{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:29:56Z","timestamp":1791995396801,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["S13 SI 0592"],"award-info":[{"award-number":["S13 SI 0592"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT 153159"],"award-info":[{"award-number":["PJT 153159"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["436138-2013"],"award-info":[{"award-number":["436138-2013"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2017-0351"],"award-info":[{"award-number":["2017-0351"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2018-06324"],"award-info":[{"award-number":["2018-06324"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012171","name":"Ontario Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001571","name":"James H. Cummings Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.redox.2024.103319","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T03:05:53Z","timestamp":1724123153000},"page":"103319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20"],"prefix":"10.1016","volume":"76","author":[{"given":"Meghan C.","family":"Hughes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofhia V.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya N.","family":"Brahmbhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"Turnbull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazari N.","family":"Polidovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison C.","family":"Garibotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Schlattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Hawke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Backx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-5888","authenticated-orcid":false,"given":"Christopher GR.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2024.103319_bib1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/humu.22758","article-title":"The TREAT-NMD DMD Global Database: analysis of more than 7,000 Duchenne muscular dystrophy mutations","volume":"36","author":"Bladen","year":"2015","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.redox.2024.103319_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00007.2015","article-title":"Absence of dystrophin disrupts skeletal muscle signaling: roles of Ca2+, reactive oxygen species, and nitric oxide in the development of muscular dystrophy","volume":"96","author":"Allen","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2024.103319_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13023-021-01758-9","article-title":"Standard of care versus new-wave corticosteroids in the treatment of Duchenne muscular dystrophy: can we do better?","volume":"16","author":"Kourakis","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.redox.2024.103319_bib4","doi-asserted-by":"crossref","DOI":"10.1177\/17562864231182934","article-title":"Cardiac therapies for Duchenne muscular dystrophy","volume":"16","author":"Shah","year":"2023","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.redox.2024.103319_bib5","doi-asserted-by":"crossref","first-page":"C718","DOI":"10.1152\/ajpcell.00249.2022","article-title":"Mitochondrial stress responses in Duchenne muscular dystrophy: metabolic dysfunction or adaptive reprogramming?","volume":"323","author":"Bellissimo","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.redox.2024.103319_bib6","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1113\/JP277306","article-title":"Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy","volume":"598","author":"Hughes","year":"2020","journal-title":"J. Physiol."},{"key":"10.1016\/j.redox.2024.103319_bib7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/jcsm.12405","article-title":"Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2 O2 emission during impaired oxidative phosphorylation","volume":"10","author":"Hughes","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.redox.2024.103319_bib8","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00726-011-0877-3","article-title":"The creatine kinase system and pleiotropic effects of creatine","volume":"40","author":"Wallimann","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.redox.2024.103319_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/978-981-10-7757-9_13","article-title":"Mitochondrial proteolipid complexes of creatine kinase","volume":"87","author":"Schlattner","year":"2018","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.redox.2024.103319_bib10","doi-asserted-by":"crossref","first-page":"37361","DOI":"10.1074\/jbc.M604123200","article-title":"Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity","volume":"281","author":"Meyer","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2024.103319_bib11","series-title":"Bioenergetics 4","author":"Nicholls","year":"2013"},{"key":"10.1016\/j.redox.2024.103319_bib12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.exger.2010.03.014","article-title":"How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis)","volume":"45","author":"Ristow","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.redox.2024.103319_bib13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10557-016-6695-9","article-title":"Cardioprotective effects of mitochondria-targeted peptide SBT-20 in two different models of rat ischemia\/reperfusion","volume":"30","author":"Dai","year":"2016","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.redox.2024.103319_bib14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1113\/jphysiol.2001.012858","article-title":"The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle","volume":"537","author":"Walsh","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.redox.2024.103319_bib15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1042\/BJ20110366","article-title":"Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle","volume":"437","author":"Perry","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.redox.2024.103319_bib16","doi-asserted-by":"crossref","first-page":"37361","DOI":"10.1074\/jbc.M604123200","article-title":"Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity","volume":"281","author":"Meyer","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2024.103319_bib17","doi-asserted-by":"crossref","first-page":"C1141","DOI":"10.1152\/ajpcell.00377.2022","article-title":"Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime","volume":"324","author":"Bellissimo","year":"2023","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.redox.2024.103319_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237138","article-title":"Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle","volume":"15","author":"Ramos","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2024.103319_bib19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/hmg\/ddv460","article-title":"Effect of genetic background on the dystrophic phenotype in mdx mice","volume":"25","author":"Coley","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.redox.2024.103319_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/cvr\/cvt009","article-title":"Redox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondria","volume":"98","author":"Frasier","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2024.103319_bib21","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.yjmcc.2012.02.009","article-title":"Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury","volume":"52","author":"Sloan","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.redox.2024.103319_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cbi.2018.12.003","article-title":"Protein S-glutathionylation: the linchpin for the transmission of regulatory information on redox buffering capacity in mitochondria","volume":"299","author":"Young","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.redox.2024.103319_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101472","article-title":"Protein S-glutathionylation reactions as a global inhibitor of cell metabolism for the desensitization of hydrogen peroxide signals","volume":"32","author":"Mailloux","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2024.103319_bib24","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1074\/jbc.M208572200","article-title":"Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues","volume":"278","author":"Wendt","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2024.103319_bib25","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/clpt.2014.174","article-title":"Serendipity and the discovery of novel compounds that restore mitochondrial plasticity","volume":"96","author":"Szeto","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.redox.2024.103319_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1124\/jpet.102.040147","article-title":"Transcellular transport of a highly polar 3+ net charge opioid tetrapeptide","volume":"304","author":"Zhao","year":"2003","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.redox.2024.103319_bib27","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1681\/ASN.2012121216","article-title":"The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin","volume":"24","author":"Birk","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.redox.2024.103319_bib28","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1089\/ars.2007.1892","article-title":"Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury","volume":"10","author":"Szeto","year":"2008","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2024.103319_bib29","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.bbabio.2015.06.006","article-title":"Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia","volume":"1847","author":"Birk","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2024.103319_bib30","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231724002970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:03:16Z","timestamp":1778853796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231724002970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":30,"alternative-id":["S2213231724002970"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2024.103319","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2024.103319","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103319"}}