{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:48:28Z","timestamp":1785862108633,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271275"],"award-info":[{"award-number":["82271275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.redox.2026.104029","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:33:31Z","timestamp":1768714411000},"page":"104029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Upregulated GBP2 exacerbates Parkinson's disease pathogenesis by impairing NIX-dependent mitophagy"],"prefix":"10.1016","volume":"90","author":[{"given":"Wenqi","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1815-7036","authenticated-orcid":false,"given":"Juan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2026.104029_bib1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1474-4422(25)00033-X","article-title":"Advances in diagnosis, classification, and management of pain in Parkinson's disease","volume":"24","author":"Tinazzi","year":"2025","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.redox.2026.104029_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1617106","article-title":"Understanding Parkinson's disease: current trends and its multifaceted complications","volume":"17","author":"Chaudhary","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.redox.2026.104029_bib3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S1474-4422(25)00125-5","article-title":"Gene therapy for Parkinson's disease: trials and technical advances","volume":"24","author":"Winston","year":"2025","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.redox.2026.104029_bib4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson's disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2026.104029_bib5","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1080\/15548627.2022.2139080","article-title":"PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models","volume":"19","author":"Han","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2026.104029_bib6","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1080\/15548627.2025.2476872","article-title":"The mitophagy receptor BNIP3L\/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype","volume":"21","author":"Field","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2026.104029_bib7","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1128\/MCB.00166-09","article-title":"Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains","volume":"29","author":"Bellot","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.redox.2026.104029_bib8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41419-021-04469-y","article-title":"BNIP3L\/NIX-mediated mitophagy: molecular mechanisms and implications for human disease","volume":"13","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104029_bib9","first-page":"2695","article-title":"The mitochondrial foundations of Parkinson's disease: therapeutic implications","volume":"16","author":"Soman","year":"2025","journal-title":"Aging Dis."},{"key":"10.1016\/j.redox.2026.104029_bib10","first-page":"1621","article-title":"Guanylate-binding proteins in virus infection","volume":"51","author":"Chhabra","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.redox.2026.104029_bib11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.tibs.2023.07.002","article-title":"Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions","volume":"48","author":"Kirkby","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.redox.2026.104029_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1708319","article-title":"From mechanisms to therapies: the multifaceted roles of guanylate-binding protein 2 in immunity, cancer, and beyond","volume":"16","author":"Cui","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.redox.2026.104029_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00430-022-00736-7","article-title":"Functional cross-species conservation of guanylate-binding proteins in innate immunity","volume":"212","author":"Schelle","year":"2023","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.redox.2026.104029_bib14","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1111\/febs.15662","article-title":"Human guanylate binding proteins: nanomachines orchestrating host defense","volume":"288","author":"Kutsch","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.redox.2026.104029_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014246","article-title":"Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner","volume":"5","author":"Britzen-Laurent","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2026.104029_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11092258","article-title":"Guanylate-binding protein 2 exerts GTPase-Dependent anti-ectromelia virus effect","volume":"11","author":"Gao","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.redox.2026.104029_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10112982","article-title":"Impact of Abeta40 and Abeta42 fibrils on the transcriptome of primary astrocytes and microglia","volume":"10","author":"Zhu","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.redox.2026.104029_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106411","article-title":"Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions","volume":"191","author":"Stoll","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.redox.2026.104029_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12929-021-00716-8","article-title":"When human guanylate-binding proteins meet viral infections","volume":"28","author":"Zhang","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.redox.2026.104029_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.559","article-title":"Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104029_bib21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s12276-024-01198-y","article-title":"The Mst1\/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress","volume":"56","author":"Jeong","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.redox.2026.104029_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41420-022-00826-8","article-title":"Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice","volume":"8","author":"Yan","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.redox.2026.104029_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110014","article-title":"Activation of the Epac\/Rap1 signaling pathway alleviates blood-brain barrier disruption and brain damage following cerebral ischemia\/reperfusion injury","volume":"117","author":"Sun","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.redox.2026.104029_bib24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41467-020-20679-y","article-title":"BNIP3L\/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects","volume":"12","author":"Choi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104029_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112886","article-title":"Soybean isoflavones protect SH-SY5Y neurons from atrazine-induced toxicity by activating mitophagy through stimulation of the BEX2\/BNIP3\/NIX pathway","volume":"227","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.redox.2026.104029_bib26","first-page":"117","article-title":"Validity of SW982 synovial cell line for studying the drugs against rheumatoid arthritis in fluvastatin-induced apoptosis signaling model","volume":"139","author":"Chang","year":"2014","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.redox.2026.104029_bib27","doi-asserted-by":"crossref","first-page":"846","DOI":"10.5551\/jat.2394","article-title":"RhoA and Rac1 changes in the atherosclerotic lesions of WHHLMI rabbits","volume":"16","author":"Ohkawara","year":"2009","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.redox.2026.104029_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26094451","article-title":"Mitochondrial dysfunction in genetic and non-genetic Parkinson's disease","volume":"26","author":"Lucchesi","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2026.104029_bib29","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s11033-025-10889-2","article-title":"Guanylate binding proteins (GBPs) as novel therapeutic targets against single-stranded RNA viruses","volume":"52","author":"Chakraborty","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.redox.2026.104029_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells9051177","article-title":"Mitochondria in health and diseases","volume":"9","author":"Javadov","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.redox.2026.104029_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118335","article-title":"Crosstalk between mitochondrial quality control and novel programmed cell death in pulmonary diseases","volume":"189","author":"Gao","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2026.104029_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.70056","article-title":"Comprehensive insights into mitophagy: mechanisms, disease associations, and therapeutic implications","volume":"126","author":"Tang","year":"2025","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.redox.2026.104029_bib33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41401-018-0077-8","article-title":"Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis","volume":"40","author":"Ren","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.redox.2026.104029_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115750","article-title":"The viral protein Poly(A) polymerase catalytic subunit interacts with guanylate-binding proteins 2 to antagonize the antiviral ability of targeting ectromelia virus","volume":"24","author":"Gao","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2026.104029_bib35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.tcb.2025.01.003","article-title":"Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import","volume":"35","author":"Clague","year":"2025","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.redox.2026.104029_bib36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.molcel.2023.11.038","article-title":"A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass","volume":"84","author":"Sun","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2026.104029_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178093","article-title":"Research advances in protein prenylation in cardiovascular diseases","volume":"1005","author":"Shi","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.redox.2026.104029_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114915","article-title":"Regulation of protein prenylation","volume":"164","author":"Jung","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2026.104029_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008364","article-title":"Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion","volume":"16","author":"Place","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.redox.2026.104029_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111017","article-title":"GBP2 upregulated in LPS-stimulated macrophages-derived exosomes accelerates septic lung injury by activating epithelial cell NLRP3 signaling","volume":"124","author":"Huang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.redox.2026.104029_bib41","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1128\/MCB.15.2.975","article-title":"Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon","volume":"15","author":"Briken","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.redox.2026.104029_bib42","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022113033","article-title":"A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease","volume":"42","author":"Cao","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2026.104029_bib43","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112767","article-title":"FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors","volume":"42","author":"Nguyen-Dien","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2026.104029_bib44","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1038\/s44319-024-00181-y","article-title":"PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF(FBXL4)","volume":"25","author":"Nguyen-Dien","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.redox.2026.104029_bib45","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112799","article-title":"FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels","volume":"42","author":"Elcocks","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2026.104029_bib46","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1042\/BST20253076","article-title":"Engineering protein prenylation: an emerging tool for selective protein modification","volume":"53","author":"Venkatachalapathy","year":"2025","journal-title":"Biochem. Soc. Trans."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726000273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726000273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:48:05Z","timestamp":1785858485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726000273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":46,"alternative-id":["S2213231726000273"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104029","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulated GBP2 exacerbates Parkinson's disease pathogenesis by impairing NIX-dependent mitophagy","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104029"}}