{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:46:50Z","timestamp":1785862010154,"version":"3.56.0"},"reference-count":128,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM153375"],"award-info":[{"award-number":["T32GM153375"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA255618"],"award-info":[{"award-number":["R01 CA255618"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020496","name":"University of Nebraska-Lincoln Nebraska Center for the Prevention of Obesity Diseases","doi-asserted-by":"publisher","award":["P20 GM104320"],"award-info":[{"award-number":["P20 GM104320"]}],"id":[{"id":"10.13039\/100020496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008114","name":"University of Nebraska-Lincoln","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["BMX-001"],"award-info":[{"award-number":["BMX-001"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["SCR_025011"],"award-info":[{"award-number":["SCR_025011"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["P30 GM106397"],"award-info":[{"award-number":["P30 GM106397"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["S10 OD030486"],"award-info":[{"award-number":["S10 OD030486"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["P30 CA036727"],"award-info":[{"award-number":["P30 CA036727"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["S10 RR027301"],"award-info":[{"award-number":["S10 RR027301"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["SCR_022467"],"award-info":[{"award-number":["SCR_022467"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["P20 GM103427"],"award-info":[{"award-number":["P20 GM103427"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["MCB-1912587"],"award-info":[{"award-number":["MCB-1912587"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["MCB-1122029"],"award-info":[{"award-number":["MCB-1122029"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.redox.2026.104020","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:47:49Z","timestamp":1768031269000},"page":"104020","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["BMX-001, a clinically relevant radioprotector, can reverse radiation-induced fibrosis when given three weeks after radiation, in part, by restoring methylation"],"prefix":"10.1016","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7943-2268","authenticated-orcid":false,"given":"Molly S.","family":"Myers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Kosmacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia Sin","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Lushnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Marky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jack M.","family":"Riethoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-142X","authenticated-orcid":false,"given":"Rebecca E.","family":"Oberley-Deegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"41","key":"10.1016\/j.redox.2026.104020_bib1","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.15585\/mmwr.mm6941a1","article-title":"Prostate cancer incidence and survival, by stage and race\/ethnicity - United States, 2001-2017","volume":"69","author":"Siegel","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.redox.2026.104020_bib2","article-title":"Prostate cancer incidence and mortality: global status and temporal trends in 89 countries from 2000 to 2019","volume":"10","author":"Wang","year":"2022","journal-title":"Front. Public Health"},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.eururo.2019.08.005","article-title":"Recent global patterns in prostate cancer incidence and mortality rates","volume":"77","author":"Culp","year":"2020","journal-title":"Eur. Urol."},{"issue":"6","key":"10.1016\/j.redox.2026.104020_bib4","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/cncr.21324","article-title":"The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines","volume":"104","author":"Delaney","year":"2005","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.redox.2026.104020_bib5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nrc2587","article-title":"Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype","volume":"9","author":"Barnett","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.redox.2026.104020_bib6","doi-asserted-by":"crossref","first-page":"8092","DOI":"10.3390\/curroncol30090587","article-title":"The current trend of radiation therapy for patients with localized prostate cancer","volume":"30","author":"Numakura","year":"2023","journal-title":"Curr. Oncol."},{"issue":"2","key":"10.1016\/j.redox.2026.104020_bib7","first-page":"146","article-title":"Radiation therapy for prostate cancer","volume":"115","author":"Gay","year":"2018","journal-title":"Mo. Med."},{"issue":"4_suppl","key":"10.1016\/j.redox.2026.104020_bib8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1200\/JCO.2024.42.4_suppl.112","article-title":"The effect of radiotherapy on the course of disease in prostatic cancer with high metastatic burden","volume":"42","author":"Falick","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.redox.2026.104020_bib9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.radonc.2022.10.005","article-title":"Recommendations for radiation therapy in oligometastatic prostate cancer: an ESTRO-ACROP Delphi consensus","volume":"176","author":"Zilli","year":"2022","journal-title":"Radiother. Oncol."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/pro6.1129","article-title":"Guidelines for radiotherapy of prostate cancer (2020 edition)","volume":"5","author":"Li","year":"2021","journal-title":"Precis. Radiat. Oncol."},{"issue":"sup1","key":"10.1016\/j.redox.2026.104020_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3109\/0284186X.2010.576115","article-title":"Curative radiation therapy in prostate cancer","volume":"50","author":"Harmenberg","year":"2011","journal-title":"Acta Oncol."},{"issue":"11","key":"10.1016\/j.redox.2026.104020_bib12","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.ejca.2012.01.026","article-title":"Prostate cancer-specific mortality after definitive radiation therapy: who dies of disease?","volume":"48","author":"Kim","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.redox.2026.104020_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105089","article-title":"The clinical manifestations and molecular pathogenesis of radiation fibrosis","volume":"103","author":"Fijardo","year":"2024","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib14","doi-asserted-by":"crossref","DOI":"10.14440\/jbm.2024.0019","article-title":"Side effects of prostate cancer therapies and potential management","volume":"11","author":"Xiao","year":"2024","journal-title":"J. Biol. Methods"},{"issue":"12","key":"10.1016\/j.redox.2026.104020_bib15","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1001\/jamaoncol.2024.4397","article-title":"Long-term adverse effects and complications after prostate cancer treatment","volume":"10","author":"Unger","year":"2024","journal-title":"JAMA Oncol."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.eururo.2018.12.003","article-title":"Pelvic complications after prostate cancer radiation therapy and their management: an international collaborative narrative review","volume":"75","author":"Matta","year":"2019","journal-title":"Eur. Urol."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.21037\/tau.2017.12.16","article-title":"Intensity-modulated radiotherapy for prostate cancer","volume":"7","author":"Fischer-Valuck","year":"2018","journal-title":"Transl. Androl. Urol."},{"issue":"7","key":"10.1016\/j.redox.2026.104020_bib18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrurol.2017.76","article-title":"The evolution of brachytherapy for prostate cancer","volume":"14","author":"Zaorsky","year":"2017","journal-title":"Nat. Rev. Urol."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib19","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1186\/s12967-023-04554-0","article-title":"Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances","volume":"21","author":"Yu","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.redox.2026.104020_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109560","article-title":"Advances in pathogenic mechanisms and management of radiation-induced fibrosis","volume":"121","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.redox.2026.104020_bib21","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1158\/1541-7786.MCR-18-0321","article-title":"Radiation-induced myofibroblasts promote tumor growth via mitochondrial ROS-activated TGF\u03b2 signaling","volume":"16","author":"Shimura","year":"2018","journal-title":"Mol. Cancer Res."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib22","article-title":"Reactive oxygen species drive epigenetic changes in radiation-induced fibrosis","volume":"2019","author":"Shrishrimal","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.redox.2026.104020_bib23","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00432-015-1974-6","article-title":"Radiation-induced fibrosis: mechanisms and implications for therapy","volume":"141","author":"Straub","year":"2015","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.redox.2026.104020_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107399","article-title":"Understanding the mechanism of radiation induced fibrosis and therapy options","volume":"204","author":"Ejaz","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib25","article-title":"Interventions for radiation-induced fibrosis in patients with breast cancer: systematic review and meta-analyses","volume":"7","author":"Nogueira","year":"2022","journal-title":"Adv. Radiat. Oncol."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib26","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1186\/s12879-024-09901-0","article-title":"Diagnostic value of the Xpert MTB\/RIF assay combined with endobronchial ultrasonography with a guide sheath for peripheral nodular pulmonary tuberculosis","volume":"24","author":"Zhou","year":"2024","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib27","article-title":"Radiotherapy-induced oxidative stress and fibrosis in breast cancer are suppressed by vactosertib, a novel, orally bioavailable TGF-\u03b2\/ALK5 inhibitor","volume":"12","author":"Park","year":"2022","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.redox.2026.104020_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095968","article-title":"Effect of amifostine in head and neck cancer patients treated with radiotherapy: a systematic review and meta-analysis based on randomized controlled trials","volume":"9","author":"Gu","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijrobp.2007.05.057","article-title":"Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in quality of life measured by EPIC score","volume":"70","author":"Simone","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2018.06.203","article-title":"Gastrointestinal-activated amifostine ameliorates morbid toxicity from stereotactic radiation in a murine model","volume":"102","author":"Molkentine","year":"2018","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"9","key":"10.1016\/j.redox.2026.104020_bib31","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/PL00002350","article-title":"Intermittent use of amifostine during postoperative radiochemotherapy and acute toxicity in rectal cancer patients","volume":"176","author":"Dunst","year":"2000","journal-title":"Strahlenther. Onkol."},{"issue":"2c","key":"10.1016\/j.redox.2026.104020_bib32","first-page":"1649","article-title":"Amifostine and curative intent chemoradiation for compromised cancer patients","volume":"23","author":"Nguyen","year":"2003","journal-title":"Anticancer Res."},{"issue":"5","key":"10.1016\/j.redox.2026.104020_bib33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/09553002.2017.1287454","article-title":"Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications","volume":"93","author":"Miousse","year":"2017","journal-title":"Int. J. Radiat. Biol."},{"issue":"8","key":"10.1016\/j.redox.2026.104020_bib34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.4161\/epi.25498","article-title":"Radiation-induced epigenetic DNA methylation modification of radiation-response pathways","volume":"8","author":"Antwih","year":"2013","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib35","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1038\/s41598-025-90247-1","article-title":"Genome-wide DNA methylation regulation analysis provides novel insights on post-radiation breast cancer","volume":"15","author":"Ji","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.redox.2026.104020_bib36","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.bbrc.2005.09.084","article-title":"Stable loss of global DNA methylation in the radiation-target tissue\u2014A possible mechanism contributing to radiation carcinogenesis?","volume":"337","author":"Koturbash","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"31","key":"10.1016\/j.redox.2026.104020_bib37","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1038\/sj.onc.1209467","article-title":"Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo","volume":"25","author":"Koturbash","year":"2006","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.redox.2026.104020_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26073342","article-title":"Effects of ionizing radiation on DNA methylation patterns and their potential as biomarkers","volume":"26","author":"Ma","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.redox.2026.104020_bib39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2307\/3577319","article-title":"The effect of ? Radiation on DNA methylation","volume":"117","author":"Kalinich","year":"1989","journal-title":"Radiat. Res."},{"key":"10.1016\/j.redox.2026.104020_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2020.103027","article-title":"Towards a comprehensive view of 8-oxo-7,8-dihydro-2'-deoxyguanosine: highlighting the intertwined roles of DNA damage and epigenetics in genomic instability","volume":"97","author":"Gorini","year":"2021","journal-title":"DNA Repair"},{"issue":"Suppl 1","key":"10.1016\/j.redox.2026.104020_bib41","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1093\/toxsci\/kfq371","article-title":"Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment","volume":"120","author":"Swenberg","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib42","doi-asserted-by":"crossref","first-page":"389","DOI":"10.31661\/jbpe.v0i0.2101-1258","article-title":"8-Hydroxy-2-Deoxyguanosine as oxidative DNA damage biomarker of medical ionizing radiation: a scoping review","volume":"11","author":"AbuArrah","year":"2021","journal-title":"J. Biomed. Phys. Eng."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12010134","article-title":"The predictive value of 8-Hydroxy-Deoxyguanosine (8-OHdG) serum concentrations in irradiated non-small cell lung carcinoma (NSCLC) patients","volume":"12","author":"Orfanakos","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib44","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0891-5849(96)00526-6","article-title":"Singlet oxygen involvement in ultraviolet (254 nm) radiation-induced formation of 8-Hydroxy-Deoxyguanosine in DNA","volume":"23","author":"Wei","year":"1997","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.redox.2026.104020_bib45","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1093\/nar\/gkaa175","article-title":"The genomic landscape of 8-oxodG reveals enrichment at specific inherently fragile promoters","volume":"48","author":"Gorini","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.redox.2026.104020_bib46","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/carcin\/16.5.1253","article-title":"DNA adduct 8-hydroxyl-2'-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase","volume":"16","author":"Turk","year":"1995","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib47","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1073\/pnas.91.4.1261","article-title":"Free radical adducts induce alterations in DNA cytosine methylation","volume":"91","author":"Weitzman","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"Supplement_5","key":"10.1016\/j.redox.2026.104020_bib48","doi-asserted-by":"crossref","first-page":"v311","DOI":"10.1093\/neuonc\/noad179.1203","article-title":"LTBK-09. Results of BMX-HGG study: a multi-institutional, randomized phase 2 clinical trial of concurrent chemoradiation with or without BMX-001 in patients with newly diagnosed high grade glioma","volume":"25","author":"Peters","year":"2023","journal-title":"Neuro Oncol."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2021.07.239","article-title":"The phase I results of a phase 1\/2 trial for patients with newly diagnosed anal cancer treated with concurrent radiation therapy, 5-Fluorouracil, Mitomycin and BMX-001","volume":"111","author":"Lin","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"15_suppl","key":"10.1016\/j.redox.2026.104020_bib50","doi-asserted-by":"crossref","first-page":"TPS2577","DOI":"10.1200\/JCO.2020.38.15_suppl.TPS2577","article-title":"BMX-HGG: phase II trial of newly diagnosed high-grade glioma treated with concurrent radiation therapy, temozolomide, and BMX-001","volume":"38","author":"Peters","year":"2020","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib51","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1177\/1091581816642766","article-title":"Nonclinical safety and toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001)","volume":"35","author":"Gad","year":"2016","journal-title":"Int. J. Toxicol."},{"issue":"16","key":"10.1016\/j.redox.2026.104020_bib52","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1089\/ars.2017.7453","article-title":"Mn porphyrin-based redox-active drugs: differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury","volume":"29","author":"Batinic-Haberle","year":"2018","journal-title":"Antioxid Redox Signal"},{"issue":"23","key":"10.1016\/j.redox.2026.104020_bib53","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.8923","article-title":"MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio\/chemotherapeutic killing of colorectal cancer cells","volume":"7","author":"Kosmacek","year":"2016","journal-title":"Oncotarget"},{"issue":"3, Supplement","key":"10.1016\/j.redox.2026.104020_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2021.07.325","article-title":"A phase 1-2 trial of concurrent radiation therapy, cisplatin and BMX-001 in locally advanced head and neck cancer","volume":"111","author":"Brizel","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.redox.2026.104020_bib55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2013.01.006","article-title":"Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+","volume":"58","author":"Weitner","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2026.104020_bib56","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.freeradbiomed.2013.05.049","article-title":"A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL\/6J mice results in mitochondrial redox abnormalities","volume":"63","author":"Ronchi","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"44","key":"10.1016\/j.redox.2026.104020_bib57","doi-asserted-by":"crossref","DOI":"10.3791\/2033","article-title":"Establishing primary adult fibroblast cultures from rodents","author":"Seluanov","year":"2010","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-16158-7","article-title":"A strategy to quantify myofibroblast activation on a continuous spectrum","volume":"12","author":"Hillsley","year":"2022","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib59","first-page":"291","article-title":"Quantification of histochemical staining by color deconvolution","volume":"23","author":"Ruifrok","year":"2001","journal-title":"Anal. Quant. Cytol. Histol."},{"issue":"10","key":"10.1016\/j.redox.2026.104020_bib60","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/bioinformatics\/btaa847","article-title":"Colour deconvolution: stain unmixing in histological imaging","volume":"37","author":"Landini","year":"2020","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.redox.2026.104020_bib62","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.redox.2026.104020_bib63","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nmeth.1828","article-title":"DNA methylome analysis using short bisulfite sequencing data","volume":"9","author":"Krueger","year":"2012","journal-title":"Nat. Methods"},{"issue":"10","key":"10.1016\/j.redox.2026.104020_bib64","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","article-title":"methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles","volume":"13","author":"Akalin","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.redox.2026.104020_bib65","series-title":"Computing RFfS","article-title":"A language and environment for statistical computing","author":"Team","year":"2024"},{"issue":"7","key":"10.1016\/j.redox.2026.104020_bib66","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2013","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib61","doi-asserted-by":"crossref","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J."},{"key":"10.1016\/j.redox.2026.104020_bib67","author":"Krueger"},{"key":"10.1016\/j.redox.2026.104020_bib68","author":"Andrews"},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib69","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.redox.2026.104020_bib70","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf018","article-title":"edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets","volume":"53","author":"Chen","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.redox.2026.104020_bib71","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2009","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.redox.2026.104020_bib73","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"issue":"9","key":"10.1016\/j.redox.2026.104020_bib74","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/bip.360260911","article-title":"Calculating thermodynamic data for transitions of any molecularity from equilibrium melting curves","volume":"26","author":"Marky","year":"1987","journal-title":"Biopolymers"},{"issue":"5","key":"10.1016\/j.redox.2026.104020_bib75","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.bbagen.2015.10.002","article-title":"Application of differential scanning calorimetry to measure the differential binding of ions, water and protons in the unfolding of DNA molecules","volume":"1860","author":"Olsen","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69352-w","article-title":"Adipocytes protect fibroblasts from radiation-induced damage by adiponectin secretion","volume":"10","author":"Kosmacek","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib77","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1667\/RR14623.1","article-title":"MnTE-2-PyP treatment, or NOX4 inhibition, protects against radiation-induced damage in mouse primary prostate fibroblasts by inhibiting the TGF-Beta 1 signaling pathway","volume":"187","author":"Chatterjee","year":"2017","journal-title":"Radiat. Res."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib78","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/antiox7010021","article-title":"The addition of manganese porphyrins during radiation inhibits prostate cancer growth and simultaneously protects normal prostate tissue from radiation damage","volume":"7","author":"Chatterjee","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2026.104020_bib79","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.freeradbiomed.2020.03.014","article-title":"Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity","volume":"152","author":"Shrishrimal","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.redox.2026.104020_bib80","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1529\/biophysj.106.101386","article-title":"Fibroblast adaptation and stiffness matching to soft elastic substrates","volume":"93","author":"Solon","year":"2007","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib81","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/cm.20041","article-title":"Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion","volume":"60","author":"Yeung","year":"2005","journal-title":"Cell Motil."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib82","doi-asserted-by":"crossref","first-page":"8879","DOI":"10.1038\/s41598-019-45078-2","article-title":"Myofibroblast modulation of cardiac myocyte structure and function","volume":"9","author":"Nagaraju","year":"2019","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.redox.2026.104020_bib83","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.18632\/aging.204825","article-title":"Human senescent fibroblasts trigger progressive lung fibrosis in mice","volume":"15","author":"Hernandez-Gonzalez","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"22","key":"10.1016\/j.redox.2026.104020_bib84","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1038\/s44318-024-00245-8","article-title":"Cellular senescence, p21, and the path to fibrosis","volume":"43","author":"Turano","year":"2024","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib85","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13014-022-02184-2","article-title":"Radiation-induced senescence: therapeutic opportunities","volume":"18","author":"Kim","year":"2023","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.redox.2026.104020_bib86","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53670","article-title":"Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation","volume":"9","author":"Bhattacharyya","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.redox.2026.104020_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.740051","article-title":"Anti-Tumor role of CAMK2B in remodeling the stromal microenvironment and inhibiting proliferation in papillary renal cell carcinoma","volume":"12","author":"Jia","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib88","doi-asserted-by":"crossref","first-page":"L86","DOI":"10.1152\/ajplung.00132.2015","article-title":"CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis","volume":"310","author":"Winters","year":"2016","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"6083","key":"10.1016\/j.redox.2026.104020_bib89","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.1220671","article-title":"Quantitative sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at single-base resolution","volume":"336","author":"Booth","year":"2012","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.redox.2026.104020_bib90","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1186\/gb-2014-15-2-r37","article-title":"The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts","volume":"15","author":"Wagner","year":"2014","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.redox.2026.104020_bib91","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.stem.2016.10.019","article-title":"DNA methylation dynamics of human hematopoietic stem cell differentiation","volume":"19","author":"Farlik","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib92","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s13059-022-02728-5","article-title":"Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability","volume":"23","author":"de","year":"2022","journal-title":"Genome Biol."},{"issue":"12","key":"10.1016\/j.redox.2026.104020_bib93","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1038\/ng1909","article-title":"DNA methylation profiling of human chromosomes 6, 20 and 22","volume":"38","author":"Eckhardt","year":"2006","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib94","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng1990","article-title":"Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome","volume":"39","author":"Weber","year":"2007","journal-title":"Nat. Genet."},{"issue":"14","key":"10.1016\/j.redox.2026.104020_bib95","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1093\/nar\/gkh739","article-title":"Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)","volume":"32","author":"Valinluck","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2026.104020_bib96","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/302051","article-title":"Oxidative stress and DNA methylation in prostate cancer","volume":"2010","author":"Donkena","year":"2010","journal-title":"Obstet. Gynecol. Int."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib97","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12864-015-1229-6","article-title":"Identification of radiation-induced aberrant hypomethylation in colon cancer","volume":"16","author":"Bae","year":"2015","journal-title":"BMC Genom."},{"issue":"10","key":"10.1016\/j.redox.2026.104020_bib98","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1158\/1541-7786.MCR-05-0074","article-title":"Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus","volume":"3","author":"Pogribny","year":"2005","journal-title":"Mol. Cancer Res."},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib99","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.bbrc.2004.06.081","article-title":"Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes","volume":"320","author":"Pogribny","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib100","doi-asserted-by":"crossref","first-page":"697","DOI":"10.18632\/aging.100920","article-title":"Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus - an aging connection","volume":"8","author":"Kovalchuk","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"21","key":"10.1016\/j.redox.2026.104020_bib101","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.4540","article-title":"OxiDIP-Seq for genome-wide mapping of damaged DNA containing 8-Oxo-2'-Deoxyguanosine","volume":"12","author":"Gorini","year":"2022","journal-title":"Bio Protoc."},{"issue":"6","key":"10.1016\/j.redox.2026.104020_bib102","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1089\/ars.2009.2876","article-title":"Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential","volume":"13","author":"Batini\u0107-Haberle","year":"2010","journal-title":"Antioxid Redox Signal"},{"issue":"16","key":"10.1016\/j.redox.2026.104020_bib103","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1093\/nar\/11.16.5701","article-title":"Calorimetric and spectroscopic investigation of drug--DNA interactions: II. Dipyrandium binding to poly d(AT)","volume":"11","author":"Marky","year":"1983","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.redox.2026.104020_bib104","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1073\/pnas.75.9.4286","article-title":"Does irehdiamine kink DNA?","volume":"75","author":"Dattagupta","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"22","key":"10.1016\/j.redox.2026.104020_bib105","doi-asserted-by":"crossref","first-page":"12870","DOI":"10.1093\/nar\/gkab509","article-title":"Cytosine base modifications regulate DNA duplex stability and metabolism","volume":"49","author":"Rausch","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib106","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1038\/s41467-023-38863-1","article-title":"Decoding protein methylation function with thermal stability analysis","volume":"14","author":"Sayago","year":"2023","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.redox.2026.104020_bib107","doi-asserted-by":"crossref","first-page":"10722","DOI":"10.1093\/nar\/gkv884","article-title":"Effects of non-CpG site methylation on DNA thermal stability: a fluorescence study","volume":"43","author":"Nardo","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"15","key":"10.1016\/j.redox.2026.104020_bib108","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1093\/nar\/gkr275","article-title":"Characterization of DNA with an 8-oxoguanine modification","volume":"39","author":"Singh","year":"2011","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib109","doi-asserted-by":"crossref","first-page":"193","DOI":"10.7150\/ijms.3635","article-title":"Cancer and radiation therapy: current advances and future directions","volume":"9","author":"Baskar","year":"2012","journal-title":"Int. J. Med. Sci."},{"issue":"9","key":"10.1016\/j.redox.2026.104020_bib110","doi-asserted-by":"crossref","DOI":"10.3390\/jpm14090932","article-title":"Treatment classification by intent in oncology-the need for meaningful definitions: curative, palliative and potentially life-prolonging","volume":"14","author":"Fekete","year":"2024","journal-title":"J. Personalized Med."},{"issue":"2","key":"10.1016\/j.redox.2026.104020_bib111","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1503\/cjs.025911","article-title":"Intentionally curative treatment of locally recurrent rectal cancer: a systematic review","volume":"56","author":"Tanis","year":"2013","journal-title":"Can. J. Surg."},{"issue":"1057","key":"10.1016\/j.redox.2026.104020_bib112","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20150292","article-title":"The curative management of synchronous rectal and prostate cancer","volume":"89","author":"Lavan","year":"2016","journal-title":"Br. J. Radiol."},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib113","first-page":"605","article-title":"Radiation therapy with curative intention in men with de novo metastatic prostate carcinoma: shoot'em all","volume":"26","author":"Montero","year":"2021","journal-title":"Rep. Practical Oncol. Radiother."},{"issue":"Forthcoming","key":"10.1016\/j.redox.2026.104020_bib114","first-page":"228","article-title":"Options for curative treatment of localized prostate cancer","volume":"118","author":"Knipper","year":"2021","journal-title":"Dtsch. Arztebl. Int."},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib115","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.prro.2020.04.002","article-title":"Radiation therapy for cervical cancer: executive summary of an ASTRO clinical practice guideline","volume":"10","author":"Chino","year":"2020","journal-title":"Pract. Radiat. Oncol."},{"issue":"8","key":"10.1016\/j.redox.2026.104020_bib116","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/nau.23721","article-title":"Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice","volume":"37","author":"Ikeda","year":"2018","journal-title":"Neurourol. Urodyn."},{"issue":"4","key":"10.1016\/j.redox.2026.104020_bib117","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.adro.2016.07.004","article-title":"Modeling of chronic radiation-induced cystitis in mice","volume":"1","author":"Zwaans","year":"2016","journal-title":"Adv. Radiat. Oncol."},{"issue":"7310","key":"10.1016\/j.redox.2026.104020_bib118","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nature09303","article-title":"Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification","volume":"466","author":"Ito","year":"2010","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib119","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1038\/s41467-024-50725-y","article-title":"Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging","volume":"15","author":"Occean","year":"2024","journal-title":"Nat. Commun."},{"issue":"5929","key":"10.1016\/j.redox.2026.104020_bib120","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.redox.2026.104020_bib121","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1093\/nar\/gku334","article-title":"Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA","volume":"42","author":"Madugundu","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2026.104020_bib122","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1748-717X-9-15","article-title":"Radiation-induced alterations of histone post-translational modification levels in lymphoblastoid cell lines","volume":"9","author":"Maroschik","year":"2014","journal-title":"Radiat. Oncol."},{"issue":"6","key":"10.1016\/j.redox.2026.104020_bib123","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.bcp.2004.05.042","article-title":"Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression","volume":"68","author":"Rahman","year":"2004","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.redox.2026.104020_bib124","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1038\/s41598-020-59163-4","article-title":"Chronic irradiation of human cells reduces histone levels and deregulates gene expression","volume":"10","author":"Lowe","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.redox.2026.104020_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113897","article-title":"Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance","volume":"43","author":"Palma","year":"2024","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.redox.2026.104020_bib126","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9121210","article-title":"Histone carbonylation is a redox-regulated epigenomic mark that accumulates with obesity and aging","volume":"9","author":"Hauck","year":"2020","journal-title":"Antioxidants"},{"issue":"9","key":"10.1016\/j.redox.2026.104020_bib127","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.tig.2024.05.012","article-title":"Histone oxidation as a new mechanism of metabolic control over gene expression","volume":"40","author":"Gantner","year":"2024","journal-title":"Trends Genet."},{"key":"10.1016\/j.redox.2026.104020_bib128","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.freeradbiomed.2021.02.027","article-title":"Oxidative stress-mediated alterations in histone post-translational modifications","volume":"170","author":"Garc\u00eda-Gim\u00e9nez","year":"2021","journal-title":"Free Radic. Biol. Med."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726000182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726000182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:46:25Z","timestamp":1785858385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726000182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":128,"alternative-id":["S2213231726000182"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104020","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BMX-001, a clinically relevant radioprotector, can reverse radiation-induced fibrosis when given three weeks after radiation, in part, by restoring methylation","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104020"}}