27","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1096\/fj.06-6644com","article-title":"Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species","volume":"21","author":"Zuckerbraun","year":"2007","journal-title":"Faseb. J."},{"key":"10.1016\/j.redox.2024.103314_bib28","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/jat.2806","article-title":"Low dose of carbon monoxide intraperitoneal injection provides potent protection against GalN\/LPS-induced acute liver injury in mice","volume":"33","author":"Wen","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.redox.2024.103314_bib29","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/74680","article-title":"Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway","volume":"6","author":"Otterbein","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.redox.2024.103314_bib30","doi-asserted-by":"crossref","first-page":"17950","DOI":"10.1074\/jbc.M108317200","article-title":"Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis","volume":"277","author":"Brouard","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2024.103314_bib31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.cca.2005.09.011","article-title":"Carbon monoxide and nitric oxide protect against tumor necrosis factor-alpha-induced apoptosis in osteoblasts: HO-1 is necessary to mediate the protection","volume":"365","author":"Chae","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.redox.2024.103314_bib32","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1084\/jem.20060845","article-title":"Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts","volume":"203","author":"Nakahira","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.redox.2024.103314_bib33","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1172\/JCI71362","article-title":"Carbon monoxide-based therapy ameliorates acute pancreatitis via TLR4 inhibition","volume":"124","author":"Xue","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.redox.2024.103314_bib34","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bcp.2015.07.035","article-title":"Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1\/TLR-4 pathway during resuscitation from hemorrhagic shock","volume":"97","author":"Ogaki","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.redox.2024.103314_bib35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2017.05.026","article-title":"Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2\u03b1-ATF4 pathway","volume":"110","author":"Kim","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2024.103314_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102371","article-title":"A bioinspired carbon monoxide delivery system prevents acute kidney injury and the progression to chronic kidney disease","volume":"54","author":"Nagasaki","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2024.103314_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2024.04.231","article-title":"Carbon monoxide-loaded cell therapy as an exercise mimetic for sarcopenia treatment","author":"Noguchi","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2024.103314_bib38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1124\/dmd.112.048744","article-title":"Carbon monoxide-bound red blood cells protect red blood cell transfusion-induced hepatic cytochrome P450 impairment in hemorrhagic-shock rats","volume":"41","author":"Ogaki","year":"2013","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.redox.2024.103314_bib39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jconrel.2021.11.039","article-title":"Nitric oxide facilitates the targeting Kupffer cells of a nano-antioxidant for the treatment of NASH","volume":"341","author":"Maeda","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.redox.2024.103314_bib40","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/j.1478-3231.2009.02006.x","article-title":"Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue","volume":"29","author":"Kudo","year":"2009","journal-title":"Liver Int."},{"key":"10.1016\/j.redox.2024.103314_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106786","article-title":"Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)","volume":"192","author":"Qiu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.redox.2024.103314_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1199519","article-title":"Activation of Kupffer cells in NAFLD and NASH: mechanisms and therapeutic interventions","volume":"11","author":"Xu","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.redox.2024.103314_bib43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41574-022-00675-6","article-title":"Macrophage functional diversity in NAFLD - more than inflammation","volume":"18","author":"Barreby","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.redox.2024.103314_bib44","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/hep.1840200227","article-title":"Inactivation of Kupffer cells prevents early alcohol-induced liver injury","volume":"20","author":"Adachi","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2024.103314_bib45","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jhep.2007.04.019","article-title":"Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis","volume":"47","author":"Rivera","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib46","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/jcb.25453","article-title":"Dietary saturated fat promotes development of hepatic inflammation through toll-like receptor 4 in mice","volume":"117","author":"Sutter","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.redox.2024.103314_bib47","doi-asserted-by":"crossref","first-page":"E730","DOI":"10.1152\/ajpendo.00225.2016","article-title":"Treatment of nonalcoholic fatty liver disease: role of AMPK","volume":"311","author":"Smith","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.redox.2024.103314_bib48","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ebiom.2018.01.008","article-title":"AMPK Re-activation suppresses hepatic steatosis but its downregulation does not promote fatty liver development","volume":"28","author":"Boudaba","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.redox.2024.103314_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154589","article-title":"Phytochemical gallic acid alleviates nonalcoholic fatty liver disease via AMPK-ACC-PPARa axis through dual regulation of lipid metabolism and mitochondrial function","volume":"109","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.redox.2024.103314_bib50","article-title":"PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2024.103314_bib51","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jhep.2005.07.031","article-title":"Ethanol reduces p38 kinase activation and cyclin D1 protein expression after partial hepatectomy in rats","volume":"44","author":"Hsu","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib52","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0168-8278(97)80266-8","article-title":"Liver regeneration: methods for monitoring and their applications","volume":"26","author":"Assy","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib53","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/hep.28440","article-title":"Akt-FoxO1 axis controls liver regeneration","volume":"63","author":"Valanejad","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2024.103314_bib54","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hep.31056","article-title":"Increased liver localization of lipopolysaccharides in human and experimental NAFLD","volume":"72","author":"Carpino","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2024.103314_bib55","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1002\/asia.201100354","article-title":"Preparation and function of poly(acrylic acid)s modified by supramolecular complex composed of porphinatoiron and a cyclodextrin dimer that bind diatomic molecules (O2 and CO) in aqueous solution","volume":"6","author":"Kano","year":"2011","journal-title":"Chem. Asian J."},{"key":"10.1016\/j.redox.2024.103314_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101314","article-title":"Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and mitochondrial function","volume":"28","author":"Upadhyay","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2024.103314_bib57","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00394-013-0594-7","article-title":"Adiponectin receptor 1 enhances fatty acid metabolism and cell survival in palmitate-treated HepG2 cells through the PI3 K\/AKT pathway","volume":"53","author":"Chou","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.redox.2024.103314_bib58","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202203286","article-title":"Fatty liver\/adipose tissue dual-targeting nanoparticles with heme oxygenase-1 inducer for amelioration of obesity, obesity-induced type 2 diabetes, and steatohepatitis","volume":"9","author":"Hong","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.redox.2024.103314_bib59","doi-asserted-by":"crossref","first-page":"278","DOI":"10.5812\/hepatmon.846","article-title":"Heme oxygenase-1 mRNA expression in egyptian patients with chronic liver disease","volume":"12","author":"Bessa","year":"2012","journal-title":"Hepat. Mon."},{"key":"10.1016\/j.redox.2024.103314_bib60","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1084\/jem.20031003","article-title":"Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1","volume":"198","author":"Zuckerbraun","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.redox.2024.103314_bib61","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-230X-10-42","article-title":"Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats","volume":"10","author":"Wei","year":"2010","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.redox.2024.103314_bib62","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.135626","article-title":"Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease","volume":"6","author":"Selen","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.redox.2024.103314_bib63","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tem.2017.05.004","article-title":"AMPK as a therapeutic target for treating metabolic diseases","volume":"28","author":"Day","year":"2017","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.redox.2024.103314_bib64","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.freeradbiomed.2017.01.022","article-title":"Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus","volume":"104","author":"Wilson","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2024.103314_bib65","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.abe7565","article-title":"Structure of an AMPK complex in an inactive, ATP-bound state","volume":"373","author":"Yan","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.redox.2024.103314_bib66","first-page":"5390","article-title":"Potential roles of AMP-activated protein kinase in liver regeneration in mice with acute liver injury","volume":"17","author":"Huang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.redox.2024.103314_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103104","article-title":"Danger-associated molecular patterns (DAMPs): molecular triggers for sterile inflammation in the liver","volume":"19","author":"Mihm","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2024.103314_bib68","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jconrel.2016.05.016","article-title":"Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis","volume":"234","author":"Nagao","year":"2016","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.redox.2024.103314_bib69","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.2147\/IJN.S118185","article-title":"Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties","volume":"11","author":"Nagao","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.redox.2024.103314_bib70","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jhep.2023.03.038","article-title":"An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH","volume":"79","author":"Tacke","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib71","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41577-021-00639-3","article-title":"Immune cell-mediated features of non-alcoholic steatohepatitis","volume":"22","author":"Huby","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.redox.2024.103314_bib72","article-title":"Resmetirom: first approval","author":"Keam","year":"2024","journal-title":"Drugs"},{"key":"10.1016\/j.redox.2024.103314_bib73","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.3350\/cmh.2022.0367","article-title":"MAFLD: how is it different from NAFLD?","volume":"29","author":"Gofton","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib74","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/hep.32499","article-title":"Are there outcome differences between NAFLD and metabolic-associated fatty liver disease?","volume":"76","author":"Younossi","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2024.103314_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22084156","article-title":"Role of insulin resistance in MAFLD","volume":"22","author":"Sakurai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2024.103314_bib76","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123485","article-title":"Carbon monoxide-induced metabolic switch in adipocytes improves insulin resistance in obese mice","volume":"3","author":"Braud","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.redox.2024.103314_bib77","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1097\/HEP.0000000000000520","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2024.103314_bib78","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","article-title":"Liver regeneration - mechanisms and models to clinical application","volume":"13","author":"Forbes","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2024.103314_bib79","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136774","article-title":"Mouse CD11b+Kupffer cells recruited from bone marrow accelerate liver regeneration after partial hepatectomy","volume":"10","author":"Nishiyama","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2024.103314_bib80","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2024.103314_bib81","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jconrel.2023.01.039","article-title":"Albumin-fused long-acting FGF21 analogue for the treatment of non-alcoholic fatty liver disease","volume":"355","author":"Chikamatsu","year":"2023","journal-title":"J. Contr. Release"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:02:45Z","timestamp":1778853765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231724002921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":81,"alternative-id":["S2213231724002921"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2024.103314","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2024.103314","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103314"}}