{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:13:50Z","timestamp":1792098830552,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"publisher","award":["ZKX20040"],"award-info":[{"award-number":["ZKX20040"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"publisher","award":["ZKX24036"],"award-info":[{"award-number":["ZKX24036"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2705100"],"award-info":[{"award-number":["2022YFC2705100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2705105"],"award-info":[{"award-number":["2022YFC2705105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2705102"],"award-info":[{"award-number":["2022YFC2705102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82090022"],"award-info":[{"award-number":["82090022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770740"],"award-info":[{"award-number":["81770740"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570813"],"award-info":[{"award-number":["82570813"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070702"],"award-info":[{"award-number":["82070702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2411073"],"award-info":[{"award-number":["W2411073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.redox.2025.103929","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:22:19Z","timestamp":1763648539000},"page":"103929","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Endothelial Lon protease 1 facilitates the redox balance to prevent glomerulosclerosis by acting on superoxide dismutase 2 ubiquitination"],"prefix":"10.1016","volume":"88","author":[{"given":"Xiaolu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixia","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqiu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3107-0429","authenticated-orcid":false,"given":"Zhanjun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.redox.2025.103929_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"Ruiz-Ortega","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"issue":"10225","key":"10.1016\/j.redox.2025.103929_bib2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"National burden of chronic kidney disease, 1990-2017: a systematic analysis for the global burden of disease study 2017","volume":"395","year":"2020","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.redox.2025.103929_bib3","first-page":"e24","article-title":"Kidney fibrosis: fundamental questions, challenges, and perspectives","volume":"11","author":"Liu","year":"2024","journal-title":"IMNA"},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s12916-024-03555-0","article-title":"Chronic kidney disease: detect, diagnose, disclose-a UK primary care perspective of barriers and enablers to effective kidney care","volume":"22","author":"Stewart","year":"2024","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.redox.2025.103929_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/ckj\/sfac218","article-title":"Temporal trends in prevalence and mortality for chronic kidney disease in China from 1990 to 2019: an analysis of the global burden of disease study 2019","volume":"16","author":"Li","year":"2023","journal-title":"Clin. Kidney J."},{"issue":"3","key":"10.1016\/j.redox.2025.103929_bib6","doi-asserted-by":"crossref","first-page":"F721","DOI":"10.1152\/ajprenal.00546.2010","article-title":"Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury","volume":"300","author":"Basile","year":"2011","journal-title":"Am. J. Physiol.-Renal."},{"issue":"12","key":"10.1016\/j.redox.2025.103929_bib7","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1681\/ASN.2008050513","article-title":"Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition","volume":"19","author":"Zeisberg","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.redox.2025.103929_bib8","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/ki.2014.143","article-title":"Endothelin and endothelin antagonists in chronic kidney disease","volume":"86","author":"Kohan","year":"2014","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/ki.2014.223","article-title":"BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease","volume":"87","author":"Kajimoto","year":"2015","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.redox.2025.103929_bib10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/dmrr.613","article-title":"Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction","volume":"22","author":"Piconi","year":"2006","journal-title":"Diabetes Metabol. Res. Rev."},{"issue":"Suppl","key":"10.1016\/j.redox.2025.103929_bib11","first-page":"S7","article-title":"Reactive oxygen species amplify glucose signalling in renal cells cultured under high glucose and in diabetic kidney","volume":"10","author":"Ha","year":"2005","journal-title":"Nephrology (Carlton)"},{"issue":"3","key":"10.1016\/j.redox.2025.103929_bib12","article-title":"Immunodynamics of macrophages in renal fibrosis","volume":"10","author":"Chung","year":"2023","journal-title":"IMNA"},{"issue":"2","key":"10.1016\/j.redox.2025.103929_bib13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/jhh.2013.55","article-title":"Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage","volume":"28","author":"Mennuni","year":"2014","journal-title":"J. Hum. Hypertens."},{"issue":"3","key":"10.1016\/j.redox.2025.103929_bib14","article-title":"The role of Lonp1 on mitochondrial functions during cardiovascular and muscular diseases","volume":"12","author":"Zanini","year":"2023","journal-title":"Antioxidants-Basel."},{"key":"10.1016\/j.redox.2025.103929_bib15","first-page":"1","article-title":"The biology of Lonp1: more than a mitochondrial protease","volume":"354","author":"Gibellini","year":"2020","journal-title":"Int. Rev. Cell. Mol. Biol."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ajhg.2014.12.003","article-title":"CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ lon protease","volume":"96","author":"Strauss","year":"2015","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.redox.2025.103929_bib17","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.celrep.2014.06.018","article-title":"ATP-Dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity","volume":"8","author":"Quir\u00f3s","year":"2014","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.redox.2025.103929_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9061783","article-title":"Impaired mitochondrial morphology and functionality in Lonp1(wt\/-) mice","volume":"9","author":"De Gaetano","year":"2020","journal-title":"J. Clin. Med."},{"issue":"22","key":"10.1016\/j.redox.2025.103929_bib19","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1111\/j.1432-1033.2004.04422.x","article-title":"Age-related impairment of mitochondrial matrix aconitase and ATP-stimulated protease in rat liver and heart","volume":"271","author":"Delaval","year":"2004","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.redox.2013.01.015","article-title":"Upregulation of the mitochondrial Lon protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging","volume":"1","author":"Ngo","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103929_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.yjmcc.2018.12.017","article-title":"Mitochondrial LonP1 protects cardiomyocytes from ischemia\/reperfusion injury in vivo","volume":"128","author":"Venkatesh","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib22","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/s41467-022-28557-5","article-title":"Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength","volume":"13","author":"Xu","year":"2022","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.redox.2025.103929_bib23","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.kint.2020.10.025","article-title":"Reduced Lon protease 1 expression in podocytes contributes to the pathogenesis of podocytopathy","volume":"99","author":"Gong","year":"2021","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.redox.2025.103929_bib24","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202216581","article-title":"LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease","volume":"15","author":"Bai","year":"2023","journal-title":"EMBO Mol. Med."},{"issue":"21","key":"10.1016\/j.redox.2025.103929_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111338","article-title":"Mitochondria as a cellular hub in infection and inflammation","volume":"22","author":"Andrieux","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.redox.2025.103929_bib26","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/1873-3468.12964","article-title":"Role of mitochondrial ROS in the brain: from physiology to neurodegeneration","volume":"592","author":"Angelova","year":"2018","journal-title":"FEBS Lett."},{"issue":"24","key":"10.1016\/j.redox.2025.103929_bib27","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1007\/s00018-015-2039-3","article-title":"Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer","volume":"72","author":"Pinti","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.redox.2025.103929_bib28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.freeradbiomed.2022.08.038","article-title":"LONP1 downregulation with ageing contributes to osteoarthritis via mitochondrial dysfunction","volume":"191","author":"He","year":"2022","journal-title":"Free Radical. Bio. Med."},{"issue":"5","key":"10.1016\/j.redox.2025.103929_bib29","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","article-title":"Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants","volume":"98","author":"Jomova","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.redox.2025.103929_bib30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000485089","article-title":"Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species","volume":"44","author":"He","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.redox.2025.103929_bib31","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13145","article-title":"Understanding oxidants and antioxidants: classical team with new players","volume":"44","author":"Ali","year":"2020","journal-title":"J. Food Biochem."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib32","article-title":"Antioxidant defenses in the human eye: a focus on metallothioneins","volume":"10","author":"\u00c1lvarez-Barrios","year":"2021","journal-title":"Antioxidants-Basel."},{"issue":"3","key":"10.1016\/j.redox.2025.103929_bib33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(02)00905-X","article-title":"Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression","volume":"33","author":"Zelko","year":"2002","journal-title":"Free Radical. Bio. Med."},{"issue":"6","key":"10.1016\/j.redox.2025.103929_bib34","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: role in redox signaling, vascular function, and diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxid Redox Sign"},{"key":"10.1016\/j.redox.2025.103929_bib35","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.freeradbiomed.2013.07.003","article-title":"Oxidative stress and vascular inflammation in aging","volume":"65","author":"El Assar","year":"2013","journal-title":"Free Radical. Bio. Med."},{"issue":"15","key":"10.1016\/j.redox.2025.103929_bib36","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1089\/ars.2012.4850","article-title":"Regulation of SOD2 in cancer by histone modifications and CpG methylation: closing the loop between redox biology and epigenetics","volume":"18","author":"Cyr","year":"2013","journal-title":"Antioxid Redox Sign"},{"issue":"5","key":"10.1016\/j.redox.2025.103929_bib37","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.117.310933","article-title":"Sirt3 impairment and SOD2 hyperacetylation in vascular oxidative stress and hypertension","volume":"121","author":"Dikalova","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103929_bib38","article-title":"PARK7 protects against chronic kidney injury and renal fibrosis by inducing SOD2 to reduce oxidative stress","volume":"12","author":"Yin","year":"2021","journal-title":"Front. Immuno."},{"issue":"3","key":"10.1016\/j.redox.2025.103929_bib39","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1681\/ASN.2008121259","article-title":"Autoimmunity in membranous nephropathy targets aldose reductase and SOD2","volume":"21","author":"Prunotto","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.redox.2025.103929_bib40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cncy.20147","article-title":"Biospecimen reporting for improved study quality (BRISQ)","volume":"119","author":"Moore","year":"2011","journal-title":"Cancer Cytopathol."},{"issue":"7","key":"10.1016\/j.redox.2025.103929_bib41","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"issue":"9","key":"10.1016\/j.redox.2025.103929_bib42","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12558","article-title":"TLR4 mutant mice are protected from renal fibrosis and chronic kidney disease progression","volume":"3","author":"Souza","year":"2015","journal-title":"Physiol. Rep."},{"issue":"13","key":"10.1016\/j.redox.2025.103929_bib43","doi-asserted-by":"crossref","first-page":"7774","DOI":"10.1167\/iovs.15-17550","article-title":"Tear production after bilateral main lacrimal gland resection in rabbits","volume":"56","author":"Bhattacharya","year":"2015","journal-title":"Invest Ophth. Vis. Sci."},{"issue":"4","key":"10.1016\/j.redox.2025.103929_bib44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1167\/tvst.10.4.32","article-title":"A novel rabbit dry eye model induced by a controlled drying system","volume":"10","author":"Chen","year":"2021","journal-title":"Transl. Vis. Sci. Techn."},{"issue":"39","key":"10.1016\/j.redox.2025.103929_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202309754","article-title":"Meis1 targets protein tyrosine phosphatase receptor J in fibroblast to retard chronic kidney disease progression","volume":"11","author":"Bai","year":"2024","journal-title":"Adv. Sci."},{"issue":"7","key":"10.1016\/j.redox.2025.103929_bib46","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12088","article-title":"Automated quantification of renal fibrosis with Sirius red and polarization contrast microscopy","volume":"2","author":"Street","year":"2014","journal-title":"Physiol. Rep."},{"issue":"10","key":"10.1016\/j.redox.2025.103929_bib47","doi-asserted-by":"crossref","first-page":"F1081","DOI":"10.1152\/ajprenal.00534.2015","article-title":"NLRP3 deletion protects against renal fibrosis and attenuates mitochondrial abnormality in mouse with 5\/6 nephrectomy","volume":"310","author":"Gong","year":"2016","journal-title":"Am. J. Physiol.-Renal."},{"key":"10.1016\/j.redox.2025.103929_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2020.101048","article-title":"Isolation, purification, and conditional immortalization of murine glomerular endothelial cells of microvascular phenotype","volume":"7","author":"Dylewski","year":"2020","journal-title":"MethodsX"},{"issue":"6","key":"10.1016\/j.redox.2025.103929_bib49","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1111\/j.1523-1755.2004.66009.x","article-title":"Isolation and characterization of conditionally immortalized mouse glomerular endothelial cell lines","volume":"66","author":"Rops","year":"2004","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100245","article-title":"Measurement of mitochondrial respiration in adherent cells by seahorse XF96 cell mito stress test","volume":"2","author":"Gu","year":"2020","journal-title":"STAR Protoc."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1364","article-title":"RNA-seq methods for transcriptome analysis","volume":"8","author":"Hrdlickova","year":"2017","journal-title":"Wires RNA"},{"issue":"2","key":"10.1016\/j.redox.2025.103929_bib52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41581-018-0098-z","article-title":"Endothelium structure and function in kidney health and disease","volume":"15","author":"Jourde-Chiche","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"10","key":"10.1016\/j.redox.2025.103929_bib53","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41573-021-00242-0","article-title":"The glomerular filtration barrier: a structural target for novel kidney therapies","volume":"20","author":"Daehn","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib54","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"3","key":"10.1016\/j.redox.2025.103929_bib55","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-Induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"issue":"7","key":"10.1016\/j.redox.2025.103929_bib56","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/ajmg.a.37029","article-title":"Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome","volume":"167","author":"Dikoglu","year":"2015","journal-title":"Am. J. Med. Genet. A"},{"issue":"17","key":"10.1016\/j.redox.2025.103929_bib57","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70090","article-title":"LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis","volume":"28","author":"Zhang","year":"2024","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.redox.2025.103929_bib58","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.freeradbiomed.2009.05.018","article-title":"Regulation of superoxide dismutase genes: implications in disease","volume":"47","author":"Miao","year":"2009","journal-title":"Free Radical. Bio. Med."},{"key":"10.1016\/j.redox.2025.103929_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101740","article-title":"SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy","volume":"37","author":"Sharma","year":"2020","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib60","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"9","key":"10.1016\/j.redox.2025.103929_bib61","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.2215\/CJN.13791215","article-title":"The players: cells involved in glomerular disease","volume":"11","author":"Kitching","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.redox.2025.103929_bib62","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12974-024-03075-x","article-title":"Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2\/ET-1 axis-controlled ERK1\/2 pathway","volume":"21","author":"Xin","year":"2024","journal-title":"J. Neuroinflammation"},{"issue":"23","key":"10.1016\/j.redox.2025.103929_bib63","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1042\/CS20240625","article-title":"Enhanced vasoconstriction in sickle cell disease is dependent on ETA receptor activation","volume":"138","author":"John Miller","year":"2024","journal-title":"Clin. Sci. (Lond.)"},{"issue":"3","key":"10.1016\/j.redox.2025.103929_bib64","article-title":"Increased renal medullary NOX-4 in female but not Male mice during the early phase of type 1 diabetes: potential role of ROS in upregulation of TGF-\u03b21 and fibronectin in collecting duct cells","volume":"12","author":"Felipe","year":"2023","journal-title":"Antioxidants (Basel)"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725004422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725004422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:09:33Z","timestamp":1773842973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725004422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":64,"alternative-id":["S2213231725004422"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103929","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial Lon protease 1 facilitates the redox balance to prevent glomerulosclerosis by acting on superoxide dismutase 2 ubiquitination","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103929","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103929"}}