{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:03:09Z","timestamp":1790402589667,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["864921"],"award-info":[{"award-number":["864921"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2022AT7P9T"],"award-info":[{"award-number":["2022AT7P9T"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["202275M25F"],"award-info":[{"award-number":["202275M25F"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.redox.2025.103645","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T12:55:01Z","timestamp":1745326501000},"page":"103645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1"],"prefix":"10.1016","volume":"83","author":[{"given":"M.","family":"Smimmo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Casale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"D'Andrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Iaccarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Brancaleone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Panza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"d\u2019Emmanuele di Villa Bianca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Katsouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mitidieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Antoniadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Papapetropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Maione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Castaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Friuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gaetani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Randazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Filipovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vellecco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103645_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1042\/CS20150521","article-title":"Cystathionine \u03b2-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia","volume":"130","author":"Vellecco","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.redox.2025.103645_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102040","article-title":"Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity","volume":"45","author":"Panza","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103645_bib3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/bph.14446","article-title":"Regulators of the transsulfuration pathway","volume":"176","author":"Sbodio","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2025.103645_bib4","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1111\/bph.14358","article-title":"Hydrogen sulfide pathway and skeletal muscle: an introductory review","volume":"175","author":"Vellecco","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2025.103645_bib5","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1111\/bph.13815","article-title":"Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system","volume":"174","author":"Cirino","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.redox.2025.103645_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/ars.2023.0352","article-title":"Emerging chemical biology of protein persulfidation","volume":"39","author":"Vignane","year":"2023","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2025.103645_bib7","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.cmet.2019.10.007","article-title":"Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-sulfhydration","volume":"30","author":"Zivanovic","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2025.103645_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax8358","article-title":"Control of protein function through oxidation and reduction of persulfidated states","volume":"6","author":"D\u00f3ka","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.redox.2025.103645_bib9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0026-0495(00)80010-4","article-title":"Intramuscular lipid content is increased in obesity and decreased by weight loss","volume":"49","author":"Goodpaster","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.redox.2025.103645_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrendo.2015.189","article-title":"Regulation of metabolism by the innate immune system","volume":"12","author":"Lackey","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.redox.2025.103645_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12950-018-0185-8","article-title":"The role of adipokines in skeletal muscle inflammation and insulin sensitivity","volume":"15","author":"Nicholson","year":"2018","journal-title":"J. Inflamm."},{"key":"10.1016\/j.redox.2025.103645_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2020.569904","article-title":"Exploring the impact of obesity on skeletal muscle function in older age","volume":"7","author":"Morgan","year":"2020","journal-title":"Front. Nutr."},{"key":"10.1016\/j.redox.2025.103645_bib13","doi-asserted-by":"crossref","first-page":"851","DOI":"10.5114\/aoms.2016.58928","article-title":"Obesity and inflammation: the linking mechanism and the complications","volume":"13","author":"Ellulu","year":"2017","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.redox.2025.103645_bib14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fphys.2018.00112","article-title":"Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity","volume":"9","author":"Collins","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.redox.2025.103645_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.redox.2025.103645_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.redox.2025.103645_bib17","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1111\/febs.12338","article-title":"Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?","volume":"280","author":"Mu\u00f1oz-C\u00e1noves","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.redox.2025.103645_bib18","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jcsm.12189","article-title":"Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis","volume":"8","author":"Tournadre","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.redox.2025.103645_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12955-017-0773-y","article-title":"The impact of obesity on health-related quality of life in Spain","volume":"15","author":"Busutil","year":"2017","journal-title":"Health Qual. Life Outcome"},{"key":"10.1016\/j.redox.2025.103645_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0026-0495(00)90588-2","article-title":"The db\/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding","volume":"49","author":"Kobayashi","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.redox.2025.103645_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.585887","article-title":"Leptin and obesity: role and clinical implication","volume":"12","author":"Obradovic","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.redox.2025.103645_bib22","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical biology of H2S signaling through persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.redox.2025.103645_bib23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41589-022-01244-8","article-title":"3-Mercaptopyruvate sulfur transferase is a protein persulfidase","volume":"19","author":"Pedre","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.redox.2025.103645_bib24","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.bbrc.2020.04.002","article-title":"Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK\/PGC-1\u03b1 pathway in skeletal muscle","volume":"526","author":"Guo","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2025.103645_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101727","article-title":"The correlation of IRE1\u03b1 oxidation with Nox4 activation in aging-associated vascular dysfunction","volume":"37","author":"Lee","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103645_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154835","article-title":"Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells","volume":"125","author":"Sadeghi","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.redox.2025.103645_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120129","article-title":"Dimethyl itaconate attenuates palmitate-induced insulin resistance in skeletal muscle cells through the AMPK\/FGF21\/PPAR\u03b4-mediated suppression of inflammation","volume":"287","author":"Park","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.redox.2025.103645_bib28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/j.2040-4603.2020.tb00136.x","article-title":"Role of skeletal muscle in insulin resistance and glucose uptake","volume":"10","author":"Merz","year":"2020","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.redox.2025.103645_bib29","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1172\/JCI67227","article-title":"AMPK, insulin resistance, and the metabolic syndrome","volume":"123","author":"Ruderman","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2025.103645_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijbiomac.2020.04.186","article-title":"FGF19 alleviates palmitate-induced atrophy in C2C12 cells by inhibiting mitochondrial overload and insulin resistance","volume":"158","author":"Sun","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.redox.2025.103645_bib31","first-page":"1","article-title":"METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPAR\u03b4-dependent pathways in skeletal muscle of mice","volume":"50","author":"Jung","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.redox.2025.103645_bib32","doi-asserted-by":"crossref","first-page":"9327","DOI":"10.3390\/ijms22179327","article-title":"Exploring the role of skeletal muscle in insulin resistance: lessons from cultured cells to animal models","volume":"22","author":"Feraco","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103645_bib33","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin resistance: review of the underlying molecular mechanisms","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.redox.2025.103645_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102307","article-title":"Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: a potential role for SIRT1","volume":"52","author":"Brunetta","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103645_bib35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.coph.2012.02.010","article-title":"SIRT1 signaling as potential modulator of skeletal muscle diseases","volume":"12","author":"Tonkin","year":"2012","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.redox.2025.103645_bib36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1242\/dmm.004655","article-title":"SirT1 in muscle physiology and disease: lessons from mouse models","volume":"3","author":"Vinciguerra","year":"2010","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.redox.2025.103645_bib37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.devcel.2008.02.004","article-title":"Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt","volume":"14","author":"Fulco","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.redox.2025.103645_bib38","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/ars.2017.7195","article-title":"Sulfhydrated sirtuin-1 increasing its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide","volume":"30","author":"Du","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2025.103645_bib39","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.18632\/oncotarget.2795","article-title":"Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.redox.2025.103645_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101813","article-title":"Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-\u03baB and STAT3","volume":"38","author":"Sun","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103645_bib41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.phrs.2017.09.023","article-title":"Reduced adipose tissue H2S in obesity","volume":"128","author":"Katsouda","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.redox.2025.103645_bib42","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1002\/ptr.6941","article-title":"Eruca sativa Mill. seed extract promotes anti-obesity and hypoglycemic effects in mice fed with a high-fat diet","volume":"35","author":"Piragine","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.redox.2025.103645_bib43","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3390\/antiox10050633","article-title":"The impact of H2S on obesity-associated metabolic disturbances","volume":"10","author":"Comas","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2025.103645_bib44","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.3390\/ijms23115955","article-title":"Beneficial effect of H2S-releasing molecules in an in vitro model of sarcopenia: relevance of glucoraphanin","volume":"23","author":"Micheli","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103645_bib45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/biom10020317","article-title":"Generation and characterization of a CRISPR\/Cas9 -induced 3-mst deficient zebrafish","volume":"10","author":"Katsouda","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.redox.2025.103645_bib46","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211894","article-title":"MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity","volume":"219","author":"Katsouda","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.redox.2025.103645_bib47","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1111\/jcmm.15587","article-title":"Hydrogen sulphide ameliorating skeletal muscle atrophy in db\/db mice via Muscle RING finger 1 S-sulfhydration","volume":"24","author":"Lu","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"Suppl 1","key":"10.1016\/j.redox.2025.103645_bib48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/ggi.12197","article-title":"Development of a simple screening test for sarcopenia in older adults","volume":"14","author":"Ishii","year":"2014","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.redox.2025.103645_bib49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2025.103645_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113833","article-title":"Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase","volume":"176","author":"Peleli","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.redox.2025.103645_bib51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fendo.2017.00029","article-title":"Systemic regulators of skeletal muscle regeneration in obesity","volume":"8","author":"Sinha","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.redox.2025.103645_bib52","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1002\/oby.21654","article-title":"Reactive oxygen species and oxidative stress in obesity-recent findings and empirical approaches","volume":"24","author":"McMurray","year":"2016","journal-title":"Obesity"},{"key":"10.1016\/j.redox.2025.103645_bib53","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3390\/antiox12030603","article-title":"Role of 3-mercaptopyruvate sulfurtransferase (3-MST) in physiology and disease","volume":"12","author":"Rao","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2025.103645_bib54","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s00125-015-3656-y","article-title":"Metabolite profiling in plasma and tissues of ob\/ob and db\/db mice identifies novel markers of obesity and type 2 diabetes","volume":"58","author":"Giesbertz","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.redox.2025.103645_bib55","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3390\/jcm10051081","article-title":"The role of the transsulfuration pathway in non-alcoholic fatty liver disease","volume":"10","author":"Werge","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.redox.2025.103645_bib56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12967-015-0610-1","article-title":"Taurine: the appeal of a safe amino acid for skeletal muscle disorders","volume":"13","author":"De Luca","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.redox.2025.103645_bib57","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.3390\/antiox10121876","article-title":"Taurine as a natural antioxidant: from direct antioxidant effects to protective action in various toxicological models","volume":"10","author":"Surai","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2025.103645_bib58","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s004180050286","article-title":"Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis","volume":"110","author":"Nagahara","year":"1998","journal-title":"Histochemistry"},{"key":"10.1016\/j.redox.2025.103645_bib59","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2025.103645_bib60","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/jb\/mvp111","article-title":"Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide","volume":"146","author":"Shibuya","year":"2009","journal-title":"J. Biochem."},{"key":"10.1016\/j.redox.2025.103645_bib61","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2319473121","article-title":"H2S preconditioning induces long-lived perturbations in O2 metabolism","volume":"121","author":"Hanna","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.redox.2025.103645_bib62","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.chembiol.2019.09.010","article-title":"A catalytic trisulfide in human sulfide quinone oxidoreductase catalyzes coenzyme A persulfide synthesis and inhibits butyrate oxidation","volume":"26","author":"Landry","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.redox.2025.103645_bib63","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12967-018-1753-7","article-title":"Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia-reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis","volume":"17","author":"Wetzel","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.redox.2025.103645_bib64","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67368","article-title":"Sulforaphane reduces obesity by reversing leptin resistance","volume":"11","author":"\u00c7ak\u0131r","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.redox.2025.103645_bib65","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10753-017-0684-4","article-title":"Hydrogen sulfide exerts anti-oxidative and anti-inflammatory effects in acute lung injury","volume":"41","author":"Zimmermann","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.redox.2025.103645_bib66","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103645_bib67","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.phrs.2016.07.026","article-title":"H2S-induced thiol-based redox switches: biochemistry and functional relevance for inflammatory diseases","volume":"111","author":"Longen","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.redox.2025.103645_bib68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3390\/antiox7100129","article-title":"Role of hydrogen sulfide in NRF2- and sirtuin-dependent maintenance of cellular redox balance","volume":"7","author":"Corsello","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2025.103645_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103014","article-title":"Loss of cardiac mitochondrial complex I persulfidation impairs NAD+ homeostasis in aging","volume":"69","author":"Drekolia","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103645_bib70","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2023.2174649","article-title":"Cystathionine \u03b3-lyase S-sulfhydrates SIRT1 to attenuate myocardial death in isoprenaline-induced heart failure","volume":"28","author":"Wu","year":"2023","journal-title":"Redox Rep."},{"key":"10.1016\/j.redox.2025.103645_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101356","article-title":"Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway","volume":"28","author":"Guan","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103645_bib72","article-title":"Regulation of SIRT1 and its roles in inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.redox.2025.103645_bib73","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1681\/ASN.2017111218","article-title":"Sirtuins in renal health and disease","volume":"29","author":"Morigi","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.redox.2025.103645_bib74","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/07853890.2010.547211","article-title":"Sirtuin 1 in lipid metabolism and obesity","volume":"43","author":"Schug","year":"2011","journal-title":"Ann. Med."},{"key":"10.1016\/j.redox.2025.103645_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-019-03506-x","article-title":"Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy","volume":"457","author":"Ahmed","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.redox.2025.103645_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116466","article-title":"Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation","volume":"174","author":"Smimmo","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2025.103645_bib77","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/01.RES.0000256090.42690.05","article-title":"AMP-activated protein kinase in metabolic control and insulin signaling","volume":"100","author":"Towler","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103645_bib78","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.81","article-title":"Regulation and function of AMPK in physiology and diseases","volume":"48","author":"Jeon","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.redox.2025.103645_bib79","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1101\/gad.17420111","article-title":"AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function","volume":"25","author":"Hardie","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.redox.2025.103645_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100929","article-title":"Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism","volume":"297","author":"Huang","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2025.103645_bib81","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.redox.2025.103645_bib82","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ab.2007.10.002","article-title":"High-throughput tissue extraction protocol for NMR- and MS-based metabolomics","volume":"372","author":"Wu","year":"2008","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.redox.2025.103645_bib83","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/14756366.2019.1611802","article-title":"Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study","volume":"34","author":"Iaccarino","year":"2019","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.redox.2025.103645_bib84","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.3390\/molecules26071841","article-title":"NMR-based metabolomic analysis for the effects of \u03b1-ketoglutarate supplementation on C2C12 myoblasts in different energy states","volume":"26","author":"Li","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.redox.2025.103645_bib85","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13395-018-0188-4","article-title":"Metabolic derangements of skeletal muscle from a murine model of glioma cachexia","volume":"9","author":"Cui","year":"2019","journal-title":"Skeletal Muscle"},{"key":"10.1016\/j.redox.2025.103645_bib86","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jmr.2009.11.012","article-title":"icoshift: a versatile tool for the rapid alignment of 1D NMR spectra","volume":"202","author":"Savorani","year":"2010","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.redox.2025.103645_bib87","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nprot.2013.055","article-title":"Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease","volume":"8","author":"Mehlem","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.redox.2025.103645_bib88","doi-asserted-by":"crossref","first-page":"369","DOI":"10.21608\/ejh.2019.5868.1033","article-title":"Histological study of the effect of platelet rich plasma on experimentally induced skeletal muscles injury in adult male albino rats","volume":"42","author":"Badr","year":"2019","journal-title":"Egyptian Journal of Histology"},{"key":"10.1016\/j.redox.2025.103645_bib89","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3629","article-title":"Analysis of generalized fibrosis in mouse tissue sections with masson's Trichrome staining","volume":"10","author":"Van De Vlekkert","year":"2020","journal-title":"BIO-PROTOCOL"},{"key":"10.1016\/j.redox.2025.103645_bib90","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/bph.14700","article-title":"Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle","volume":"177","author":"Vellecco","year":"2020","journal-title":"Br. J. Pharmacol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725001582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725001582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:19:14Z","timestamp":1762607954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725001582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":90,"alternative-id":["S2213231725001582"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103645","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103645"}}