{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T14:00:58Z","timestamp":1793628058176,"version":"4.5.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473364"],"award-info":[{"award-number":["82473364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871859"],"award-info":[{"award-number":["81871859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172811"],"award-info":[{"award-number":["82172811"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2025A04J3776"],"award-info":[{"award-number":["2025A04J3776"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.redox.2026.104098","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:15:32Z","timestamp":1771892132000},"page":"104098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["ALDH1L2 induces resistance to chemotherapy in small cell lung cancer by inhibiting ferroptosis"],"prefix":"10.1016","volume":"91","author":[{"given":"Yueming","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.redox.2026.104098_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168661","article-title":"Current and future development in lung cancer diagnosis","volume":"22","author":"Nooreldeen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10299","key":"10.1016\/j.redox.2026.104098_bib2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(21)00312-3","article-title":"Lung cancer","volume":"398","author":"Thai","year":"2021","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.redox.2026.104098_bib3","first-page":"620","article-title":"Clinical insights into small cell lung cancer: tumor heterogeneity, diagnosis, therapy, and future directions","volume":"73","author":"Megyesfalvi","year":"2023","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.redox.2026.104098_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1001\/jamaoncol.2022.5631","article-title":"Emerging strategies for the treatment of small cell lung cancer: a review","volume":"9","author":"Petty","year":"2023","journal-title":"JAMA Oncol."},{"issue":"9804","key":"10.1016\/j.redox.2026.104098_bib5","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(11)60165-7","article-title":"Small-cell lung cancer","volume":"378","author":"van Meerbeeck","year":"2011","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.redox.2026.104098_bib6","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/hep.28574","article-title":"Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis","volume":"64","author":"Sun","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.redox.2026.104098_bib7","doi-asserted-by":"crossref","first-page":"7333","DOI":"10.1038\/s41467-021-27452-9","article-title":"A targetable LIFR-NF-\u03baB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis","volume":"12","author":"Yao","year":"2021","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.redox.2026.104098_bib8","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41419-021-03998-w","article-title":"Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines","volume":"12","author":"Zheng","year":"2021","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.redox.2026.104098_bib9","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.redox.2026.104098_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.redox.2026.104098_bib11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.redox.2026.104098_bib12","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1038\/s41467-021-22336-4","article-title":"Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes","volume":"12","author":"Bebber","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104098_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-3-319-98788-0_10","article-title":"ALDH1L1 and ALDH1L2 folate regulatory enzymes in cancer","volume":"1032","author":"Krupenko","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"issue":"30","key":"10.1016\/j.redox.2026.104098_bib14","doi-asserted-by":"crossref","first-page":"23056","DOI":"10.1074\/jbc.M110.128843","article-title":"ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase","volume":"285","author":"Krupenko","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1-3","key":"10.1016\/j.redox.2026.104098_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cbi.2011.01.008","article-title":"Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase","volume":"191","author":"Strickland","year":"2011","journal-title":"Chem. Biol. Interact."},{"issue":"6","key":"10.1016\/j.redox.2026.104098_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112562","article-title":"ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis","volume":"42","author":"Hennequart","year":"2023","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.redox.2026.104098_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105090","article-title":"Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil","volume":"299","author":"Li","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.redox.2026.104098_bib18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41416-022-01835-1","article-title":"TXN inhibitor impedes radioresistance of colorectal cancer cells with decreased ALDH1L2 expression via TXN\/NF-\u03baB signaling pathway","volume":"127","author":"Yu","year":"2022","journal-title":"Br. J. Cancer"},{"issue":"13","key":"10.1016\/j.redox.2026.104098_bib19","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1089\/ars.2012.4599","article-title":"Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling","volume":"19","author":"Hanschmann","year":"2013","journal-title":"Antioxidants Redox Signal."},{"issue":"2-3","key":"10.1016\/j.redox.2026.104098_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0168-8227(99)00037-6","article-title":"Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin","volume":"45","author":"Chae","year":"1999","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"Database issue","key":"10.1016\/j.redox.2026.104098_bib21","first-page":"D955","article-title":"Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells","volume":"41","author":"Yang","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.redox.2026.104098_bib22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"issue":"7563","key":"10.1016\/j.redox.2026.104098_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature14664","article-title":"Comprehensive genomic profiles of small cell lung cancer","volume":"524","author":"George","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.redox.2026.104098_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cell.2023.12.004","article-title":"Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies","volume":"187","author":"Liu","year":"2024","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.redox.2026.104098_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104471","article-title":"NRBF2 regulates the chemoresistance of small cell lung cancer by interacting with the P62 protein in the autophagy process","volume":"25","author":"Shen","year":"2022","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.redox.2026.104098_bib26","article-title":"Mitochondrial dysfunction in cancer and neurodegenerative diseases: spotlight on Fatty acid oxidation and lipoperoxidation products","volume":"5","author":"Barrera","year":"2016","journal-title":"Antioxidants (Basel)"},{"issue":"9","key":"10.1016\/j.redox.2026.104098_bib27","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.redox.2026.104098_bib28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.redox.2026.104098_bib29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.21037\/atm-21-6942","article-title":"The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review","volume":"10","author":"Liu","year":"2022","journal-title":"Ann. Transl. Med."},{"issue":"6","key":"10.1016\/j.redox.2026.104098_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells9061505","article-title":"Ferroptosis and cancer: Mitochondria meet the \"Iron Maiden\" cell death","volume":"9","author":"Battaglia","year":"2020","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.redox.2026.104098_bib31","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.redox.2026.104098_bib32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.chembiol.2020.03.013","article-title":"The chemistry and biology of ferroptosis","volume":"27","author":"Stockwell","year":"2020","journal-title":"Cell Chem. Biol."},{"issue":"13","key":"10.1016\/j.redox.2026.104098_bib33","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1177\/1535370216642039","article-title":"Featured article: accelerated decline of physical strength in peroxiredoxin-3 knockout mice","volume":"241","author":"Zhang","year":"2016","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"6","key":"10.1016\/j.redox.2026.104098_bib34","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/HYPERTENSIONAHA.109.130054","article-title":"Mitochondria and reactive oxygen species","volume":"53","author":"Addabbo","year":"2009","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.redox.2026.104098_bib35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cvsm.2007.10.004","article-title":"Mitochondrial pathophysiology, reactive oxygen species, and cardiovascular diseases","volume":"38","author":"Gao","year":"2008","journal-title":"Vet Clin. North Am Small Anim. Pract."},{"issue":"2","key":"10.1016\/j.redox.2026.104098_bib36","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/BJ20091541","article-title":"Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling","volume":"425","author":"Cox","year":"2009","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.redox.2026.104098_bib37","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.molcel.2012.05.030","article-title":"Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria","volume":"46","author":"Kil","year":"2012","journal-title":"Mol. Cell"},{"issue":"18","key":"10.1016\/j.redox.2026.104098_bib38","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1089\/ars.2019.7803","article-title":"Metabolic responses to reductive stress","volume":"32","author":"Xiao","year":"2020","journal-title":"Antioxidants Redox Signal."},{"issue":"21","key":"10.1016\/j.redox.2026.104098_bib39","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1016\/j.molcel.2023.09.025","article-title":"Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases","volume":"83","author":"Cui","year":"2023","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.redox.2026.104098_bib40","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.freeradbiomed.2008.04.030","article-title":"Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates","volume":"45","author":"Brown","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.redox.2026.104098_bib41","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/BJ20101156","article-title":"Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3","volume":"432","author":"Peskin","year":"2010","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.redox.2026.104098_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039404","article-title":"Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells","volume":"7","author":"Newick","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.redox.2026.104098_bib43","article-title":"Unique cellular and biochemical features of human mitochondrial peroxiredoxin 3 establish the molecular basis for its specific reaction with Thiostrepton","volume":"10","author":"Nelson","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"8","key":"10.1016\/j.redox.2026.104098_bib44","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/cbin.11359","article-title":"New insights into small-cell lung cancer development and therapy","volume":"44","author":"Wang","year":"2020","journal-title":"Cell Biol. Int."},{"issue":"5","key":"10.1016\/j.redox.2026.104098_bib45","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s43018-022-00358-1","article-title":"Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer","volume":"3","author":"Guo","year":"2022","journal-title":"Nat. Cancer"},{"issue":"3","key":"10.1016\/j.redox.2026.104098_bib46","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cmet.2018.06.005","article-title":"Inosine monophosphate dehydrogenase dependence in a subset of small cell lung cancers","volume":"28","author":"Huang","year":"2018","journal-title":"Cell Metab."},{"issue":"7577","key":"10.1016\/j.redox.2026.104098_bib47","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature15726","article-title":"Oxidative stress inhibits distant metastasis by human melanoma cells","volume":"527","author":"Piskounova","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.redox.2026.104098_bib48","article-title":"ALDH1L2 drives HCC progression through TAM polarization","volume":"7","author":"Li","year":"2025","journal-title":"JHEP Rep."},{"issue":"2","key":"10.1016\/j.redox.2026.104098_bib49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","article-title":"Oxidative stress in cancer","volume":"38","author":"Hayes","year":"2020","journal-title":"Cancer Cell"},{"issue":"18","key":"10.1016\/j.redox.2026.104098_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186695","article-title":"Disorders of human coenzyme Q10 metabolism: an overview","volume":"21","author":"Hargreaves","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.redox.2026.104098_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25021314","article-title":"Mitochondrial glutathione in cellular redox homeostasis and disease manifestation","volume":"25","author":"Chen","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.redox.2026.104098_bib52","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1096\/fj.05-4107com","article-title":"Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury","volume":"19","author":"Kc","year":"2005","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.redox.2026.104098_bib53","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0016-5085(98)70644-4","article-title":"Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat","volume":"114","author":"Sokol","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2026.104098_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.semcancer.2017.04.005","article-title":"Mitochondrial ROS control of cancer","volume":"47","author":"Idelchik","year":"2017","journal-title":"Semin. Cancer Biol."},{"issue":"16","key":"10.1016\/j.redox.2026.104098_bib55","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/S0960-9822(01)00393-1","article-title":"Cooperative action of antioxidant defense systems in Drosophila","volume":"11","author":"Missirlis","year":"2001","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.redox.2026.104098_bib56","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10787-024-01587-9","article-title":"Thiostrepton: multifaceted biological activities and its applications in treatment of inflammatory diseases","volume":"33","author":"Asikaer","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"17","key":"10.1016\/j.redox.2026.104098_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179717","article-title":"Thiostrepton as a potential therapeutic agent for hepatocellular carcinoma","volume":"25","author":"Su","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.redox.2026.104098_bib58","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1158\/1535-7163.MCT-08-0188","article-title":"Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression","volume":"7","author":"Kwok","year":"2008","journal-title":"Mol. Cancer Therapeut."},{"issue":"8","key":"10.1016\/j.redox.2026.104098_bib59","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1097\/IGC.0000000000001063","article-title":"Targeting FOXM1 improves cytotoxicity of Paclitaxel and cisplatinum in platinum-resistant ovarian cancer","volume":"27","author":"Westhoff","year":"2017","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"7","key":"10.1016\/j.redox.2026.104098_bib60","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41419-022-05082-3","article-title":"Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3\/GPX4 signalling","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.redox.2026.104098_bib61","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.lungcan.2012.10.019","article-title":"FoxM1 expression is significantly associated with cisplatin-based chemotherapy resistance and poor prognosis in advanced non-small cell lung cancer patients","volume":"79","author":"Wang","year":"2013","journal-title":"Lung Cancer"},{"issue":"29","key":"10.1016\/j.redox.2026.104098_bib62","article-title":"FOXM1 inhibition enhances the therapeutic outcome of lung cancer immunotherapy by modulating PD-L1 expression and cell proliferation","volume":"9","author":"Madhi","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"8","key":"10.1016\/j.redox.2026.104098_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/eji.70035","article-title":"The Streptomyces metabolite Thiostrepton inhibits regulatory T cell differentiation and function to boost antitumor immune responses","volume":"55","author":"Silva","year":"2025","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.redox.2026.104098_bib64","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3892\/or.2013.2654","article-title":"Inhibition of FOXM1 by thiostrepton sensitizes medulloblastoma to the effects of chemotherapy","volume":"30","author":"Lin","year":"2013","journal-title":"Oncol. Rep."},{"issue":"9","key":"10.1016\/j.redox.2026.104098_bib65","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nchem.1114","article-title":"The transcription factor FOXM1 is a cellular target of the natural product thiostrepton","volume":"3","author":"Hegde","year":"2011","journal-title":"Nat. Chem."},{"issue":"8","key":"10.1016\/j.redox.2026.104098_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006593","article-title":"FoxM1 is a general target for proteasome inhibitors","volume":"4","author":"Bhat","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.redox.2026.104098_bib67","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molcel.2008.01.009","article-title":"Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin","volume":"30","author":"Harms","year":"2008","journal-title":"Mol. Cell"},{"issue":"44","key":"10.1016\/j.redox.2026.104098_bib68","doi-asserted-by":"crossref","first-page":"eady4492","DOI":"10.1126\/sciadv.ady4492","article-title":"Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy","volume":"11","author":"Nelson","year":"2025","journal-title":"Sci. Adv."},{"issue":"17","key":"10.1016\/j.redox.2026.104098_bib69","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.4161\/cc.8.17.9414","article-title":"Wild-type p53 protects normal cells against apoptosis induced by thiostrepton","volume":"8","author":"Halasi","year":"2009","journal-title":"Cell Cycle"},{"issue":"8","key":"10.1016\/j.redox.2026.104098_bib70","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/pros.21116","article-title":"New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer","volume":"70","author":"Pandit","year":"2010","journal-title":"Prostate"},{"issue":"9","key":"10.1016\/j.redox.2026.104098_bib71","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.bcp.2012.01.027","article-title":"Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes","volume":"83","author":"Qiao","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.redox.2026.104098_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174661","article-title":"The bacterial thiopeptide thiostrepton. An update of its mode of action, pharmacological properties and applications","volume":"914","author":"Bailly","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.redox.2026.104098_bib73","doi-asserted-by":"crossref","first-page":"4035516","DOI":"10.1155\/2023\/4035516","article-title":"Thiostrepton-Nanomedicine, a TLR9 inhibitor, attenuates sepsis-induced inflammation in mice","volume":"2023","author":"Esparza","year":"2023","journal-title":"Mediat. Inflamm."},{"issue":"32","key":"10.1016\/j.redox.2026.104098_bib74","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1038\/s41388-019-0842-2","article-title":"Proteomic analysis reveals a role for PAX8 in peritoneal colonization of high grade serous ovarian cancer that can be targeted with micelle encapsulated thiostrepton","volume":"38","author":"Hardy","year":"2019","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.redox.2026.104098_bib75","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1158\/1535-7163.MCT-11-0536","article-title":"Micelle-encapsulated thiostrepton as an effective nanomedicine for inhibiting tumor growth and for suppressing FOXM1 in human xenografts","volume":"10","author":"Wang","year":"2011","journal-title":"Mol. Cancer Therapeut."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726000960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726000960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:58:13Z","timestamp":1777625893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726000960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":75,"alternative-id":["S2213231726000960"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104098","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ALDH1L2 induces resistance to chemotherapy in small cell lung cancer by inhibiting ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104098"}}