{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:37:01Z","timestamp":1793234221791,"version":"4.5.0"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.redox.2025.103667","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T14:51:53Z","timestamp":1746715913000},"page":"103667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Targeting mitochondria in bone and cartilage diseases: A narrative review"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9172-6031","authenticated-orcid":false,"given":"Daniel H.","family":"Mendelsohn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nike","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-Hoi","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald Man Yeung","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Sch\u00f6nmehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaqif","family":"El Khassawna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Heiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Brochhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.redox.2025.103667_bib1","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.3390\/cimb45050283","article-title":"Mitochondria have made a long evolutionary path from ancient bacteria immigrants within eukaryotic cells to essential cellular hosts and key players in human health and disease","volume":"45","author":"Atlante","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.redox.2025.103667_bib2","article-title":"Mitochondrial quality control and its role in osteoporosis","volume":"14","author":"Yan","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.redox.2025.103667_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bcp.2019.03.008","article-title":"Role of mitochondrial dysfunction on rheumatic diseases","volume":"165","author":"Vaamonde-Garc\u00eda","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib4","doi-asserted-by":"crossref","DOI":"10.33425\/2769-6294.1014","article-title":"The role of mitochondria in cartilage degenerative disorders","volume":"2","author":"Nalapko","year":"2022","journal-title":"Int J Biomed Res Prac"},{"issue":"9","key":"10.1016\/j.redox.2025.103667_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23094571","article-title":"Structural analysis of mitochondrial dynamics-from cardiomyocytes to osteoblasts: a critical review","volume":"23","author":"Mendelsohn","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bone.2010.04.593","article-title":"Enhanced mitochondrial biogenesis contributes to Wnt induced osteoblastic differentiation of C3H10T1\/2 cells","volume":"47","author":"An","year":"2010","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.redox.2025.103667_bib7","first-page":"1203","article-title":"Mitochondrial function in bone resorption and formation","volume":"69","author":"Ikeda","year":"2011","journal-title":"Nihon rinsho. Japanese journal of clinical medicine"},{"key":"10.1016\/j.redox.2025.103667_bib8","article-title":"Amino acid metabolism in skeletal cells","volume":"17","author":"Devignes","year":"2022","journal-title":"BoneKEy Rep."},{"key":"10.1016\/j.redox.2025.103667_bib9","article-title":"Role of amino acid metabolism in mitochondrial homeostasis","volume":"11","author":"Li","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.redox.2025.103667_bib10","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.joca.2010.07.003","article-title":"Mitochondrial function is altered in articular chondrocytes of an endemic osteoarthritis, Kashin-Beck disease","volume":"18","author":"Liu","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"4","key":"10.1016\/j.redox.2025.103667_bib11","first-page":"3308","article-title":"Effect of chondrocyte mitochondrial dysfunction on cartilage degeneration: a possible pathway for osteoarthritis pathology at the subcellular level","volume":"20","author":"Liu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.redox.2025.103667_bib12","article-title":"Mitochondrial dysfunction and therapeutic perspectives in osteoporosis","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib13","doi-asserted-by":"crossref","DOI":"10.15761\/JTBR.1000101","article-title":"Mitochondriopathies and bone health","volume":"1","author":"Roberta","year":"2018","journal-title":"J Tre Bio Res."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbrc.2017.09.045","article-title":"Direct effects of mitochondrial dysfunction on poor bone health in Leigh syndrome","volume":"493","author":"Kato","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.redox.2025.103667_bib15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1182\/blood-2012-12-468637","article-title":"Osteocytes link bone maintenance to blood homeostasis","volume":"121","author":"Link","year":"2013","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.redox.2025.103667_bib16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s11914-021-00688-6","article-title":"Energy metabolism of osteocytes","volume":"19","author":"Karthik","year":"2021","journal-title":"Curr. Osteoporos. Rep."},{"issue":"11","key":"10.1016\/j.redox.2025.103667_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw7215","article-title":"Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network","volume":"5","author":"Gao","year":"2019","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib18","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1038\/s41467-024-46095-0","article-title":"Osteocyte mitochondria regulate angiogenesis of transcortical vessels","volume":"15","author":"Liao","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2025.103667_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bone.2016.05.011","article-title":"Regional differences in oxidative metabolism and mitochondrial activity among cortical bone osteocytes","volume":"90","author":"Frikha-Benayed","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.redox.2025.103667_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2019.151422","article-title":"The osteocyte: a multifunctional cell within the bone","volume":"227","author":"Tresguerres","year":"2020","journal-title":"Ann. Anat."},{"issue":"8","key":"10.1016\/j.redox.2025.103667_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081812","article-title":"Regulation of mitochondrial structure and dynamics by the cytoskeleton and mechanical factors","volume":"18","author":"Bartol\u00e1k-Suki","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.redox.2025.103667_bib22","first-page":"751","article-title":"Molecular mechanisms in bone mechanotransduction","volume":"32","author":"Maycas","year":"2017","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.redox.2025.103667_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101315","article-title":"Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis","volume":"67","author":"Jiang","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.redox.2025.103667_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jot.2021.04.005","article-title":"The role of osteocytes-specific molecular mechanism in regulation of mechanotransduction - a systematic review","volume":"29","author":"Li","year":"2021","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.redox.2025.103667_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101845","article-title":"NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression","volume":"40","author":"S\u00e1nchez-de-Diego","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevBiomedEng.2021035327","article-title":"Bone bioelectricity and bone-cell response to electrical stimulation: a review","volume":"49","author":"deVet","year":"2021","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"10.1016\/j.redox.2025.103667_bib27","article-title":"Oxidative phosphorylation in bone cells","volume":"18","author":"Sabini","year":"2023","journal-title":"BoneKEy Rep."},{"issue":"3","key":"10.1016\/j.redox.2025.103667_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1210\/er.2017-00064","article-title":"Energy metabolism of the osteoblast: implications for osteoporosis","volume":"38","author":"Lee","year":"2017","journal-title":"Endocr. Rev."},{"issue":"23","key":"10.1016\/j.redox.2025.103667_bib29","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1073\/pnas.1324290111","article-title":"Up-regulation of glycolytic metabolism is required for HIF1\u03b1-driven bone formation","volume":"111","author":"Regan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2025.103667_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.coemr.2023.100473","article-title":"Hypoxia signaling in bone physiology and energy metabolism","volume":"32","author":"Valle-Tenney","year":"2023","journal-title":"Current Opinion in Endocrine and Metabolic Research"},{"issue":"12","key":"10.1016\/j.redox.2025.103667_bib31","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007997","article-title":"Wnt signaling in bone development and disease: making stronger bone with Wnts","volume":"4","author":"Regard","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"13","key":"10.1016\/j.redox.2025.103667_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136651","article-title":"Osteoblast differentiation and signaling: established concepts and emerging topics","volume":"22","author":"Ponzetti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.redox.2025.103667_bib33","doi-asserted-by":"crossref","first-page":"C1220","DOI":"10.1152\/ajpcell.2000.279.4.C1220","article-title":"Bioenergetics and mitochondrial transmembrane potential during differentiation of cultured osteoblasts","volume":"279","author":"Komarova","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib34","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/1535370218821063","article-title":"The involvement of mitochondrial fission in maintenance of the stemness of bone marrow mesenchymal stem cells","volume":"244","author":"Feng","year":"2019","journal-title":"Exp. Biol. Med."},{"issue":"14","key":"10.1016\/j.redox.2025.103667_bib35","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.7150\/ijbs.46627","article-title":"The role of autophagy and mitophagy in bone metabolic disorders","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib36","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2023.01.003","article-title":"Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis","volume":"35","author":"Suh","year":"2023","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/cdd.2017.144","article-title":"SIRT3\/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress","volume":"25","author":"Gao","year":"2018","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-023-05595-5","article-title":"PINK1\/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2025.103667_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117112","article-title":"Toward understanding the cellular control of vertebrate mineralization: the potential role of mitochondria","volume":"185","author":"Shapiro","year":"2024","journal-title":"Bone"},{"issue":"35","key":"10.1016\/j.redox.2025.103667_bib40","doi-asserted-by":"crossref","first-page":"14170","DOI":"10.1073\/pnas.1208916109","article-title":"The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation","volume":"109","author":"Boonrungsiman","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2025.103667_bib41","article-title":"Sirtuins mediate mitochondrial quality control mechanisms: a novel therapeutic target for osteoporosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"4","key":"10.1016\/j.redox.2025.103667_bib42","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00418-018-1636-2","article-title":"Recent advances in osteoclast biology","volume":"149","author":"Ono","year":"2018","journal-title":"Histochem. Cell Biol."},{"issue":"11","key":"10.1016\/j.redox.2025.103667_bib43","first-page":"1577","article-title":"Role of mitochondria in osteoclast function","volume":"23","author":"Miyazaki","year":"2013","journal-title":"Clin. Calcium"},{"key":"10.1016\/j.redox.2025.103667_bib44","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cyto.2018.06.013","article-title":"From macrophage to osteoclast - how metabolism determines function and activity","volume":"112","author":"Kubatzky","year":"2018","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.redox.2025.103667_bib45","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/jbmr.3398","article-title":"PGC1\u03b2 organizes the osteoclast cytoskeleton by mitochondrial biogenesis and activation","volume":"33","author":"Zhang","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.redox.2025.103667_bib46","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.bbrc.2020.04.155","article-title":"Autophagy-dependent mitochondrial function regulates osteoclast differentiation and maturation","volume":"527","author":"Aoki","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.redox.2025.103667_bib47","article-title":"Mitochondrial transfer regulates cell fate through metabolic remodeling in osteoporosis","volume":"10","author":"Cai","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"14","key":"10.1016\/j.redox.2025.103667_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20143576","article-title":"Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases","volume":"20","author":"Agidigbi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2_suppl","key":"10.1016\/j.redox.2025.103667_bib49","doi-asserted-by":"crossref","first-page":"1102S","DOI":"10.1177\/19476035211063858","article-title":"Role of mitochondria in physiology of chondrocytes and diseases of osteoarthritis and rheumatoid arthritis","volume":"13","author":"Kan","year":"2021","journal-title":"Cartilage"},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib50","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.joca.2021.11.003","article-title":"ERK1\/2-mediated activation of DRP1 regulates mitochondrial dynamics and apoptosis in chondrocytes","volume":"30","author":"Ansari","year":"2022","journal-title":"Osteoarthr. Cartil."},{"issue":"5","key":"10.1016\/j.redox.2025.103667_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13579","article-title":"TGF-\u03b23 mediates mitochondrial dynamics through the p-Smad3\/AMPK pathway","volume":"57","author":"Du","year":"2024","journal-title":"Cell Prolif."},{"issue":"3","key":"10.1016\/j.redox.2025.103667_bib52","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/jor.1100020304","article-title":"Characterization of growth plate mitochondria","volume":"2","author":"Stambough","year":"1984","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2319\/062805-210R.1","article-title":"Apoptosis of growth plate chondrocytes occurs through a mitochondrial pathway","volume":"77","author":"Teixeira","year":"2007","journal-title":"Angle Orthod."},{"issue":"24","key":"10.1016\/j.redox.2025.103667_bib54","doi-asserted-by":"crossref","first-page":"18270","DOI":"10.1074\/jbc.M109.098616","article-title":"Phosphate-induced apoptosis of hypertrophic chondrocytes is associated with a decrease in mitochondrial membrane potential and is dependent upon Erk1\/2 phosphorylation","volume":"285","author":"Miedlich","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.redox.2025.103667_bib55","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/art.10837","article-title":"Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes","volume":"48","author":"Maneiro","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.redox.2025.103667_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118602","article-title":"Role of mitochondria in mediating chondrocyte response to mechanical stimuli","volume":"263","author":"He","year":"2020","journal-title":"Life Sci."},{"issue":"14","key":"10.1016\/j.redox.2025.103667_bib57","doi-asserted-by":"crossref","first-page":"9132","DOI":"10.1074\/jbc.M804178200","article-title":"Effects of hyaluronic acid on mitochondrial function and mitochondria-driven apoptosis following oxidative stress in human chondrocytes","volume":"284","author":"Grishko","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2025.103667_bib58","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-0716-1119-7_14","article-title":"Mitochondrial biogenesis, activity, and DNA isolation in chondrocytes","volume":"2245","author":"Wang","year":"2021","journal-title":"Methods Mol. Biol."},{"issue":"6","key":"10.1016\/j.redox.2025.103667_bib59","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in innate immune responses","volume":"11","author":"West","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.redox.2025.103667_bib60","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/164309","article-title":"Powering the immune system: mitochondria in immune function and deficiency","volume":"2014","author":"Walker","year":"2014","journal-title":"J Immunol Res"},{"key":"10.1016\/j.redox.2025.103667_bib61","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3389\/fimmu.2018.01605","article-title":"Diverse roles of mitochondria in immune responses: novel insights into immuno-metabolism","volume":"9","author":"Angajala","year":"2018","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.redox.2025.103667_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052668","article-title":"The role of mitochondria in immune-cell-mediated tissue regeneration and ageing","volume":"22","author":"Su","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103667_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.549889","article-title":"Mitochondria synergize with P2 receptors to regulate human T cell function","volume":"11","author":"Ledderose","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib64","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2012.10.020","article-title":"Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling","volume":"38","author":"Sena","year":"2013","journal-title":"Immunity"},{"issue":"19","key":"10.1016\/j.redox.2025.103667_bib65","doi-asserted-by":"crossref","first-page":"10607","DOI":"10.1073\/pnas.180143997","article-title":"Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes","volume":"97","author":"Hoth","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"10","key":"10.1016\/j.redox.2025.103667_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110912","article-title":"Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle","volume":"39","author":"Urbanczyk","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2025.103667_bib67","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1038\/ncomms7750","article-title":"Mitochondrial function provides instructive signals for activation-induced B-cell fates","volume":"6","author":"Jang","year":"2015","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.redox.2025.103667_bib68","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1016\/j.jmb.2018.07.003","article-title":"How mitochondrial metabolism contributes to macrophage phenotype and functions","volume":"430","author":"Benmoussa","year":"2018","journal-title":"J. Mol. Biol."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib69","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jbmr.2974","article-title":"SOD2 and Sirt3 control osteoclastogenesis by regulating mitochondrial ROS","volume":"32","author":"Kim","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.redox.2025.103667_bib70","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-immunol-101819-082015","article-title":"Mitochondrial metabolism regulation of T cell-mediated immunity","volume":"39","author":"Steinert","year":"2021","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.redox.2025.103667_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065709","article-title":"Ultrastructural evidence of mitochondrial dysfunction in osteomyelitis patients","volume":"24","author":"Mendelsohn","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.redox.2025.103667_bib72","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1042\/EBC20170114","article-title":"Emerging therapies for mitochondrial diseases","volume":"62","author":"Hirano","year":"2018","journal-title":"Essays Biochem."},{"issue":"3","key":"10.1016\/j.redox.2025.103667_bib73","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2174\/1874467212666181127151059","article-title":"Mitochondria-targeted drugs","volume":"12","author":"Zinovkin","year":"2019","journal-title":"Curr. Mol. Pharmacol."},{"issue":"8","key":"10.1016\/j.redox.2025.103667_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31323","article-title":"Mitochondria-specific antioxidant MitoTEMPO alleviates senescence of bone marrow mesenchymal stem cells in ovariectomized rats","volume":"239","author":"Li","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.redox.2025.103667_bib75","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.omtn.2022.10.012","article-title":"Mitochondrion-targeted RNA therapies as a potential treatment strategy for mitochondrial diseases","volume":"30","author":"Chernega","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"6","key":"10.1016\/j.redox.2025.103667_bib76","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","article-title":"The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species","volume":"40","author":"Bordt","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.redox.2025.103667_bib77","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2193706","article-title":"Mitochondrial division inhibitor 1 attenuates mitophagy in a rat model of acute lung injury","volume":"2019","author":"Luo","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.redox.2025.103667_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.778569","article-title":"Effects of mdivi-1 on neural mitochondrial dysfunction and mitochondria-mediated apoptosis in ischemia-reperfusion injury after stroke: a systematic review of preclinical studies","volume":"14","author":"Nhu","year":"2021","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib79","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/1873-3468.13963","article-title":"Dynamin-related protein 1 positively regulates osteoclast differentiation and bone loss","volume":"595","author":"Jeong","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.redox.2025.103667_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124194","article-title":"Mitochondrial transplantation: a promising therapy for mitochondrial disorders","volume":"658","author":"Jiao","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.redox.2025.103667_bib81","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mito.2022.02.007","article-title":"Mitochondrial transplantation for organ rescue","volume":"64","author":"McCully","year":"2022","journal-title":"Mitochondrion"},{"issue":"6","key":"10.1016\/j.redox.2025.103667_bib82","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/FJC.0000000000001247","article-title":"Mitochondrial transplantation: a unique treatment strategy","volume":"79","author":"Zhou","year":"2022","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib83","doi-asserted-by":"crossref","first-page":"169","DOI":"10.21037\/tp.2018.02.02","article-title":"Mitochondrial transplantation: applications for pediatric patients with congenital heart disease","volume":"7","author":"Emani","year":"2018","journal-title":"Transl. Pediatr."},{"key":"10.1016\/j.redox.2025.103667_bib84","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.mito.2017.03.004","article-title":"Mitochondrial transplantation: from animal models to clinical use in humans","volume":"34","author":"McCully","year":"2017","journal-title":"Mitochondrion"},{"issue":"39","key":"10.1016\/j.redox.2025.103667_bib85","article-title":"Mitochondria transplantation to bone marrow stromal cells promotes angiogenesis during bone repair","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib86","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/php.12864","article-title":"Mechanisms and mitochondrial redox signaling in photobiomodulation","volume":"94","author":"Hamblin","year":"2018","journal-title":"Photochem. Photobiol."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib87","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1109\/JSTQE.2013.2273411","article-title":"Cellular and molecular mechanisms of photobiomodulation (Low-Power laser therapy)","volume":"20","author":"Karu","year":"2014","journal-title":"IEEE J. Sel. Top. Quant. Electron."},{"issue":"3","key":"10.1016\/j.redox.2025.103667_bib88","doi-asserted-by":"crossref","DOI":"10.1109\/JSTQE.2016.2561201","article-title":"Proposed mechanisms of photobiomodulation or low-level light therapy","volume":"22","author":"Freitas","year":"2016","journal-title":"IEEE J. Sel. Top. Quant. Electron."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib89","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/ijmd.ijmd_60_17","article-title":"Photobiomodulation and oral wound healing","volume":"7","author":"Vinesh","year":"2017","journal-title":"Indian J. Multidiscip. Dent."},{"key":"10.1016\/j.redox.2025.103667_bib90","article-title":"Does photobiomodulation alter mitochondrial dynamics?","author":"Da Trajano","year":"2024","journal-title":"Photochem. Photobiol."},{"issue":"9","key":"10.1016\/j.redox.2025.103667_bib91","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094347","article-title":"Mitochondrial bioenergetic, photobiomodulation and trigeminal branches nerve damage, what's the connection? A review","volume":"22","author":"Ravera","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103667_bib92","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3389\/fgene.2019.01335","article-title":"Mitochondrial genetics and epigenetics in osteoarthritis","volume":"10","author":"Rego-P\u00e9rez","year":"2019","journal-title":"Front. Genet."},{"issue":"3","key":"10.1016\/j.redox.2025.103667_bib93","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031467","article-title":"Mitochondrial genome editing to treat human osteoarthritis-A narrative review","volume":"23","author":"Zhong","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.redox.2025.103667_bib94","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s11010-023-04818-9","article-title":"The role and intervention of mitochondrial metabolism in osteoarthritis","volume":"479","author":"Qi","year":"2024","journal-title":"Mol. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.redox.2025.103667_bib95","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/ars.2009.2788","article-title":"Potential therapeutic benefits of strategies directed to mitochondria","volume":"13","author":"Camara","year":"2010","journal-title":"Antioxidants Redox Signal."},{"issue":"427","key":"10.1016\/j.redox.2025.103667_bib96","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan5372","article-title":"Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis","volume":"10","author":"Coleman","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.redox.2025.103667_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10020265","article-title":"Emerging natural-product-based treatments for the management of osteoarthritis","volume":"10","author":"P\u00e9rez-Lozano","year":"2021","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.redox.2025.103667_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/ph16071044","article-title":"Drug delivery strategies and nanozyme technologies to overcome limitations for targeting oxidative stress in osteoarthritis","volume":"16","author":"Aldrich","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.redox.2025.103667_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119601","article-title":"Implantable and degradable antioxidant poly(\u03b5-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment","volume":"230","author":"Liang","year":"2020","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.redox.2025.103667_bib100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155709","article-title":"Cyclophilin D knock-out mice show enhanced resistance to osteoporosis and to metabolic changes observed in aging bone","volume":"11","author":"Shum","year":"2016","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.redox.2025.103667_bib101","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10091394","article-title":"Biophysical modulation of the mitochondrial metabolism and redox in bone homeostasis and osteoporosis: how biophysics converts into bioenergetics","volume":"10","author":"Wang","year":"2021","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib102","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1002\/j.2040-4603.2023.tb00253.x","article-title":"Aging and bone metabolism","volume":"13","author":"Pignolo","year":"2023","journal-title":"Compr. Physiol."},{"issue":"4","key":"10.1016\/j.redox.2025.103667_bib103","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10488","article-title":"Bone aging, cellular senescence, and osteoporosis","volume":"5","author":"Pignolo","year":"2021","journal-title":"JBMR Plus"},{"issue":"4","key":"10.1016\/j.redox.2025.103667_bib104","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.bbrc.2016.05.135","article-title":"Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation","volume":"476","author":"Ming","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.redox.2025.103667_bib105","article-title":"Flourishing antibacterial strategies for osteomyelitis therapy","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"9","key":"10.1016\/j.redox.2025.103667_bib106","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1080\/14787210.2017.1372192","article-title":"Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis","volume":"15","author":"Ford","year":"2017","journal-title":"Expert Rev. Anti Infect. Ther."},{"issue":"4","key":"10.1016\/j.redox.2025.103667_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175262","article-title":"Drp1-dependent mitochondrial fission mediates osteogenic dysfunction in inflammation through elevated production of reactive oxygen species","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"issue":"21","key":"10.1016\/j.redox.2025.103667_bib108","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111338","article-title":"Mitochondria as a cellular hub in infection and inflammation","volume":"22","author":"Andrieux","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.redox.2025.103667_bib109","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.biocel.2013.06.014","article-title":"Mitochondria: metabolic regulators of innate immune responses to pathogens and cell stress","volume":"45","author":"Lartigue","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"11","key":"10.1016\/j.redox.2025.103667_bib110","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/dneu.22519","article-title":"To mdivi-1 or not to mdivi-1: is that the question?","volume":"77","author":"Smith","year":"2017","journal-title":"Dev Neurobiol"},{"key":"10.1016\/j.redox.2025.103667_bib111","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jot.2023.12.006","article-title":"Implants coating strategies for antibacterial treatment in fracture and defect models: a systematic review of animal studies","volume":"45","author":"Li","year":"2024","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.redox.2025.103667_bib112","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.actbio.2023.03.044","article-title":"Hydrogel delivery of DNase I and liposomal vancomycin to eradicate fracture-related methicillin-resistant staphylococcus aureus infection and support osteoporotic fracture healing","volume":"164","author":"Li","year":"2023","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib113","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98625-1","article-title":"Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair","volume":"11","author":"Hollenberg","year":"2021","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.redox.2025.103667_bib114","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1080\/17453670610013277","article-title":"Altered expression of mitochondrial genes in response to fracture in old rats","volume":"77","author":"Meyer","year":"2006","journal-title":"Acta Orthop."},{"issue":"7","key":"10.1016\/j.redox.2025.103667_bib115","doi-asserted-by":"crossref","first-page":"8565","DOI":"10.1096\/fj.201900082RR","article-title":"Lgr5-overexpressing mesenchymal stem cells augment fracture healing through regulation of Wnt\/ERK signaling pathways and mitochondrial dynamics","volume":"33","author":"Lin","year":"2019","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.redox.2025.103667_bib116","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13287-020-01704-9","article-title":"Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing","volume":"11","author":"Guo","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.redox.2025.103667_bib117","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6408278","article-title":"Mitochondria-targeted antioxidant SkQ1 improves dermal wound healing in genetically diabetic mice","volume":"2017","author":"Demyanenko","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.redox.2025.103667_bib118","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jcyt.2024.02.027","article-title":"Effects of mitochondrial transplantation on chronic pressure wound healing in a human patient","volume":"26","author":"Taner","year":"2024","journal-title":"Cytotherapy"},{"key":"10.1016\/j.redox.2025.103667_bib119","article-title":"Photobiomodulation hastens diabetic wound healing via modulation of the PI3K\/AKT\/FoxO1 pathway in an adipose derived stem cell-fibroblast co-culture","volume":"12","author":"Rajendran","year":"2022","journal-title":"J. Photochem. Photobiol., A"},{"issue":"23","key":"10.1016\/j.redox.2025.103667_bib120","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.3390\/app9235114","article-title":"Healing effects of photobiomodulation on diabetic wounds","volume":"9","author":"Houreld","year":"2019","journal-title":"Appl. Sci."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725001806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725001806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:06:56Z","timestamp":1749715616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725001806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":120,"alternative-id":["S2213231725001806"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103667","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting mitochondria in bone and cartilage diseases: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103667","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103667"}}