{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:17:53Z","timestamp":1783142273249,"version":"3.54.6"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"publisher","award":["T32 GM135066"],"award-info":[{"award-number":["T32 GM135066"]}],"id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM140935"],"award-info":[{"award-number":["T32 GM140935"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM135066"],"award-info":[{"award-number":["T32 GM135066"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35 GM147014"],"award-info":[{"award-number":["R35 GM147014"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35 GM118027"],"award-info":[{"award-number":["R35 GM118027"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P41 GM108538"],"award-info":[{"award-number":["P41 GM108538"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009429","name":"Israel National Road Safety Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.redox.2026.104181","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:06:06Z","timestamp":1776841566000},"page":"104181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1"],"prefix":"10.1016","volume":"93","author":[{"given":"Nicholas L.","family":"Arp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzziah S.","family":"Urquiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Morgenstern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Schrope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Votava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven V.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack J.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Huttenlocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Coon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-5358","authenticated-orcid":false,"given":"Jing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2026.104181_bib1","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1089\/ars.2017.7403","article-title":"Protein S-Nitrosylation: determinants of specificity and enzymatic regulation of S-Nitrosothiol-Based signaling","volume":"30","author":"Stomberski","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.redox.2026.104181_bib2","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.cell.2022.06.010","article-title":"Nitric oxide signaling in health and disease","volume":"185","author":"Lundberg","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104181_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101550","article-title":"Nitric oxide in cellular adaptation and disease","volume":"34","author":"Gantner","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104181_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tem.2022.02.005","article-title":"A matter of time: temporal structure and functional relevance of macrophage metabolic rewiring","volume":"33","author":"Seim","year":"2022","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.redox.2026.104181_bib5","article-title":"Metabolic programming of macrophage functions and pathogens control","volume":"24","author":"jie Koo","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104181_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/metabo10110429","article-title":"Nitric oxide in macrophage immunometabolism: hiding in plain sight","volume":"10","author":"Palmieri","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.redox.2026.104181_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-00478-8","article-title":"Redox regulation of immunometabolism","volume":"21","author":"Muri","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.redox.2026.104181_bib8","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/s42255-025-01337-3","article-title":"Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide","volume":"7","author":"John","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.redox.2026.104181_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-40738-4","article-title":"Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming","volume":"14","author":"Palmieri","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104181_bib10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s42255-019-0083-2","article-title":"Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-\u03b3 stimulation","volume":"1","author":"Seim","year":"2019","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.redox.2026.104181_bib11","doi-asserted-by":"crossref","first-page":"6676","DOI":"10.1038\/ncomms7676","article-title":"Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization","volume":"6","author":"Lu","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104181_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103123","article-title":"Redox regulation of macrophages","volume":"72","author":"Tran","year":"2024","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.redox.2026.104181_bib13","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41423-022-00902-0","article-title":"Redox regulation of the immune response","volume":"19","author":"Morris","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.redox.2026.104181_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adu4369","article-title":"Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages","volume":"11","author":"Stoolman","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.redox.2026.104181_bib15","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.1126\/sciadv.adq7307","article-title":"Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion","volume":"11","author":"Zotta","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.redox.2026.104181_bib16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.celrep.2019.06.018","article-title":"Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation","volume":"28","author":"Bailey","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104181_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-14433-7","article-title":"Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase","volume":"11","author":"Palmieri","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104181_bib18","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.bbagen.2011.03.008","article-title":"Regulation of mitochondrial processes by protein S-Nitrosylation","volume":"1820","author":"Piantadosi","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2026.104181_bib19","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1084\/jem.20070198","article-title":"Nitrite augments tolerance to ischemia\/reperfusion injury via the modulation of mitochondrial electron transfer","volume":"204","author":"Shiva","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.redox.2026.104181_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41589-022-01153-w","article-title":"Nitric oxide-driven modifications of lipoic arm inhibit \u03b1-ketoacid dehydrogenases","volume":"19","author":"Seim","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.redox.2026.104181_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105333","article-title":"Reactive nitrogen species inhibit branched chain alpha-ketoacid dehydrogenase complex and impact muscle cell metabolism","volume":"299","author":"Arp","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2026.104181_bib22","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.celrep.2018.06.081","article-title":"Nitric oxide engages an anti-inflammatory feedback loop mediated by Peroxiredoxin 5 in phagocytes","volume":"24","author":"Graham","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104181_bib23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2014.10.575","article-title":"Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation","volume":"79","author":"McNeill","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2026.104181_bib24","article-title":"Mass spectrometry-based proteomic exploration of diverse murine macrophage cellular models","volume":"8","author":"Gudgeon","year":"2024","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.redox.2026.104181_bib25","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.celrep.2016.09.008","article-title":"Mitochondrial dysfunction prevents repolarization of inflammatory macrophages","volume":"17","author":"Van den Bossche","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104181_bib26","doi-asserted-by":"crossref","first-page":"18572","DOI":"10.1073\/pnas.1417816112","article-title":"Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation","volume":"111","author":"Anand","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2026.104181_bib27","doi-asserted-by":"crossref","first-page":"18285","DOI":"10.1074\/jbc.RA119.011067","article-title":"AKR1A1 is a novel mammalian S-nitroso-glutathione reductase","volume":"294","author":"Stomberski","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2026.104181_bib28","doi-asserted-by":"crossref","first-page":"10228","DOI":"10.1093\/nar\/gks827","article-title":"Nrf2\u2013MafG heterodimers contribute globally to antioxidant and metabolic networks","volume":"40","author":"Hirotsu","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2026.104181_bib29","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1093\/nar\/gkq212","article-title":"Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis","volume":"38","author":"Malhotra","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2026.104181_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.toxlet.2012.12.026","article-title":"Identification of aldo-keto reductases as NRF2-target marker genes in human cells","volume":"218","author":"Jung","year":"2013","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.redox.2026.104181_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","volume":"7","author":"Kobayashi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104181_bib32","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1074\/jbc.RA118.004947","article-title":"Molecular recognition of S-nitrosothiol substrate by its cognate protein denitrosylase","volume":"294","author":"Stomberski","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2026.104181_bib33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41586-018-0749-z","article-title":"Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury","volume":"565","author":"Zhou","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.redox.2026.104181_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.106601","article-title":"The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming","volume":"14","author":"Grimmett","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.redox.2026.104181_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111538","article-title":"A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis","volume":"41","author":"Stomberski","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104181_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh2169","article-title":"A single\u2013cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"issue":"9","key":"10.1016\/j.redox.2026.104181_bib37","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/s41588-019-0481-0","article-title":"A global overview of pleiotropy and genetic architecture in complex traits","volume":"51","author":"Watanabe","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.redox.2026.104181_bib38","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1016\/j.cell.2023.11.009","article-title":"An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling","volume":"186","author":"Zhou","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104181_bib39","doi-asserted-by":"crossref","first-page":"16386","DOI":"10.1021\/ja2070889","article-title":"Itaconic acid is a mammalian metabolite induced during macrophage activation","volume":"133","author":"Strelko","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.redox.2026.104181_bib40","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1073\/pnas.1218599110","article-title":"Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production","volume":"110","author":"Michelucci","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2026.104181_bib41","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab."},{"issue":"7702","key":"10.1016\/j.redox.2026.104181_bib42","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41586-018-0052-z","article-title":"Electrophilic properties of itaconate and derivatives regulate the I\u03baB\u03b6\u2013ATF3 inflammatory axis","volume":"556","author":"Bambouskova","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.redox.2026.104181_bib43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.redox.2026.104181_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112658","article-title":"Dimethyl itaconate induces long-term innate immune responses and confers protection against infection","volume":"42","author":"Ferreira","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.redox.2026.104181_bib45","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in immunoregulation and therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2026.104181_bib46","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104181_bib47","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1002\/eji.201141783","article-title":"Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states","volume":"41","author":"Ivashkiv","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.redox.2026.104181_bib48","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nri1630","article-title":"Negative regulation of toll-like receptor-mediated immune responses","volume":"5","author":"Liew","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.redox.2026.104181_bib49","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1073\/pnas.95.13.7631","article-title":"Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione","volume":"95","author":"Clementi","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.redox.2026.104181_bib50","doi-asserted-by":"crossref","first-page":"37448","DOI":"10.1074\/jbc.M707543200","article-title":"S-nitrosation of mitochondrial complex I depends on its structural conformation","volume":"282","author":"Galkin","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2026.104181_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101354","article-title":"Inducible nitric oxide synthase-derived extracellular nitric oxide flux regulates proinflammatory responses at the single cell level","volume":"28","author":"Somasundaram","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104181_bib52","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.molcel.2021.08.018","article-title":"Redox metabolism: ROS as specific molecular regulators of cell signaling and function","volume":"81","author":"Lennicke","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2026.104181_bib53","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s42255-025-01224-x","article-title":"Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1\u03b2 release during NLRP3 inflammasome activation","volume":"7","author":"Casey","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.redox.2026.104181_bib54","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.immuni.2025.06.006","article-title":"Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity","volume":"58","author":"Clark","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2026.104181_bib55","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.tibs.2025.09.004","article-title":"Interconnectivity of mitochondrial protein biogenesis and quality control","volume":"50","author":"Ghifari","year":"2025","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.redox.2026.104181_bib56","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1126\/science.1079368","article-title":"Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide","volume":"299","author":"Nisoli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.redox.2026.104181_bib57","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1096\/fj.05-5189fje","article-title":"Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1\u03b1","volume":"20","author":"Borniquel","year":"2006","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.redox.2026.104181_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/srep38210","article-title":"PGC-1\u03b1 dictates endothelial function through regulation of eNOS expression","volume":"6","author":"Craige","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2026.104181_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102164","article-title":"Mitochondrial iron\u2013sulfur clusters: structure, function, and an emerging role in vascular biology","volume":"47","author":"Read","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104181_bib60","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.it.2025.06.001","article-title":"Plans within plans: post-transcriptional regulation governs macrophage responses","volume":"46","author":"Smith","year":"2025","journal-title":"Trends Immunol."},{"key":"10.1016\/j.redox.2026.104181_bib61","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.redox.2015.09.027","article-title":"Post-Translational nitric oxide\u2013dependent modifications in immune system","volume":"5","author":"Mart\u00ednez-Ruiz","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104181_bib62","article-title":"An integrated toolbox to profile macrophage immunometabolism","volume":"2","author":"Verberk","year":"2022","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.redox.2026.104181_bib63","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.chembiol.2023.06.008","article-title":"Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome","volume":"30","author":"Yan","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.redox.2026.104181_bib64","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2818.2012.03675.x","article-title":"3-D PSF fitting for fluorescence microscopy: implementation and localization application","volume":"249","author":"Kirshner","year":"2013","journal-title":"J. Microsc."},{"key":"10.1016\/j.redox.2026.104181_bib65","doi-asserted-by":"crossref","first-page":"E87","DOI":"10.1152\/ajpendo.00457.2019","article-title":"A pipeline for multidimensional confocal analysis of mitochondrial morphology, function, and dynamics in pancreatic \u03b2-cells","volume":"318","author":"Chaudhry","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.redox.2026.104181_bib66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0003-2697(89)90710-0","article-title":"Quantification of cells cultured on 96-well plates","volume":"182","author":"Kueng","year":"1989","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.redox.2026.104181_bib67","doi-asserted-by":"crossref","first-page":"9818","DOI":"10.1021\/ac1021166","article-title":"Metabolomic analysis and visualization engine for LC - MS data","volume":"82","author":"Melamud","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.redox.2026.104181_bib68","article-title":"LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine","volume":"14","author":"Clasquin","year":"2012","journal-title":"Curr. Protoc. Bioinformatics Chapter"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726001795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726001795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:51:42Z","timestamp":1783140702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726001795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":68,"alternative-id":["S2213231726001795"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104181","relation":{"has-preprint":[{"id-type":"doi","id":"10.64898\/2025.12.31.697202","asserted-by":"object"}]},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104181"}}