{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:47:32Z","timestamp":1789829252343,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023-MS-12"],"award-info":[{"award-number":["2023-MS-12"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071688"],"award-info":[{"award-number":["82071688"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471752"],"award-info":[{"award-number":["82471752"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.redox.2025.103586","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:59:01Z","timestamp":1741240741000},"page":"103586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia"],"prefix":"10.1016","volume":"82","author":[{"given":"Tong","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103586_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.678055","article-title":"The interplay of glucagon-like peptide-1 receptor trafficking and signalling in pancreatic beta cells","volume":"12","author":"Marzook","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.redox.2025.103586_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2023.11.009","article-title":"Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation","volume":"36","author":"Wong","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2025.103586_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114348","article-title":"Activation of glucagon-like peptide-1 receptor in microglia exerts protective effects against sepsis-induced encephalopathy via attenuating endoplasmic reticulum stress-associated inflammation and apoptosis in a mouse model of sepsis","volume":"363","author":"Yi","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.redox.2025.103586_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74912-1","article-title":"GLP-1 receptor agonist ameliorates experimental lung fibrosis","volume":"10","author":"Fandi\u00f1o","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2025.103586_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41374-018-0170-0","article-title":"Glucagon-like peptide-1 receptor activation alleviates lipopolysaccharide-induced acute lung injury in mice via maintenance of endothelial barrier function","volume":"99","author":"Xu","year":"2019","journal-title":"Lab. Invest."},{"key":"10.1016\/j.redox.2025.103586_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/ACI.0000000000000797","article-title":"Evaluating the glucagon-like peptide-1 receptor in managing asthma","volume":"22","author":"Wu","year":"2022","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.redox.2025.103586_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2021.102003","article-title":"Glucagon-like peptide 1 receptor (GLP-1R) agonist relieved asthmatic airway inflammation via suppression of NLRP3 inflammasome activation in obese asthma mice model","volume":"67","author":"Hur","year":"2021","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.redox.2025.103586_bib8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/cea.14252","article-title":"Dual GIPR and GLP-1R agonist tirzepatide inhibits aeroallergen-induced allergic airway inflammation in mouse model of obese asthma","volume":"53","author":"Toki","year":"2023","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.redox.2025.103586_bib9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1164\/rccm.202004-0993OC","article-title":"Asthma exacerbations in patients with type 2 diabetes and asthma on glucagon-like peptide-1 receptor agonists","volume":"203","author":"Foer","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.redox.2025.103586_bib10","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3892\/mmr.2017.6618","article-title":"Overexpression of GLP-1 receptors suppresses proliferation and cytokine release by airway smooth muscle cells of patients with chronic obstructive pulmonary disease via activation of ABCA1","volume":"16","author":"Sun","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.redox.2025.103586_bib11","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1210\/en.2014-1685","article-title":"Activation of the GLP-1 receptor by liraglutide increases ACE2 expression, reversing right ventricle hypertrophy, and improving the production of SP-A and SP-B in the lungs of type 1 diabetes rats","volume":"156","author":"Roman\u00ed-P\u00e9rez","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.redox.2025.103586_bib12","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1210\/en.2012-1786","article-title":"Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant-protein levels in litters from normal and nitrofen-treated pregnant rats","volume":"154","author":"Roman\u00ed-P\u00e9rez","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.redox.2025.103586_bib13","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1210\/en.2013-1666","article-title":"Glucagon-like peptide-1 (GLP-1) reduces mortality and improves lung function in a model of experimental obstructive lung disease in female mice","volume":"154","author":"Viby","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.redox.2025.103586_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25010649","article-title":"Descriptive and functional genomics in neonatal respiratory distress syndrome: from lung development to targeted therapies","volume":"25","author":"Anciuc-Crauciuc","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103586_bib15","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00431-017-3009-6","article-title":"The economic impact of prematurity and bronchopulmonary dysplasia","volume":"176","author":"\u00c1lvarez-Fuente","year":"2017","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.redox.2025.103586_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2021.12.018","article-title":"Severity of bronchopulmonary dysplasia and neurodevelopmental outcome at 2 and 5 Years corrected age","volume":"243","author":"Katz","year":"2022","journal-title":"J. Pediatr."},{"key":"10.1016\/j.redox.2025.103586_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41572-019-0127-7","article-title":"Bronchopulmonary dysplasia","volume":"5","author":"Th\u00e9baud","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.redox.2025.103586_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102865","article-title":"Emerging role of metabolic reprogramming in hyperoxia-associated neonatal diseases","volume":"66","author":"Sun","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103586_bib19","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00341.2020","article-title":"Heterogeneous groups of alveolar type II cells in lung homeostasis and repair","volume":"319","author":"Chen","year":"2020","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.redox.2025.103586_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052566","article-title":"The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung","volume":"22","author":"Ruaro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103586_bib21","doi-asserted-by":"crossref","first-page":"L861","DOI":"10.1152\/ajplung.00099.2014","article-title":"Hyperoxia stimulates the transdifferentiation of type II alveolar epithelial cells in newborn rats","volume":"308","author":"Hou","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.redox.2025.103586_bib22","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.3892\/ijmm.2020.4766","article-title":"Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN-induced putative kinase 1-Parkin and Nip3-like protein X-mediated mitophagy disorders","volume":"46","author":"Yu","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.redox.2025.103586_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.587267","article-title":"The specific connexin 43-inhibiting peptide Gap26 improved alveolar development of neonatal rats with hyperoxia exposure","volume":"12","author":"Qing","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.redox.2025.103586_bib24","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nprot.2009.95","article-title":"Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase","volume":"4","author":"DuPage","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.redox.2025.103586_bib25","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00191.2023","article-title":"Defining signals that promote human alveolar type I differentiation","volume":"326","author":"Li","year":"2024","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.redox.2025.103586_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat3392","article-title":"Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models","volume":"10","author":"Killion","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.redox.2025.103586_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.838410","article-title":"Recent advances in incretin-based pharmacotherapies for the treatment of obesity and diabetes","volume":"13","author":"Tan","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.redox.2025.103586_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121546","article-title":"Dulaglutide impedes depressive-like behavior persuaded by chronic social defeat stress model in male C57BL\/6 mice: implications on GLP-1R and cAMP\/PKA signaling pathway in the hippocampus","volume":"320","author":"Darwish","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.redox.2025.103586_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132256","article-title":"Achyranthes bidentata polysaccharide ameliorates type 2 diabetes mellitus by gut microbiota-derived short-chain fatty acids-induced activation of the GLP-1\/GLP-1R\/cAMP\/PKA\/CREB\/INS pathway","volume":"270","author":"Xia","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.redox.2025.103586_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2020.05.001","article-title":"GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function","volume":"31","author":"Timper","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2025.103586_bib31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s42255-020-0209-6","article-title":"Resolution of NASH and hepatic fibrosis by the GLP-1R\/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis","volume":"2","author":"Boland","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.redox.2025.103586_bib32","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/cvr\/cvz002","article-title":"The intestine responds to heart failure by enhanced mitochondrial fusion through glucagon-like peptide-1 signalling","volume":"115","author":"Naruse","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2025.103586_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2024.171200","article-title":"Immunomodulation and inflammation: role of GLP-1R and GIPR expressing cells within the gut","volume":"176","author":"Morrow","year":"2024","journal-title":"Peptides"},{"key":"10.1016\/j.redox.2025.103586_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2022.08.003","article-title":"Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation","volume":"34","author":"Wong","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2025.103586_bib35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s12033-020-00269-5","article-title":"m6A RNA methylation: ramifications for gene expression and human Health","volume":"62","author":"Karthiya","year":"2020","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.redox.2025.103586_bib36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12943-020-01204-7","article-title":"The potential role of RNA N6-methyladenosine in Cancer progression","volume":"19","author":"Wang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.redox.2025.103586_bib37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12943-022-01500-4","article-title":"The role of m6A RNA methylation in cancer metabolism","volume":"21","author":"An","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.redox.2025.103586_bib38","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.molmed.2023.03.005","article-title":"N6-methyladenosine-mediated gene regulation and therapeutic implications","volume":"29","author":"Liu","year":"2023","journal-title":"Trends Mol. Med."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725000990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725000990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:25:04Z","timestamp":1787225104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725000990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":38,"alternative-id":["S2213231725000990"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103586","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103586"}}