{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:30:19Z","timestamp":1792373419369,"version":"4.4.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013740","name":"Plastic Surgery Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013740","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA282478"],"award-info":[{"award-number":["R01CA282478"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA254110"],"award-info":[{"award-number":["R01CA254110"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013140","name":"Colorectal Cancer Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013140","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016606","name":"Riley Children's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.redox.2025.103848","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T22:40:19Z","timestamp":1756593619000},"page":"103848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling"],"prefix":"10.1016","volume":"86","author":[{"given":"Sonia","family":"Kiran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall S.","family":"Wireman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Peil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana K.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Sierra","family":"Potchanant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratan","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah Z.","family":"Vilseck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanya","family":"Haiaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millie M.","family":"Georgiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa L.","family":"Fishel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9472-1826","authenticated-orcid":false,"given":"Mark R.","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.redox.2025.103848_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10010014","article-title":"Targeting pancreatic cancer cell plasticity: the latest in therapeutics","volume":"10","author":"Smigiel","year":"2018","journal-title":"Cancers (Basel)"},{"issue":"1\u20132","key":"10.1016\/j.redox.2025.103848_bib2","first-page":"54","article-title":"Evolution of the redox function in mammalian apurinic\/apyrimidinic endonuclease","volume":"643","author":"Georgiadis","year":"2008","journal-title":"Mutat. Res."},{"issue":"2","key":"10.1016\/j.redox.2025.103848_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.dnarep.2007.09.008","article-title":"Knockdown of the DNA repair and redox signaling protein Ape1\/Ref-1 blocks ovarian cancer cell and tumor growth","volume":"7","author":"Fishel","year":"2008","journal-title":"DNA Repair (Amst)"},{"issue":"3\u20134","key":"10.1016\/j.redox.2025.103848_bib4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.mam.2007.04.005","article-title":"The DNA base excision repair protein Ape1\/Ref-1 as a therapeutic and chemopreventive target","volume":"28","author":"Fishel","year":"2007","journal-title":"Mol. Aspect. Med."},{"issue":"3\u20134","key":"10.1016\/j.redox.2025.103848_bib5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/ars.2005.7.367","article-title":"The intracellular localization of APE1\/Ref-1: more than a passive phenomenon?","volume":"7","author":"Tell","year":"2005","journal-title":"Antioxidants Redox Signal."},{"issue":"2","key":"10.1016\/j.redox.2025.103848_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0921-8777(00)00046-X","article-title":"Going APE over ref-1","volume":"461","author":"Evans","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.redox.2025.103848_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107092","article-title":"New Ref-1\/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types","volume":"201","author":"Gampala","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"9","key":"10.1016\/j.redox.2025.103848_bib8","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1158\/1535-7163.MCT-11-0107","article-title":"Impact of APE1\/Ref-1 redox inhibition on pancreatic tumor growth","volume":"10","author":"Fishel","year":"2011","journal-title":"Mol. Cancer Therapeut."},{"issue":"1","key":"10.1016\/j.redox.2025.103848_bib9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.drudis.2020.10.015","article-title":"The multifunctional APE1 DNA repair\u2013redox signaling protein as a drug target in human disease","volume":"26","author":"Caston","year":"2021","journal-title":"Drug Discov. Today"},{"issue":"11","key":"10.1016\/j.redox.2025.103848_bib10","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1089\/ars.2008.2120","article-title":"Role of the multifunctional DNA repair and redox signaling protein Ape1\/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1","volume":"10","author":"Luo","year":"2008","journal-title":"Antioxidants Redox Signal."},{"issue":"4","key":"10.1016\/j.redox.2025.103848_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2174\/187152008784220294","article-title":"DNA repair proteins as molecular targets for cancer therapeutics","volume":"8","author":"Kelley","year":"2008","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.redox.2025.103848_bib12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1089\/ars.2008.2218","article-title":"Going ape as an approach to cancer therapeutics","volume":"11","author":"Bapat","year":"2009","journal-title":"Antioxidants Redox Signal."},{"issue":"5","key":"10.1016\/j.redox.2025.103848_bib13","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1182\/blood-2006-08-044172","article-title":"Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain","volume":"109","author":"Zou","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.redox.2025.103848_bib14","series-title":"Chemically Induced Partial Unfolding of the Multifunctional Apurinic\/apyrimidinic Endonuclease 1","author":"Rai","year":"2023"},{"issue":"7","key":"10.1016\/j.redox.2025.103848_bib15","first-page":"2165","article-title":"Ref-1 inhibitor APX2009 regulates hypoxia signaling in murine subretinal neovascularization and human retinal endothelial cells","volume":"65","author":"Muniyandi","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.redox.2025.103848_bib16","article-title":"Functional heterogeneity of fibroblasts in primary tumors and metastases","author":"Cheng","year":"2024","journal-title":"Trends Cancer"},{"issue":"24","key":"10.1016\/j.redox.2025.103848_bib17","doi-asserted-by":"crossref","first-page":"13408","DOI":"10.3390\/ijms222413408","article-title":"Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma: an update on heterogeneity and therapeutic targeting","volume":"22","author":"Vaish","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.redox.2025.103848_bib18","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1053\/j.gastro.2016.03.040","article-title":"Mounting pressure in the microenvironment: fluids, solids, and cells in pancreatic ductal adenocarcinoma","volume":"150","author":"DuFort","year":"2016","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.redox.2025.103848_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.492","article-title":"Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress","volume":"8","author":"Chan","year":"2017","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.redox.2025.103848_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41392-020-00341-1","article-title":"Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer","volume":"5","author":"Bulle","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"8","key":"10.1016\/j.redox.2025.103848_bib21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41575-020-0300-1","article-title":"Pancreatic cancer stroma: an update on therapeutic targeting strategies","volume":"17","author":"Hosein","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2025.103848_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/srep29389","article-title":"Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression","volume":"6","author":"Nassour","year":"2016","journal-title":"Sci. Rep."},{"issue":"13","key":"10.1016\/j.redox.2025.103848_bib23","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1093\/nar\/gkn416","article-title":"A new APE1\/Ref-1-dependent pathway leading to reduction of NF-{kappa}B and AP-1, and activation of their DNA-binding activity","volume":"36","author":"Ando","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2025.103848_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.826617","article-title":"RelA is an essential target for enhancing cellular responses to the DNA Repair\/Ref-1 redox signaling protein and restoring perturbated cellular redox homeostasis in mouse PDAC cells","volume":"12","author":"Mijit","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.redox.2025.103848_bib25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.freeradbiomed.2023.11.009","article-title":"Dual role of PRDX1 in redox-regulation and tumorigenesis: past and future","volume":"210","author":"Guan","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.redox.2025.103848_bib26","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/1878-0261.12138","article-title":"APE1\/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing","volume":"11","author":"Shah","year":"2017","journal-title":"Mol. Oncol."},{"issue":"6","key":"10.1016\/j.redox.2025.103848_bib27","article-title":"Role of cytosolic 2-Cys Prx1 and Prx2 in Redox signaling","volume":"8","author":"Kim","year":"2019","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.redox.2025.103848_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2016.03.018","article-title":"Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases","volume":"163","author":"Park","year":"2016","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.redox.2025.103848_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101959","article-title":"Peroxiredoxins wear many hats: factors that fashion their peroxide sensing personalities","volume":"42","author":"Bolduc","year":"2021","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.redox.2025.103848_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3892\/mco.2017.1129","article-title":"The role of peroxiredoxins in cancer","volume":"6","author":"Nicolussi","year":"2017","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.redox.2025.103848_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114896","article-title":"New insights into the roles of peroxiredoxins in cancer","volume":"164","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.redox.2025.103848_bib32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejso.2014.11.037","article-title":"Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer","volume":"41","author":"Cai","year":"2015","journal-title":"Eur. J. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.redox.2025.103848_bib33","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/jcmm.16132","article-title":"Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models","volume":"25","author":"Caston","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.redox.2025.103848_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102977","article-title":"In vitro and in vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer","volume":"69","author":"Mijit","year":"2024","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.redox.2025.103848_bib35","doi-asserted-by":"crossref","first-page":"13759","DOI":"10.1038\/s41598-018-32034-9","article-title":"Blocking HIF signaling via novel inhibitors of CA9 and APE1\/Ref-1 dramatically affects pancreatic cancer cell survival","volume":"8","author":"Logsdon","year":"2018","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.redox.2025.103848_bib36","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1038\/s41416-021-01270-8","article-title":"Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours","volume":"124","author":"Gampala","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.redox.2025.103848_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF00203823","article-title":"High-level production of uniformly (1)(5)N- and (1)(3)C-enriched fusion proteins in Escherichia coli","volume":"7","author":"Jansson","year":"1996","journal-title":"J. Biomol. NMR"},{"issue":"47","key":"10.1016\/j.redox.2025.103848_bib38","doi-asserted-by":"crossref","first-page":"16505","DOI":"10.1021\/ja053564h","article-title":"Comparisons of NMR spectral quality and success in crystallization demonstrate that NMR and X-ray crystallography are complementary methods for small protein structure determination","volume":"127","author":"Snyder","year":"2005","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.redox.2025.103848_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10456-024-09966-0","article-title":"Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor","volume":"28","author":"Muniyandi","year":"2025","journal-title":"Angiogenesis"},{"issue":"16","key":"10.1016\/j.redox.2025.103848_bib40","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.redox.2025.103848_bib41","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"5","key":"10.1016\/j.redox.2025.103848_bib42","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nprot.2016.051","article-title":"Computational protein-ligand docking and virtual drug screening with the AutoDock suite","volume":"11","author":"Forli","year":"2016","journal-title":"Nat. Protoc."},{"issue":"suppl_2","key":"10.1016\/j.redox.2025.103848_bib43","doi-asserted-by":"crossref","first-page":"W375","DOI":"10.1093\/nar\/gkm216","article-title":"MolProbity: all-atom contacts and structure validation for proteins and nucleic acids","volume":"35","author":"Davis","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"Pt 1","key":"10.1016\/j.redox.2025.103848_bib44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"issue":"2","key":"10.1016\/j.redox.2025.103848_bib45","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/ct100578z","article-title":"PROPKA3: consistent treatment of internal and surface residues in empirical pKa predictions","volume":"7","author":"Olsson","year":"2011","journal-title":"J. Chem. Theor. Comput."},{"issue":"41","key":"10.1016\/j.redox.2025.103848_bib46","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.1021\/bi500676p","article-title":"High-resolution crystal structures reveal plasticity in the metal binding site of apurinic\/apyrimidinic endonuclease I","volume":"53","author":"He","year":"2014","journal-title":"Biochemistry"},{"issue":"13","key":"10.1016\/j.redox.2025.103848_bib47","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.redox.2025.103848_bib48","unstructured":"MGLTools: Autodocktools. 1.5.7. Molecular Graphics Laboratory: the Scripps Research Institute1999-2011."},{"key":"10.1016\/j.redox.2025.103848_bib49","unstructured":"The Pymol Molecular Graphics System. 2.5.2. Schrodinger LLC: New York, New York."},{"issue":"5","key":"10.1016\/j.redox.2025.103848_bib50","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1158\/1078-0432.CCR-23-2548","article-title":"Spatial gene-expression profiling unveils immuno-oncogenic programs of NF1-Associated peripheral nerve sheath tumor progression","volume":"30","author":"Mitchell","year":"2024","journal-title":"Clin. Cancer Res."},{"issue":"17","key":"10.1016\/j.redox.2025.103848_bib51","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1158\/1078-0432.CCR-22-2854","article-title":"Combined CDK4\/6 and ERK1\/2 inhibition enhances antitumor activity in NF1-Associated plexiform neurofibroma","volume":"29","author":"Flint","year":"2023","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.redox.2025.103848_bib52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/1878-0261.13552","article-title":"Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression","volume":"18","author":"Chowdhury","year":"2024","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.redox.2025.103848_bib53","article-title":"Cysteine 65 in Ref-1 is essential for Ref-1 redox function and transcriptional regulation in humanPDAC cells","author":"Mijiti Maihemuti","year":"2022","journal-title":"Soc. Redox Biol. Med."},{"issue":"6","key":"10.1016\/j.redox.2025.103848_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/pro.70148","article-title":"Chemically induced partial unfolding of the multifunctional apurinic\/apyrimidinic endonuclease 1","volume":"34","author":"Rai","year":"2025","journal-title":"Protein Sci."},{"key":"10.1016\/j.redox.2025.103848_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107092","article-title":"New Ref-1\/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types","volume":"201","author":"Gampala","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"8","key":"10.1016\/j.redox.2025.103848_bib56","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","article-title":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts","volume":"9","author":"Elyada","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.redox.2025.103848_bib57","article-title":"Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes","author":"Peng","year":"2024","journal-title":"bioRxiv"},{"issue":"4","key":"10.1016\/j.redox.2025.103848_bib58","doi-asserted-by":"crossref","first-page":"208","DOI":"10.33696\/Signaling.5.126","article-title":"Combating PDAC drug resistance: the role of Ref-1 inhibitors in accelerating progress in pancreatic cancer research","volume":"5","author":"Kpenu","year":"2024","journal-title":"J. Cell. Signal"},{"issue":"1","key":"10.1016\/j.redox.2025.103848_bib59","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13046-021-02046-x","article-title":"Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target","volume":"40","author":"Gampala","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.redox.2025.103848_bib60","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1073\/pnas.94.8.3633","article-title":"AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1","volume":"94","author":"Hirota","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.redox.2025.103848_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15020416","article-title":"Optimizing first-line chemotherapy in metastatic pancreatic cancer: efficacy of FOLFIRINOX versus Nab-Paclitaxel plus gemcitabine","volume":"15","author":"Di Costanzo","year":"2023","journal-title":"Cancers (Basel)"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725003611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725003611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:06:52Z","timestamp":1778854012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725003611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":61,"alternative-id":["S2213231725003611"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103848","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The absence of Peroxiredoxin-1 in human pancreatic ductal adenocarcinoma (PDAC) markedly reduces cell survival and tumor growth when coupled with the inhibition of Ref-1 redox signaling","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103848","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103848"}}