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Physiol."},{"key":"10.1016\/j.redox.2025.103892_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11097","article-title":"Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture","volume":"7","author":"Stritt","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.redox.2025.103892_bib99","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-5793(97)00019-7","article-title":"Expression of human TRPC genes in the megakaryocytic cell lines MEG01, DAMI and HEL","volume":"403","author":"Berg","year":"1997","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.redox.2025.103892_bib100","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00281-015-0527-z","article-title":"Role of renal TRP channels in physiology and pathology","volume":"38","author":"Tomilin","year":"2016","journal-title":"Semin. 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