{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:25:54Z","timestamp":1792790754070,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2023AH053319"],"award-info":[{"award-number":["2023AH053319"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.redox.2026.104007","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:47:14Z","timestamp":1768610834000},"page":"104007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Inhibition of SDE2 promotes autophagy-dependent ferroptosis in multiple myeloma"],"prefix":"10.1016","volume":"91","author":[{"given":"Liang","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2026.104007_bib1","first-page":"273","article-title":"Multiple myeloma: an old disease with new hope for the future","volume":"51","author":"Zaidi","year":"2001","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.redox.2026.104007_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102284","article-title":"Roadmap to cure multiple myeloma","volume":"100","author":"Rodriguez-Otero","year":"2021","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.redox.2026.104007_bib3","first-page":"301","article-title":"Multiple myeloma: charging toward a bright future","volume":"57","author":"Katzel","year":"2007","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.redox.2026.104007_bib4","first-page":"422","article-title":"Understanding biology to tackle the disease: multiple myeloma from bench to bedside, and back","volume":"64","author":"Bianchi","year":"2014","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.redox.2026.104007_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-pharmtox-010919-023603","article-title":"Proteasome inhibitor drugs","volume":"60","author":"Fricker","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.redox.2026.104007_bib6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s40265-017-0689-1","article-title":"Immunomodulatory drugs in multiple myeloma: mechanisms of action and clinical experience","volume":"77","author":"Holstein","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.redox.2026.104007_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043136","article-title":"Monoclonal antibodies: the greatest resource to treat multiple myeloma","volume":"24","author":"De Luca","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2026.104007_bib8","first-page":"2599","article-title":"Ubiquitin receptor PSMD4\/Rpn10 is a novel therapeutic target in multiple myeloma","volume":"141","author":"Du","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.redox.2026.104007_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076019","article-title":"Autophagy: a potential therapeutic target to tackle drug resistance in multiple myeloma","volume":"24","author":"Bashiri","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2026.104007_bib10","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1038\/s41467-022-31430-0","article-title":"The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma","volume":"13","author":"Vo","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104007_bib11","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/cncr.31335","article-title":"Targeting autophagy in cancer","volume":"124","author":"Onorati","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.redox.2026.104007_bib12","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021110031","article-title":"The multifaceted role of autophagy in cancer","volume":"41","author":"Russell","year":"2022","journal-title":"Embo j"},{"key":"10.1016\/j.redox.2026.104007_bib13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.redox.2026.104007_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/cac2.12250","article-title":"Ferroptosis in cancer and cancer immunotherapy","volume":"42","author":"Zhao","year":"2022","journal-title":"Cancer Commun."},{"key":"10.1016\/j.redox.2026.104007_bib15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/15548627.2019.1635380","article-title":"MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4","volume":"16","author":"Wu","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2026.104007_bib16","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1182\/bloodadvances.2022008241","article-title":"TRIM21 enhances bortezomib sensitivity in multiple myeloma by halting prosurvival autophagy","volume":"7","author":"Chen","year":"2023","journal-title":"Blood Adv."},{"key":"10.1016\/j.redox.2026.104007_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104961","article-title":"CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy","volume":"100","author":"Tang","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.redox.2026.104007_bib18","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41388-024-03020-5","article-title":"Bone marrow stromal cells dictate lanosterol biosynthesis and ferroptosis of multiple myeloma","volume":"43","author":"Jiang","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.redox.2026.104007_bib19","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1007\/s11864-024-01250-z","article-title":"Research progress on ferroptosis in multiple myeloma","volume":"25","author":"Li","year":"2024","journal-title":"Curr. Treat. Options Oncol."},{"key":"10.1016\/j.redox.2026.104007_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/cdd.2012.72","article-title":"Ubiquitination and selective autophagy","volume":"20","author":"Shaid","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104007_bib21","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1186\/s12967-024-05565-1","article-title":"Ubiquitination regulates autophagy in cancer: simple modifications, promising targets","volume":"22","author":"Wu","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.redox.2026.104007_bib22","article-title":"Regulation of ferroptosis pathway by ubiquitination","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.redox.2026.104007_bib23","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","article-title":"Cellular degradation systems in ferroptosis","volume":"28","author":"Chen","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104007_bib24","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1038\/s41467-020-19162-5","article-title":"SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks","volume":"11","author":"Rageul","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104007_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.15252\/embj.201796751","article-title":"Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing","volume":"37","author":"Thakran","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2026.104007_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/narcan\/zcaa010","article-title":"Proteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells","volume":"2","author":"Luo","year":"2020","journal-title":"NAR Cancer"},{"key":"10.1016\/j.redox.2026.104007_bib27","doi-asserted-by":"crossref","DOI":"10.1177\/15330338221090093","article-title":"Immunotherapeutic significance of a prognostic alternative splicing signature in bladder cancer","volume":"21","author":"Chen","year":"2022","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.redox.2026.104007_bib28","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1080\/15548627.2025.2477443","article-title":"HMBOX1 reverses autophagy mediated 5-fluorouracil resistance through promoting HACE1-induced ubiquitination and degradation of ATG5 in colorectal cancer","volume":"21","author":"Gao","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2026.104007_bib29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcancer.2019.03.002","article-title":"Ferroptosis is a type of autophagy-dependent cell death","volume":"66","author":"Zhou","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.redox.2026.104007_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118077","article-title":"FTY720 induces ferroptosis and autophagy via PP2A\/AMPK pathway in multiple myeloma cells","volume":"260","author":"Zhong","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.redox.2026.104007_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114955","article-title":"Design, synthesis and pharmacological evaluation of beta-carboline derivatives as potential antitumor agent via targeting autophagy","volume":"246","author":"Ao","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.redox.2026.104007_bib32","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/s41419-022-05448-7","article-title":"PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma","volume":"13","author":"Hu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104007_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102413","article-title":"NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells","volume":"55","author":"Zhou","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104007_bib34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/ars.2022.0202","article-title":"Autophagy-dependent ferroptosis in cancer","volume":"39","author":"Chen","year":"2023","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.redox.2026.104007_bib35","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1080\/15548627.2022.2111635","article-title":"TMEM164 is a new determinant of autophagy-dependent ferroptosis","volume":"19","author":"Liu","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2026.104007_bib36","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1093\/nar\/gkab647","article-title":"SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing","volume":"49","author":"Floro","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2026.104007_bib37","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41419-023-06222-z","article-title":"The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104007_bib38","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41419-023-06300-2","article-title":"Imatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination","volume":"14","author":"Sun","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104007_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41418-023-01239-5","article-title":"TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11\/xCT K11-linked ubiquitination and degradation","volume":"31","author":"Wang","year":"2024","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104007_bib40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41419-023-05716-0","article-title":"The interaction between ferroptosis and inflammatory signaling pathways","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726000054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726000054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:37:53Z","timestamp":1773189473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726000054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":40,"alternative-id":["S2213231726000054"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104007","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of SDE2 promotes autophagy-dependent ferroptosis in multiple myeloma","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104007"}}