{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:13:20Z","timestamp":1789409600100,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330011"],"award-info":[{"award-number":["82330011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070236"],"award-info":[{"award-number":["82070236"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20339"],"award-info":[{"award-number":["U21A20339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2020-I2M-5-003"],"award-info":[{"award-number":["2020-I2M-5-003"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.redox.2025.103802","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T19:08:35Z","timestamp":1754420915000},"page":"103802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["13-methylpalmatine alleviates myocardial ischemia\/reperfusion injury by potentially targeting the C5a-C5aR1 axis to inhibit neutrophil extracellular trap formation"],"prefix":"10.1016","volume":"86","author":[{"given":"Miao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tieshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueshi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103802_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2025.103802_bib2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1161\/CIRCRESAHA.122.321153","article-title":"Interdependent nuclear co-trafficking of ASPP1 and p53 aggravates cardiac ischemia\/reperfusion injury","volume":"132","author":"Yang","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103802_bib3","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.7150\/thno.91180","article-title":"Single-cell RNA sequencing reveals S100a9hi macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia\u2012reperfusion","volume":"14","author":"Shen","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.redox.2025.103802_bib4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.scib.2024.02.003","article-title":"Single-cell profile reveals the landscape of cardiac immunity and identifies a cardio-protective Ym-1hi neutrophil in myocardial ischemia\u2013reperfusion injury","volume":"69","author":"Dong","year":"2024","journal-title":"Sci. Bull."},{"key":"10.1016\/j.redox.2025.103802_bib5","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/ard-2022-223568","article-title":"Neutrophil extracellular trap-associated carbamylation and histones trigger osteoclast formation in rheumatoid arthritis","volume":"82","author":"O'Neil","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.redox.2025.103802_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202400304","article-title":"Nucleus\u2010targeting photosensitizers enhance neutrophil extracellular traps for efficient eradication of multidrug\u2010resistant bacterial infections","volume":"36","author":"Wang","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.redox.2025.103802_bib7","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.immuni.2023.02.015","article-title":"STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion","volume":"56","author":"Yang","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2025.103802_bib8","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/CIRCULATIONAHA.117.032636","article-title":"Cholesterol efflux pathways suppress inflammasome activation, NETosis, and atherogenesis","volume":"138","author":"Westerterp","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103802_bib9","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.apsb.2021.10.016","article-title":"Prmt1 upregulated by Hdc deficiency aggravates acute myocardial infarction via NETosis","volume":"12","author":"Zhang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.redox.2025.103802_bib10","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1093\/eurheartj\/ehae205","article-title":"Myocardial reperfusion injury exacerbation due to ALDH2 deficiency is mediated by neutrophil extracellular traps and prevented by leukotriene C4 inhibition","volume":"45","author":"Yang","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.redox.2025.103802_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/JCI147191","article-title":"KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression","volume":"132","author":"Tang","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2025.103802_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155909","article-title":"Berberine alleviates ulcerative colitis by inhibiting inflammation through targeting IRGM1","volume":"133","author":"Meng","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.redox.2025.103802_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155517","article-title":"Berberine promotes the degradation of phenylacetic acid to prevent thrombosis by modulating gut microbiota","volume":"128","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.redox.2025.103802_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108583","article-title":"Palmatine attenuates the doxorubicin-induced inflammatory response, oxidative damage and cardiomyocyte apoptosis","volume":"106","author":"Cheng","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.redox.2025.103802_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117100","article-title":"Palmatine reverse aristolochic acid-induced heart failure through activating EGFR pathway via upregulating IKBKB","volume":"285","author":"Hu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.redox.2025.103802_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176395","article-title":"Palmatine alleviates cardiac fibrosis by inhibiting fibroblast activation through the STAT3 pathway","volume":"967","author":"Lin","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.redox.2025.103802_bib17","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.fct.2009.05.031","article-title":"Palmatine from Coptidis rhizoma reduces ischemia\u2013reperfusion-mediated acute myocardial injury in the rat","volume":"47","author":"Kim","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.redox.2025.103802_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117342","article-title":"13-Methylpalmatine improves myocardial infarction injury by inhibiting CHOP-mediated cross-talk between endoplasmic reticulum and mitochondria","volume":"179","author":"Jiang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2025.103802_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0165-2478(03)00052-X","article-title":"Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody","volume":"88","author":"Afsaneh","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.redox.2025.103802_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(96)00090-3","article-title":"Neutrophils and myocardial reperfusion injury","volume":"72","author":"Williams","year":"1996","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.redox.2025.103802_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/cvr\/cvu153","article-title":"Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury","volume":"103","author":"De Hoog","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2025.103802_bib22","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1002\/ptr.7703","article-title":"Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow","volume":"37","author":"Li","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.redox.2025.103802_bib23","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163105","article-title":"C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps","volume":"133","author":"Silva","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2025.103802_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adi9575","article-title":"Disrupted degradative sorting of TLR7 is associated with human lupus","volume":"9","author":"Mishra","year":"2024","journal-title":"Sci Immunol"},{"key":"10.1016\/j.redox.2025.103802_bib25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41575-023-00871-3","article-title":"Neutrophils: from IBD to the gut microbiota","volume":"21","author":"Danne","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2025.103802_bib26","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/CIRCULATIONAHA.118.036044","article-title":"Dectin-1 contributes to myocardial ischemia\/reperfusion injury by regulating macrophage polarization and neutrophil infiltration","volume":"139","author":"Fan","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103802_bib27","doi-asserted-by":"crossref","first-page":"16598","DOI":"10.1021\/acs.jmedchem.1c01174","article-title":"Development of potent and selective agonists for complement C5a receptor 1 with in vivo activity","volume":"64","author":"Gorman","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.redox.2025.103802_bib28","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1038\/s41467-021-23611-0","article-title":"Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2025.103802_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153216","article-title":"Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice","volume":"76","author":"Yu","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.redox.2025.103802_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107413","article-title":"Palmatine protects against atherosclerosis by gut microbiota and phenylalanine metabolism","volume":"209","author":"Wang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.redox.2025.103802_bib31","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.redox.2025.103802_bib32","article-title":"Neutrophil extracellular ttraps-inhibiting and fouling-resistant polysulfoxides potently prevent postoperative adhesion, tumor recurrence, and metastasis","volume":"36","author":"Jiafeng","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.redox.2025.103802_bib33","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/CIRCRESAHA.116.309692","article-title":"Neutrophil extracellular traps in atherosclerosis and atherothrombosis","volume":"120","author":"D\u00f6ring","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103802_bib34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12964-023-01379-8","article-title":"Neutrophil extracellular traps mediated by platelet microvesicles promote thrombosis and brain injury in acute ischemic stroke","volume":"22","author":"Gao","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.redox.2025.103802_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41392-023-01497-2","article-title":"Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression","volume":"8","author":"He","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.redox.2025.103802_bib36","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1093\/cvr\/cvab329","article-title":"Neutrophil extracellular traps: from physiology to pathology","volume":"118","author":"Hidalgo","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2025.103802_bib37","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1161\/01.CIR.87.2.536","article-title":"Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leukocyte activation","volume":"87","author":"Shandelya","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103802_bib38","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1161\/01.CIR.97.22.2259","article-title":"Myocardial infarction and apoptosis after myocardial ischemia and reperfusion","volume":"97","author":"Vakeva","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103802_bib39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41422-023-00779-2","article-title":"Mechanism of activation and biased signaling in complement receptor C5aR1","volume":"33","author":"Feng","year":"2023","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2025.103802_bib40","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1128\/IAI.01197-15","article-title":"Real-time imaging of interactions of neutrophils with cryptococcus neoformans demonstrates a crucial role of complement C5a-C5aR signaling","volume":"84","author":"Sun","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.redox.2025.103802_bib41","doi-asserted-by":"crossref","DOI":"10.1172\/JCI168277","article-title":"Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1","volume":"133","author":"Beach","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2025.103802_bib42","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2007.03.152","article-title":"C5aR-mediated myocardial ischemia\/reperfusion injury","volume":"357","author":"Zhang","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2025.103802_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2023.06.173","article-title":"Platelet specific C5A receptor (C5AR) 1 deficiency improves cardiac function in a murine model of acute myocardial infarction","volume":"379","author":"Schommer","year":"2023","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.redox.2025.103802_bib44","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1038\/s41467-021-23499-w","article-title":"The C5a\/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets","volume":"12","author":"Nording","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2025.103802_bib45","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.1055\/a-2156-8048","article-title":"The platelet anaphylatoxin receptor C5aR1 (CD88) is a promising target for modulating vessel growth in response to ischemia (a)","volume":"7","author":"Nording","year":"2023","journal-title":"TH open : companion journal to thrombosis and haemostasis"},{"key":"10.1016\/j.redox.2025.103802_bib46","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1182\/bloodadvances.2021006891","article-title":"Platelets regulate ischemia-induced revascularization and angiogenesis by secretion of growth factor-modulating factors","volume":"7","author":"Nording","year":"2023","journal-title":"Blood Adv."},{"key":"10.1016\/j.redox.2025.103802_bib47","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1055\/a-2434-4905","article-title":"Cardiac repair after myocardial infarction is controlled by a complement C5a receptor 1-driven signaling cascade","volume":"125","author":"Asare","year":"2025","journal-title":"Thrombosis and haemostasis"},{"key":"10.1016\/j.redox.2025.103802_bib48","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1172\/JCI141374","article-title":"Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis","volume":"130","author":"Skendros","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2025.103802_bib49","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2024.2447406","article-title":"C5a\/C5aR regulates Th1\/Th2 imbalance in sepsis-associated lung injury by promoting neutrophil activation to increase PAD4 expression","volume":"57","author":"Lu","year":"2025","journal-title":"Ann. Med."},{"key":"10.1016\/j.redox.2025.103802_bib50","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.canlet.2021.12.027","article-title":"Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis","volume":"529","author":"Ortiz-Espinosa","year":"2022","journal-title":"Cancer letters"},{"issue":"Pt B","key":"10.1016\/j.redox.2025.103802_bib51","article-title":"Complement component 5a receptor 1 and leukotriene B4 receptor 1 regulate neutrophil extracellular trap (NET) formation through Rap1a\/B-Raf\/ERK signaling pathway and their deficiency in term low birth weight newborns leads to deficient NETosis","volume":"142","author":"Das","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.redox.2025.103802_bib52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","article-title":"Multitarget strategies to reduce myocardial ischemia\/reperfusion injury","volume":"73","author":"Davidson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.redox.2025.103802_bib53","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tem.2023.10.010","article-title":"Regulated cell death in myocardial ischemia\u2013reperfusion injury","volume":"35","author":"Xiang","year":"2024","journal-title":"Trends Endocrinol Metab"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725003155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725003155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:06:26Z","timestamp":1778853986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725003155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":53,"alternative-id":["S2213231725003155"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103802","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"13-methylpalmatine alleviates myocardial ischemia\/reperfusion injury by potentially targeting the C5a-C5aR1 axis to inhibit neutrophil extracellular trap formation","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103802","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103802"}}