{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:12:17Z","timestamp":1787065937563,"version":"build-2736575974"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013416","name":"Indian Institute of Science Education and Research Kolkata","doi-asserted-by":"publisher","award":["2023-0210"],"award-info":[{"award-number":["2023-0210"]}],"id":[{"id":"10.13039\/501100013416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"India Ministry of Science &amp; Technology Department of Science and Technology","doi-asserted-by":"publisher","award":["DST\/TDT\/TC\/RARE\/2022\/32"],"award-info":[{"award-number":["DST\/TDT\/TC\/RARE\/2022\/32"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100029379","name":"Arthur N. Rupe Foundation","doi-asserted-by":"publisher","award":["JBR\/2023\/000005"],"award-info":[{"award-number":["JBR\/2023\/000005"]}],"id":[{"id":"10.13039\/100029379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM79465"],"award-info":[{"award-number":["GM79465"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009053","name":"Wellcome Trust DBT India Alliance","doi-asserted-by":"publisher","award":["IA\/I\/16\/1\/502369"],"award-info":[{"award-number":["IA\/I\/16\/1\/502369"]}],"id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008628","name":"Ministry of Electronics and Information technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Education, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.redox.2025.103971","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:35:40Z","timestamp":1765560940000},"page":"103971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Repurposing melatonin's therapeutic potential in Wilson disease: Addressing copper overload and redox imbalance"],"prefix":"10.1016","volume":"89","author":[{"given":"Raviranjan","family":"Pandey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan Narayan","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakiba","family":"Rohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaustav","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa","family":"Bargakshatriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Pruthwiraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debosmita","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurav","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saptarshi","family":"Maji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan T.","family":"Pezacki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit K.","family":"Pramanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashima","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelanjana","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitava","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9806-6320","authenticated-orcid":false,"given":"Arnab","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.redox.2025.103971_bib1","doi-asserted-by":"crossref","first-page":"797S","DOI":"10.1093\/ajcn\/63.5.797","article-title":"Copper biochemistry and molecular biology","volume":"63","author":"Linder","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s42003-024-06716-2","volume":"7","author":"Paul","year":"2024","journal-title":"Commun. Biol."},{"issue":"1\u20132","key":"10.1016\/j.redox.2025.103971_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0300-483X(03)00159-8","article-title":"Copper toxicity, oxidative stress, and antioxidant nutrients","volume":"189","author":"Gaetke","year":"2003","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.redox.2025.103971_bib4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1074\/jbc.R800055200","article-title":"New roles for copper metabolism in cell proliferation, signaling, and disease","volume":"284","author":"Turski","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"5415","key":"10.1016\/j.redox.2025.103971_bib5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.284.5415.805","article-title":"Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase","volume":"284","author":"Rae","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.redox.2025.103971_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103256","article-title":"Deadly excess copper","volume":"75","author":"Sailer","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2025.103971_bib7","first-page":"25","article-title":"Free radicals and medicine","volume":"23","author":"Swartz","year":"2005","journal-title":"Biomed. EPR, Part A: Free Radicals, Metals, Medicine, and Physiology"},{"issue":"1\u20132","key":"10.1016\/j.redox.2025.103971_bib8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0300-483X(03)00159-8","article-title":"Copper toxicity, oxidative stress, and antioxidant nutrients","volume":"189","author":"Gaetke","year":"2003","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.redox.2025.103971_bib9","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.bmc.2009.01.069","article-title":"Generation of superoxide radicals by copper\u2013glutathione complexes: redox consequences associated with their interaction with reduced glutathione","volume":"17","author":"Speisky","year":"2009","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"10.1016\/j.redox.2025.103971_bib10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nchembio.72","article-title":"Mechanisms for copper acquisition, distribution, and regulation","volume":"4","author":"Kim","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib11","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1053\/j.gastro.2018.11.032","article-title":"Activation of autophagy, observed in liver tissues from patients with wilson disease and from ATP7B-Deficient animals, protects hepatocytes from copper-induced apoptosis","volume":"156","author":"Polishchuk","year":"2019","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.redox.2025.103971_bib12","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1039\/C6MT00176A","article-title":"Copper trafficking to the secretory pathway","volume":"8","author":"Lutsenko","year":"2016","journal-title":"Metallomics"},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cld.2017.06.011","article-title":"Wilson disease: diagnosis, treatment, and Follow-Up","volume":"21","author":"Schilsky","year":"2017","journal-title":"Clin. Liver Dis."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/gut.2005.087262","article-title":"Clinical presentation, diagnosis, and long-term outcome of Wilson's disease: a cohort study","volume":"56","author":"Merle","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.redox.2025.103971_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/nyas.12437","article-title":"Clinical considerations for an effective medical therapy in Wilson's disease","volume":"1315","author":"Weiss","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.redox.2025.103971_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/cld.349","article-title":"Wilson disease: clinical manifestations, diagnosis, and treatment","volume":"27","author":"Schilsky","year":"2014","journal-title":"Clin. Liver Dis."},{"issue":"10","key":"10.1016\/j.redox.2025.103971_bib18","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.biochi.2009.07.012","article-title":"Wilson disease: current status and the future","volume":"91","author":"Schilsky","year":"2009","journal-title":"Biochimie"},{"issue":"6","key":"10.1016\/j.redox.2025.103971_bib19","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1002\/hep.22261","article-title":"Diagnosis and treatment of Wilson disease: an update","volume":"47","author":"Roberts","year":"2008","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.redox.2025.103971_bib20","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1007\/s10072-023-06895-6","article-title":"Early neurological deterioration in Wilson's disease: a systematic literature review and meta-analysis","volume":"44","author":"Antos","year":"2023","journal-title":"Neurol. Sci."},{"issue":"3","key":"10.1016\/j.redox.2025.103971_bib21","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1067\/mem.2003.72","article-title":"British anti-lewisite (dimercaprol): an amazing history","volume":"41","author":"Vilensky","year":"2003","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.redox.2025.103971_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41572-018-0018-3","article-title":"Wilson disease","volume":"4","author":"Cz\u0142onkowska","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib23","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cgh.2013.09.025","article-title":"Long-term outcomes of patients with Wilson disease in a large Austrian cohort","volume":"12","author":"Beinhardt","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib24","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.cgh.2013.11.009","article-title":"Long-term outcome for Wilson disease: 85% good","volume":"12","author":"Schilsky","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2025.103971_bib25","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1007\/s10072-025-08388-0","article-title":"Improvement in sleep following treatment initiation in newly diagnosed, treatment-na\u00efve patients with Wilson's disease","volume":"46","author":"Jernajczyk","year":"2025","journal-title":"Neurol. Sci."},{"issue":"5","key":"10.1016\/j.redox.2025.103971_bib26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/physiol.00011.2014","article-title":"Melatonin: exceeding expectations","volume":"29","author":"Reiter","year":"2014","journal-title":"Physiology"},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/cns.12588","article-title":"Melatonin stimulates the SIRT1\/Nrf2 signaling pathway counteracting lipopolysaccharide (LPS)-induced oxidative stress to rescue postnatal rat brain","volume":"23","author":"Shah","year":"2017","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-079X.1998.tb00361.x","article-title":"The interaction of melatonin and its precursors with aluminium, cadmium, copper, iron, lead, and zinc: an adsorptive voltammetric study","volume":"24","author":"Limson","year":"1998","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2004.00181.x","article-title":"Melatonin mitigates mitochondrial malfunction","volume":"38","author":"Le\u00f3n","year":"2005","journal-title":"J. Pineal Res."},{"issue":"7","key":"10.1016\/j.redox.2025.103971_bib30","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/jnr.24220","article-title":"The neuroprotective role of melatonin in neurological disorders","volume":"96","author":"Alghamdi","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.redox.2025.103971_bib31","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1039\/D4BM01609B","article-title":"Melatonin and the nervous system: nanomedicine perspectives","author":"Luo","year":"2025","journal-title":"Biomater. Sci."},{"issue":"6586","key":"10.1016\/j.redox.2025.103971_bib32","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Svetkov","year":"2022","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib33","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1053\/j.gastro.2011.12.048","article-title":"Diverse functional properties of wilson disease ATP7B variants","volume":"142","author":"Huster","year":"2012","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib34","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008656","article-title":"Caspase functions in cell death and disease","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"3","key":"10.1016\/j.redox.2025.103971_bib35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: under promises but over delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.redox.2025.103971_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2019.109408","article-title":"Melatonin: a hypothesis regarding its use to treat wilson disease","volume":"133","author":"Sharma","year":"2019","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.redox.2025.103971_bib37","first-page":"211","article-title":"The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity","volume":"26","author":"Tongklanakarin","year":"2004","journal-title":"Songklanakarin J. Sci. Technol."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","article-title":"Melatonin as a natural ally against oxidative stress: a physicochemical examination","volume":"51","author":"Galano","year":"2011","journal-title":"J. Pineal Res."},{"issue":"5","key":"10.1016\/j.redox.2025.103971_bib39","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","article-title":"Glutathione peroxidases","volume":"1830","author":"Brigelius-Floh\u00e9","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.redox.2025.103971_bib40","article-title":"Potential therapeutic role of melatonin in hepatobiliary diseases: current evidence and clinical observations","volume":"74","author":"Gonciarz","year":"2023","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.redox.2025.103971_bib41","series-title":"Solution NMR of Paramagnetic Molecules: Applications to Metallobiomolecules and Models","author":"Bertini","year":"2001"},{"issue":"10","key":"10.1016\/j.redox.2025.103971_bib42","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.biochi.2009.03.013","article-title":"A\u03b2-Mediated ROS production by Cu ions: structural insights, mechanisms and relevance to alzheimer's disease","volume":"91","author":"Hureau","year":"2009","journal-title":"Biochimie"},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib43","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/anie.200300637","article-title":"Diffusion NMR spectroscopy in supramolecular and combinatorial chemistry: an old parameter\u2014new insights","volume":"44","author":"Cohen","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"issue":"8","key":"10.1016\/j.redox.2025.103971_bib44","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3390\/cells8080903","article-title":"Antioxidant and pro-oxidant activities of melatonin in the presence of copper and polyphenols in vitro and in vivo","volume":"8","author":"Wang","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/jpi.12196","article-title":"Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis","volume":"58","author":"Galano","year":"2015","journal-title":"J. Pineal Res."},{"issue":"17","key":"10.1016\/j.redox.2025.103971_bib46","doi-asserted-by":"crossref","first-page":"6161","DOI":"10.1039\/C2DT32252H","article-title":"Complex formation equilibria of Cu(II) and Zn(II) with triethylenetetramine and its Mono- and Di-acetyl metabolites","volume":"42","author":"Nurchi","year":"2013","journal-title":"Dalton Trans."},{"key":"10.1016\/j.redox.2025.103971_bib47","article-title":"Octahedral Copper(II)-Diimine complexes of the type Cu(trien)(diimine)2","volume":"49","author":"Sharma","year":"2020","journal-title":"Dalton Trans."},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/10409230903044914","article-title":"Reducing oxidative\/nitrosative stress: a newly-discovered genre for melatonin","volume":"44","author":"Reiter","year":"2009","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.redox.2025.103971_bib49","series-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"2006"},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib50","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(89)90213-3","article-title":"Rapid measurement of binding constants and heats of binding using a new titration calorimeter","volume":"179","author":"Wiseman","year":"1989","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00232-002-1040-6","article-title":"Function and regulation of the mammalian copper-transporting ATPases: insights from biochemical and cell biological approaches","volume":"191","author":"Lutsenko","year":"2003","journal-title":"J. Membr. Biol."},{"issue":"32","key":"10.1016\/j.redox.2025.103971_bib52","doi-asserted-by":"crossref","first-page":"11179","DOI":"10.1073\/pnas.0406547102","article-title":"Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron X-ray fluorescence microscopy","volume":"102","author":"Yang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"5","key":"10.1016\/j.redox.2025.103971_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/liv.70089","article-title":"Relative exchangeable copper, exchangeable copper and total copper in the diagnosis of wilson disease","volume":"45","author":"Lorenzen","year":"2025","journal-title":"Liver Int."},{"issue":"12","key":"10.1016\/j.redox.2025.103971_bib54","doi-asserted-by":"crossref","first-page":"m1532","DOI":"10.1107\/S1600536812047745","article-title":"[(Triethylenetetramine)copper(II)]-\u03bc-cyanido-\u03ba2N:C-[bis(cyanido-\u03baC)copper(I)]","volume":"68","author":"Corfield","year":"2012","journal-title":"Acta Crystallogr. E Struct. Rep. Online"},{"issue":"17","key":"10.1016\/j.redox.2025.103971_bib55","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional regulation by Nrf2","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.redox.2025.103971_bib56","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2412816122","article-title":"A histochemical approach to activity-based copper sensing reveals cuproplasia-dependent vulnerabilities in cancer","volume":"122","author":"Messina","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.pharmtox.010909.105600","article-title":"Mechanisms of cell protection by heme Oxygenase-1","volume":"50","author":"ozzelino","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"11","key":"10.1016\/j.redox.2025.103971_bib58","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.freeradbiomed.2011.08.035","article-title":"Measuring E(GSH) and H2O2 with roGFP2-Based redox probes","volume":"51","author":"Morgan","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"32","key":"10.1016\/j.redox.2025.103971_bib59","doi-asserted-by":"crossref","first-page":"16644","DOI":"10.1074\/jbc.M116.727248","article-title":"The activity of menkes disease protein ATP7A is essential for redox balance in mitochondria","volume":"291","author":"Bhattacharjee","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.redox.2025.103971_bib60","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2025.103971_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105210","article-title":"Effect of melatonin supplementation on oxidative stress parameters: a systematic review and meta-analysis","volume":"161","author":"Morvaridzadeh","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.redox.2025.103971_bib62","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib64","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cbi.2010.06.013","article-title":"Mechanisms underlying iron and copper ions toxicity in biological systems: pro-oxidant activity and protein-binding effects","volume":"188","author":"Letelier","year":"2010","journal-title":"Chem. Biol. Interact."},{"issue":"41","key":"10.1016\/j.redox.2025.103971_bib65","doi-asserted-by":"crossref","first-page":"15038","DOI":"10.1073\/pnas.0601945103","article-title":"Selective fluorescent imaging of superoxide In vivo using ethidium-based probes","volume":"103","author":"Robinson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib66","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.freeradbiomed.2009.05.018","article-title":"mRegulation of superoxide dismutase genes: implications in disease","volume":"47","author":"Miao","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.redox.2025.103971_bib67","first-page":"835S","volume":"88","author":"Hern\u00e1ndez","year":"2008","journal-title":"Zebrafish (Danio rerio) as a Model for Studying the Genetic Basis of Copper Toxicity, Deficiency, and Metabolism. Am. J. Clin. Nutr."},{"key":"10.1016\/j.redox.2025.103971_bib68","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","article-title":"Identification of ROS using oxidized DCFDA and flow-cytometry","volume":"594","author":"Eruslanov","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1074\/jbc.M116.760876","article-title":"The intestinal copper exporter CUA-1 is required for systemic copper homeostasis in Caenorhabditis elegans","volume":"292","author":"Chun","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.redox.2025.103971_bib70","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41589-018-0062-z","article-title":"Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system","volume":"14","author":"Xiao","year":"2018","journal-title":"Nat. Chem. Biol."},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib71","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1124\/dmd.104.002410","article-title":"Metabolism of melatonin by human cytochromes P450","volume":"33","author":"Ma","year":"2005","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib72","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jconrel.2011.01.030","article-title":"Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery","volume":"152","author":"Cheng","year":"2011","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.redox.2025.103971_bib73","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","article-title":"Nanocarriers as an emerging platform for cancer therapy","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"issue":"4","key":"10.1016\/j.redox.2025.103971_bib74","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0162-0134(00)80200-7","article-title":"Copper(I) complexes of penicillamine and glutathione","volume":"10","author":"\u00d6sterberg","year":"1979","journal-title":"J. Inorg. Biochem."},{"issue":"3","key":"10.1016\/j.redox.2025.103971_bib75","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/pcp\/pcy226","article-title":"Melatonin alleviates copper toxicity via improving copper sequestration and ROS scavenging in cucumber","volume":"60","author":"Cao","year":"2019","journal-title":"Plant Cell Physiol."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib76","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12514","article-title":"Melatonin and its metabolites vs oxidative stress: from individual actions to collective protection","volume":"65","author":"Galano","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.redox.2025.103971_bib77","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.freeradbiomed.2018.10.402","article-title":"The multiple protective roles and molecular mechanisms of melatonin and its precursor N-Acetylserotonin in targeting brain injury and liver damage and in maintaining bone health","volume":"130","author":"Luo","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.redox.2025.103971_bib78","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00441-019-03036-4","article-title":"The C. elegans intestine: organogenesis, digestion, and physiology","volume":"377","author":"Dimov","year":"2019","journal-title":"Cell Tissue Res."},{"issue":"8","key":"10.1016\/j.redox.2025.103971_bib79","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1542-3565(05)00484-2","article-title":"Wilson's disease","volume":"3","author":"Ferenci","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib80","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"issue":"16","key":"10.1016\/j.redox.2025.103971_bib81","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jcc.20290","article-title":"The amber biomolecular simulation programs","volume":"26","author":"Case","year":"2005","journal-title":"J. Comput. Chem."},{"issue":"13","key":"10.1016\/j.redox.2025.103971_bib82","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/jcc.21224","article-title":"PACKMOL: a package for building initial configurations for molecular dynamics simulations","volume":"30","author":"Mart\u00ednez","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"8","key":"10.1016\/j.redox.2025.103971_bib83","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.redox.2025.103971_bib84","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00214-007-0310-x","volume":"120","author":"Zhao","year":"2008","journal-title":"Theor. Chem. Acc."},{"issue":"1","key":"10.1016\/j.redox.2025.103971_bib85","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0301-0104(81)85090-2","article-title":"Electrostatic interaction of a solute with a continuum. A direct utilization of Ab Initio molecular potentials for the prediction of solvent effects","volume":"55","author":"Miertu\u0161","year":"1981","journal-title":"Chem. Phys."},{"issue":"2","key":"10.1016\/j.redox.2025.103971_bib86","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0301-0104(82)85072-6","article-title":"Approximate evaluations of the electrostatic free energy and internal energy changes in solution processes","volume":"65","author":"Miertu\u0161","year":"1982","journal-title":"Chem. Phys."},{"issue":"10","key":"10.1016\/j.redox.2025.103971_bib87","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/jcc.540151009","article-title":"GEPOL: an improved description of molecular surfaces. 3. A new algorithm for the computation of a solvent-excluding surface","volume":"15","author":"Pascual-Ahuir","year":"1994","journal-title":"J. Comput. Chem."},{"issue":"8","key":"10.1016\/j.redox.2025.103971_bib88","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1021\/cr9904009","article-title":"Quantum mechanical continuum solvation models","volume":"105","author":"Tomasi","year":"2005","journal-title":"Chem. Rev."},{"key":"10.1016\/j.redox.2025.103971_bib89","series-title":"Gaussian 16, Revision C.01","author":"Frisch","year":"2016"},{"issue":"2","key":"10.1016\/j.redox.2025.103971_bib90","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/acs.bioconjchem.0c00667","article-title":"Redox-responsive nanocapsules for the spatiotemporal release of miltefosine in lysosome: protection against leishmania","volume":"32","author":"Tiwari","year":"2021","journal-title":"Bioconjug. Chem."},{"issue":"17","key":"10.1016\/j.redox.2025.103971_bib91","doi-asserted-by":"crossref","first-page":"8820","DOI":"10.1021\/acs.langmuir.3c03933","article-title":"Micropores in hollow organic cage nanocapsule as a size exclusion gate: cage entrapped Pd(II)-Catalyst for efficient cross-coupling reaction","volume":"40","author":"Bargakshatriya","year":"2024","journal-title":"Langmuir"},{"issue":"9","key":"10.1016\/j.redox.2025.103971_bib92","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfad051","article-title":"Wilson disease\u2013causing mutations in the carboxyl terminus of ATP7B regulates its localization and golgi exit selectively in the unpolarized cells","volume":"15","author":"Chakraborty","year":"2023","journal-title":"Metallomics"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725004847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231725004847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:41:35Z","timestamp":1773920495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231725004847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":92,"alternative-id":["S2213231725004847"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2025.103971","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repurposing melatonin's therapeutic potential in Wilson disease: Addressing copper overload and redox imbalance","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2025.103971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103971"}}