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Lett."},{"key":"10.1016\/j.redox.2025.103933_bib117","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0140-6736(00)02075-4","article-title":"The antioxidant paradox","volume":"355","author":"Halliwell","year":"2000","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.redox.2025.103933_bib118","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1365-2125.2012.04272.x","article-title":"The antioxidant paradox: less paradoxical now?","volume":"75","author":"Halliwell","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.redox.2025.103933_bib119","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1196\/annals.1354.004","article-title":"The free radical fantasy: a panoply of paradoxes","volume":"1067","author":"Howes","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.redox.2025.103933_bib120","article-title":"Nanocatalytic medicine","volume":"0","author":"Yang","year":"2019","journal-title":"Adv. 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