{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:07:48Z","timestamp":1778857668408,"version":"3.51.4"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2025-00520396"],"award-info":[{"award-number":["RS-2025-00520396"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2025-25396990"],"award-info":[{"award-number":["RS-2025-25396990"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2025-25396823"],"award-info":[{"award-number":["RS-2025-25396823"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.redox.2026.104173","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:35:57Z","timestamp":1776285357000},"page":"104173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The zinc\u2013nitric oxide axis in acute brain injury: Convergent oxidative\u2013nitrative stress, peroxynitrite signaling, and therapeutic targets"],"prefix":"10.1016","volume":"93","author":[{"given":"Hyun Wook","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Ho","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7492-579X","authenticated-orcid":false,"given":"Sang Won","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.redox.2026.104173_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cells11040667","article-title":"Administration of an acidic sphingomyelinase (ASMase) inhibitor, imipramine, reduces hypoglycemia-induced hippocampal neuronal death","volume":"11","author":"Kho","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.redox.2026.104173_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2024.e00357","article-title":"A phosphodiesterase 4 (PDE4) inhibitor, amlexanox, reduces neuroinflammation and neuronal death after pilocarpine-induced seizure","author":"Yang","year":"2024","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.redox.2026.104173_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156457","article-title":"L-theanine ameliorates traumatic-brain-injury-induced hippocampal neuronal death in rats","volume":"139","author":"Park","year":"2025","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib4","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1186\/s12951-025-03793-1","article-title":"Advanced nitric oxide-activated calcium overload and zinc ion-amplified oxidative imbalance in ferroptosis\/apoptosis","volume":"23","author":"Zhou","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"10","key":"10.1016\/j.redox.2026.104173_bib5","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1038\/jcbfm.2008.61","article-title":"Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death","volume":"28","author":"Suh","year":"2008","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"4","key":"10.1016\/j.redox.2026.104173_bib6","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1007\/s12035-016-9857-7","article-title":"Neuronal nitric oxide synthase negatively regulates zinc-induced nigrostriatal dopaminergic neurodegeneration","volume":"54","author":"Singh","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.redox.2026.104173_bib7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.freeradbiomed.2014.05.021","article-title":"Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide","volume":"73","author":"Lourenco","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.redox.2026.104173_bib8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jtemb.2014.06.021","article-title":"Significance of Zn(2+) signaling in cognition: insight from synaptic Zn(2+) dyshomeostasis","volume":"28","author":"Takeda","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"11","key":"10.1016\/j.redox.2026.104173_bib9","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1007\/s11064-017-2353-2","article-title":"Differential effects of Low- and high-dose zinc supplementation on synaptic plasticity and neurogenesis in the hippocampus of control and high-fat diet-fed mice","volume":"42","author":"Nam","year":"2017","journal-title":"Neurochem. Res."},{"issue":"9","key":"10.1016\/j.redox.2026.104173_bib10","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/jcbfm.2009.80","article-title":"Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats","volume":"29","author":"Suh","year":"2009","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.redox.2026.104173_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.nbd.2014.11.001","article-title":"Angiopoietin-1 blocks neurotoxic zinc entry into cortical cells via PIP2 hydrolysis-mediated ion channel inhibition","volume":"81","author":"Lim","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.redox.2026.104173_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114230","article-title":"Extracellular zinc regulates contextual fear memory formation in male rats through MMP-BDNF-TrkB pathway in dorsal hippocampus and basolateral amygdala","volume":"439","author":"Khan","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.redox.2026.104173_bib13","article-title":"Protective effects of phosphodiesterase 5 inhibitor, mirodenafil, on traumatic brain injury-induced neuronal death","volume":"285","author":"Park","year":"2025","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.redox.2026.104173_bib14","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/sj.jcbfm.9600449","article-title":"iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite","volume":"27","author":"Kawano","year":"2007","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"3\u20134","key":"10.1016\/j.redox.2026.104173_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10522-018-9756-6","article-title":"Mitigating peroxynitrite mediated mitochondrial dysfunction in aged rat brain by mitochondria-targeted antioxidant MitoQ","volume":"19","author":"Maiti","year":"2018","journal-title":"Biogerontology"},{"issue":"11","key":"10.1016\/j.redox.2026.104173_bib16","article-title":"The inhibition of zinc excitotoxicity and AMPK phosphorylation by a novel zinc chelator, 2G11, ameliorates neuronal death induced by global cerebral ischemia","volume":"11","author":"Hong","year":"2022","journal-title":"Antioxidants (Basel)."},{"issue":"4","key":"10.1016\/j.redox.2026.104173_bib17","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1172\/JCI30077","article-title":"Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase","volume":"117","author":"Suh","year":"2007","journal-title":"J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.redox.2026.104173_bib18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/exnr.2002.7990","article-title":"The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture","volume":"177","author":"Kim","year":"2002","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.redox.2026.104173_bib19","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0306-4522(02)00399-8","article-title":"Nitric oxide causes apparent release of zinc from presynaptic boutons","volume":"115","author":"Frederickson","year":"2002","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.redox.2026.104173_bib20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0896-6273(04)00015-7","article-title":"Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels","volume":"41","author":"Bossy-Wetzel","year":"2004","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.redox.2026.104173_bib21","first-page":"708","article-title":"Zinc in traumatic brain injury: from neuroprotection to neurotoxicity","volume":"16","author":"Morris","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"9","key":"10.1016\/j.redox.2026.104173_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfae039","article-title":"Insight into brain metallothioneins from bidirectional Zn2+ signaling in synaptic dynamics","volume":"16","author":"Takeda","year":"2024","journal-title":"Metallomics"},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0014-4886(03)00382-0","article-title":"Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury","volume":"184","author":"Lee","year":"2003","journal-title":"Exp. Neurol."},{"issue":"8","key":"10.1016\/j.redox.2026.104173_bib24","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.freeradbiomed.2007.01.022","article-title":"Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes","volume":"42","author":"Bishop","year":"2007","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2026.104173_bib26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neuropharm.2014.03.017","article-title":"nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep","volume":"83","author":"Drury","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.redox.2026.104173_bib27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.expneurol.2018.01.012","article-title":"Zn(2+)-induced disruption of neuronal mitochondrial function: synergism with Ca(2+), critical dependence upon cytosolic Zn(2+) buffering, and contributions to neuronal injury","volume":"302","author":"Ji","year":"2018","journal-title":"Exp. Neurol."},{"issue":"12","key":"10.1016\/j.redox.2026.104173_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbabio.2020.148290","article-title":"Modulation of peroxynitrite produced via mitochondrial nitric oxide synthesis during Ca(2+) and succinate-induced oxidative stress in cardiac isolated mitochondria","volume":"1861","author":"Gerdes","year":"2020","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"issue":"4","key":"10.1016\/j.redox.2026.104173_bib29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2174\/1567202617999200819142021","article-title":"Propofol protects against TNF-alpha-induced blood-brain barrier disruption via the PIM-1\/eNOS\/NO pathway","volume":"17","author":"Lu","year":"2020","journal-title":"Curr. Neurovascular Res."},{"issue":"8","key":"10.1016\/j.redox.2026.104173_bib30","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.bbagen.2014.12.013","article-title":"S-Nitrosylation in neurogenesis and neuronal development","volume":"1850","author":"Okamoto","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.redox.2026.104173_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068709","article-title":"Hypothalamic S-nitrosylation contributes to the counter-regulatory response impairment following recurrent hypoglycemia","volume":"8","author":"Fioramonti","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.redox.2026.104173_bib32","first-page":"3918","article-title":"Developmental alcohol exposure impairs activity-dependent S-Nitrosylation of NDEL1 for neuronal maturation","volume":"27","author":"Saito","year":"2017","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.redox.2026.104173_bib33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.niox.2016.10.001","article-title":"Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases","volume":"63","author":"Wynia-Smith","year":"2017","journal-title":"Nitric Oxide"},{"issue":"2","key":"10.1016\/j.redox.2026.104173_bib34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1177\/1073858418772548","article-title":"Mitochondrial Zn(2+) accumulation: a potential trigger of hippocampal ischemic injury","volume":"25","author":"Ji","year":"2019","journal-title":"Neuroscientist"},{"issue":"8","key":"10.1016\/j.redox.2026.104173_bib35","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrd2222","article-title":"Peroxynitrite: biochemistry, pathophysiology and development of therapeutics","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.redox.2026.104173_bib36","doi-asserted-by":"crossref","first-page":"H630","DOI":"10.1152\/ajpheart.00389.2020","article-title":"Peroxynitrite decomposition catalyst enhances respiratory function in isolated brain mitochondria","volume":"320","author":"Albuck","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.redox.2026.104173_bib37","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1152\/physrev.00005.2022","article-title":"The superoxide radical switch in the biology of nitric oxide and peroxynitrite","volume":"102","author":"Piacenza","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.redox.2026.104173_bib38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.freeradbiomed.2022.02.008","article-title":"Depletion of iNOS-positive inflammatory cells decelerates neuronal degeneration and alleviates cerebral ischemic damage by suppressing the inflammatory response","volume":"181","author":"Li","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.redox.2026.104173_bib39","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1038\/s41594-025-01602-9","article-title":"Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration","volume":"32","author":"Miao","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"5","key":"10.1016\/j.redox.2026.104173_bib40","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.redox.2026.104173_bib41","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/cns.13657","article-title":"Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2\/GPX4 defense pathway","volume":"27","author":"Ge","year":"2021","journal-title":"CNS Neurosci. Ther."},{"issue":"13\u201314","key":"10.1016\/j.redox.2026.104173_bib42","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.addr.2008.05.002","article-title":"Mitochondrial nitric oxide synthase, mitochondrial brain dysfunction in aging, and mitochondria-targeted antioxidants","volume":"60","author":"Navarro","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.redox.2026.104173_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114601","article-title":"Zinc accumulation in mitochondria promotes ischemia-induced BBB disruption through Drp1-dependent mitochondria fission","volume":"377","author":"Qi","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.redox.2026.104173_bib44","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.bbabio.2011.09.002","article-title":"Cytochrome c oxidase and nitric oxide in action: molecular mechanisms and pathophysiological implications","volume":"1817","author":"Sarti","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.redox.2026.104173_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9050489","article-title":"The multifaceted roles of zinc in neuronal mitochondrial dysfunction","volume":"9","author":"Liu","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.redox.2026.104173_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114757","article-title":"Mitochondria-lysosome-extracellular vesicles axis and nanotheranostics in neurodegenerative diseases","volume":"376","author":"Kou","year":"2024","journal-title":"Exp. Neurol."},{"issue":"47","key":"10.1016\/j.redox.2026.104173_bib47","doi-asserted-by":"crossref","first-page":"10616","DOI":"10.1523\/JNEUROSCI.2469-04.2004","article-title":"Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation","volume":"24","author":"Zhang","year":"2004","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib48","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1471-4159.2008.05349.x","article-title":"Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production","volume":"106","author":"Windelborn","year":"2008","journal-title":"J. Neurochem."},{"issue":"3\u20134","key":"10.1016\/j.redox.2026.104173_bib49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0891-5849(00)00318-X","article-title":"Peroxynitrite formed by mitochondrial NO synthase promotes mitochondrial Ca2+ release","volume":"29","author":"Bringold","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2026.104173_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115121","article-title":"The role of redox-mediated lysosomal dysfunction and therapeutic strategies","volume":"165","author":"He","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2026.104173_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.895750","article-title":"Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly","volume":"16","author":"Kim","year":"2022","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib52","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1756-6606-3-30","article-title":"Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes","volume":"3","author":"Lee","year":"2010","journal-title":"Mol. Brain"},{"key":"10.1016\/j.redox.2026.104173_bib53","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12868-015-0179-x","article-title":"Blocking a vicious cycle nNOS\/peroxynitrite\/AMPK by S-nitrosoglutathione: implication for stroke therapy","volume":"16","author":"Khan","year":"2015","journal-title":"BMC Neurosci."},{"issue":"8","key":"10.1016\/j.redox.2026.104173_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084243","article-title":"Roles of nitric oxide in brain ischemia and reperfusion","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.redox.2026.104173_bib55","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1007\/s12035-022-02788-5","article-title":"Targeting iNOS alleviates early brain injury after experimental subarachnoid hemorrhage via promoting ferroptosis of M1 microglia and reducing neuroinflammation","volume":"59","author":"Qu","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.redox.2026.104173_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032950","article-title":"The protective role of glutathione on zinc-induced neuron death after brain injuries","volume":"24","author":"Park","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2026.104173_bib57","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5828056","article-title":"Metallothionein in brain disorders","volume":"2017","author":"Juarez-Rebollar","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"42","key":"10.1016\/j.redox.2026.104173_bib58","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0627-25.2025","article-title":"Metallothionein III mediates Ca(2+)-Dependent Zn(2+) spikes to inhibit dendritic arborization","volume":"45","author":"Salvagio","year":"2025","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.redox.2026.104173_bib59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ccc.2019.12.009","article-title":"Nitric oxide and endothelial dysfunction","volume":"36","author":"Cyr","year":"2020","journal-title":"Crit. Care Clin."},{"issue":"3","key":"10.1016\/j.redox.2026.104173_bib60","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.bbamcr.2013.12.006","article-title":"Nitric oxide-matrix metaloproteinase-9 interactions: biological and pharmacological significance--NO and MMP-9 interactions","volume":"1843","author":"O'Sullivan","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.redox.2026.104173_bib61","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/stem.3194","article-title":"Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus","volume":"38","author":"Choi","year":"2020","journal-title":"Stem Cell."},{"issue":"6","key":"10.1016\/j.redox.2026.104173_bib62","first-page":"2727","article-title":"Neuronal zinc transporter ZnT3 modulates cerebral ischemia-induced blood-brain barrier disruption","volume":"15","author":"Qi","year":"2023","journal-title":"Aging Dis."},{"issue":"28","key":"10.1016\/j.redox.2026.104173_bib63","doi-asserted-by":"crossref","first-page":"9936","DOI":"10.1073\/pnas.0502552102","article-title":"Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.redox.2026.104173_bib64","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.freeradbiomed.2017.01.034","article-title":"Combined NADPH and the NOX inhibitor apocynin provides greater anti-inflammatory and neuroprotective effects in a mouse model of stroke","volume":"104","author":"Qin","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2026.104173_bib65","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-981-15-0602-4_4","article-title":"AMPK and autophagy","volume":"1206","author":"Li","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib66","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1038\/s41467-023-38401-z","article-title":"Redefining the role of AMPK in autophagy and the energy stress response","volume":"14","author":"Park","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104173_bib67","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.2147\/IJN.S442623","article-title":"Zinc oxide nanoparticles exacerbate epileptic seizures by modulating the TLR4-Autophagy axis","volume":"19","author":"Ke","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"10.1016\/j.redox.2026.104173_bib68","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5483\/BMBRep.2024-0043","article-title":"GPR40-full agonist AM1638 alleviates palmitate-induced oxidative damage in H9c2 cells via an AMPK-dependent pathway","volume":"58","author":"Yun","year":"2025","journal-title":"BMB Rep."},{"key":"10.1016\/j.redox.2026.104173_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135263","article-title":"Zinc promotes autophagy and inhibits apoptosis through AMPK\/mTOR signaling pathway after spinal cord injury","volume":"736","author":"Lin","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.redox.2026.104173_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102344","article-title":"TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS\/AMPK\/mTOR\/autophagy signaling","volume":"53","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"issue":"48","key":"10.1016\/j.redox.2026.104173_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq0898","article-title":"Angiogenic adipokine C1q-TNF-related protein 9 ameliorates myocardial infarction via histone deacetylase 7-mediated MEF2 activation","volume":"8","author":"Lee","year":"2022","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib72","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10565-024-09933-x","article-title":"CTRP9 attenuates peripheral nerve injury-induced mechanical allodynia and thermal hyperalgesia through regulating spinal microglial polarization and neuroinflammation mediated by AdipoR1 in male mice","volume":"40","author":"Liu","year":"2024","journal-title":"Cell Biol. Toxicol."},{"issue":"10","key":"10.1016\/j.redox.2026.104173_bib73","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.7150\/ijbs.111216","article-title":"Amlexanox ameliorates traumatic brain injury by restoring autophagy-lysosomal function via cAMP signaling modulation","volume":"21","author":"Woo","year":"2025","journal-title":"Int. J. Biol. Sci."},{"issue":"12","key":"10.1016\/j.redox.2026.104173_bib74","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/s42255-022-00707-5","article-title":"Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity","volume":"4","author":"Hu","year":"2022","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib75","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12974-025-03594-1","article-title":"Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke","volume":"22","author":"Won","year":"2025","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib76","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s44321-024-00168-1","article-title":"A novel anti-epileptogenesis strategy of temporal lobe epilepsy based on nitric oxide donor","volume":"17","author":"Zhu","year":"2025","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"10.1016\/j.redox.2026.104173_bib77","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1089\/ars.2010.3331","article-title":"Hypothalamic nitric oxide in hypoglycemia detection and counterregulation: a two-edged sword","volume":"14","author":"Fioramonti","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2026.104173_bib78","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/1742-2094-9-225","article-title":"Prevention of hypoglycemia-induced neuronal death by minocycline","volume":"9","author":"Won","year":"2012","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"10.1016\/j.redox.2026.104173_bib79","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70187","article-title":"Propofol suppresses ferroptosis via modulating eNOS\/NO signaling pathway to improve traumatic brain injury","volume":"14","author":"Zheng","year":"2024","journal-title":"Brain Behav."},{"issue":"10","key":"10.1016\/j.redox.2026.104173_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048543","article-title":"Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.redox.2026.104173_bib81","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jtemb.2014.07.007","article-title":"Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrus","volume":"28","author":"Choi","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib82","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41392-023-01679-y","article-title":"Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"6","key":"10.1016\/j.redox.2026.104173_bib83","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.celrep.2019.09.070","article-title":"Metformin improves mitochondrial respiratory activity through activation of AMPK","volume":"29","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104173_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.720288","article-title":"Effects of iron and zinc on mitochondria: potential mechanisms of glaucomatous injury","volume":"9","author":"Tang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.redox.2026.104173_bib85","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13050784","article-title":"Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation","volume":"13","author":"Madireddy","year":"2023","journal-title":"Brain Sci."},{"issue":"9","key":"10.1016\/j.redox.2026.104173_bib86","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1161\/STROKEAHA.118.021179","article-title":"Synergistic interaction between zinc and reactive oxygen species amplifies ischemic brain injury in rats","volume":"49","author":"Zhao","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.redox.2026.104173_bib87","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.taap.2018.12.018","article-title":"The interaction of zinc and the blood-brain barrier under physiological and ischemic conditions","volume":"364","author":"Qi","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.redox.2026.104173_bib88","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/WNR.0000000000001577","volume":"32","author":"Chen","year":"2021","journal-title":"Neuroreport"},{"issue":"5","key":"10.1016\/j.redox.2026.104173_bib89","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10571-009-9391-5","article-title":"A comparative evaluation of the response to peroxynitrite by a brain endothelial cell line and control of the effects by drug targeting","volume":"29","author":"Bolton","year":"2009","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.redox.2026.104173_bib90","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.freeradbiomed.2017.04.026","article-title":"Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration","volume":"108","author":"Lourenco","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.redox.2026.104173_bib91","doi-asserted-by":"crossref","first-page":"H295","DOI":"10.1152\/ajpheart.00720.2019","article-title":"Nitric oxide synthase inhibitors negatively regulate respiration in isolated rodent cardiac and brain mitochondria","volume":"318","author":"Sakamuri","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"9","key":"10.1016\/j.redox.2026.104173_bib94","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093375","article-title":"A novel zinc chelator, 1H10, ameliorates experimental autoimmune encephalomyelitis by modulating zinc toxicity and AMPK activation","volume":"21","author":"Choi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.redox.2026.104173_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102189","article-title":"ZnT3 gene deletion reduces colchicine-induced dentate granule cell degeneration","volume":"18","author":"Choi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.redox.2026.104173_bib96","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s12031-020-01481-3","article-title":"Role of Metallothionein-1 and Metallothionein-2 in the neuroprotective mechanism of sevoflurane preconditioning in mice","volume":"70","author":"Liu","year":"2020","journal-title":"J. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.redox.2026.104173_bib97","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s12311-018-0934-5","article-title":"Inhibition of inducible nitric oxide synthase attenuates deficits in synaptic plasticity and brain functions following traumatic brain injury","volume":"17","author":"Wang","year":"2018","journal-title":"Cerebellum"},{"issue":"5","key":"10.1016\/j.redox.2026.104173_bib98","doi-asserted-by":"crossref","first-page":"E995","DOI":"10.1152\/ajpendo.00398.2017","article-title":"IL6 and LIF mRNA expression in skeletal muscle is regulated by AMPK and the transcription factors NFYC, ZBTB14, and SP1","volume":"315","author":"Nylen","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.redox.2026.104173_bib99","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12011-023-03667-3","article-title":"The role of glycogen synthase Kinase-3beta in the zinc-mediated neuroprotective effect of metformin in rats with glutamate neurotoxicity","volume":"202","author":"Oruc","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"issue":"11\u201312","key":"10.1016\/j.redox.2026.104173_bib92","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1080\/10715762.2017.1400666","article-title":"Hydrogen sulfide ameliorates zinc-induced cell death in neuroblastoma SH-SY5Y cells","volume":"51","author":"Shimoji","year":"2017","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.redox.2026.104173_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110217","article-title":"Therapeutic effects of CORM3 and NaHS in chronic kidney disease induced cognitive impairment via the interaction between carbon monoxide and hydrogen sulfide on Nrf2\/HO-1 signaling pathway in rats","volume":"368","author":"Hamidizad","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.redox.2026.104173_bib101","article-title":"GYY4137-Derived hydrogen sulfide donates electrons to the mitochondrial electron transport chain via sulfide: quinone oxidoreductase in endothelial cells","volume":"12","author":"Star","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.redox.2026.104173_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122912","article-title":"Zinc sulfide nanoparticles serve as gas slow-release bioreactors for H(2)S therapy of ischemic stroke","volume":"315","author":"Li","year":"2025","journal-title":"Biomaterials"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726001710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726001710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:09:58Z","timestamp":1778854198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726001710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":101,"alternative-id":["S2213231726001710"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104173","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The zinc\u2013nitric oxide axis in acute brain injury: Convergent oxidative\u2013nitrative stress, peroxynitrite signaling, and therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104173"}}