{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:33:21Z","timestamp":1793936001840,"version":"4.8.0"},"reference-count":229,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.redox.2025.103495","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T17:22:51Z","timestamp":1736529771000},"page":"103495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Understanding cataract development in axial myopia: The contribution of oxidative stress and related pathways"],"prefix":"10.1016","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-2456","authenticated-orcid":false,"given":"Marta","family":"\u015awierczy\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Tronina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Sm\u0119dowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103495_bib1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/iovs.18-25957","article-title":"Imi - defining and classifying myopia: a proposed set of standards for clinical and epidemiologic studies","volume":"60","author":"Flitcroft","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib2","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1167\/iovs.06-0716","article-title":"Ethnic differences in the impact of parental myopia: findings from a population-based study of 12-year-old Australian children","volume":"48","author":"Ip","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib3","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1167\/iovs.14-14149","article-title":"Genome-wide association studies of refractive error and myopia, lessons learned, and implications for the future","volume":"55","author":"Hysi","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib4","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/bjophthalmol-2015-307724","article-title":"Global variations and time trends in the prevalence of childhood myopia, a systematic review and quantitative meta-analysis: implications for aetiology and early prevention","volume":"100","author":"Rudnicka","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib5","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2147\/OPTH.S241435","article-title":"Pathogenesis and prevention of worsening axial elongation in pathological myopia","volume":"14","author":"Pugazhendhi","year":"2020","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112472","article-title":"Advances in biomedical study of the myopia-related signaling pathways and mechanisms","volume":"145","author":"Yang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2025.103495_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10792-024-02942-z","article-title":"Aqueous humor protein markers in myopia: a review","volume":"44","author":"Shao","year":"2024","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib8","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2025.103495_bib9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ophtha.2018.10.029","article-title":"Potential lost productivity resulting from the global burden of myopia: systematic review, meta-analysis, and modeling","volume":"126","author":"Naidoo","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2025.103495_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/ICL.0000000000000223","article-title":"Complications of pathologic myopia","volume":"42","author":"Cho","year":"2016","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.redox.2025.103495_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1167\/iovs.61.4.49","article-title":"The complications of myopia: a review and meta-analysis","volume":"61","author":"Haarman","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib12","article-title":"Refractive error and eye health: an umbrella review of meta-analyses","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.redox.2025.103495_bib13","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.ajo.2013.06.005","article-title":"Myopia and age-related cataract: a systematic review and meta-analysis","volume":"156","author":"Pan","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib14","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.ophtha.2018.07.026","article-title":"Six-year incidence of and risk factors for cataract surgery in a multi-ethnic asian population: the Singapore epidemiology of eye diseases study","volume":"125","author":"Tan","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2025.103495_bib15","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.ophtha.2021.04.032","article-title":"The risks and benefits of myopia control","volume":"128","author":"Bullimore","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2025.103495_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108709","article-title":"Hallmarks of lens aging and cataractogenesis","volume":"210","author":"Wishart","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib17","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1167\/iovs.19-27535","article-title":"Molecular processes implicated in human age- related nuclear cataract","volume":"60","author":"Truscott","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib18","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","volume":"9","year":"2021","journal-title":"Lancet Global Health"},{"key":"10.1016\/j.redox.2025.103495_bib19","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s41433-020-0806-3","article-title":"Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis","volume":"34","author":"Hashemi","year":"2020","journal-title":"Eye (Lond)."},{"key":"10.1016\/j.redox.2025.103495_bib20","series-title":"Oxygen in Vitreoretinal Physiology and Pathology","first-page":"459","author":"Holekamp","year":"2014"},{"key":"10.1016\/j.redox.2025.103495_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10384-014-0318-4","article-title":"Preserve the (intraocular) environment: the importance of maintaining normal oxygen gradients in the eye","volume":"58","author":"Beebe","year":"2014","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib22","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.exer.2004.12.007","article-title":"Age-related nuclear cataract-oxidation is the key","volume":"80","author":"Truscott","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0891-5849(02)01304-7","article-title":"Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2","volume":"34","author":"Shang","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ajo.2004.09.046","article-title":"Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation","volume":"139","author":"Holekamp","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100847","article-title":"Vitreous and vision degrading Myodesopsia","volume":"79","author":"Sebag","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib26","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1167\/iovs.13-12609","article-title":"Computational model for oxygen transport and consumption in human vitreous","volume":"54","author":"Filas","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ajo.2008.04.004","article-title":"Prevalence of cataract type in relation to axial length in subjects with high myopia and emmetropia in an Indian population","volume":"146","author":"Mehdizadeh","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib28","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1098\/rstb.2010.0228","article-title":"Vitreoretinal influences on lens function and cataract","volume":"366","author":"Beebe","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1167\/iovs.03-0820","article-title":"Importance of vitreous liquefaction in age-related cataract","volume":"45","author":"Harocopos","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.exer.2008.09.003","article-title":"Enzyme- induced posterior vitreous detachment in the rat produces increased lens nuclear pO2 levels","volume":"88","author":"Giblin","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/cxo.12203","article-title":"Hyperbaric oxygen therapy and the possibility of ocular complications or contraindications","volume":"98","author":"McMonnies","year":"2015","journal-title":"Clin. Exp. Optom."},{"key":"10.1016\/j.redox.2025.103495_bib32","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.clinbiochem.2003.12.001","article-title":"Oxidative stress and antioxidant status in patients undergoing prolonged exposure to hyperbaric oxygen","volume":"37","author":"Benedetti","year":"2004","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.redox.2025.103495_bib33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/bjo.68.2.113","article-title":"Nuclear cataract and myopia during hyperbaric oxygen therapy","volume":"68","author":"Palmquist","year":"1984","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib34","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1136\/bjo.86.11.1274","article-title":"Development of myopia as a hazard for workers in pneumatic caissons","volume":"86","author":"Onoo","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib35","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0002-9394(88)90180-8","article-title":"Nuclear sclerosis after vitrectomy for idiopathic epiretinal membranes","volume":"105","author":"de Bustros","year":"1988","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib36","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0002-9394(14)72377-3","article-title":"Nuclear sclerotic cataract after vitrectomy for idiopathic epiretinal membranes causing macular pucker","volume":"111","author":"Cherfan","year":"1991","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib37","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0002-9394(14)73812-7","article-title":"Progression of nuclear sclerosis and long-term visual results of vitrectomy with transforming growth factor beta-2 for macular holes","volume":"119","author":"Thompson","year":"1995","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib38","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/S0161-6420(95)30844-5","article-title":"Nuclear sclerotic cataract after vitrectomy in patients younger than 50 years of age","volume":"102","author":"Melberg","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2025.103495_bib39","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.ophtha.2005.02.014","article-title":"Nonvitrectomizing vitreous surgery for epiretinal membrane long-term follow-up","volume":"112","author":"Sawa","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2025.103495_bib40","first-page":"6","article-title":"Comparison of lens oxidative damage induced by vitrectomy and\/or hyperoxia in rabbits","volume":"10","author":"Yan","year":"2017","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib41","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ajo.2020.09.017","article-title":"Vitreous structure and visual function in myopic vitreopathy causing vision- degrading myodesopsia","volume":"224","author":"Nguyen","year":"2021","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib42","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12920-023-01673-x","article-title":"Mendelian randomization study confirms causal relationship between myopia and vitreous disorders","volume":"16","author":"Xu","year":"2023","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.redox.2025.103495_bib43","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0161-6420(82)34610-2","article-title":"Synchysis senilis and posterior vitreous detachment","volume":"89","author":"Foos","year":"1982","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2025.103495_bib44","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1038\/s41433-021-01732-6","article-title":"Progression of posterior vitreous detachment after cataract surgery","volume":"36","author":"Hayashi","year":"2022","journal-title":"Eye (Lond)."},{"key":"10.1016\/j.redox.2025.103495_bib45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00006982-199515020-00005","article-title":"A clinical study of the development of posterior vitreous detachment in high myopia","volume":"15","author":"Morita","year":"1995","journal-title":"Retina"},{"key":"10.1016\/j.redox.2025.103495_bib46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00055735-199606000-00012","article-title":"Age of onset of posterior vitreous detachment","volume":"7","author":"Yonemoto","year":"1996","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0014-4835(65)80037-9","article-title":"Cytological and biochemical studies on the developing chicken vitreous","volume":"4","author":"Balazs","year":"1965","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0014-4835(64)80003-8","article-title":"The chemical composition of the human vitreous body as related to age and myopia","volume":"3","author":"Berman","year":"1964","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib49","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.bbadis.2017.03.022","article-title":"Impaired vitreous composition and retinal pigment epithelium function in the FoxG1::LRP2 myopic mice","volume":"1863","author":"Cases","year":"2017","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.redox.2025.103495_bib50","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1167\/iovs.14-14366","article-title":"Preservation of the structure of enzymatically-degraded bovine vitreous using synthetic proteoglycan mimics","volume":"55","author":"Zhang","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib51","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s00417-014-2768-2","article-title":"Changes of TGF-\u03b22, MMP-2, and TIMP-2 levels in the vitreous of patients with high myopia","volume":"252","author":"Zhuang","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib52","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/02713689608995835","article-title":"Cleavage of structural components of mammalian vitreous by endogenous matrix metalloproteinase-2","volume":"15","author":"Brown","year":"1996","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155308","article-title":"Proinflammatory and angiogenesis-related cytokines in vitreous samples of highly myopic patients","volume":"137","author":"Wei","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.redox.2025.103495_bib54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.21037\/atm.2020.01.63","article-title":"Pathological myopia- induced antioxidative proteins in the vitreous humor","volume":"8","author":"Wei","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.redox.2025.103495_bib55","article-title":"Isotope- coded protein label based quantitative proteomic analysis reveals significant up- regulation of apolipoprotein A1 and ovotransferrin in the myopic chick vitreous","volume":"7","author":"Yu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2025.103495_bib56","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/02713683.2019.1646772","article-title":"Increased levels of DKK1 in vitreous fluid of patients with pathological myopia and the correlation between DKK1 levels and axial length","volume":"45","author":"Peng","year":"2020","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib57","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1681\/ASN.2008060566","article-title":"Wnt\/beta-catenin signaling promotes renal interstitial fibrosis","volume":"20","author":"He","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.redox.2025.103495_bib58","doi-asserted-by":"crossref","first-page":"21469","DOI":"10.18632\/oncotarget.7412","article-title":"Mitochondrial stress controls the radiosensitivity of the oxygen effect: implications for radiotherapy","volume":"7","author":"Richardson","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.redox.2025.103495_bib59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.exer.2008.05.018","article-title":"Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations","volume":"88","author":"Brennan","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib60","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1080\/02713683.2023.2276679","article-title":"Investigation of mitochondrial homeostasis changes in lens epithelium of high- myopic cataract","volume":"49","author":"Sun","year":"2024","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib61","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3233\/JAD-2010-091675","article-title":"Behavioral effects induced by mitochondria-targeted antioxidant SkQ1 in Wistar and senescence-accelerated OXYS rats","volume":"21","author":"Stefanova","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.redox.2025.103495_bib62","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/13813455.2020.1819337","article-title":"Omentin-1 promotes mitochondrial biogenesis via PGC1\u03b1-AMPK pathway in chondrocytes","volume":"129","author":"Li","year":"2023","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.redox.2025.103495_bib63","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4830418","article-title":"The Nrf2\/PGC1\u03b1 pathway regulates antioxidant and proteasomal activity to alter cisplatin sensitivity in ovarian cancer","volume":"2020","author":"Deng","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2025.103495_bib64","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41586-018-0211-2","article-title":"Structural basis of mitochondrial receptor binding and constriction by DRP1","volume":"558","author":"Kalia","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.redox.2025.103495_bib65","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.redox.2025.103495_bib66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbadis.2016.09.020","article-title":"Parkin elimination of mitochondria is important for maintenance of lens epithelial cell ROS levels and survival upon oxidative stress exposure","volume":"1863","author":"Brennan","year":"2017","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.redox.2025.103495_bib67","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-4684-8231-7_11","article-title":"Electrical and metabolic manifestations of receptor and higher-order neuron activity in vertebrate retina","volume":"24","author":"Sickel","year":"1972","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.redox.2025.103495_bib68","first-page":"1261","article-title":"Some features of ocular microcirculation in myopia","volume":"9","author":"Avetisov","year":"1977","journal-title":"Ann. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib69","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/jop.1991.7.83","article-title":"Ocular pulse amplitude in myopia","volume":"7","author":"Shih","year":"1991","journal-title":"J. Ocul. Pharmacol."},{"key":"10.1016\/j.redox.2025.103495_bib70","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/02713689308999467","article-title":"Reduction in choroidal blood flow occurs in chicks wearing goggles that induce eye growth toward myopia","volume":"12","author":"Shih","year":"1993","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib71","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1523\/JNEUROSCI.4468-06.2007","article-title":"Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation","volume":"27","author":"Abramov","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.redox.2025.103495_bib72","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ajpath.2016.08.022","article-title":"Mechanistic insights into pathological changes in the diabetic retina: implications for targeting diabetic retinopathy","volume":"187","author":"Roy","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.redox.2025.103495_bib73","doi-asserted-by":"crossref","first-page":"11324","DOI":"10.3390\/ijms150711324","article-title":"Endothelial dysfunction in chronic inflammatory diseases","volume":"15","author":"Steyers","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib74","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0014-4835(79)90114-3","article-title":"A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments","volume":"28","author":"Stone","year":"1979","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib75","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12886-020-01377-1","article-title":"Morphologic and biochemical changes in the retina and sclera induced by form deprivation high myopia in Guinea pigs","volume":"20","author":"Zi","year":"2020","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib76","article-title":"Alteration of retinal metabolism and oxidative stress may implicate myopic eye growth: evidence from discovery and targeted proteomics in an animal model","volume":"221","author":"Yu","year":"2020","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.redox.2025.103495_bib77","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-4835(89)90088-2","article-title":"Lipid peroxidation and human cataractogenesis in diabetes and severe myopia","volume":"49","author":"Simonelli","year":"1989","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib78","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1385\/AO:38:2:103","article-title":"Role of malondialdehyde and superoxide dismutase in cataractogenesis","volume":"38","author":"Bhatia","year":"2006","journal-title":"Ann. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib79","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1136\/bjo.80.9.840","article-title":"Role of lipid peroxidation in the pathogenesis of myopic and senile cataract","volume":"80","author":"Micelli-Ferrari","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib80","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/0891-5849(95)02219-8","article-title":"Lipid peroxidation products in human subretinal fluid","volume":"20","author":"Bosch-Morell","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib81","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0005-2760(89)90222-1","article-title":"Lens opacity induced by lipid peroxidation products as a model of cataract associated with retinal disease","volume":"1004","author":"Babizhayev","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2025.103495_bib82","first-page":"608","article-title":"A lipid peroxidative mechanism for posterior subcapsular cataract formation in the rabbit: a possible model for cataract formation in tapetoretinal diseases","volume":"25","author":"Goosey","year":"1984","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib83","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1167\/iovs.17-21612","article-title":"Risk factors for posterior subcapsular cataract in retinitis pigmentosa","volume":"58","author":"Fujiwara","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib84","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/750637","article-title":"Oxidative stress in myopia","volume":"2015","author":"Francisco","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2025.103495_bib85","doi-asserted-by":"crossref","first-page":"7508","DOI":"10.1167\/iovs.14-14294","article-title":"Effects of dopaminergic agents on progression of naturally occurring myopia in albino Guinea pigs (Cavia porcellus)","volume":"55","author":"Jiang","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib86","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.freeradbiomed.2010.04.016","article-title":"Assessment of antioxidant capacity in vitro and in vivo","volume":"49","author":"Niki","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib87","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3341\/kjo.2016.30.3.172","article-title":"Oxidative stress levels in aqueous humor from high myopic patients","volume":"30","author":"Kim","year":"2016","journal-title":"Kor. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109670","article-title":"Association between inflammatory cytokines and oxidative stress levels in aqueous humor with axial length in human myopia","volume":"237","author":"Yu","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib89","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.redox.2018.08.012","article-title":"DNA hypermethylation-mediated downregulation of antioxidant genes contributes to the early onset of cataracts in highly myopic eyes","volume":"19","author":"Zhu","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103495_bib90","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuint.2006.04.010","article-title":"Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms","volume":"49","author":"Pannu","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.redox.2025.103495_bib91","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jpba.2016.03.032","article-title":"Looking into aqueous humor through metabolomics spectacles - exploring its metabolic characteristics in relation to myopia","volume":"127","author":"Barbas-Bernardos","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.redox.2025.103495_bib92","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-4835(02)00268-3","article-title":"May nitric oxide molecule have a role in the pathogenesis of human cataract?","volume":"76","author":"Ornek","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib93","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/exer.1999.0761","article-title":"The Nitrite\/alpha crystallin reaction: a possible mechanism in lens matrix damage","volume":"70","author":"Paik","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib94","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/oxfordjournals.jbchem.a022814","article-title":"Aminoguanidine- treatment results in the inhibition of lens opacification and calpain-mediated proteolysis in Shumiya cataract rats (SCR)","volume":"128","author":"Inomata","year":"2000","journal-title":"J. Biochem."},{"key":"10.1016\/j.redox.2025.103495_bib95","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3389\/fphys.2020.00463","article-title":"Imbalance between oxidative stress and growth factors in human high myopia","volume":"11","author":"M\u00e9rida","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.redox.2025.103495_bib96","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0021-9258(18)48474-8","article-title":"8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions","volume":"267","author":"Cheng","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2025.103495_bib97","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/15563650903468803","article-title":"Plasma level of malondialdehyde in the cases of acute paraquat intoxication","volume":"48","author":"Gil","year":"2010","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.redox.2025.103495_bib98","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0003-2697(92)90188-D","article-title":"Detection and possible origins of aminomalonic acid in protein hydrolysates","volume":"201","author":"Copley","year":"1992","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.redox.2025.103495_bib99","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/13510002.1996.11747038","article-title":"Changes in rat plasma-free fatty acid composition under oxidative stress induced by carbon tetrachloride: decrease of polyunsaturated fatty acids and increase of palmitoleic acid","volume":"2","author":"Yamamoto","year":"1996","journal-title":"Redox Rep."},{"key":"10.1016\/j.redox.2025.103495_bib100","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s12031-015-0559-9","article-title":"In vitro neuroprotective effect of shikimic acid against hydrogen peroxide-induced oxidative stress","volume":"56","author":"Rabelo","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.redox.2025.103495_bib101","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1016\/S0960-894X(02)00479-1","article-title":"Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants","volume":"12","author":"Jung","year":"2002","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.redox.2025.103495_bib102","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuro.2011.12.015","article-title":"Contrasting protective effects of cannabinoids against oxidative stress and amyloid-\u03b2 evoked neurotoxicity in vitro","volume":"33","author":"Harvey","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.redox.2025.103495_bib103","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41433-020-0968-z","article-title":"Serum metabolic signatures of high myopia among older Chinese adults","volume":"35","author":"Ke","year":"2021","journal-title":"Eye (Lond)."},{"key":"10.1016\/j.redox.2025.103495_bib104","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ijbiomac.2007.08.005","article-title":"Ovotransferrin possesses SOD-like superoxide anion scavenging activity that is promoted by copper and manganese binding","volume":"41","author":"Ibrahim","year":"2007","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.redox.2025.103495_bib105","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/BJ20111889","article-title":"Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death","volume":"443","author":"Fukuhara","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.redox.2025.103495_bib106","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.freeradbiomed.2015.04.034","article-title":"Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation","volume":"88","author":"Ishii","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib107","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1080\/10715760600918142","article-title":"Protein oxidation and aging","volume":"40","author":"Stadtman","year":"2006","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.redox.2025.103495_bib108","article-title":"Quantitative phosphoproteomic comparison of lens proteins in highly myopic cataract and age-related cataract","volume":"2021","author":"Zhang","year":"2021","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.redox.2025.103495_bib109","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-4835(90)90005-F","article-title":"Glutathione levels in human lens: regional distribution in different forms of cataract","volume":"50","author":"Pau","year":"1990","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib110","first-page":"2461","article-title":"Protein oxidation and lens opacity in humans","volume":"41","author":"Boscia","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib111","first-page":"1515","article-title":"L-carnitine alleviates oxidative stress-related damage via MAPK signaling in human lens epithelial cells exposed to H2O2","volume":"44","author":"Li","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib112","first-page":"159","article-title":"Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells","volume":"17","author":"Osada","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.redox.2025.103495_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.109804","article-title":"Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues","volume":"355","author":"Thompson","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.redox.2025.103495_bib114","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1023\/A:1015905010086","article-title":"Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB\/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation","volume":"234\u2013235","author":"Rahman","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.redox.2025.103495_bib115","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41598-018-19216-1","article-title":"Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells","volume":"8","author":"Szczesny","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2025.103495_bib116","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1152\/ajprenal.00487.2012","article-title":"Reactive oxygen species and IRF1 stimulate IFN\u03b1 production by proximal tubules during ischemic AKI","volume":"305","author":"Winterberg","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.redox.2025.103495_bib117","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.freeradbiomed.2004.06.021","article-title":"Nuclear factor kappaB and activating protein 1 are involved in differentiation-related resistance to oxidative stress in skeletal muscle cells","volume":"37","author":"Catani","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib118","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043313","article-title":"Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive","volume":"7","author":"Zgheib","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103495_bib119","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5698931","article-title":"Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2025.103495_bib120","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.3390\/cimb44090296","article-title":"Myopia development in tree shrew is associated with chronic inflammatory reactions","volume":"44","author":"Ku","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.redox.2025.103495_bib121","first-page":"150","article-title":"The expression of cytokines in aqueous humor of high myopic patients with cataracts","volume":"26","author":"Zhang","year":"2020","journal-title":"Mol. Vis."},{"key":"10.1016\/j.redox.2025.103495_bib122","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1038\/s41598-019-39652-x","article-title":"Inflammatory cytokines in highly myopic eyes","volume":"9","author":"Yuan","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2025.103495_bib123","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exer.2015.03.017","article-title":"Proinflammatory status in the aqueous humor of high myopic cataract eyes","volume":"142","author":"Zhu","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib124","first-page":"729","article-title":"Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states","volume":"152","author":"Pagenstecher","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.redox.2025.103495_bib125","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1182\/blood.V94.6.2080","article-title":"Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas","volume":"94","author":"Kossakowska","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.redox.2025.103495_bib126","first-page":"1777","article-title":"Basal membrane complex architecture is disrupted during posterior subcapsular cataract formation in Royal College of Surgeons rats","volume":"20","author":"Joy","year":"2014","journal-title":"Mol. Vis."},{"key":"10.1016\/j.redox.2025.103495_bib127","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1056\/NEJMoa0807865","article-title":"An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist","volume":"360","author":"Aksentijevich","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.redox.2025.103495_bib128","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/bjo.84.3.332","article-title":"M.R. Stanford, Role of cytokines in the pathogenesis of posterior capsule opacification","volume":"84","author":"Meacock","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib129","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/1529-0131(200001)43:1<38::AID-ANR6>3.0.CO;2-L","article-title":"Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis","volume":"43","author":"Taylor","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.redox.2025.103495_bib130","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3390\/biom13091328","article-title":"Biomarker signature in aqueous humor mirrors lens epithelial cell activation: new biomolecular aspects from cataractogenic myopia","volume":"13","author":"De Piano","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.redox.2025.103495_bib131","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2961742","article-title":"Association between MMP\/TIMP levels in the aqueous humor and plasma with axial lengths in myopia patients","volume":"2020","author":"Yue","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.redox.2025.103495_bib132","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.1029425","article-title":"Difference in aqueous concentration and vitreous mass of cytokines in high myopias with and without choroidal neovascularization","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.redox.2025.103495_bib133","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00417-004-0950-7","article-title":"Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients","volume":"243","author":"Funatsu","year":"2005","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib134","first-page":"121","article-title":"CXCL10\/IP-10 in infectious diseases pathogenesis and potential therapeutic implications","volume":"22","author":"Liu","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.redox.2025.103495_bib135","doi-asserted-by":"crossref","first-page":"7571","DOI":"10.4049\/jimmunol.166.12.7571","article-title":"Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells","volume":"166","author":"Salcedo","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.redox.2025.103495_bib136","first-page":"637","article-title":"Multiplex bead analysis of vitreous and serum concentrations of inflammatory and proangiogenic factors in diabetic patients","volume":"14","author":"Maier","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.redox.2025.103495_bib137","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/19336918.2022.2029237","article-title":"TNF-\u03b1 regulates the composition of the basal lamina and cell-matrix adhesions in gingival epithelial cells","volume":"16","author":"Mezawa","year":"2022","journal-title":"Cell Adhes. Migrat."},{"key":"10.1016\/j.redox.2025.103495_bib138","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12886-021-01860-3","article-title":"Relationship between the higher inflammatory cytokines level in the aqueous humor of Fuchs uveitis syndrome and the presence of cataract","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib139","first-page":"3483","article-title":"Concanavalin A-induced posterior subcapsular cataract: a new model of cataractogenesis","volume":"34","author":"Gwon","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib140","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ophtha.2012.07.006","article-title":"Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa","volume":"120","author":"Yoshida","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2025.103495_bib141","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1080\/09553002.2020.1812759","article-title":"Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation","volume":"96","author":"Richardson","year":"2020","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.redox.2025.103495_bib142","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2147\/OPTH.S84790","article-title":"Vitamin D deficiency and posterior subcapsular cataract","volume":"9","author":"Brown","year":"2015","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107693","article-title":"Enhanced EGF receptor-signaling potentiates TGF\u03b2-induced lens epithelial-mesenchymal transition","volume":"185","author":"Shu","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib144","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000084508","article-title":"Transforming growth factor- beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation","volume":"179","author":"de Iongh","year":"2005","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.redox.2025.103495_bib145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214431","article-title":"TGF-\u03b2\/Smad signalling activation by HTRA1 regulates the function of human lens epithelial cells and its mechanism in posterior subcapsular congenital cataract","volume":"23","author":"Lin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib146","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s11010-020-04034-9","article-title":"Moderate oxidative stress promotes epithelial-mesenchymal transition in the lens epithelial cells via the TGF- \u03b2\/Smad and Wnt\/\u03b2-catenin pathways","volume":"476","author":"Chen","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.redox.2025.103495_bib147","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.ajpath.2017.07.018","article-title":"Reduced glutathione level promotes epithelial-mesenchymal transition in lens epithelial cells via a Wnt\/\u03b2-catenin-mediated pathway: relevance for cataract therapy","volume":"187","author":"Wei","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.redox.2025.103495_bib148","first-page":"895","article-title":"Glutathione and catalase suppress TGFbeta-induced cataract-related changes in cultured rat lenses and lens epithelial explants","volume":"15","author":"Chamberlain","year":"2009","journal-title":"Mol. Vis."},{"key":"10.1016\/j.redox.2025.103495_bib149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.01.020","article-title":"Growth factor regulation of lens development","volume":"280","author":"Lovicu","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.redox.2025.103495_bib150","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/258591","article-title":"Human aqueous humor levels of TGF- \u03b22: relationship with axial length","volume":"2014","author":"Jia","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.redox.2025.103495_bib151","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-4835(02)00278-6","article-title":"Alpha-crystallin","volume":"76","author":"Horwitz","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib152","first-page":"249","article-title":"Cataract blindness-challenges for the 21st century","volume":"79","author":"Brian","year":"2001","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.redox.2025.103495_bib153","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2174\/156652409789105598","article-title":"Effects of alpha-crystallin on lens cell function and cataract pathology","volume":"9","author":"Andley","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib154","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1073\/pnas.94.3.884","article-title":"Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B- crystallin","volume":"94","author":"Brady","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.redox.2025.103495_bib155","first-page":"2924","article-title":"AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach","volume":"42","author":"Brady","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib156","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2415-3-3","article-title":"Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens","volume":"3","author":"Boyle","year":"2003","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib157","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/iub.176","article-title":"Modulation of alpha-crystallin chaperone activity: a target to prevent or delay cataract?","volume":"61","author":"Kumar","year":"2009","journal-title":"IUBMB Life"},{"issue":"1792","key":"10.1016\/j.redox.2025.103495_bib158","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.bbadis.2009.06.011","article-title":"A novel mutation (F71L) in alphaA- crystallin with defective chaperone-like function associated with age-related cataract","volume":"1792","author":"Bhagyalaxmi","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2025.103495_bib159","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1167\/iovs.10-7094","article-title":"Proteomic analysis of human age-related nuclear cataracts and normal lens nuclei","volume":"52","author":"Su","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib160","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ophtha.2015.10.007","article-title":"Longitudinal study of age- related cataract using dynamic light scattering: loss of \u03b1-crystallin leads to nuclear cataract development","volume":"123","author":"Datiles","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.redox.2025.103495_bib161","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1134\/S000629792203004X","article-title":"Protein aggregation and cataract: role of age-related modifications and mutations in \u03b1-crystallins","volume":"87","author":"Budnar","year":"2022","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.redox.2025.103495_bib162","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11357-010-9171-7","article-title":"Racemisation and human cataract. D-Ser, D-Asp\/Asn and D-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses","volume":"33","author":"Hooi","year":"2011","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.redox.2025.103495_bib163","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.exer.2012.10.013","article-title":"Accelerated aging of Asp 58 in \u03b1A crystallin and human cataract formation","volume":"106","author":"Hooi","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib164","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/jcmm.13363","article-title":"Racemization at the Asp 58 residue in \u03b1A-crystallin from the lens of high myopic cataract patients","volume":"22","author":"Zhu","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib165","first-page":"815","article-title":"The function of filensin and phakinin in lens transparency","volume":"14","author":"Oka","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.redox.2025.103495_bib166","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1007\/s10571-023-01427-4","article-title":"Antioxidant system and endoplasmic reticulum stress in cataracts","volume":"43","author":"Zhang","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.redox.2025.103495_bib167","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.08.003","article-title":"Age-related cataracts: role of unfolded protein response, Ca2+ mobilization, epigenetic DNA modifications, and loss of Nrf2\/Keap1 dependent cytoprotection","volume":"60","author":"Periyasamy","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib168","article-title":"UPR activation and the down- regulation of \u03b1-crystallin in human high myopia-related cataract lens epithelium","volume":"10","author":"Yang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103495_bib169","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2147\/DDDT.S218467","article-title":"KLF6 induces apoptosis in human lens epithelial cells through the ATF4-ATF3-CHOP Axis","volume":"14","author":"Tian","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.redox.2025.103495_bib170","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/iub.396","article-title":"Biology of Kr\u00fcppel-like factor 6 transcriptional regulator in cell life and death","volume":"62","author":"Andreoli","year":"2010","journal-title":"IUBMB Life"},{"key":"10.1016\/j.redox.2025.103495_bib171","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/jb\/mvr143","article-title":"CHOP is a multifunctional transcription factor in the ER stress response","volume":"151","author":"Nishitoh","year":"2012","journal-title":"J. Biochem."},{"key":"10.1016\/j.redox.2025.103495_bib172","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2174\/1566524017666170306122643","article-title":"Molecular basis of human diseases and targeted therapy based on small-molecule inhibitors of ER stress-induced signaling pathways","volume":"17","author":"Rozpedek","year":"2017","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib173","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1038\/s41467-021-22041-2","article-title":"Aberrant TGF-\u03b21 signaling activation by MAF underlies pathological lens growth in high myopia","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2025.103495_bib174","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajo.2018.01.007","article-title":"Inferior decentration of multifocal intraocular lenses in myopic eyes","volume":"188","author":"Zhu","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/bjophthalmol-2015-306656","article-title":"Factors influencing 1-year rotational stability of AcrySof Toric intraocular lenses","volume":"100","author":"Zhu","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib176","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.tig.2017.08.001","article-title":"Signaling and gene regulatory networks in mammalian lens development","volume":"33","author":"Cvekl","year":"2017","journal-title":"Trends Genet."},{"key":"10.1016\/j.redox.2025.103495_bib177","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.2147\/IJGM.S354935","article-title":"Identification of the potential key genes and pathways involved in lens changes of high myopia","volume":"15","author":"Lai","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.redox.2025.103495_bib178","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1074\/jbc.M306248200","article-title":"Activation of the pro-survival phosphatidylinositol 3- kinase\/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor","volume":"279","author":"Horowitz","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2025.103495_bib179","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13412","article-title":"Single-cell RNA sequencing: inhibited Notch2 signalling underlying the increased lens fibre cells differentiation in high myopia","volume":"56","author":"Yao","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.redox.2025.103495_bib180","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","article-title":"Notch signaling in development, tissue homeostasis, and disease","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2025.103495_bib181","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jcmgh.2017.01.012","article-title":"Notch as a driver of gastric epithelial cell proliferation","volume":"3","author":"Demitrack","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.redox.2025.103495_bib182","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ydbio.2011.11.011","article-title":"Conditional ablation of the Notch2 receptor in the ocular lens","volume":"362","author":"Saravanamuthu","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.redox.2025.103495_bib183","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.3892\/mmr.2017.6345","article-title":"Identification of proteins in the aqueous humor associated with cataract development using iTRAQ methodology","volume":"15","author":"Xiang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.redox.2025.103495_bib184","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.clinbiochem.2015.08.006","article-title":"Proteomic analysis of aqueous humor proteins associated with cataract development","volume":"48","author":"Ji","year":"2015","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.redox.2025.103495_bib185","first-page":"933","article-title":"Quantitative proteomics analysis with iTRAQ in human lenses with nuclear cataracts of different axial lengths","volume":"22","author":"Zhou","year":"2016","journal-title":"Mol. Vis."},{"key":"10.1016\/j.redox.2025.103495_bib186","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4419-8216-2_1","article-title":"An introduction to epigenetics","volume":"711","author":"Ballestar","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.redox.2025.103495_bib187","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1093\/carcin\/23.7.1103","article-title":"The impact of chromatin in human cancer: linking DNA methylation to gene silencing","volume":"23","author":"Ballestar","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.redox.2025.103495_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148442","article-title":"Circular RNAs: epigenetic regulators of PTEN expression and function in cancer","volume":"916","author":"Farazi","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.redox.2025.103495_bib189","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mrfmmm.2014.05.010","article-title":"Expression and methylation of DNA repair genes in lens epithelium cells of age-related cataract","volume":"766\u2013767","author":"Li","year":"2014","journal-title":"Mutat. Res."},{"key":"10.1016\/j.redox.2025.103495_bib190","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3109\/02713683.2014.957778","article-title":"Altered DNA methylation and expression profiles of 8-oxoguanine DNA glycosylase 1 in lens tissue from age- related cataract patients","volume":"40","author":"Wang","year":"2015","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib191","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1167\/iovs.15-16618","article-title":"LOXL1 hypermethylation in pseudoexfoliation syndrome in the uighur population","volume":"56","author":"Ye","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib192","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12886-016-0309-y","article-title":"CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells","volume":"16","author":"Liu","year":"2016","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib193","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1096\/fj.12-213702","article-title":"Down-regulation and CpG island hypermethylation of CRYAA in age-related nuclear cataract","volume":"26","author":"Zhou","year":"2012","journal-title":"Faseb. J."},{"key":"10.1016\/j.redox.2025.103495_bib194","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00417-015-2949-7","article-title":"\u03b1A-crystallin gene CpG islands hypermethylation in nuclear cataract after pars plana vitrectomy","volume":"253","author":"Zhu","year":"2015","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081900","article-title":"Epigenetic regulation of \u03b1A- crystallin in high myopia-induced dark nuclear cataract","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103495_bib196","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/bj3340057","article-title":"Thioltransferase activity of bovine lens glutathione S-transferase","volume":"334","author":"Dal Monte","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.redox.2025.103495_bib197","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/exer.1993.1039","article-title":"Difference in glutathione S-transferase response to oxidative stress between porcine and bovine lens","volume":"56","author":"Nishinaka","year":"1993","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib198","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/02713689309024625","article-title":"Distribution and activity of glutathione-S-transferase in normal human lenses and in cataractous human epithelia","volume":"12","author":"Huang","year":"1993","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib199","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/02713683.2016.1185129","article-title":"Aberrant epigenetic alterations of glutathione-S-transferase P1 in age-related nuclear cataract","volume":"42","author":"Chen","year":"2017","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib200","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.biophys.30.1.421","article-title":"Properties and biological activities of thioredoxins","volume":"30","author":"Powis","year":"2001","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/j.redox.2025.103495_bib201","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1167\/iovs.14-15452","article-title":"Loss of thiol repair systems in human cataractous lenses","volume":"56","author":"Wei","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib202","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.exer.2004.07.001","article-title":"Thioredoxin reductase may be essential for the normal growth of hyperbaric oxygen- treated human lens epithelial cells","volume":"79","author":"Padgaonkar","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib203","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/php.12404","article-title":"Thioredoxin reductase activity may be more important than GSH level in protecting human lens epithelial cells against UVA light","volume":"91","author":"Padgaonkar","year":"2015","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.redox.2025.103495_bib204","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0891-5849(00)00313-0","article-title":"The role of the redox protein thioredoxin in cell growth and cancer","volume":"29","author":"Powis","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib205","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108128","article-title":"Circular RNA HIPK3 regulates human lens epithelial cell dysfunction by targeting the miR-221-3p\/PI3K\/AKT pathway in age-related cataract","volume":"198","author":"Cui","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.redox.2025.103495_bib206","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.18632\/aging.202470","article-title":"CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract","volume":"13","author":"Liu","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.redox.2025.103495_bib207","doi-asserted-by":"crossref","first-page":"17271","DOI":"10.18632\/aging.103683","article-title":"Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p","volume":"12","author":"Liang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.redox.2025.103495_bib208","doi-asserted-by":"crossref","first-page":"8953","DOI":"10.1080\/21655979.2021.1990196","article-title":"Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5'-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner","volume":"12","author":"Zhou","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.redox.2025.103495_bib209","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3390\/jcm12030813","article-title":"The differential expression of circular RNAs and the role of circAFF1 in lens epithelial cells of high-myopic cataract","volume":"12","author":"Ma","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.redox.2025.103495_bib210","first-page":"3485","article-title":"MiR-34 promotes apoptosis of lens epithelial cells in cataract rats via the TGF-\u03b2\/Smads signaling pathway","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib211","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078279","article-title":"Ectopic activation of Wnt\/\u03b2-catenin signaling in lens fiber cells results in cataract formation and aberrant fiber cell differentiation","volume":"8","author":"Antosova","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103495_bib212","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2174\/1874467213666200908120501","article-title":"Quercetin inhibits AQP1 translocation in high-glucose-cultured SRA01\/04 cells through PI3K\/Akt\/mTOR pathway","volume":"14","author":"He","year":"2021","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.redox.2025.103495_bib213","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1582-4934.2012.01654.x","article-title":"Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells","volume":"17","author":"Kubo","year":"2013","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.redox.2025.103495_bib214","doi-asserted-by":"crossref","first-page":"9880","DOI":"10.1021\/bi301323n","article-title":"\u03b1- Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains","volume":"51","author":"Janco","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.redox.2025.103495_bib215","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102967","article-title":"Oxidative stress in the eye and its role in the pathophysiology of ocular diseases","volume":"68","author":"B\u00f6hm","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103495_bib216","doi-asserted-by":"crossref","first-page":"352S","DOI":"10.1093\/ajcn\/53.1.352S","article-title":"Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention","volume":"53","author":"Jacques","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.redox.2025.103495_bib217","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/ajcn\/66.4.911","article-title":"Long-term vitamin C supplement use and prevalence of early age-related lens opacities","volume":"66","author":"Jacques","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.redox.2025.103495_bib218","first-page":"1439","article-title":"A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9","volume":"10","year":"2001","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib219","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1076\/opep.9.1.49.1717","article-title":"The Roche European American Cataract Trial (REACT): a randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract","volume":"9","author":"Chylack","year":"2002","journal-title":"Ophthalmic Epidemiol."},{"key":"10.1016\/j.redox.2025.103495_bib220","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1001\/archophthalmol.2010.266","article-title":"Age-related cataract in a randomized trial of vitamins E and C in men","volume":"128","author":"Christen","year":"2010","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib221","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3945\/ajcn.2009.28528","article-title":"Vitamin C supplements and the risk of age-related cataract: a population-based prospective cohort study in women","volume":"91","author":"Rautiainen","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.redox.2025.103495_bib222","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/aje\/kws279","article-title":"High-dose supplements of vitamins C and E, low-dose multivitamins, and the risk of age-related cataract: a population-based prospective cohort study of men","volume":"15","author":"Zheng Selin","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.redox.2025.103495_bib223","first-page":"1804","article-title":"A protective role for glutathione-dependent reduction of dehydroascorbic acid in lens epithelium","volume":"36","author":"Sasaki","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103495_bib224","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2415-13-52","article-title":"Fruit and vegetable intake and vitamins C and E are associated with a reduced prevalence of cataract in a Spanish Mediterranean population","volume":"13","author":"Pastor-Valero","year":"2013","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib225","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10792-013-9795-6","article-title":"Diet and cataract: a case-control study","volume":"34","author":"Theodoropoulou","year":"2014","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib226","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1042893","article-title":"Selenium intake help prevent age-related cataract formation: evidence from NHANES 2001-2008","volume":"10","author":"Xu","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.redox.2025.103495_bib227","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/archopht.118.11.1556","article-title":"Vitamin supplement use and incident cataracts in a population-based study","volume":"118","author":"Mares-Perlman","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.redox.2025.103495_bib228","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/acel.12645","article-title":"Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress","volume":"16","author":"Liu","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.redox.2025.103495_bib229","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114048","article-title":"Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6\/p-Nrf2\/GPX4 and SIRT6\/NCOA4\/FTH1 pathways","volume":"157","author":"Mi","year":"2023","journal-title":"Biomed. Pharmacother."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725000084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725000084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T10:33:19Z","timestamp":1741948399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725000084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":229,"alternative-id":["S2213231725000084"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103495","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding cataract development in axial myopia: The contribution of oxidative stress and related pathways","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103495","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103495"}}