{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:07:43Z","timestamp":1788253663630,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-103872RB-I00"],"award-info":[{"award-number":["PID2019-103872RB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Community of Madrid","doi-asserted-by":"publisher","award":["TEC-2024\/BIO-307"],"award-info":[{"award-number":["TEC-2024\/BIO-307"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Spain Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["FPU20\/02920"],"award-info":[{"award-number":["FPU20\/02920"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.redox.2025.103697","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T20:34:03Z","timestamp":1748723643000},"page":"103697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Silicon-enriched meat consumption mitigates brain cortex damage associated with diabetic dyslipidemia in a late-stage type 2 diabetes mellitus rat model"],"prefix":"10.1016","volume":"85","author":[{"given":"Roc\u00edo","family":"Redondo-Castillejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Apaza","family":"Ticona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Macho-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ar\u00e1nzazu","family":"Bocanegra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Garcimart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Hern\u00e1ndez-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Parfenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bastida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Elvira","family":"L\u00f3pez-Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"S\u00e1nchez-Muniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Bened\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103697_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102302","article-title":"Impaired cerebral blood flow in type 2 diabetes mellitus \u2013 a comparative study with subjective cognitive decline, vascular dementia and Alzheimer's disease subjects","volume":"27","author":"Chau","year":"2020","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.redox.2025.103697_bib2","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.3390\/cells11233767","article-title":"Development of dementia in type 2 diabetes patients: mechanisms of insulin resistance and antidiabetic drug development","volume":"11","author":"Singh","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.redox.2025.103697_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/ddr.21643","article-title":"Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease","volume":"81","author":"Kulas","year":"2020","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.redox.2025.103697_bib4","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.3233\/JAD-240659","article-title":"Oxidative stress in Alzheimer's disease: the shortcomings of antioxidant therapies","volume":"101","author":"Pappolla","year":"2024","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.redox.2025.103697_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3233\/ADR-210299","article-title":"A new hypothesis for Alzheimer's disease: the lipid invasion model","volume":"6","author":"Rudge","year":"2022","journal-title":"J Alzheimers Dis Rep"},{"key":"10.1016\/j.redox.2025.103697_bib6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/jnnp.74.1.70","article-title":"Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging","volume":"74","author":"Starr","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.redox.2025.103697_bib7","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3390\/antiox10050740","article-title":"The controversial role of 24-S-hydroxycholesterol in Alzheimer's disease","volume":"10","author":"Gamba","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2025.103697_bib8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.freeradbiomed.2018.04.001","article-title":"Oxidant-specific biomarkers of oxidative stress. Association with atherosclerosis and implication for antioxidant effects","volume":"120","author":"Niki","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103697_bib9","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1007\/s12035-023-03529-y","article-title":"Reexamining the causes and effects of cholesterol deposition in the brains of patients with Alzheimer's disease","volume":"60","author":"Hu","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.redox.2025.103697_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2015.00119","article-title":"Oxidized cholesterol as the driving force behind the development of Alzheimer's disease","volume":"7","author":"Gamba","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.redox.2025.103697_bib11","article-title":"Connecting the dots between hypercholesterolemia and Alzheimer's disease: a potential mechanism based on 27-hydroxycholesterol","volume":"16","author":"Wu","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.redox.2025.103697_bib12","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.3390\/ijms25052698","article-title":"New insights into oxidative stress and inflammatory response in neurodegenerative diseases","volume":"25","author":"Scarian","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103697_bib13","article-title":"Oxidative stress: the nexus of obesity and cognitive dysfunction in diabetes","volume":"14","author":"Li","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.redox.2025.103697_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/102158","article-title":"Diabetes and the brain: oxidative stress, inflammation, and autophagy","volume":"2014","author":"Muriach","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2025.103697_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1179\/1476830513Y.0000000092","article-title":"Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms","volume":"17","author":"Freeman","year":"2014","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.redox.2025.103697_bib16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.18632\/aging.100431","article-title":"Inflammatory cause of metabolic syndrome via brain stress and NF-\u03baB","volume":"4","author":"Cai","year":"2012","journal-title":"Aging"},{"key":"10.1016\/j.redox.2025.103697_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6882-14-384","article-title":"Organic silicon protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide effects","volume":"14","author":"Garcimart\u00edn","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.redox.2025.103697_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.chemosphere.2015.04.060","article-title":"Silicon as neuroprotector or neurotoxic in the human neuroblastoma SH-SY5Y cell line","volume":"135","author":"Garcimart\u00edn","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.redox.2025.103697_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1370536","article-title":"Silicon in prevention of atherosclerosis and other age-related diseases","volume":"11","author":"Dudek","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.redox.2025.103697_bib20","doi-asserted-by":"crossref","DOI":"10.12775\/QS.2024.35.56079","article-title":"Therapeutic potential of silicon supplementation in age-related diseases: a comprehensive review","volume":"35","author":"Koczkodaj","year":"2024","journal-title":"Quality in Sport"},{"key":"10.1016\/j.redox.2025.103697_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200104","article-title":"Could duodenal molecular mechanisms be involved in the hypocholesterolemic effect of silicon used as functional ingredient in late-stage type 2 diabetes mellitus?","volume":"66","author":"Hern\u00e1ndez-Mart\u00edn","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.redox.2025.103697_bib22","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.3390\/foods13121794","article-title":"Silicon as a functional meat ingredient improves jejunal and hepatic cholesterol homeostasis in a late-stage type 2 diabetes mellitus rat model","volume":"13","author":"Hern\u00e1ndez-Mart\u00edn","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.redox.2025.103697_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252111405","article-title":"Silicon-enriched meat ameliorates diabetic dyslipidemia by improving cholesterol, bile acid metabolism and ileal barrier integrity in rats with late-stage type 2 diabetes","volume":"25","author":"Hern\u00e1ndez-Mart\u00edn","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103697_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147469","article-title":"Effects of silicon vs. Hydroxytyrosol-enriched restructured pork on liver oxidation status of aged rats fed high-saturated\/high-cholesterol diets","volume":"11","author":"Santos-L\u00f3pez","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103697_bib25","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.3945\/jn.115.213934","article-title":"Silicon-enriched restructured pork affects the lipoprotein profile, VLDL oxidation, and LDL receptor gene expression in aged rats fed an atherogenic diet","volume":"145","author":"Garcimart\u00edn","year":"2015","journal-title":"J. Nutr."},{"key":"10.1016\/j.redox.2025.103697_bib26","doi-asserted-by":"crossref","DOI":"10.1039\/D4FO06277A","article-title":"Antioxidant and anti-inflammatory effects of silicon-enriched meat on distal colonic barrier function in a diabetic dyslipemia rat model","author":"Hern\u00e1ndez-Mart\u00edn","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.redox.2025.103697_bib27","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.3390\/nu11071558","article-title":"The nutritional components of beer and its relationship with neurodegeneration and Alzheimer's disease","volume":"11","author":"S\u00e1nchez-Muniz","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.redox.2025.103697_bib28","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.fct.2018.06.004","article-title":"Can nonalcoholic beer, silicon and hops reduce the brain damage and behavioral changes induced by aluminum nitrate in young male Wistar rats?","volume":"118","author":"Merino","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.redox.2025.103697_bib29","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3233\/JAD-160972","article-title":"Silicic acid and beer consumption reverses the metal imbalance and the prooxidant status induced by aluminum nitrate in mouse brain","volume":"56","author":"Gonz\u00e1lez-Mu\u00f1oz","year":"2017","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.redox.2025.103697_bib30","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.3945\/jn.116.243204","article-title":"Silicon alleviates nonalcoholic steatohepatitis by reducing apoptosis in aged wistar rats fed a high-saturated fat, high-cholesterol diet","volume":"147","author":"Garcimart\u00edn","year":"2017","journal-title":"J. Nutr."},{"key":"10.1016\/j.redox.2025.103697_bib31","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1016\/j.atherosclerosis.2014.05.599","article-title":"Effects of silicon inclusion in restructured meat-enriched diet on lipoprotein profile and composition in aged wistar rats","volume":"235","author":"Garcimart\u00edn","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.redox.2025.103697_bib32","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1039\/D3FO04103D","article-title":"Silicon-enriched meat positively improves plasma lipidaemia and lipoproteinaemia, LDLr, and insulin capability and the signalling pathway induced by an atherogenic diet in late-stage type 2 diabetes mellitus rats","volume":"15","author":"Hern\u00e1ndez-Mart\u00edn","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.redox.2025.103697_bib33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s43450-022-00236-y","article-title":"Anti-melanogenic and anti-inflammatory activities of Hibiscus sabdariffa","volume":"32","author":"Apaza Ticona","year":"2022","journal-title":"Revista Brasileira de Farmacognosia"},{"key":"10.1016\/j.redox.2025.103697_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0003-9861(78)90479-4","article-title":"Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase","volume":"186","author":"Kono","year":"1978","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.redox.2025.103697_bib35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0003-2697(88)90554-4","article-title":"A spectrophotometric method for determination of catalase activity in small tissue samples","volume":"174","author":"Johansson","year":"1988","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.redox.2025.103697_bib36","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.enzmictec.2008.05.004","article-title":"Determination of rat and mice arylesterase activity using serum mimetics","volume":"43","author":"Nus","year":"2008","journal-title":"Enzym. Microb. Technol."},{"key":"10.1016\/j.redox.2025.103697_bib37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2025.103697_bib38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.redox.2025.103697_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110124","article-title":"Carob fruit extract-enriched meat, as preventive and curative treatments, improves gut microbiota and colonic barrier integrity in a late-stage T2DM model","volume":"141","author":"Macho-Gonz\u00e1lez","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.redox.2025.103697_bib40","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.biocel.2016.06.008","article-title":"Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases","volume":"81","author":"Castellazzi","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.redox.2025.103697_bib41","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/antiox9050456","article-title":"Arylesterase activity of paraoxonase-1 in serum and cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia","volume":"9","author":"Romani","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2025.103697_bib42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.redox.2016.09.001","article-title":"Changes in brain oxysterols at different stages of Alzheimer's disease: their involvement in neuroinflammation","volume":"10","author":"Testa","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103697_bib43","first-page":"537","article-title":"25-Hydroxycholesterol as a signaling molecule of the nervous system","volume":"87","author":"Odnoshivkina","year":"2022","journal-title":"Biochemistry"},{"key":"10.1016\/j.redox.2025.103697_bib44","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jsbmb.2017.11.009","article-title":"Diabetes induces mitochondrial dysfunction and alters cholesterol homeostasis and neurosteroidogenesis in the rat cerebral cortex","volume":"178","author":"Romano","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.redox.2025.103697_bib45","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/jnc.15228","article-title":"24S-hydroxycholesterol: cellular effects and variations in brain diseases","volume":"157","author":"Sodero","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.redox.2025.103697_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.619916","article-title":"Increased plasma level of 24S-hydroxycholesterol and polymorphism of CYP46A1 SNP (rs754203) are associated with mild cognitive impairment in patients with type 2 diabetes","volume":"13","author":"Shi","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.redox.2025.103697_bib47","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.chemphyslip.2011.06.006","article-title":"Pathways of cholesterol oxidation via non-enzymatic mechanisms","volume":"164","author":"Iuliano","year":"2011","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.redox.2025.103697_bib48","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1471-4159.1974.tb04293.x","article-title":"Glutathione peroxidase levels in brain","volume":"22","author":"de Marchena","year":"1974","journal-title":"J. Neurochem."},{"key":"10.1016\/j.redox.2025.103697_bib49","article-title":"Silicon-containing water intake confers antioxidant effect, gastrointestinal protection, and gut microbiota modulation in the rodents","volume":"16","author":"Wu","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103697_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110839","article-title":"Signature of paraoxonases in the altered redox homeostasis in Alzheimer's disease","volume":"388","author":"Beggiato","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.redox.2025.103697_bib51","first-page":"9","article-title":"Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection","volume":"43","author":"Costa","year":"2013","journal-title":"Neurotoxicology (Little Rock)"},{"key":"10.1016\/j.redox.2025.103697_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1347535","article-title":"Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol","volume":"18","author":"Spanos","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.redox.2025.103697_bib53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cbi.2016.08.016","article-title":"Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model","volume":"258","author":"Arafa","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.redox.2025.103697_bib54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/B978-0-12-809454-9.00010-X","article-title":"Neuroinflammation, type 2 diabetes, and dementia","author":"Wong","year":"2018","journal-title":"Type 2 Diabetes and Dementia"},{"key":"10.1016\/j.redox.2025.103697_bib55","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.3390\/antiox11101972","article-title":"Trends in gliosis in obesity, and the role of antioxidants as a therapeutic alternative","volume":"11","author":"Bandala","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2025.103697_bib56","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.freeradbiomed.2021.01.042","article-title":"Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in down syndrome","volume":"165","author":"Lanzillotta","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103697_bib57","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3390\/molecules27030950","article-title":"Mechanistic insight into oxidative stress-triggered signaling pathways and type 2 diabetes","volume":"27","author":"Singh","year":"2022","journal-title":"Molecules (Basel)"},{"key":"10.1016\/j.redox.2025.103697_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212366","article-title":"Diabetes and cognitive impairment: a role for glucotoxicity and dopaminergic dysfunction","volume":"22","author":"Pignalosa","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103697_bib59","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.redox.2025.103697_bib60","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.cmet.2010.11.006","article-title":"Diabetes and insulin in regulation of brain cholesterol metabolism","volume":"12","author":"Suzuki","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2025.103697_bib61","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1471-4159.2004.02422.x","article-title":"Glycogen synthase kinase 3: a drug target for CNS therapies","volume":"89","author":"Bhat","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.redox.2025.103697_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154869","article-title":"Glucose transporter 3 in neuronal glucose metabolism: health and diseases","volume":"123","author":"Peng","year":"2021","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.redox.2025.103697_bib63","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.redox.2017.04.004","article-title":"Hydrogen peroxide modifies both activity and isoforms of acetylcholinesterase in human neuroblastoma SH-SY5Y cells","volume":"12","author":"Garcimart\u00edn","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103697_bib64","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejphar.2013.08.008","article-title":"Insulin, cognition, and dementia","volume":"719","author":"Cholerton","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.redox.2025.103697_bib65","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3390\/metabo13030384","article-title":"Neurotransmitters in type 2 diabetes and the control of systemic and central energy balance","volume":"13","author":"Al-Sayyar","year":"2023","journal-title":"Metabolites"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725002101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725002101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:47:36Z","timestamp":1779446856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725002101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":65,"alternative-id":["S2213231725002101"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103697","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silicon-enriched meat consumption mitigates brain cortex damage associated with diabetic dyslipidemia in a late-stage type 2 diabetes mellitus rat model","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103697","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103697"}}