{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:43Z","timestamp":1791229603924,"version":"4.1.0"},"reference-count":167,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000035","name":"Institute of Nutrition Metabolism and Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006127","name":"Queen's University Faculty of Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010231","name":"Banting Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.redox.2025.103541","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T03:19:24Z","timestamp":1739503164000},"page":"103541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease"],"prefix":"10.1016","volume":"81","author":[{"given":"Abhishek","family":"Shastry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia S.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Kuriakose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.M.H.","family":"Veeneman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Ryan","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C.T.","family":"Hindmarch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9760-342X","authenticated-orcid":false,"given":"Kimberly J.","family":"Dunham-Snary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103541_bib1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.gheart.2016.10.024","article-title":"The global burden of disease study and the preventable burden of NCD","volume":"11","author":"Benziger","year":"2016","journal-title":"Global Heart"},{"key":"10.1016\/j.redox.2025.103541_bib2","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.redox.2025.103541_bib3","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1016\/S2214-109X(19)30484-X","article-title":"Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: a pooled analysis of population-based surveys","volume":"8","author":"Miranda","year":"2020","journal-title":"The Lancet Global Health"},{"key":"10.1016\/j.redox.2025.103541_bib4","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103541_bib5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41574-022-00690-7","article-title":"The burden and risks of emerging complications of diabetes mellitus","volume":"18","author":"Tomic","year":"2022","journal-title":"Nature Reviews Endocrinology"},{"key":"10.1016\/j.redox.2025.103541_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600552","article-title":"Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by nontargeted metabolite profiling approach","volume":"61","author":"Tovar","year":"2017","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.redox.2025.103541_bib7","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cjca.2010.12.054","article-title":"Cardiometabolic risk in Canada: a detailed analysis and position paper by the cardiometabolic risk working group","volume":"27","author":"Leiter","year":"2011","journal-title":"Canadian Journal of Cardiology"},{"key":"10.1016\/j.redox.2025.103541_bib8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1559-4572.2009.00054.x","article-title":"Pathogenesis and pathophysiology of the cardiometabolic syndrome","volume":"11","author":"Kirk","year":"2009","journal-title":"Journal of clinical hypertension (Greenwich, Conn.)"},{"key":"10.1016\/j.redox.2025.103541_bib9","article-title":"Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2022 update","volume":"194","author":"Rahul","year":"2022","journal-title":"Canadian Medical Association Journal"},{"key":"10.1016\/j.redox.2025.103541_bib10","article-title":"World obesity Atlas 2023","volume":"2023\u201303\u201302","author":"Tim","year":"2023","journal-title":"World Obesity Federation"},{"key":"10.1016\/j.redox.2025.103541_bib11","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.2337\/diacare.27.10.2317","article-title":"Differences in diabetes prevalence, incidence, and mortality among the elderly of four racial\/ethnic groups: whites, blacks, hispanics, and asians","volume":"27","author":"McBean","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.redox.2025.103541_bib12","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1001\/jama.283.17.2253","article-title":"Incident type 2 diabetes mellitus in african American and white adults: the atherosclerosis risk in communities study","volume":"283","author":"Brancati","year":"2000","journal-title":"Jama"},{"key":"10.1016\/j.redox.2025.103541_bib13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.ijo.0803179","article-title":"Characteristics and prevalence of the metabolic syndrome among three ethnic groups in Canada","volume":"30","author":"Liu","year":"2006","journal-title":"International Journal of Obesity"},{"key":"10.1016\/j.redox.2025.103541_bib14","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1001\/jama.2017.19546","article-title":"Association of modifiable risk factors in young adulthood with racial disparity in incident type 2 diabetes during middle adulthood","volume":"318","author":"Bancks","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.redox.2025.103541_bib15","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1503\/cmaj.150787","article-title":"Lifetime risk of diabetes among First Nations and non-First Nations people","volume":"188","author":"Turin","year":"2016","journal-title":"Cmaj"},{"key":"10.1016\/j.redox.2025.103541_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.dsx.2007.05.003","article-title":"Metabolic syndrome prevalence in an urban African American population","volume":"1","author":"Shaya","year":"2007","journal-title":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews"},{"key":"10.1016\/j.redox.2025.103541_bib17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1001\/jama.2015.10029","article-title":"Prevalence of and trends in diabetes among adults in the United States, 1988-2012","volume":"314","author":"Menke","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.redox.2025.103541_bib18","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1001\/jama.2014.11494","article-title":"Prevalence and incidence trends for diagnosed diabetes among adults aged 20 to 79 Years, United States, 1980-2012","volume":"312","author":"Geiss","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.redox.2025.103541_bib19","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1001\/archinte.167.17.1853","article-title":"Mechanisms for racial and ethnic disparities in glycemic control in middle-aged and older Americans in the health and retirement study","volume":"167","author":"Heisler","year":"2007","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.redox.2025.103541_bib20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41576-021-00414-z","article-title":"The genetics of obesity: from discovery to biology","volume":"23","author":"Loos","year":"2022","journal-title":"Nature Reviews Genetics"},{"key":"10.1016\/j.redox.2025.103541_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/bmb\/ldx022","article-title":"The contribution of genetics and environment to obesity","volume":"123","author":"Albuquerque","year":"2017","journal-title":"British Medical Bulletin"},{"key":"10.1016\/j.redox.2025.103541_bib22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCGENETICS.108.828467","article-title":"Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels. Circulation","volume":"2","author":"Huang","year":"2009","journal-title":"Cardiovascular Genetics"},{"key":"10.1016\/j.redox.2025.103541_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0250697","article-title":"Common genetic variants associated with obesity in an African-American and Hispanic\/Latino population","volume":"16","author":"Chalazan","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103541_bib24","first-page":"505","article-title":"Analysis of metabolic syndrome components in >15 000 african Americans identifies pleiotropic variants","volume":"7","author":"Carty","year":"2014","journal-title":"Circulation: Cardiovascular Genetics"},{"key":"10.1016\/j.redox.2025.103541_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00439-021-02407-8","article-title":"SNP characteristics and validation success in genome wide association studies","volume":"141","author":"Gorlova","year":"2022","journal-title":"Hum Genet"},{"key":"10.1016\/j.redox.2025.103541_bib26","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nature04338","article-title":"Genome sequence, comparative analysis and haplotype structure of the domestic dog","volume":"438","author":"Lindblad-Toh","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.redox.2025.103541_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.redox.2025.103541_bib28","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1093\/molbev\/msx197","article-title":"Large variation in the ratio of mitochondrial to nuclear mutation rate across animals: implications for genetic diversity and the use of mitochondrial DNA as a molecular marker","volume":"34","author":"Allio","year":"2017","journal-title":"Molecular Biology and Evolution"},{"key":"10.1016\/j.redox.2025.103541_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060204","article-title":"Direct estimation of the mitochondrial DNA mutation rate in Drosophila melanogaster","volume":"6","author":"Haag-Liautard","year":"2008","journal-title":"PLOS Biology"},{"key":"10.1016\/j.redox.2025.103541_bib30","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200061","article-title":"The rise and rise of mitochondrial DNA mutations","volume":"10","author":"Lawless","year":"2020","journal-title":"Open Biology"},{"key":"10.1016\/j.redox.2025.103541_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annual Review of Genetics"},{"key":"10.1016\/j.redox.2025.103541_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/biom13010126","article-title":"Insulin resistance in mitochondrial diabetes","volume":"13","author":"Takano","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.redox.2025.103541_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2024.05.022","article-title":"The rate and nature of mitochondrial DNA mutations in human pedigrees","author":"\u00c1rnad\u00f3ttir","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.redox.2025.103541_bib34","first-page":"613","article-title":"Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages","volume":"46","author":"Schurr","year":"1990","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.redox.2025.103541_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/genetics\/130.1.139","article-title":"Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations","volume":"130","author":"Ballinger","year":"1992","journal-title":"Genetics"},{"key":"10.1016\/j.redox.2025.103541_bib36","first-page":"133","article-title":"Analysis of mtDNA variation in African populations reveals the most ancient of all human continent-specific haplogroups","volume":"57","author":"Chen","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.redox.2025.103541_bib37","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/genetics\/144.4.1835","article-title":"Classification of European mtDNAs from an analysis of three European populations","volume":"144","author":"Torroni","year":"1996","journal-title":"Genetics"},{"key":"10.1016\/j.redox.2025.103541_bib38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/CIRCGENETICS.115.001308","article-title":"Endothelial cell bioenergetics and mitochondrial DNA damage differ in humans having african or west eurasian maternal ancestry. Circulation","volume":"9","author":"Krzywanski","year":"2016","journal-title":"Cardiovascular genetics"},{"key":"10.1016\/j.redox.2025.103541_bib39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF01003594","article-title":"Muscle fibre type populations of human leg muscles","volume":"7","author":"Edgerton","year":"1975","journal-title":"The Histochemical Journal"},{"key":"10.1016\/j.redox.2025.103541_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12682-z","article-title":"High-fat diet-induced insulin resistance in single skeletal muscle fibers is fiber type selective","volume":"7","author":"Pataky","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.redox.2025.103541_bib41","doi-asserted-by":"crossref","first-page":"E592","DOI":"10.1152\/ajpendo.00277.2013","article-title":"Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models","volume":"306","author":"Ostler","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.redox.2025.103541_bib42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cmet.2007.10.013","article-title":"Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance","volume":"7","author":"Koves","year":"2008","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib43","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1038\/sj.ijo.0801498","article-title":"Lipotoxic diseases of nonadipose tissues in obesity","volume":"24","author":"Unger","year":"2000","journal-title":"International Journal of Obesity"},{"key":"10.1016\/j.redox.2025.103541_bib44","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cmet.2006.05.003","article-title":"Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1","volume":"3","author":"Um","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.redox.2025.103541_bib45","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00125-020-05335-w","article-title":"Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity","volume":"64","author":"Houzelle","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.redox.2025.103541_bib46","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/oby.23227","article-title":"Skeletal muscle energy metabolism in obesity","volume":"29","author":"Mengeste","year":"2021","journal-title":"Obesity"},{"key":"10.1016\/j.redox.2025.103541_bib47","doi-asserted-by":"crossref","first-page":"E521","DOI":"10.1152\/ajpendo.00069.2021","article-title":"Mito-Mendelian interactions alter in vivo glucose metabolism and insulin sensitivity in healthy mice","volume":"321","author":"Sammy","year":"2021","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.redox.2025.103541_bib48","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s001250050866","article-title":"A common mitochondrial DNA variant is associated with insulin resistance in adult life","volume":"41","author":"Poulton","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.redox.2025.103541_bib49","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/jdi.13629","article-title":"Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals","volume":"13","author":"Shen","year":"2022","journal-title":"Journal of Diabetes Investigation"},{"key":"10.1016\/j.redox.2025.103541_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17086-7","article-title":"Mitochondrial DNA mutations associated with type 2 diabetes mellitus in Chinese Uyghur population","volume":"7","author":"Jiang","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.redox.2025.103541_bib51","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.freeradbiomed.2013.09.007","article-title":"Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility","volume":"65","author":"Dunham-Snary","year":"2013","journal-title":"Free radical biology & medicine"},{"key":"10.1016\/j.redox.2025.103541_bib52","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ebiom.2018.08.036","article-title":"Mitochondrial - nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivo","volume":"36","author":"Dunham-Snary","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.redox.2025.103541_bib53","doi-asserted-by":"crossref","first-page":"16028","DOI":"10.1073\/pnas.1906896116","article-title":"Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy","volume":"116","author":"Kopinski","year":"2019","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.redox.2025.103541_bib54","doi-asserted-by":"crossref","first-page":"E4033","DOI":"10.1073\/pnas.1414028111","article-title":"Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming","volume":"111","author":"Picard","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.redox.2025.103541_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122137","article-title":"Metabolomics and mitochondrial dysfunction in cardiometabolic disease","volume":"333","author":"Shastry","year":"2023","journal-title":"Life Sciences"},{"key":"10.1016\/j.redox.2025.103541_bib56","series-title":"Origin of Eukaryotic Cells: Evidence and Research Implications for a Theory of the Origin and Evolution of Microbial, Plant, and Animal Cells on the Precambrian Earth","author":"Margulis","year":"1970"},{"key":"10.1016\/j.redox.2025.103541_bib57","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0022-5193(67)90079-3","article-title":"On the origin of mitosing cells","volume":"14","author":"Sagan","year":"1967","journal-title":"J Theor Biol"},{"key":"10.1016\/j.redox.2025.103541_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060204","article-title":"Direct estimation of the mitochondrial DNA mutation rate in Drosophila melanogaster","volume":"6","author":"Haag-Liautard","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1016\/j.redox.2025.103541_bib59","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1073\/pnas.76.4.1967","article-title":"Rapid evolution of animal mitochondrial DNA","volume":"76","author":"Brown","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.redox.2025.103541_bib60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrfmmm.2005.12.012","article-title":"Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors","volume":"599","author":"Zheng","year":"2006","journal-title":"Mutat Res"},{"key":"10.1016\/j.redox.2025.103541_bib61","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature02517","article-title":"Premature ageing in mice expressing defective mitochondrial DNA polymerase","volume":"429","author":"Trifunovic","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.redox.2025.103541_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003794","article-title":"Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage","volume":"9","author":"Kennedy","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.redox.2025.103541_bib63","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1073\/pnas.94.2.514","article-title":"Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress","volume":"94","author":"Yakes","year":"1997","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.redox.2025.103541_bib64","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.1976","article-title":"Generation of mitochondrial-nuclear eXchange mice via pronuclear transfer","volume":"6","author":"Kesterson","year":"2016","journal-title":"Bio Protoc"},{"key":"10.1016\/j.redox.2025.103541_bib65","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2337\/diab.37.6.707","article-title":"Genetic analysis of glucose tolerance in inbred mouse strains. Evidence for polygenic control","volume":"37","author":"Kaku","year":"1988","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2025.103541_bib66","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12944-020-01271-1","article-title":"Hepatic steatosis induced in C57BL\/6 mice by a non-ss oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD(+)\/NADH ratio","volume":"19","author":"Berge","year":"2020","journal-title":"LIPIDS IN HEALTH AND DISEASE"},{"key":"10.1016\/j.redox.2025.103541_bib67","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5935\/abc.20130029","article-title":"The oxidative response of mouse hearts is modulated by genetic background","volume":"100","author":"Santos-Silva","year":"2013","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.redox.2025.103541_bib68","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00125-005-1680-z","article-title":"A genetic and physiological study of impaired glucose homeostasis control in C57BL\/6J mice","volume":"48","author":"Toye","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.redox.2025.103541_bib69","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.2337\/db06-0358","article-title":"Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL\/6J mice","volume":"55","author":"Freeman","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2025.103541_bib70","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1440-1746.2007.05150.x","article-title":"Interstrain differences in susceptibility to non-alcoholic steatohepatitis","volume":"23","author":"Yamazaki","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.redox.2025.103541_bib71","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1161\/01.RES.86.10.1078","article-title":"Determinants of atherosclerosis susceptibility in the C3H and C57BL\/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism","volume":"86","author":"Shi","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.redox.2025.103541_bib72","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0021-9150(99)00400-1","article-title":"C3H apoE(-\/-) mice have less atherosclerosis than C57BL apoE(-\/-) mice despite having a more atherogenic serum lipid profile","volume":"151","author":"Grimsditch","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.redox.2025.103541_bib73","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/BJ20131433","article-title":"Mitochondrial-nuclear genome interactions in non-alcoholic fatty liver disease in mice","volume":"461","author":"Betancourt","year":"2014","journal-title":"Biochem J"},{"key":"10.1016\/j.redox.2025.103541_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092730","article-title":"Transcriptomic signature of right ventricular failure in experimental pulmonary arterial hypertension: deep sequencing demonstrates mitochondrial, fibrotic, inflammatory and angiogenic abnormalities","volume":"19","author":"Potus","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.redox.2025.103541_bib75","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1042\/BJ20130029","article-title":"Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload","volume":"455","author":"Fetterman","year":"2013","journal-title":"Biochem J"},{"key":"10.1016\/j.redox.2025.103541_bib76","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1158\/0008-5472.CAN-17-2194","article-title":"Mitochondrial haplotype alters mammary cancer tumorigenicity and metastasis in an oncogenic driver-dependent manner","volume":"77","author":"Brinker","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.redox.2025.103541_bib77","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s10555-018-9773-6","article-title":"Mitochondrial polymorphisms contribute to aging phenotypes in MNX mouse models","volume":"37","author":"Vivian","year":"2018","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.redox.2025.103541_bib78","doi-asserted-by":"crossref","first-page":"E521","DOI":"10.1152\/ajpendo.00069.2021","article-title":"Mito-Mendelian interactions alter in vivo glucose metabolism and insulin sensitivity in healthy mice","volume":"321","author":"Sammy","year":"2021","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib79","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1093\/nar\/gkg739","article-title":"Revisiting the mouse mitochondrial DNA sequence","volume":"31","author":"Bayona-Bafaluy","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.redox.2025.103541_bib80","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1152\/jappl.2001.90.5.1900","article-title":"Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse","volume":"90","author":"Allen","year":"2001","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.redox.2025.103541_bib81","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","article-title":"Fiber types in mammalian skeletal muscles","volume":"91","author":"Schiaffino","year":"2011","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.redox.2025.103541_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.arres.2023.100065","article-title":"Study on the relationship between selenium and cadmium in diseased human lungs","volume":"7","author":"Smith","year":"2023","journal-title":"Adv Redox Res"},{"issue":"Suppl 12","key":"10.1016\/j.redox.2025.103541_bib83","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1097\/JOM.0000000000001687","article-title":"Benzo[a]pyrene perturbs mitochondrial and amino acid metabolism in lung epithelial cells and has similar correlations with metabolic changes in human serum","volume":"61","author":"Smith","year":"2019","journal-title":"J Occup Environ Med"},{"key":"10.1016\/j.redox.2025.103541_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106323","article-title":"Metabolome-wide association study of flavorant vanillin exposure in bronchial epithelial cells reveals disease-related perturbations in metabolism","volume":"147","author":"Smith","year":"2021","journal-title":"Environment International"},{"key":"10.1016\/j.redox.2025.103541_bib85","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1097\/JOM.0000000000000773","article-title":"High-resolution metabolomics assessment of military personnel: evaluating analytical strategies for chemical detection","volume":"58","author":"Liu","year":"2016","journal-title":"J Occup Environ Med"},{"key":"10.1016\/j.redox.2025.103541_bib86","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/acs.analchem.6b01214","article-title":"xMSannotator: an R package for network-based annotation of high-resolution metabolomics data","volume":"89","author":"Uppal","year":"2017","journal-title":"Anal Chem"},{"key":"10.1016\/j.redox.2025.103541_bib87","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: the human metabolome database","volume":"35","author":"Wishart","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.redox.2025.103541_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005752","article-title":"mixOmics: an R package for 'omics feature selection and multiple data integration","volume":"13","author":"Rohart","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.redox.2025.103541_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-12-253","article-title":"Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems","volume":"12","author":"L\u00ea Cao","year":"2011","journal-title":"BMC bioinformatics"},{"key":"10.1016\/j.redox.2025.103541_bib90","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.redox.2025.103541_bib91","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society: Series B (Methodological)"},{"key":"10.1016\/j.redox.2025.103541_bib92","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13682","article-title":"Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults","volume":"21","author":"Chou","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.redox.2025.103541_bib93","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/cam4.4933","article-title":"Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer","volume":"12","author":"Thaiparambil","year":"2023","journal-title":"Cancer Medicine"},{"key":"10.1016\/j.redox.2025.103541_bib94","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12859-023-05233-z","article-title":"multiWGCNA: an R package for deep mining gene co-expression networks in multi-trait expression data","volume":"24","author":"Tommasini","year":"2023","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.redox.2025.103541_bib95","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.numecd.2019.05.055","article-title":"Dietary fat intake and metabolic syndrome in adults: a systematic review","volume":"29","author":"Julibert","year":"2019","journal-title":"Nutrition, Metabolism and Cardiovascular Diseases"},{"key":"10.1016\/j.redox.2025.103541_bib96","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5621701","article-title":"Dietary patterns and their association with metabolic syndrome and their components in middle-class adults from damascus, Syria: a cross-sectional study","volume":"2022","author":"Atasi","year":"2022","journal-title":"Journal of Nutrition and Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib97","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.redox.2025.103541_bib98","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.redox.2025.103541_bib99","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/oby.2011.36","article-title":"Body adiposity and type 2 diabetes: increased risk with a high body fat percentage even having a normal BMI","volume":"19","author":"G\u00f3mez-Ambrosi","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.redox.2025.103541_bib100","doi-asserted-by":"crossref","DOI":"10.1093\/function\/zqad020","article-title":"Skeletal muscle consequences of phosphatidylethanolamine synthesis deficiency","volume":"4","author":"Grapentine","year":"2023","journal-title":"Function"},{"key":"10.1016\/j.redox.2025.103541_bib101","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4062\/biomolther.2014.017","article-title":"Metabolism of very long-chain Fatty acids: genes and pathophysiology","volume":"22","author":"Sassa","year":"2014","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.redox.2025.103541_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070728","article-title":"Role of cardiolipin in mitochondrial function and dynamics in health and disease: molecular and pharmacological aspects","volume":"8","author":"Paradies","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.redox.2025.103541_bib103","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4112","article-title":"Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer","volume":"32","author":"Sonkar","year":"2019","journal-title":"NMR Biomed"},{"key":"10.1016\/j.redox.2025.103541_bib104","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1194\/jlr.R700019-JLR200","article-title":"Phosphatidylcholine and choline homeostasis","volume":"49","author":"Li","year":"2008","journal-title":"Journal of lipid research"},{"key":"10.1016\/j.redox.2025.103541_bib105","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.clnu.2019.04.025","article-title":"Metabolically unhealthy overweight individuals have high lysophosphatide levels, phospholipase activity, and oxidative stress","volume":"39","author":"Kim","year":"2020","journal-title":"Clinical Nutrition"},{"key":"10.1016\/j.redox.2025.103541_bib106","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2265.2011.04244.x","article-title":"The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes","volume":"76","author":"Ha","year":"2012","journal-title":"Clinical Endocrinology"},{"key":"10.1016\/j.redox.2025.103541_bib107","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41569-020-00465-5","article-title":"Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging","volume":"18","author":"Ng","year":"2021","journal-title":"Nature Reviews Cardiology"},{"key":"10.1016\/j.redox.2025.103541_bib108","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/983814","article-title":"Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions","volume":"2012","author":"Snel","year":"2012","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.redox.2025.103541_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101669","article-title":"Methodological advancements in organ-specific ectopic lipid quantitative characterization: effects of high fat diet on muscle and liver intracellular lipids","volume":"68","author":"Grepper","year":"2023","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib110","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1139\/H07-083","article-title":"Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1\u03b1: implications for metabolic disease","volume":"32","author":"Muoio","year":"2007","journal-title":"Applied Physiology, Nutrition, and Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib111","doi-asserted-by":"crossref","first-page":"9597","DOI":"10.1073\/pnas.1409229111","article-title":"Role of diacylglycerol activation of PKC\u03b8 in lipid-induced muscle insulin resistance in humans","volume":"111","author":"Szendroedi","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.redox.2025.103541_bib112","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022116","article-title":"Gene expression pattern in transmitochondrial cytoplasmic hybrid cells harboring type 2 diabetes-associated mitochondrial DNA haplogroups","volume":"6","author":"Hwang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103541_bib113","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00439-005-0046-4","article-title":"Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns","volume":"118","author":"Mohlke","year":"2005","journal-title":"Human Genetics"},{"key":"10.1016\/j.redox.2025.103541_bib114","first-page":"26","article-title":"Endothelial cell bioenergetics and mitochondrial DNA damage differ in humans having african or west eurasian maternal ancestry","volume":"9","author":"Krzywanski","year":"2016","journal-title":"Circulation: Cardiovascular Genetics"},{"key":"10.1016\/j.redox.2025.103541_bib115","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/labinvest.2011.95","article-title":"The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics","volume":"91","author":"Krzywanski","year":"2011","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.redox.2025.103541_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101568","article-title":"An evolutionary, or \u201cMitocentric\u201d perspective on cellular function and disease","volume":"36","author":"Brown","year":"2020","journal-title":"Redox Biology"},{"key":"10.1016\/j.redox.2025.103541_bib117","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1152\/physiolgenomics.00069.2014","article-title":"Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction","volume":"46","author":"Hou\u0161t\u011bk","year":"2014","journal-title":"Physiological Genomics"},{"key":"10.1016\/j.redox.2025.103541_bib118","doi-asserted-by":"crossref","first-page":"S471","DOI":"10.33549\/physiolres.934740","article-title":"Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat","volume":"70","author":"Pravenec","year":"2021","journal-title":"Physiol Res"},{"key":"10.1016\/j.redox.2025.103541_bib119","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1101\/gr.6548207","article-title":"Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains","volume":"17","author":"Pravenec","year":"2007","journal-title":"Genome Res"},{"key":"10.1016\/j.redox.2025.103541_bib120","doi-asserted-by":"crossref","first-page":"H484","DOI":"10.1152\/ajpheart.00371.2022","article-title":"Mitochondrial haplotype modulates genome expression and mitochondrial structure\/function in cardiomyocytes following volume overload","volume":"324","author":"Guichard","year":"2023","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/j.redox.2025.103541_bib121","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mitoco.2022.10.002","article-title":"The metabolism and function of phospholipids in Mitochondria","volume":"1","author":"Dong","year":"2023","journal-title":"Mitochondrial Communications"},{"key":"10.1016\/j.redox.2025.103541_bib122","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1007\/s00125-021-05430-6","article-title":"Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity","volume":"64","author":"Mendham","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.redox.2025.103541_bib123","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1096\/fj.201802117R","article-title":"A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling","volume":"33","author":"Van Der Veen","year":"2019","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.redox.2025.103541_bib124","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1038\/s41598-018-24976-x","article-title":"Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men","volume":"8","author":"Lee","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.redox.2025.103541_bib125","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12944-018-0687-7","article-title":"Elevated whole muscle phosphatidylcholine: phosphatidylethanolamine ratio coincides with reduced SERCA activity in murine overloaded plantaris muscles","volume":"17","author":"Fajardo","year":"2018","journal-title":"Lipids in Health and Disease"},{"issue":"120","key":"10.1016\/j.redox.2025.103541_bib126","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1152\/japplphysiol.00664.2015","article-title":"Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans","volume":"1985","author":"Newsom","year":"2016","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.redox.2025.103541_bib127","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010037","article-title":"Restoration of sarcoplasmic reticulum Ca(2+) ATPase (SERCA) activity prevents age-related muscle atrophy and weakness in mice","volume":"22","author":"Qaisar","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.redox.2025.103541_bib128","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1021\/bi9822224","article-title":"Phosphatidylethanolamine modulates Ca-ATPase function and dynamics","volume":"38","author":"Hunter","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.redox.2025.103541_bib129","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2337\/db15-0659","article-title":"Skeletal muscle phospholipid metabolism regulates insulin sensitivity and contractile function","volume":"65","author":"Funai","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2025.103541_bib130","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI65726","article-title":"Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling","volume":"123","author":"Funai","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.redox.2025.103541_bib131","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1074\/jbc.M112.434183","article-title":"Phosphatidylethanolamine deficiency in mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology","volume":"288","author":"Tasseva","year":"2013","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.redox.2025.103541_bib132","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes"},{"key":"10.1016\/j.redox.2025.103541_bib133","first-page":"338","article-title":"Chicken or egg? Mitochondrial phospholipids and oxidative stress in disuse-induced skeletal muscle atrophy","volume":"38","author":"Miranda","year":"2023","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.redox.2025.103541_bib134","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax8352","article-title":"Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity","volume":"5","author":"Heden","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.redox.2025.103541_bib135","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2337\/diabetes.50.2.404","article-title":"Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid","volume":"50","author":"Maddux","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.redox.2025.103541_bib136","doi-asserted-by":"crossref","first-page":"E938","DOI":"10.1152\/ajpendo.00010.2021","article-title":"Genetically increasing flux through \u03b2-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance","volume":"320","author":"Smith","year":"2021","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib137","doi-asserted-by":"crossref","first-page":"E168","DOI":"10.1152\/ajpendo.00227.2018","article-title":"Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity","volume":"316","author":"Ngo","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.redox.2025.103541_bib138","doi-asserted-by":"crossref","DOI":"10.1172\/JCI135963","article-title":"Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle","volume":"131","author":"Ferrara","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.redox.2025.103541_bib139","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101104R","article-title":"Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding","volume":"35","author":"Ferrara","year":"2021","journal-title":"Faseb j"},{"key":"10.1016\/j.redox.2025.103541_bib140","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1210\/jc.2017-01727","article-title":"High incomplete skeletal muscle fatty acid oxidation explains low muscle insulin sensitivity in poorly controlled T2D","volume":"103","author":"Gavin","year":"2018","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib141","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.bbalip.2013.11.013","article-title":"Micromolar changes in lysophosphatidylcholine concentration cause minor effects on mitochondrial permeability but major alterations in function","volume":"1841","author":"Hollie","year":"2014","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"},{"key":"10.1016\/j.redox.2025.103541_bib142","doi-asserted-by":"crossref","DOI":"10.3390\/genes13101889","article-title":"Cardiolipin regulates mitochondrial ultrastructure and function in mammalian cells","volume":"13","author":"Jiang","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.redox.2025.103541_bib143","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd6322","article-title":"Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle","volume":"7","author":"Prola","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.redox.2025.103541_bib144","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0026-0495(73)90269-2","article-title":"The glucose-alanine cycle","volume":"22","author":"Felig","year":"1973","journal-title":"Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190904","article-title":"PGC-1\u03b1 regulates alanine metabolism in muscle cells","volume":"13","author":"Hatazawa","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103541_bib146","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s42255-021-00369-9","article-title":"Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes","volume":"3","author":"Okun","year":"2021","journal-title":"Nature Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102217","article-title":"Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle","volume":"24","author":"Egami","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.redox.2025.103541_bib148","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12933-022-01677-4","article-title":"Specific triacylglycerol, diacylglycerol, and lyso-phosphatidylcholine species for the prediction of type 2 diabetes: a \u223c 16-year prospective study in Chinese","volume":"21","author":"Zhong","year":"2022","journal-title":"Cardiovascular Diabetology"},{"key":"10.1016\/j.redox.2025.103541_bib149","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14214-1","article-title":"Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains","volume":"7","author":"Montgomery","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.redox.2025.103541_bib150","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.cmet.2015.04.001","article-title":"The CDP-ethanolamine pathway regulates skeletal muscle diacylglycerol content and mitochondrial biogenesis without altering insulin sensitivity","volume":"21","author":"Selathurai","year":"2015","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100100","article-title":"Differential contributions of choline phosphotransferases CPT1 and CEPT1 to the biosynthesis of choline phospholipids","volume":"62","author":"Horibata","year":"2021","journal-title":"J Lipid Res"},{"key":"10.1016\/j.redox.2025.103541_bib152","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1007\/s00018-013-1539-2","article-title":"Regulation of pyruvate metabolism and human disease","volume":"71","author":"Gray","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.redox.2025.103541_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2024.104895","article-title":"Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk","volume":"137","author":"Vianello","year":"2024","journal-title":"Experimental and Molecular Pathology"},{"key":"10.1016\/j.redox.2025.103541_bib154","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1172\/JCI96036","article-title":"mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion","volume":"127","author":"Quinn","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.redox.2025.103541_bib155","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphyslip.2020.104914","article-title":"CDP-diacylglycerol, a critical intermediate in lipid metabolism","volume":"230","author":"Jennings","year":"2020","journal-title":"Chemistry and Physics of Lipids"},{"key":"10.1016\/j.redox.2025.103541_bib156","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.apsb.2021.12.011","article-title":"Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases","volume":"12","author":"Guan","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.redox.2025.103541_bib157","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40659-023-00436-3","article-title":"Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells","volume":"56","author":"Abrigo","year":"2023","journal-title":"Biological Research"},{"key":"10.1016\/j.redox.2025.103541_bib158","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.tim.2022.10.003","article-title":"Gut microbiota-bile acid-skeletal muscle axis","volume":"31","author":"Mancin","year":"2023","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.redox.2025.103541_bib159","article-title":"Bile acids induce alterations in mitochondrial function in skeletal muscle fibers","volume":"11","author":"Abrigo","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.redox.2025.103541_bib160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102056","article-title":"Selective PPAR\u03b4 agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway","volume":"298","author":"Kouno","year":"2022","journal-title":"J Biol Chem"},{"key":"10.1016\/j.redox.2025.103541_bib161","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2169\/internalmedicine.56.7796","article-title":"The associations between circulating bile acids and the muscle volume in patients with non-alcoholic fatty liver disease (NAFLD)","volume":"56","author":"Kobayashi","year":"2017","journal-title":"Intern Med"},{"key":"10.1016\/j.redox.2025.103541_bib162","doi-asserted-by":"crossref","first-page":"28382","DOI":"10.1074\/jbc.M111.234732","article-title":"Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome","volume":"286","author":"Liaset","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.redox.2025.103541_bib163","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/jdi.13614","article-title":"Role of skeletal muscle lipids in the pathogenesis of insulin resistance of obesity and type 2 diabetes","volume":"12","author":"Gilbert","year":"2021","journal-title":"Journal of Diabetes Investigation"},{"key":"10.1016\/j.redox.2025.103541_bib164","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1053\/beem.2000.0123","article-title":"Steroid metabolism in metabolic syndrome X","volume":"15","author":"Walker","year":"2001","journal-title":"Best Practice & Research Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.redox.2025.103541_bib165","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s42269-022-00952-4","article-title":"Sorting of exclusive mitochondrial proteins from the Mitoproteome database","volume":"46","author":"Yadav","year":"2022","journal-title":"Bulletin of the National Research Centre"},{"issue":"Suppl 2","key":"10.1016\/j.redox.2025.103541_bib166","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.2337\/dc09-S302","article-title":"Skeletal muscle insulin resistance is the primary defect in type 2 diabetes","volume":"32","author":"DeFronzo","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.redox.2025.103541_bib167","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0002-9149(02)02554-7","article-title":"Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus","volume":"90","author":"Petersen","year":"2002","journal-title":"American Journal of Cardiology"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725000540?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725000540?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T13:54:25Z","timestamp":1742306065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725000540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":167,"alternative-id":["S2213231725000540"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103541","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.12.19.629398","asserted-by":"object"}]},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103541","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103541"}}