{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:30:07Z","timestamp":1784215807153,"version":"3.55.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20210431"],"award-info":[{"award-number":["20210431"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20240906"],"award-info":[{"award-number":["20240906"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021\\u201302801"],"award-info":[{"award-number":["2021\\u201302801"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2024\\u201302930"],"award-info":[{"award-number":["2024\\u201302930"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009400","name":"Heinrich Heine University D\u00fcsseldorf Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1116 TP06"],"award-info":[{"award-number":["SFB1116 TP06"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003484","name":"Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003484","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["RS2022-0674"],"award-info":[{"award-number":["RS2022-0674"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.redox.2025.103768","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T20:35:27Z","timestamp":1752611727000},"page":"103768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Divergent roles of red cell arginase in humans and mice: RBC Arg1 KO mice show preserved systemic l-arginine bioavailability and infarct size in vivo"],"prefix":"10.1016","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-1492","authenticated-orcid":false,"given":"Sophia K.","family":"Heuser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthea","family":"LoBue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Heard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hocks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsiana","family":"Suvorava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron-Patrick","family":"Cadeddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Strupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Dunaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbing","family":"Zhuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy L.","family":"Gelhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Heinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Germing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Feelisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Carlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brant","family":"Isakson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon O.","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0593-1192","authenticated-orcid":false,"given":"Miriam M.","family":"Cortese-Krott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib1","doi-asserted-by":"crossref","DOI":"10.1124\/pharmrev.124.001271","article-title":"Biochemistry, pharmacology, and in vivo function of arginases","volume":"77","author":"Heuser","year":"2025","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.redox.2025.103768_bib2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0736-5748(94)90083-3","article-title":"Subcellular location and differential antibody specificity of arginase in tissue culture and whole animals","volume":"12","author":"Spector","year":"1994","journal-title":"Int. J. Dev. Neurosci."},{"issue":"15","key":"10.1016\/j.redox.2025.103768_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155291","article-title":"Arginase as a potential biomarker of disease progression: a molecular imaging perspective","volume":"21","author":"Clemente","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/abbi.2001.2324","article-title":"Expression, purification, and characterization of human type II arginase","volume":"389","author":"Colleluori","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"issue":"16","key":"10.1016\/j.redox.2025.103768_bib5","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1161\/01.CIR.0000092948.04444.C7","article-title":"Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels","volume":"108","author":"Berkowitz","year":"2003","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib6","first-page":"H342","article-title":"Arginase modulates nitric oxide production in activated macrophages","volume":"274","author":"Chang","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"4 Pt 2","key":"10.1016\/j.redox.2025.103768_bib7","first-page":"F646","article-title":"Arginine metabolism in experimental glomerulonephritis: interaction between nitric oxide synthase and arginase","volume":"267","author":"Cook","year":"1994","journal-title":"Am. J. Physiol."},{"issue":"5","key":"10.1016\/j.redox.2025.103768_bib8","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/01.hjh.0000166837.78559.93","article-title":"Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats","volume":"23","author":"Demougeot","year":"2005","journal-title":"J. Hypertens."},{"issue":"25","key":"10.1016\/j.redox.2025.103768_bib9","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1161\/CIRCULATIONAHA.112.140335","article-title":"Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus","volume":"126","author":"Shemyakin","year":"2012","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib10","doi-asserted-by":"crossref","first-page":"H159","DOI":"10.1152\/ajpheart.00774.2011","article-title":"Diabetes-induced vascular dysfunction involves arginase I","volume":"302","author":"Romero","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7","key":"10.1016\/j.redox.2025.103768_bib11","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1096\/fj.00-0681fje","article-title":"Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function","volume":"15","author":"Zhang","year":"2001","journal-title":"FASEB J."},{"issue":"11","key":"10.1016\/j.redox.2025.103768_bib12","article-title":"Deletion of endothelial arginase 1 does not improve vasomotor function in diabetic mice","volume":"6","author":"Chennupati","year":"2018","journal-title":"Phys. Rep."},{"key":"10.1016\/j.redox.2025.103768_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.niox.2022.06.004","article-title":"Downregulation of eNOS and preserved endothelial function in endothelial-specific arginase 1-deficient mice","volume":"125\u2013126","author":"Heuser","year":"2022","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.redox.2025.103768_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.niox.2022.09.002","article-title":"There is no direct competition between arginase and nitric oxide synthase for the common substrate l-arginine","volume":"129","author":"Momma","year":"2022","journal-title":"Nitric Oxide"},{"issue":"4","key":"10.1016\/j.redox.2025.103768_bib15","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1152\/japplphysiol.91393.2008","article-title":"Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats","volume":"107","author":"Kim","year":"1985","journal-title":"J. Appl. Physiol."},{"issue":"12","key":"10.1016\/j.redox.2025.103768_bib16","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1073\/pnas.0506589103","article-title":"Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism","volume":"103","author":"Steppan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.redox.2025.103768_bib17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1476-5381.2009.00291.x","article-title":"Arginase: an emerging key player in the mammalian immune system","volume":"158","author":"Munder","year":"2009","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.redox.2025.103768_bib18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1189\/jlb.0911453","article-title":"Pivotal advance: arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes","volume":"91","author":"Van den Bossche","year":"2012","journal-title":"J. Leukoc. Biol."},{"issue":"8","key":"10.1016\/j.redox.2025.103768_bib19","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1096\/fj.04-3416fje","article-title":"Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo","volume":"19","author":"Kropf","year":"2005","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.redox.2025.103768_bib20","doi-asserted-by":"crossref","first-page":"2579s","DOI":"10.3945\/jn.115.226621","article-title":"Arginine metabolism revisited","volume":"146","author":"Morris","year":"2016","journal-title":"J. Nutr."},{"key":"10.1016\/j.redox.2025.103768_bib21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3389\/fimmu.2014.00544","article-title":"Evolutionary roots of arginase expression and regulation","volume":"5","author":"Dzik","year":"2014","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.redox.2025.103768_bib22","doi-asserted-by":"crossref","first-page":"1602S","DOI":"10.1093\/jn\/137.6.1602S","article-title":"Arginine metabolism: boundaries of our knowledge","volume":"137","author":"Morris","year":"2007","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/j.redox.2025.103768_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/mgme.1998.2677","article-title":"Molecular basis of hyperargininemia: structure-function consequences of mutations in human liver arginase","volume":"64","author":"Ash","year":"1998","journal-title":"Mol. Genet. Metabol."},{"issue":"1\u20132","key":"10.1016\/j.redox.2025.103768_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ymgme.2022.08.005","article-title":"Epidemiology, methods of diagnosis, and clinical management of patients with arginase 1 deficiency (ARG1-D): a systematic review","volume":"137","author":"Bin Sawad","year":"2022","journal-title":"Mol. Genet. Metabol."},{"issue":"4","key":"10.1016\/j.redox.2025.103768_bib25","first-page":"330","article-title":"Natural history of arginase 1 deficiency and the unmet needs of patients: a systematic review of case reports","volume":"63","author":"Bin Sawad","year":"2022","journal-title":"JIMD Rep"},{"issue":"3","key":"10.1016\/j.redox.2025.103768_bib26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ymgme.2004.11.004","article-title":"Hyperargininemia due to liver arginase deficiency","volume":"84","author":"Crombez","year":"2005","journal-title":"Mol. Genet. Metabol."},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jimd.12564","article-title":"The role and control of arginine levels in arginase 1 deficiency","volume":"46","author":"Diaz","year":"2023","journal-title":"J. Inherit. Metab. Dis."},{"issue":"11","key":"10.1016\/j.redox.2025.103768_bib28","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1007\/BF02026716","article-title":"Absence of erythrocyte arginase protein in Japanese patients with hyperargininemia","volume":"150","author":"Hayakawa","year":"1991","journal-title":"Eur. J. Pediatr."},{"issue":"Suppl 1","key":"10.1016\/j.redox.2025.103768_bib29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1023\/A:1005313809037","article-title":"The human arginases and arginase deficiency","volume":"21","author":"Iyer","year":"1998","journal-title":"J. Inherit. Metab. Dis."},{"issue":"2","key":"10.1016\/j.redox.2025.103768_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ajmg.c.30091","article-title":"Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency","volume":"142C","author":"Scaglia","year":"2006","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"13","key":"10.1016\/j.redox.2025.103768_bib31","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1128\/MCB.22.13.4491-4498.2002","article-title":"Mouse model for human arginase deficiency","volume":"22","author":"Iyer","year":"2002","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.redox.2025.103768_bib32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ymgme.2013.06.020","article-title":"Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse","volume":"110","author":"Kasten","year":"2013","journal-title":"Mol. Genet. Metabol."},{"issue":"11","key":"10.1016\/j.redox.2025.103768_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080001","article-title":"Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism","volume":"8","author":"Sin","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.redox.2025.103768_bib34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0009-8981(70)90063-X","article-title":"Arginase activity in erythrocytes of healthy and ill children","volume":"28","author":"Azizi","year":"1970","journal-title":"Clin. Chim. Acta"},{"issue":"6","key":"10.1016\/j.redox.2025.103768_bib35","first-page":"1138","article-title":"Comparison of arginase activity in red blood cells of lower mammals, primates, and man: evolution to high activity in primates","volume":"37","author":"Spector","year":"1985","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.redox.2025.103768_bib36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1096-7192(02)00034-3","article-title":"Expression of the liver form of arginase in erythrocytes","volume":"76","author":"Kim","year":"2002","journal-title":"Mol. Genet. Metabol."},{"issue":"3","key":"10.1016\/j.redox.2025.103768_bib37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/clinchem\/22.3.323","article-title":"Use of enzyme-loaded erythrocytes in in-vitro correction of arginase-deficient erythrocytes in familial hyperargininemia","volume":"22","author":"Adriaenssens","year":"1976","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.redox.2025.103768_bib38","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1203\/00006450-197206000-00003","article-title":"Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and in liver","volume":"6","author":"Shih","year":"1972","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib39","first-page":"79","article-title":"Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency","volume":"32","author":"Spector","year":"1980","journal-title":"Am. J. Hum. Genet."},{"issue":"12","key":"10.1016\/j.redox.2025.103768_bib40","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1203\/00006450-198312000-00003","article-title":"Immunologic studies of arginase in tissues of normal human adult and arginase-deficient patients","volume":"17","author":"Spector","year":"1983","journal-title":"Pediatr. Res."},{"issue":"37","key":"10.1016\/j.redox.2025.103768_bib41","doi-asserted-by":"crossref","first-page":"15049","DOI":"10.1073\/pnas.1307058110","article-title":"Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity","volume":"110","author":"Yang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.redox.2025.103768_bib42","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jacc.2018.05.052","article-title":"Erythrocytes from patients with type 2 diabetes induce endothelial dysfunction via arginase I","volume":"72","author":"Zhou","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.redox.2025.103768_bib43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF00210403","article-title":"Molecular basis of phenotypic variation in patients with argininemia","volume":"96","author":"Uchino","year":"1995","journal-title":"Hum. Genet."},{"issue":"6","key":"10.1016\/j.redox.2025.103768_bib44","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/00043426-200011000-00009","article-title":"Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome","volume":"22","author":"Morris","year":"2000","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.294.1.81","article-title":"Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease","volume":"294","author":"Morris","year":"2005","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12967-023-04824-x","article-title":"Red blood cell-derived arginase release in hemolytic uremic syndrome","volume":"22","author":"Friberg","year":"2024","journal-title":"J. Transl. Med."},{"issue":"12","key":"10.1016\/j.redox.2025.103768_bib47","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1161\/ATVBAHA.122.318338","article-title":"Arginase-1 deletion in erythrocytes promotes vascular calcification via enhanced GSNOR (S-Nitrosoglutathione reductase) expression and NO signaling in smooth muscle cells","volume":"42","author":"Gogiraju","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.redox.2025.103768_bib48","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ni.1671","article-title":"Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens","volume":"9","author":"El Kasmi","year":"2008","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gene.20020","article-title":"Transgenic Cre expression mice for generation of erythroid-specific gene alterations","volume":"39","author":"Peterson","year":"2004","journal-title":"Genesis"},{"issue":"8","key":"10.1016\/j.redox.2025.103768_bib50","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1182\/blood-2012-09-456079","article-title":"Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis","volume":"121","author":"Liu","year":"2013","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.redox.2025.103768_bib51","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/CIRCULATIONAHA.120.049606","article-title":"Red blood cell and endothelial eNOS independently regulate circulating nitric oxide metabolites and blood pressure","volume":"144","author":"Leo","year":"2021","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.redox.2025.103768_bib52","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.redox.2025.103768_bib53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/CIRCRESAHA.112.272302","article-title":"MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation","volume":"111","author":"Johnstone","year":"2012","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.redox.2025.103768_bib54","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0021-9258(18)51085-1","article-title":"Colorimetric determination of urea","volume":"157","author":"Archibald","year":"1945","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib55","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9258(17)41231-2","article-title":"Gasometric and photometric measurement of arginase activity","volume":"165","author":"Van Slyke","year":"1946","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.redox.2025.103768_bib56","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1073\/pnas.0306706101","article-title":"Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo","volume":"101","author":"Bryan","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2025.103768_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13041-014-0092-8","article-title":"Protein tyrosine phosphatase receptor type R is required for purkinje cell responsiveness in cerebellar long-term depression","volume":"8","author":"Erkens","year":"2015","journal-title":"Mol. Brain"},{"key":"10.1016\/j.redox.2025.103768_bib58","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.freeradbiomed.2019.10.003","article-title":"The obligatory role of host microbiota in bioactivation of dietary nitrate","volume":"145","author":"Moretti","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.redox.2025.103768_bib59","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1097\/HJH.0000000000002834","article-title":"Red blood cells from patients with pre-eclampsia induce endothelial dysfunction","volume":"39","author":"McCann Haworth","year":"2021","journal-title":"J. Hypertens."},{"key":"10.1016\/j.redox.2025.103768_bib60","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8309698","article-title":"Nrf2 deficiency unmasks the significance of nitric oxide synthase activity for cardioprotection","volume":"2018","author":"Erkens","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2025.103768_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107927","article-title":"The role of CD71(+) erythroid cells in the regulation of the immune response","volume":"228","author":"Grzywa","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.redox.2025.103768_bib62","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/s42003-021-02914-4","article-title":"Potent but transient immunosuppression of T-cells is a general feature of CD71(+) erythroid cells","volume":"4","author":"Grzywa","year":"2021","journal-title":"Commun. Biol."},{"issue":"22","key":"10.1016\/j.redox.2025.103768_bib63","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.jacc.2009.02.036","article-title":"Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk","volume":"53","author":"Tang","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.redox.2025.103768_bib64","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3945\/jn.116.240382","article-title":"Supplemental citrulline is more efficient than arginine in increasing systemic arginine availability in mice","volume":"147","author":"Agarwal","year":"2017","journal-title":"J. Nutr."},{"issue":"5","key":"10.1016\/j.redox.2025.103768_bib65","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF00496818","article-title":"Immunohistochemical localisation of arginase in human liver using monoclonal antibodies against human liver arginase","volume":"87","author":"Multhaupt","year":"1987","journal-title":"Histochemistry"},{"issue":"28\u201329","key":"10.1016\/j.redox.2025.103768_bib66","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1016\/j.febslet.2006.11.003","article-title":"Arginase-flotillin interaction brings arginase to red blood cell membrane","volume":"580","author":"Jiang","year":"2006","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.redox.2025.103768_bib67","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1182\/blood.V97.4.1141","article-title":"Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts","volume":"97","author":"Salzer","year":"2001","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.redox.2025.103768_bib68","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1182\/blood-2004-07-2521","article-title":"Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity","volume":"105","author":"Munder","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.redox.2025.103768_bib69","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3389\/fimmu.2020.00938","article-title":"Myeloid cell-derived arginase in cancer immune response","volume":"11","author":"Grzywa","year":"2020","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.redox.2025.103768_bib70","doi-asserted-by":"crossref","first-page":"1602S","DOI":"10.1093\/jn\/137.6.1602S","article-title":"Arginine metabolism: boundaries of our Knowledge123","volume":"137","author":"Morris","year":"2007","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.redox.2025.103768_bib71","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.blre.2013.02.002","article-title":"Red cell investigations: art and artefacts","volume":"27","author":"Minetti","year":"2013","journal-title":"Blood Rev."},{"key":"10.1016\/j.redox.2025.103768_bib72","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.redox.2017.08.020","article-title":"Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease","volume":"14","author":"Cortese-Krott","year":"2018","journal-title":"Redox Biol."},{"issue":"20","key":"10.1016\/j.redox.2025.103768_bib73","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1182\/blood-2012-07-442277","article-title":"Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease","volume":"120","author":"Cortese-Krott","year":"2012","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.redox.2025.103768_bib74","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1182\/blood-2005-08-3166","article-title":"L-arginine import via cationic amino acid transporter CAT1 is essential for both differentiation and proliferation of erythrocytes","volume":"107","author":"Shima","year":"2006","journal-title":"Blood"},{"issue":"20","key":"10.1016\/j.redox.2025.103768_bib75","first-page":"2520","article-title":"Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A","volume":"141","author":"Gonzalez-Menendez","year":"2023","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.redox.2025.103768_bib76","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.stemcr.2021.04.001","article-title":"Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2","volume":"16","author":"Shahbaz","year":"2021","journal-title":"Stem Cell Rep."},{"issue":"2","key":"10.1016\/j.redox.2025.103768_bib77","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1164\/rccm.200309-1304OC","article-title":"Decreased arginine bioavailability and increased serum arginase activity in asthma","volume":"170","author":"Morris","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.redox.2025.103768_bib78","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jacbts.2018.03.006","article-title":"Red blood cells in type 2 diabetes impair cardiac post-ischemic recovery through an arginase-dependent modulation of nitric oxide synthase and reactive oxygen species","volume":"3","author":"Yang","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.redox.2025.103768_bib79","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-4939-7428-3_3","article-title":"Mouse models of erythropoiesis and associated diseases","volume":"1698","author":"Parker","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"9","key":"10.1016\/j.redox.2025.103768_bib80","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725002812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725002812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:07:40Z","timestamp":1778854060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725002812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":80,"alternative-id":["S2213231725002812"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103768","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Divergent roles of red cell arginase in humans and mice: RBC Arg1 KO mice show preserved systemic l-arginine bioavailability and infarct size in vivo","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103768"}}