{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:26:40Z","timestamp":1793993200022,"version":"4.8.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174049"],"award-info":[{"award-number":["82174049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073861"],"award-info":[{"award-number":["82073861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574423"],"award-info":[{"award-number":["82574423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.redox.2025.103919","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:44:10Z","timestamp":1762332250000},"page":"103919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Estrogen receptor \u03b2 deficiency increases the susceptibility to ulcerative colitis by inducing mitochondrial fission and consequently accelerating senescence of colonic epithelial cells"],"prefix":"10.1016","volume":"88","author":[{"given":"Yilei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mianjiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-2064","authenticated-orcid":false,"given":"Yue","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103919_bib1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1001\/jama.2023.23814","article-title":"What is ulcerative colitis?","volume":"331","author":"Voelker","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.redox.2025.103919_bib2","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2025.103919_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202404274","article-title":"Sensing of liver-derived nicotinamide by intestinal group 2 innate lymphoid cells links liver cirrhosis and ulcerative colitis susceptibility","volume":"11","author":"Shen","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.redox.2025.103919_bib4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ng.3314","article-title":"The support of human genetic evidence for approved drug indications","volume":"47","author":"Nelson","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2025.103919_bib5","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1053\/j.gastro.2015.08.001","article-title":"Genetics of inflammatory bowel diseases","volume":"149","author":"McGovern","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2025.103919_bib6","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1136\/gutjnl-2023-329650","article-title":"Emerging interleukin targets in the tumour microenvironment: implications for the treatment of gastrointestinal tumours","volume":"72","author":"Dickerson","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.redox.2025.103919_bib7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/jgh.14872","article-title":"The epidemiology of inflammatory bowel disease: east meets west","volume":"35","author":"Mak","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2025.103919_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.apsb.2024.11.014","article-title":"Facilitation of mucosal healing by estrogen receptor \u03b2 in ulcerative colitis through suppression of branched-chain amino acid transport and subsequent triggering of autophagy in colonic epithelial cells","volume":"15","author":"Guo","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.redox.2025.103919_bib9","first-page":"904","article-title":"Sex-based differences in the incidence of inflammatory bowel diseases-pooled analysis of population-based studies from the Asia-Pacific region, aliment","volume":"49","author":"Shah","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.redox.2025.103919_bib10","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/j.1572-0241.2007.01700.x","article-title":"Hormonal replacement therapy after menopause is protective of disease activity in women with inflammatory bowel disease","volume":"103","author":"Kane","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.redox.2025.103919_bib11","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1042\/EBC20210010","article-title":"Estrogen receptor actions in colitis","volume":"65","author":"Garcia-Villatoro","year":"2021","journal-title":"Essays Biochem."},{"key":"10.1016\/j.redox.2025.103919_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1187259","article-title":"Profiling estrogen, progesterone, and androgen receptors in colorectal cancer in relation to gender, menopausal status, clinical stage, and tumour sidedness","volume":"14","author":"Refaat","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.redox.2025.103919_bib13","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1053\/j.gastro.2018.08.029","article-title":"Identification of menopausal and reproductive risk factors for microscopic colitis-results from the nurses' health study","volume":"155","author":"Burke","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2025.103919_bib14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jare.2024.06.004","article-title":"Estrogen receptor \u03b2 activation alleviates inflammatory bowel disease by suppressing NLRP3-dependent IL-1\u03b2 production in macrophages via downregulation of intracellular calcium level","volume":"71","author":"Zhu","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.redox.2025.103919_bib15","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1096\/fj.201901638RR","article-title":"Pharmacological activation of ER\u03b2 by arctigenin maintains the integrity of intestinal epithelial barrier in inflammatory bowel diseases","volume":"34","author":"Tao","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.redox.2025.103919_bib16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/ibd\/izab039","article-title":"Aging and IBD: a new challenge for clinicians and researchers","volume":"28","author":"Faye","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.redox.2025.103919_bib17","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s00535-019-01606-5","article-title":"Management of elderly ulcerative colitis in Japan","volume":"54","author":"Higashiyama","year":"2019","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.redox.2025.103919_bib18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1053\/j.gastro.2008.04.008","article-title":"Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage","volume":"135","author":"Risques","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2025.103919_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100938","article-title":"Intestinal epithelial barrier functions in ageing","volume":"54","author":"Branca","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.redox.2025.103919_bib20","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.apsb.2021.03.043","article-title":"DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS\u2012STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.redox.2025.103919_bib21","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.apsb.2024.01.014","article-title":"Small molecule conjugates with selective estrogen receptor \u03b2 agonism promote anti-aging benefits in metabolism and skin recovery","volume":"14","author":"Zahr","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.redox.2025.103919_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111513","article-title":"A role for estrogen in skin ageing and dermal biomechanics","volume":"197","author":"Wilkinson","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.redox.2025.103919_bib23","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1002\/ptr.7861","article-title":"A review on phytoestrogens: current status and future direction","volume":"37","author":"Patra","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.redox.2025.103919_bib24","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.3389\/fimmu.2018.01903","article-title":"The natural agonist of estrogen receptor \u03b2 silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis","volume":"9","author":"Dupuis","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.redox.2025.103919_bib25","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1002\/ptr.8196","article-title":"Phytoestrogens: chemistry, potential health benefits, and their medicinal importance","volume":"38","author":"Chavda","year":"2024","journal-title":"Phytother Res."},{"key":"10.1016\/j.redox.2025.103919_bib26","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/ptr.7495","article-title":"Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ER\u03b2\/TRIM21\/PHB1 pathway","volume":"36","author":"Tao","year":"2022","journal-title":"Phytother Res."},{"key":"10.1016\/j.redox.2025.103919_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111552","article-title":"Arctigenin promotes mucosal healing in ulcerative colitis through facilitating focal adhesion assembly and colonic epithelial cell migration via targeting focal adhesion kinase","volume":"128","author":"Guo","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.redox.2025.103919_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41586-019-0992-y","article-title":"Colonic epithelial cell diversity in health and inflammatory bowel disease","volume":"567","author":"Parikh","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.redox.2025.103919_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170771","article-title":"Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing","volume":"133","author":"Ahmad","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2025.103919_bib30","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s43587-023-00473-3","article-title":"Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems","volume":"3","author":"Girotra","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.redox.2025.103919_bib31","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41556-023-01343-1","article-title":"Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal","volume":"26","author":"Newman","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2025.103919_bib32","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41569-022-00703-y","article-title":"The role of mitochondrial fission in cardiovascular health and disease","volume":"19","author":"Quiles","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.redox.2025.103919_bib33","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrd4309","article-title":"Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework","volume":"13","author":"Cook","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.redox.2025.103919_bib34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.molmet.2018.05.009","article-title":"Estrogen receptor subcellular localization and cardiometabolism","volume":"15","author":"Gourdy","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.redox.2025.103919_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1210\/endrev\/bnac017","article-title":"Estrogen receptor signaling in the immune system","volume":"44","author":"Chakraborty","year":"2023","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.redox.2025.103919_bib36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.beem.2015.04.008","article-title":"Estrogen receptor alpha and beta in health and disease","volume":"29","author":"Jia","year":"2015","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.redox.2025.103919_bib37","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/13697137.2017.1360861","article-title":"Experience of menopause in women with inflammatory bowel disease: pilot study","volume":"20","author":"Donaldson","year":"2017","journal-title":"Climacteric"},{"key":"10.1016\/j.redox.2025.103919_bib38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.gtc.2016.02.007","article-title":"Caring for women with inflammatory bowel disease","volume":"45","author":"Feagins","year":"2016","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1016\/j.redox.2025.103919_bib39","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1053\/j.gastro.2022.07.062","article-title":"The rising burden of inflammatory bowel disease in Denmark over two decades: a nationwide cohort study","volume":"163","author":"Agrawal","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2025.103919_bib40","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in health and disease","volume":"169","author":"He","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.redox.2025.103919_bib41","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1016\/j.cgh.2015.02.020","article-title":"Changes in the gastric mucosa with aging","volume":"13","author":"Sonnenberg","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2025.103919_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8135985","article-title":"Autophagy: multiple mechanisms to protect skin from ultraviolet radiation-driven photoaging","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.redox.2025.103919_bib43","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial dysfunction in cell senescence and aging","volume":"132","author":"Miwa","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2025.103919_bib44","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.redox.2025.103919_bib45","first-page":"402","article-title":"Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction","volume":"22","author":"Xiu","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.redox.2025.103919_bib46","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ncb3586","article-title":"Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence","volume":"19","author":"Gl\u00fcck","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2025.103919_bib47","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41586-023-06621-4","article-title":"Apoptotic stress causes mtDNA release during senescence and drives the SASP","volume":"622","author":"Victorelli","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.redox.2025.103919_bib48","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13046-022-02262-z","article-title":"Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway","volume":"41","author":"Li","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.redox.2025.103919_bib49","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1038\/s41388-022-02365-z","article-title":"TFAM downregulation promotes autophagy and ESCC survival through mtDNA stress-mediated STING pathway","volume":"41","author":"Li","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2025.103919_bib50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2015.04.059","article-title":"Estrogen amelioration of A\u03b2-induced defects in mitochondria is mediated by mitochondrial signaling pathway involving ER\u03b2, AKAP and Drp1","volume":"1616","author":"Sarkar","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.redox.2025.103919_bib51","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.biocel.2013.04.007","article-title":"The over-expression of ERbeta modifies estradiol effects on mitochondrial dynamics in breast cancer cell line","volume":"45","author":"Sastre-Serra","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.redox.2025.103919_bib52","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.3390\/nu15061536","article-title":"Systematic literature review of the nutrient status, intake, and diet quality of Chinese children across different age groups","volume":"15","author":"Ayling","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.redox.2025.103919_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.actpsy.2024.104260","article-title":"The association between soyfoods or soybean products consumption and executive functioning among Chinese adolescents: a cross-sectional multicenter study","volume":"246","author":"Song","year":"2024","journal-title":"Acta Psychol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172500432X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172500432X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T16:05:26Z","timestamp":1766160326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221323172500432X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":53,"alternative-id":["S221323172500432X"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103919","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estrogen receptor \u03b2 deficiency increases the susceptibility to ulcerative colitis by inducing mitochondrial fission and consequently accelerating senescence of colonic epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103919","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103919"}}