{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:07:06Z","timestamp":1791338826726,"version":"4.3.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008385","name":"Cystic Fibrosis Research Foundation","doi-asserted-by":"publisher","award":["FFC#4\/2021"],"award-info":[{"award-number":["FFC#4\/2021"]}],"id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.redox.2025.103944","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:43:01Z","timestamp":1764117781000},"page":"103944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Beyond CFTR: Ivacaftor's role in restoring cellular redox balance and preventing ferroptosis"],"prefix":"10.1016","volume":"89","author":[{"given":"Michela","family":"Rubin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Artusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Rossetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Gucciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Di Paolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bosello Travain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Zeppilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Orian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Miotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pedro","family":"Friedmann Angeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Cozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103944_bib1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1183\/13993003.00592-2015","article-title":"Report of the European Respiratory Society\/European Cystic Fibrosis Society task force on the care of adults with cystic fibrosis","volume":"47","author":"Elborn","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.redox.2025.103944_bib2","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20212006","article-title":"Molecular mechanisms of cystic fibrosis - how mutations lead to misfunction and guide therapy","volume":"42","author":"Farinha","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.redox.2025.103944_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310678","article-title":"Tissue-Specific regulation of CFTR gene expression","volume":"24","author":"Blotas","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103944_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-016-2391-y","article-title":"Role of CFTR in epithelial physiology","volume":"74","author":"Saint-Criq","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.redox.2025.103944_bib5","unstructured":"Cystic Fibrosis mutation database, (n.d.). http:\/\/www.genet.sickkids.on.ca\/Home.html (accessed May 28, 2025)."},{"key":"10.1016\/j.redox.2025.103944_bib6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jcf.2013.12.003","article-title":"The relative frequency of CFTR mutation classes in European patients with cystic fibrosis","volume":"13","author":"De Boeck","year":"2014","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.redox.2025.103944_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.01662","article-title":"CFTR modulators: the changing face of cystic fibrosis in the era of precision medicine","volume":"10","author":"Lopes-Pacheco","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.redox.2025.103944_bib8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2174\/138945011795378586","article-title":"Targeting CFTR: how to treat cystic fibrosis by CFTR-repairing therapies","volume":"12","author":"Amaral","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.redox.2025.103944_bib9","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0140-6736(23)01609-4","article-title":"Series Cystic Fibrosis 1 CFTR modulator therapy: transforming the landscape of clinical care in cystic fibrosis","volume":"402","author":"Taylor-Cousar","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2025.103944_bib10","doi-asserted-by":"crossref","first-page":"18825","DOI":"10.1073\/pnas.0904709106","article-title":"Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770","volume":"106","author":"Van Goor","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2025.103944_bib11","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa1908639","article-title":"Others, elexacaftor\u2013tezacaftor\u2013ivacaftor for cystic fibrosis with a single Phe508del allele","volume":"381","author":"Middleton","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.redox.2025.103944_bib12","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S2213-2600(22)00504-5","article-title":"Safety and efficacy of vanzacaftor\u2013tezacaftor\u2013deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials","volume":"11","author":"Uluer","year":"2023","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.redox.2025.103944_bib13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S2213-2600(24)00411-9","article-title":"Vanzacaftor-tezacaftor-deutivacaftor versus elexacaftor-tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years and older (SKYLINE Trials VX20-121-102 and VX20-121-103): results from two randomised, active-controlled, phase 3 trials","volume":"13","author":"Keating","year":"2025","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.redox.2025.103944_bib14","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1165\/rcmb.2005-0473OC","article-title":"Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice","volume":"35","author":"Velsor","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.redox.2025.103944_bib15","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.jcf.2020.10.006","article-title":"Defective immunometabolism pathways in cystic fibrosis macrophages","volume":"20","author":"Hamilton","year":"2021","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.redox.2025.103944_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.arres.2022.100040","article-title":"Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas","volume":"5","author":"O'Malley","year":"2022","journal-title":"Advances in Redox Research"},{"key":"10.1016\/j.redox.2025.103944_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e39244","article-title":"Heightened mitochondrial respiration in CF cells is normalised by triple CFTR modulator therapy through mechanisms involving calcium","volume":"10","author":"Jarosz-Griffiths","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.redox.2025.103944_bib18","series-title":"Proc Am Thorac Soc","first-page":"387","article-title":"Role of endoplasmic reticulum stress in cystic fibrosis-related airway inflammatory responses","author":"Ribeiro","year":"2010"},{"key":"10.1016\/j.redox.2025.103944_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003367","article-title":"Dysfunction of Nrf-2 in CF epithelia leads to excess intracellular H2O2 and inflammatory cytokine production","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2025.103944_bib20","author":"Lands"},{"key":"10.1016\/j.redox.2025.103944_bib21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/thx.52.6.557","article-title":"Pulmonary oxidative stress response in young children with cystic fibrosis","volume":"52","author":"Hull","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.redox.2025.103944_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s10863-016-9663-y","article-title":"Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function","volume":"48","author":"Atlante","year":"2016","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.redox.2025.103944_bib23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40659-021-00361-3","article-title":"Increased susceptibility of cystic fibrosis airway epithelial cells to ferroptosis","volume":"54","author":"Maniam","year":"2021","journal-title":"Biol. Res."},{"key":"10.1016\/j.redox.2025.103944_bib24","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/ajcn\/80.2.374","article-title":"Antioxidant deficiency in cystic fibrosis: when is the right time to take action?","volume":"80","author":"Back","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.redox.2025.103944_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"issue":"11","key":"10.1016\/j.redox.2025.103944_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-024-07244-x","article-title":"Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications","volume":"15","author":"Zheng","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2025.103944_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/ars.2017.7115","article-title":"GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues","volume":"29","author":"Maiorino","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2025.103944_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10040891","article-title":"The selenoprotein glutathione peroxidase 4: from molecular mechanisms to novel therapeutic opportunities","volume":"10","author":"Weaver","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.redox.2025.103944_bib29","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.redox.2025.103944_bib30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2025.103944_bib31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41589-020-0501-5","article-title":"Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles","volume":"16","author":"Eaton","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.redox.2025.103944_bib32","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.redox.2025.103944_bib33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.freeradbiomed.2022.08.044","article-title":"Overlooked and valuable facts to know in the NRF2\/KEAP1 field","volume":"192","author":"Kopacz","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103944_bib34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0003-2697(80)90139-6","article-title":"Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine","volume":"106","author":"Griffith","year":"1980","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.redox.2025.103944_bib35","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.redox.2025.103944_bib36","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1158\/0008-5472.CAN-06-2298","article-title":"Generation of a stable antioxidant response element\u2013driven reporter gene cell line and its use to show redox-dependent activation of Nrf2 by cancer chemotherapeutic agents","volume":"66","author":"Wang","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2025.103944_bib37","doi-asserted-by":"crossref","first-page":"7937","DOI":"10.1007\/s00216-014-8255-0","article-title":"LC\/MS lipid profiling from human serum: a new method for global lipid extraction","volume":"406","author":"Pellegrino","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.redox.2025.103944_bib38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1590\/S0103-50532011000400012","article-title":"Electrochemical oxidation of caffeic and ferulic acid derivatives in aprotic medium","volume":"22","author":"Salas-Reyes","year":"2011","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.redox.2025.103944_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jorganchem.2015.01.005","article-title":"Iron chelation and redox chemistry of anthranilic acid and 3-hydroxyanthranilic acid: a comparison of two structurally related kynurenine pathway metabolites to obtain improved insights into their potential role in neurological disease development","volume":"782","author":"Chobot","year":"2015","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.redox.2025.103944_bib40","author":"Frisch","year":"2016","journal-title":"Gaussian 16 Rev. C.01"},{"key":"10.1016\/j.redox.2025.103944_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00214-007-0310-x","volume":"120","author":"Zhao","year":"2008","journal-title":"Theor. Chem. Acc."},{"key":"10.1016\/j.redox.2025.103944_bib42","doi-asserted-by":"crossref","first-page":"12441","DOI":"10.1039\/C5CP00628G","article-title":"Predicting accurate absolute binding energies in aqueous solution: thermodynamic considerations for electronic structure methods","volume":"17","author":"Jensen","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.redox.2025.103944_bib43","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.1021\/jp810292n","article-title":"Universal solvation model based on Solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions","volume":"113","author":"V Marenich","year":"2009","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.redox.2025.103944_bib44","doi-asserted-by":"crossref","first-page":"21856","DOI":"10.1021\/acs.inorgchem.4c02534","article-title":"Radical scavenging and anti-ferroptotic molecular mechanism of olanzapine: insight from a computational analysis","volume":"63","author":"Zeppilli","year":"2024","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.redox.2025.103944_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115399","article-title":"CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress","volume":"166","author":"Wu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2025.103944_bib46","author":"Portal"},{"key":"10.1016\/j.redox.2025.103944_bib47","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/crj.13513","article-title":"Systemic oxidative stress in children with cystic fibrosis with bacterial infection including Pseudomonas Aeruginosa","volume":"16","author":"Bennemann","year":"2022","journal-title":"Clin. Res. J"},{"key":"10.1016\/j.redox.2025.103944_bib48","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1203\/00006450-199410000-00013","article-title":"Evidence for increased oxidative damage in patients with cystic fibrosis","volume":"36","author":"Brown","year":"1994","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.redox.2025.103944_bib49","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46450","article-title":"Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations","volume":"8","author":"Csan\u00e1dy","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.redox.2025.103944_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108180","article-title":"In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G\/A234D) in primary human rectal and nasal epithelial cells","volume":"26","author":"Kleinfelder","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.redox.2025.103944_bib51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/ijms23010024","article-title":"Rare trafficking cftr mutations involve distinct cellular retention machineries and require different rescuing strategies","volume":"23","author":"Ramalho","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103944_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7612182","article-title":"RTA-408 protects kidney from ischemia-reperfusion injury in mice via activating Nrf2 and downstream GSH biosynthesis gene","volume":"2017","author":"Han","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"12","key":"10.1016\/j.redox.2025.103944_bib53","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2025.103944_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-05787-z","article-title":"Molecular characterization of AIFM2\/FSP1 inhibition by iFSP1-like molecules","volume":"14","author":"Xavier da Silva","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2025.103944_bib55","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.chembiol.2025.04.002","article-title":"N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4","volume":"32","author":"Zheng","year":"2025","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.redox.2025.103944_bib56","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione peroxidase 4 senses and translates oxidative stress into 12\/15-Lipoxygenase Dependent- and AIF-Mediated cell death","volume":"8","author":"Seiler","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2025.103944_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2507","article-title":"A pathology atlas of the human cancer transcriptome","volume":"357","author":"Uhlen","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.redox.2025.103944_bib58","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.redox.2015.12.005","article-title":"The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation","volume":"8","author":"Liu","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103944_bib59","author":"Benabdeslam"},{"key":"10.1016\/j.redox.2025.103944_bib60","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1164\/rccm.200311-1516OC","article-title":"Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis","volume":"170","author":"Kettle","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.redox.2025.103944_bib61","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1038\/s41467-022-29905-1","article-title":"A targetable CoQ-FSP1 axis drives ferroptosis-and radiation-resistance in KEAP1 inactive lung cancers","volume":"13","author":"Koppula","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2025.103944_bib62","doi-asserted-by":"crossref","first-page":"6312","DOI":"10.1039\/D5CP00690B","article-title":"Concerted proton electron transfer or hydrogen atom transfer? An unequivocal strategy to discriminate these mechanisms in model systems","volume":"27","author":"Zeppilli","year":"2025","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.redox.2025.103944_bib63","doi-asserted-by":"crossref","first-page":"9776","DOI":"10.1021\/jm5012808","article-title":"Discovery of N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator","volume":"57","author":"Hadida","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.redox.2025.103944_bib64","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1172\/JCI96273","article-title":"Clinically approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia","volume":"129","author":"Borcherding","year":"2019","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.redox.2025.103944_bib65","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10863-018-9748-x","article-title":"Aberrant GSH reductase and NOX activities concur with defective CFTR to pro-oxidative imbalance in cystic fibrosis airways","volume":"50","author":"de Bari","year":"2018","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.redox.2025.103944_bib66","doi-asserted-by":"crossref","first-page":"590","DOI":"10.33594\/000000437","article-title":"Induced lipid peroxidation causes ferroptotic cell death in airways","volume":"55","author":"Ousingsawat","year":"2021","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.redox.2025.103944_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127728","article-title":"Induction of ferroptosis: a new strategy for the control of bacterial infections","volume":"284","author":"Guo","year":"2024","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.redox.2025.103944_bib68","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04083-22","article-title":"Mutual effects of single and combined CFTR modulators and bacterial infection in cystic fibrosis","volume":"11","author":"Cigana","year":"2023","journal-title":"Microbiol. Spectr."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725004574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725004574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:01:49Z","timestamp":1773871309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725004574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":68,"alternative-id":["S2213231725004574"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103944","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond CFTR: Ivacaftor's role in restoring cellular redox balance and preventing ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103944","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103944"}}