{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:57:58Z","timestamp":1793073478941,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015640","name":"Tongji Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018806","name":"Department of Science and Technology of Hubei Province","doi-asserted-by":"publisher","award":["2023BCB013"],"award-info":[{"award-number":["2023BCB013"]}],"id":[{"id":"10.13039\/501100018806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330010"],"award-info":[{"award-number":["82330010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241034"],"award-info":[{"award-number":["82241034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.redox.2025.103970","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:40:55Z","timestamp":1765593655000},"page":"103970","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Rapamycin preserves cardiac function in autoimmune myocarditis by reprogramming Cxcl9+ macrophages via the mTORC1\u2013C\/EBP\u03b2\u2013OSM axis"],"prefix":"10.1016","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1962-0530","authenticated-orcid":false,"given":"Yan","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoquan","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2025.103970_bib1","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1056\/NEJMra2114478","article-title":"Myocarditis","volume":"387","author":"Basso","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.redox.2025.103970_bib2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0140-6736(11)60648-X","article-title":"Myocarditis","volume":"379","author":"Sagar","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2025.103970_bib3","first-page":"455","article-title":"Update on myocarditis - what we know so far and where we may be heading","volume":"10","author":"Rroku","year":"2021","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"10.1016\/j.redox.2025.103970_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/pin.12868","article-title":"Inflammation in myocardial disease: from myocarditis to dilated cardiomyopathy","volume":"70","author":"Imanaka-Yoshida","year":"2020","journal-title":"Pathol. Int."},{"key":"10.1016\/j.redox.2025.103970_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007405","article-title":"Management of acute myocarditis and chronic inflammatory cardiomyopathy: an expert consensus document","volume":"13","author":"Ammirati","year":"2020","journal-title":"Circ. Heart Fail"},{"key":"10.1016\/j.redox.2025.103970_bib6","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s11427-023-2421-0","article-title":"Chinese society of cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis","volume":"67","author":"Chinese Society of Cardiology","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.redox.2025.103970_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehaf192","article-title":"ESC guidelines for the management of myocarditis and pericarditis","author":"Schulz-Menger","year":"2025","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.redox.2025.103970_bib8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1186\/s12916-025-04301-w","article-title":"The efficacy and safety of hydroxychloroquine in patients with chronic inflammatory cardiomyopathy: a multicenter randomized study (HYPIC trial)","volume":"23","author":"He","year":"2025","journal-title":"BMC Med."},{"key":"10.1016\/j.redox.2025.103970_bib9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11886-022-01680-x","article-title":"State-of-the-Art of endomyocardial biopsy on acute myocarditis and chronic inflammatory cardiomyopathy","volume":"24","author":"Ammirati","year":"2022","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.redox.2025.103970_bib10","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1007\/s11427-022-2273-3","article-title":"Immunopathogenesis and immunomodulatory therapy for myocarditis","volume":"66","author":"He","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.redox.2025.103970_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12237214","article-title":"Biomarkers in acute myocarditis and chronic inflammatory cardiomyopathy: an updated review of the literature","volume":"12","author":"Crisci","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.redox.2025.103970_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41569-020-00435-x","article-title":"Myocarditis and inflammatory cardiomyopathy: current evidence and future directions","volume":"18","author":"Tschope","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.redox.2025.103970_bib13","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCRESAHA.114.302022","article-title":"Mammalian target of rapamycin signaling in cardiac physiology and disease","volume":"114","author":"Sciarretta","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103970_bib14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/CIRCRESAHA.117.311147","article-title":"New insights into the role of mTOR signaling in the cardiovascular system","volume":"122","author":"Sciarretta","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103970_bib15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nri3901","article-title":"Regulation of innate immune cell function by mTOR","volume":"15","author":"Weichhart","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.redox.2025.103970_bib16","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41423-021-00791-9","article-title":"Metabolism of tissue macrophages in homeostasis and pathology","volume":"19","author":"Wculek","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.redox.2025.103970_bib17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41569-021-00624-2","article-title":"The role of cellular senescence in cardiac disease: basic biology and clinical relevance","volume":"19","author":"Mehdizadeh","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.redox.2025.103970_bib18","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","article-title":"Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload","volume":"109","author":"McMullen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103970_bib19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/CIRCULATIONAHA.117.030811","article-title":"Cardioprotective role of Myeloid-derived suppressor cells in heart failure","volume":"138","author":"Zhou","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103970_bib20","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.biocel.2013.04.021","article-title":"Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho\/myocardin-related transcription factor--a signaling pathway","volume":"45","author":"Wang","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.redox.2025.103970_bib21","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.stem.2011.08.013","article-title":"Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling","volume":"9","author":"Kubin","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.redox.2025.103970_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031811","article-title":"The role of Oncostatin M and its receptor complexes in cardiomyocyte protection, regeneration, and failure","volume":"23","author":"Kubin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2025.103970_bib23","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/CIRCULATIONAHA.119.043545","article-title":"Single-cell RNA sequencing to dissect the immunological network of autoimmune myocarditis","volume":"142","author":"Hua","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103970_bib24","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCRESAHA.120.318437","article-title":"LncRNA ZNF593-AS alleviates contractile dysfunction in dilated cardiomyopathy","volume":"128","author":"Fan","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103970_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13010150","article-title":"Myocarditis and chronic inflammatory Cardiomyopathy, from acute inflammation to chronic inflammatory damage: an update on pathophysiology and diagnosis","volume":"13","author":"Uccello","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.redox.2025.103970_bib26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/ejhf.796","article-title":"Myocardial expression of toll-like receptor 4 predicts the response to immunosuppressive therapy in patients with virus-negative chronic inflammatory cardiomyopathy","volume":"19","author":"Chimenti","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.redox.2025.103970_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.124.011729","article-title":"IL1RAP blockade with a monoclonal antibody reduces cardiac inflammation and preserves heart function in viral and autoimmune myocarditis","volume":"17","author":"Lema","year":"2024","journal-title":"Circ. Heart Fail"},{"key":"10.1016\/j.redox.2025.103970_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.110029","article-title":"Baicalein reduces cardiac inflammatory infiltration in EAM mice by blocking the CCL2-CCR2 signaling axis through its binding with TNF-alpha and CCR2","volume":"145","author":"Tong","year":"2025","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.redox.2025.103970_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s42255-023-00952-2","article-title":"A leucine-macrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets","volume":"6","author":"Rose","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.redox.2025.103970_bib30","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.cmet.2023.09.010","article-title":"Metabolic support by macrophages sustains colonic epithelial homeostasis","volume":"35","author":"Fritsch","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2025.103970_bib31","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1164\/rccm.202307-1273OC","article-title":"Aberrant lipid metabolism in macrophages is associated with granuloma formation in sarcoidosis","volume":"209","author":"Lim","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.redox.2025.103970_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.122.062551","article-title":"Expansion of pathogenic cardiac macrophages in immune checkpoint inhibitor myocarditis","volume":"149","author":"Ma","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103970_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41392-025-02143-9","article-title":"Spatiotemporal transcriptomics elucidates the pathogenesis of fulminant viral myocarditis","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2025.103970_bib34","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/CIRCRESAHA.108.192179","article-title":"CXCL10 inhibits viral replication through recruitment of natural killer cells in coxsackievirus B3-induced myocarditis","volume":"104","author":"Yuan","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103970_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaz1974","article-title":"The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages","volume":"5","author":"Calcagno","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.redox.2025.103970_bib36","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.15252\/embr.201439837","article-title":"Deficiency in mTORC1-controlled C\/EBPbeta-mRNA translation improves metabolic health in mice","volume":"16","author":"Zidek","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.redox.2025.103970_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.tig.2019.11.005","article-title":"Emerging role of C\/EBPbeta and epigenetic DNA methylation in ageing","volume":"36","author":"Niehrs","year":"2020","journal-title":"Trends Genet."},{"key":"10.1016\/j.redox.2025.103970_bib38","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1080\/15548627.2019.1703353","article-title":"C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis","volume":"16","author":"Shao","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2025.103970_bib39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijrobp.2023.07.033","article-title":"Oncostatin M\/Oncostatin M receptor signal induces radiation-induced heart fibrosis by regulating SMAD4 in fibroblast","volume":"118","author":"Xu","year":"2024","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.redox.2025.103970_bib40","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIRCULATIONAHA.119.044484","article-title":"gp130 controls cardiomyocyte proliferation and heart regeneration","volume":"142","author":"Li","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2025.103970_bib41","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/CIRCRESAHA.118.314048","article-title":"Hippo deficiency leads to cardiac dysfunction accompanied by cardiomyocyte dedifferentiation during pressure overload","volume":"124","author":"Ikeda","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.redox.2025.103970_bib42","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00395-013-0396-3","article-title":"Therapeutic targeting of the oncostatin M receptor-beta prevents inflammatory heart failure","volume":"109","author":"Poling","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.redox.2025.103970_bib43","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/abbs\/gmv137","article-title":"Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf\/Mek\/Erk signaling pathway","volume":"48","author":"Zhang","year":"2016","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.redox.2025.103970_bib44","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1038\/s41467-019-10859-w","article-title":"Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M","volume":"10","author":"Abe","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2025.103970_bib45","doi-asserted-by":"crossref","first-page":"6514","DOI":"10.1039\/D2TB00623E","article-title":"Injectable hydrogel with dual-sensitive behavior for targeted delivery of oncostatin M to improve cardiac restoration after myocardial infarction","volume":"10","author":"Jiang","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.redox.2025.103970_bib46","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/jcmm.12501","article-title":"OSM) protects against cardiac ischaemia\/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity","volume":"19","author":"Sun","year":"2015","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.redox.2025.103970_bib47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1126\/science.adi8828","article-title":"Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage","volume":"389","author":"Hoagland","year":"2025","journal-title":"Science"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725004835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725004835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:50:46Z","timestamp":1768931446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725004835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":47,"alternative-id":["S2213231725004835"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103970","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapamycin preserves cardiac function in autoimmune myocarditis by reprogramming Cxcl9+ macrophages via the mTORC1\u2013C\/EBP\u03b2\u2013OSM axis","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103970","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103970"}}