{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:50:18Z","timestamp":1789091418070,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["444776998"],"award-info":[{"award-number":["444776998"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["314061271-TRR 205"],"award-info":[{"award-number":["314061271-TRR 205"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WI 5359\/2-1"],"award-info":[{"award-number":["WI 5359\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RE 752\/31-1"],"award-info":[{"award-number":["RE 752\/31-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["694913"],"award-info":[{"award-number":["694913"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2012_A103"],"award-info":[{"award-number":["2012_A103"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2019_A104"],"award-info":[{"award-number":["2019_A104"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2015_A228"],"award-info":[{"award-number":["2015_A228"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.redox.2025.103498","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T16:58:51Z","timestamp":1736960331000},"page":"103498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["EGR1 regulates oxidative stress and aldosterone production in adrenal cells and aldosterone-producing adenomas"],"prefix":"10.1016","volume":"80","author":[{"given":"Yingxian","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Tetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuolun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanas","family":"Mir-Bashiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bidlingmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kn\u00f6sel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kemter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2388-6444","authenticated-orcid":false,"given":"Tracy Ann","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103498_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mce.2013.11.022","article-title":"Development of monoclonal antibodies against human CYP11B1 and CYP11B2","volume":"383","author":"Gomez-Sanchez","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.redox.2025.103498_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.mce.2014.05.002","article-title":"Adrenal CYP11B1\/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies","volume":"392","author":"Nakamura","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.redox.2025.103498_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1210\/clinem\/dgaa484","article-title":"International histopathology consensus for unilateral primary aldosteronism","volume":"106","author":"Williams","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.redox.2025.103498_bib4","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.redox.2025.103498_bib5","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/ng.2695","article-title":"Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism","volume":"45","author":"Scholl","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2025.103498_bib6","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ng.2716","article-title":"Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension","volume":"45","author":"Azizan","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2025.103498_bib7","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06315","article-title":"Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism","volume":"4","author":"Scholl","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.redox.2025.103498_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41588-018-0048-5","article-title":"CLCN2 chloride channel mutations in familial hyperaldosteronism type II","volume":"50","author":"Scholl","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2025.103498_bib9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41588-018-0053-8","article-title":"A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism","volume":"50","author":"Fernandes-Rosa","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2025.103498_bib10","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/s41588-023-01498-5","article-title":"Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism","volume":"55","author":"Rege","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2025.103498_bib11","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ng.2550","article-title":"Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension","volume":"45","author":"Beuschlein","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2025.103498_bib12","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","article-title":"Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma","volume":"64","author":"Fernandes-Rosa","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2025.103498_bib13","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1161\/HYPERTENSIONAHA.119.14177","article-title":"Genetic, cellular, and molecular heterogeneity in adrenals with aldosterone-producing adenoma","volume":"75","author":"De Sousa","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2025.103498_bib14","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1210\/clinem\/dgac408","article-title":"Histopathology and genetic causes of primary aldosteronism in young adults","volume":"107","author":"Nanba","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.redox.2025.103498_bib15","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/HYPERTENSIONAHA.118.11086","article-title":"Cellular and genetic causes of idiopathic hyperaldosteronism","volume":"72","author":"Omata","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2025.103498_bib16","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S2213-8587(22)00253-4","article-title":"Adrenal surgery for bilateral primary aldosteronism: an international retrospective cohort study","volume":"10","author":"Williams","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.redox.2025.103498_bib17","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1161\/HYPERTENSIONAHA.121.17348","article-title":"Single-center prospective cohort study on the histopathology, genotype, and postsurgical outcomes of patients with primary aldosteronism","volume":"78","author":"Meyer","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2025.103498_bib18","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1530\/JOE-13-0346","article-title":"Oxidative stress and adrenocortical insufficiency","volume":"221","author":"Prasad","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.redox.2025.103498_bib19","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41419-020-2385-4","article-title":"Active steroid hormone synthesis renders adrenocortical cells highly susceptible to type II ferroptosis induction","volume":"11","author":"Weigand","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2025.103498_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12061283","article-title":"Docosahexaenoic acid as master regulator of cellular antioxidant defenses: a systematic review","volume":"12","author":"Borgonovi","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2025.103498_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/JOE-07-0570","article-title":"Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway","volume":"198","author":"Abidi","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.redox.2025.103498_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.redox.2025.103498_bib23","doi-asserted-by":"crossref","first-page":"22269","DOI":"10.1073\/pnas.1912700116","article-title":"Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis","volume":"116","author":"Belavgeni","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.redox.2025.103498_bib24","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1161\/HYPERTENSIONAHA.120.16774","article-title":"BEX1 is differentially expressed in aldosterone-producing adenomas and protects human adrenocortical cells from ferroptosis","volume":"77","author":"Yang","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2025.103498_bib25","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1089\/ars.2011.4176","article-title":"NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells","volume":"17","author":"Rajamohan","year":"2012","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2025.103498_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2025.103498_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.redox.2025.103498_bib28","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/sj.npp.1300187","article-title":"Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain","volume":"28","author":"Madrigal","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.redox.2025.103498_bib29","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","article-title":"Transferrin receptor is a specific ferroptosis marker","volume":"30","author":"Feng","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2025.103498_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13153716","article-title":"Primary aldosteronism: metabolic reprogramming and the pathogenesis of aldosterone-producing adenomas","volume":"13","author":"Gong","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.redox.2025.103498_bib31","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1161\/HYPERTENSIONAHA.123.20921","article-title":"Primary aldosteronism: spatial multiomics mapping of genotype-dependent heterogeneity and tumor expansion of aldosterone-producing adenomas","volume":"80","author":"Gong","year":"2023","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2025.103498_bib32","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1021\/acs.jmedchem.1c00569","article-title":"Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer","volume":"64","author":"Xu","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.redox.2025.103498_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1530\/EJE-15-0148","article-title":"Integration of transcriptome and methylome analysis of aldosterone-producing adenomas","volume":"173","author":"Murakami","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.redox.2025.103498_bib34","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1161\/HYPERTENSIONAHA.120.15998","article-title":"Effect of dietary sodium modulation on pig adrenal steroidogenesis and transcriptome profiles","volume":"76","author":"Vohra","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2025.103498_bib35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1677\/JME-08-0112","article-title":"Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis","volume":"42","author":"Nogueira","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.redox.2025.103498_bib36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physiolgenomics.00098.2010","article-title":"Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis","volume":"42a","author":"Romero","year":"2010","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.redox.2025.103498_bib37","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1074\/jbc.M208394200","article-title":"Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity","volume":"278","author":"Baek","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2025.103498_bib38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.7326\/0003-4819-130-2-199901190-00021","article-title":"Severe hepatotoxicity associated with troglitazone","volume":"130","author":"Herrine","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.redox.2025.103498_bib39","doi-asserted-by":"crossref","first-page":"13104","DOI":"10.3390\/ijms131013104","article-title":"Disease progression mediated by egr-1 associated signaling in response to oxidative stress","volume":"13","author":"Pagel","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103498_bib40","doi-asserted-by":"crossref","first-page":"10216","DOI":"10.18632\/aging.205920","article-title":"Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration","volume":"16","author":"Zheng","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.redox.2025.103498_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102703","article-title":"The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1","volume":"62","author":"Cheff","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103498_bib42","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41419-023-06333-7","article-title":"ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2025.103498_bib43","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.7150\/jca.95328","article-title":"EGR1 promotes erastin-induced ferroptosis through activating nrf2-HMOX1 signaling pathway in breast cancer cells","volume":"15","author":"Lin","year":"2024","journal-title":"J. Cancer"},{"key":"10.1016\/j.redox.2025.103498_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174403","article-title":"The Egr-1\/miR-15a-5p\/GPX4 axis regulates ferroptosis in acute myocardial infarction","volume":"909","author":"Fan","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.redox.2025.103498_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103419","article-title":"Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRAS(G12C) inhibitor resistant tumors","volume":"78","author":"Wang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103498_bib46","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.celrep.2017.07.055","article-title":"The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity","volume":"20","author":"Xie","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2025.103498_bib47","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1634\/stemcells.2006-0238","article-title":"Microarray analyses support a role for Nurr1 in resistance to oxidative stress and neuronal differentiation in neural stem cells","volume":"25","author":"Sousa","year":"2007","journal-title":"Stem Cell."},{"key":"10.1016\/j.redox.2025.103498_bib48","article-title":"BMS-470539 attenuates oxidative stress and neuronal apoptosis via mc1r\/cAMP\/PKA\/Nurr1 signaling pathway in a neonatal hypoxic-ischemic rat model","volume":"2022","author":"Yu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2025.103498_bib49","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1210\/en.2009-0977","article-title":"Regulation of aldosterone synthase by activator transcription factor\/cAMP response element-binding protein family members","volume":"151","author":"Nogueira","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.redox.2025.103498_bib50","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/HYPERTENSIONAHA.123.21446","article-title":"Single-Nucleus analysis reveals tumor heterogeneity of aldosterone-producing adenoma","volume":"81","author":"Murakami","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.redox.2025.103498_bib51","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1038\/s41467-023-39901-8","article-title":"ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2025.103498_bib52","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13046-017-0656-4","article-title":"Inhibition of EGR1 inhibits glioma proliferation by targeting CCND1 promoter","volume":"36","author":"Chen","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.redox.2025.103498_bib53","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/71020","article-title":"New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury","volume":"5","author":"Santiago","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.redox.2025.103498_bib54","doi-asserted-by":"crossref","first-page":"10684","DOI":"10.1074\/jbc.M116.720698","article-title":"A positive feed-forward loop associating EGR1 and PDGFA promotes proliferation and self-renewal in glioblastoma stem cells","volume":"291","author":"Sakakini","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2025.103498_bib55","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1161\/HYPERTENSIONAHA.119.13476","article-title":"Primary aldosteronism: KCNJ5 mutations and adrenocortical cell growth","volume":"74","author":"Yang","year":"2019","journal-title":"Hypertension"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725000114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725000114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:04:10Z","timestamp":1778853850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725000114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":55,"alternative-id":["S2213231725000114"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103498","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EGR1 regulates oxidative stress and aldosterone production in adrenal cells and aldosterone-producing adenomas","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103498","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103498"}}