{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:17:09Z","timestamp":1793297829258,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515012074"],"award-info":[{"award-number":["2021A1515012074"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["2022JBGS13"],"award-info":[{"award-number":["2022JBGS13"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012612"],"award-info":[{"award-number":["2025A1515012612"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202411015"],"award-info":[{"award-number":["SZSM202411015"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303028"],"award-info":[{"award-number":["82303028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970674"],"award-info":[{"award-number":["31970674"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.redox.2026.104151","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:25:40Z","timestamp":1775100340000},"page":"104151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Targeting HIF-1\u03b1 promotes ferroptosis and boosts antitumor immunity in MSS colorectal cancer"],"prefix":"10.1016","volume":"93","author":[{"given":"Zhiying","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangcai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7243-3487","authenticated-orcid":false,"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.redox.2026.104151_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14092241","article-title":"Biomarkers of response and resistance to immunotherapy in microsatellite stable colorectal cancer: toward a new personalized medicine","volume":"14","author":"Huyghe","year":"2022","journal-title":"Cancers."},{"issue":"3","key":"10.1016\/j.redox.2026.104151_bib2","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.redox.2026.104151_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1112276","article-title":"Advances in immune checkpoint inhibitor combination strategies for microsatellite stable colorectal cancer","volume":"13","author":"Ros","year":"2023","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.redox.2026.104151_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00535-019-01620-7","article-title":"Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancers","volume":"55","author":"Eso","year":"2019","journal-title":"J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.redox.2026.104151_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108077","article-title":"Single-cell transcriptome analysis of Colon cancer cell response to 5-Fluorouracil-Induced DNA damage","volume":"32","author":"Park","year":"2020","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.redox.2026.104151_bib6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.redox.2026.104151_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.redox.2026.104151_bib8","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s43018-023-00715-8","article-title":"Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance","volume":"5","author":"Zheng","year":"2024","journal-title":"Nat. Cancer"},{"issue":"1","key":"10.1016\/j.redox.2026.104151_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.redox.2026.104151_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s13691-024-00678-2","article-title":"BRAF-mutant microsatellite-stable rectal cancer with acquired KRAS mutation leading to drug resistance in liver metastasis","volume":"13","author":"Shigeyasu","year":"2024","journal-title":"Int. Cancer Conf. J."},{"key":"10.1016\/j.redox.2026.104151_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/gastro\/goaf051","article-title":"BMP6 ubiquitination mediated by SMURF1 suppresses ferroptosis and diminishes sensitivity to doxorubicin in gastric cancer","volume":"13","author":"Xu","year":"2025","journal-title":"Gastroenterol. Rep."},{"issue":"2","key":"10.1016\/j.redox.2026.104151_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001369","article-title":"Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity","volume":"8","author":"Efimova","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.redox.2026.104151_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2020.1862949","article-title":"Ferroptosis becomes immunogenic: implications for anticancer treatments","volume":"10","author":"Tang","year":"2020","journal-title":"OncoImmunology"},{"issue":"7755","key":"10.1016\/j.redox.2026.104151_bib14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.redox.2026.104151_bib15","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139434","article-title":"TYRO3 induces anti-PD-1\/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis","volume":"131","author":"Jiang","year":"2021","journal-title":"J. Clin. Investig."},{"issue":"5","key":"10.1016\/j.redox.2026.104151_bib16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.redox.2026.104151_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103205","article-title":"Hypoxia and the endometrium: an indispensable role for HIF-1\u03b1 as therapeutic strategies","volume":"73","author":"Dai","year":"2024","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.redox.2026.104151_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.cmet.2015.08.007","article-title":"PDK1-Dependent metabolic reprogramming dictates metastatic potential in breast cancer","volume":"22","author":"Dupuy","year":"2015","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.redox.2026.104151_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41573-023-00848-6","article-title":"Targeting hypoxia-inducible factors: therapeutic opportunities and challenges","volume":"23","author":"Yuan","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"12","key":"10.1016\/j.redox.2026.104151_bib20","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1038\/s41593-023-01476-4","article-title":"Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage","volume":"26","author":"Wei","year":"2023","journal-title":"Nat. Neurosci."},{"issue":"27","key":"10.1016\/j.redox.2026.104151_bib21","article-title":"Transcriptional repression of aerobic glycolysis by OVOL2 in breast cancer","volume":"9","author":"Zhang","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"4","key":"10.1016\/j.redox.2026.104151_bib22","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.7150\/ijbs.90774","article-title":"USP21 deubiquitinates and stabilizes HSP90 and ENO1 to promote aerobic glycolysis and proliferation in cholangiocarcinoma","volume":"20","author":"Xu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"7","key":"10.1016\/j.redox.2026.104151_bib23","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/cac2.12158","article-title":"The role of the HIF\u20101\u03b1\/ALYREF\/PKM2 axis in glycolysis and tumorigenesis of bladder cancer","volume":"41","author":"Wang","year":"2021","journal-title":"Cancer Commun."},{"issue":"1","key":"10.1016\/j.redox.2026.104151_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-024-03263-w","article-title":"The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration","volume":"44","author":"Cencioni","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.redox.2026.104151_bib25","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/neuonc\/noae040","article-title":"HIF1\u03b1\/ATF3 partake in PGK1 K191\/K192 succinylation by modulating P4HA1\/succinate signaling in glioblastoma","volume":"26","author":"Yang","year":"2024","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.redox.2026.104151_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110609","article-title":"P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression","volume":"105","author":"Zhou","year":"2023","journal-title":"Cell. Signal."},{"issue":"5","key":"10.1016\/j.redox.2026.104151_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.02.001","article-title":"Mapping the mouse cell atlas by microwell-seq","volume":"172","author":"Han","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.redox.2026.104151_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-43548-w","article-title":"ID1 expressing macrophages support cancer cell stemness and limit CD8+ T cell infiltration in colorectal cancer","volume":"14","author":"Shang","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.redox.2026.104151_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-022-00478-z","article-title":"The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling","volume":"8","author":"Zhang","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.redox.2026.104151_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.77457","article-title":"HIF-1\u03b1 induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury","volume":"11","author":"Woods","year":"2022","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.redox.2026.104151_bib31","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cmet.2022.09.021","article-title":"Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy","volume":"35","author":"Yang","year":"2023","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.redox.2026.104151_bib32","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/cam4.112","article-title":"BAY 87\u20102243, a highly potent and selective inhibitor of hypoxia\u2010induced gene activation has antitumor activities by inhibition of mitochondrial complex I","volume":"2","author":"Ellinghaus","year":"2013","journal-title":"Cancer Med."},{"key":"10.1016\/j.redox.2026.104151_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40170-015-0138-0","article-title":"Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth","volume":"3","author":"Schockel","year":"2015","journal-title":"Cancer Metabol."},{"issue":"12","key":"10.1016\/j.redox.2026.104151_bib34","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/s41568-025-00864-1","article-title":"Decoding ferroptosis for cancer therapy","volume":"25","author":"Wahida","year":"2025","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.redox.2026.104151_bib35","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1136\/gutjnl-2022-327909","article-title":"Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade","volume":"72","author":"Conche","year":"2023","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.redox.2026.104151_bib36","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/cac2.12487","article-title":"The crosstalk between ferroptosis and anti\u2010tumor immunity in the tumor microenvironment: molecular mechanisms and therapeutic controversy","volume":"43","author":"Zheng","year":"2023","journal-title":"Cancer Commun."},{"issue":"1","key":"10.1016\/j.redox.2026.104151_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-024-01772-w","article-title":"Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer","volume":"9","author":"Ma","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2026.104151_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1493420","article-title":"P4HA1: an important target for treating fibrosis related diseases and cancer","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.redox.2026.104151_bib39","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1053\/j.gastro.2024.07.038","article-title":"Atlas of metastatic gastric cancer links ferroptosis to disease progression and immunotherapy response","volume":"167","author":"Cheng","year":"2024","journal-title":"Gastroenterology"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726001497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726001497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:10:31Z","timestamp":1778854231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726001497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":39,"alternative-id":["S2213231726001497"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104151","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting HIF-1\u03b1 promotes ferroptosis and boosts antitumor immunity in MSS colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104151"}}