{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:18:50Z","timestamp":1783095530490,"version":"3.54.6"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["F31DE031508"],"award-info":[{"award-number":["F31DE031508"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["F31DE034608"],"award-info":[{"award-number":["F31DE034608"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM142748"],"award-info":[{"award-number":["R35GM142748"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.redox.2026.104194","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:55:42Z","timestamp":1778050542000},"page":"104194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Redox signaling modulates nitrite transport in a commensal Streptococcus"],"prefix":"10.1016","volume":"94","author":[{"given":"Sara E.","family":"Edmonds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Baty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Scoffield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.redox.2026.104194_bib1","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J. Bacteriol."},{"issue":"6","key":"10.1016\/j.redox.2026.104194_bib2","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.1073\/pnas.1522149113","article-title":"Biogeography of a human oral microbiome at the micron scale","volume":"113","author":"Mark Welch","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2026.104194_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-0757.2006.00187.x","article-title":"Bacterial interactions and successions during plaque development","volume":"42","author":"Kolenbrander","year":"2000","journal-title":"Periodontol"},{"issue":"2","key":"10.1016\/j.redox.2026.104194_bib4","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.chom.2020.07.009","article-title":"Oral microbiome geography: Micron-scale habitat and niche","volume":"28","author":"Mark Welch","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.redox.2026.104194_bib5","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1574-6941.2008.00585.x","article-title":"Role of hydrogen peroxide in competition and cooperation between Streptococcus gordonii and Actinomyces naeslundii","volume":"66","author":"Jakubovics","year":"2008","journal-title":"FEMS Microbiol. Ecol."},{"issue":"21","key":"10.1016\/j.redox.2026.104194_bib6","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1128\/JB.187.21.7193-7203.2005","article-title":"Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm","volume":"187","author":"Kreth","year":"2005","journal-title":"J. Bacteriol."},{"issue":"13","key":"10.1016\/j.redox.2026.104194_bib7","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1128\/JB.00276-08","article-title":"Streptococcal antagonism in oral biofilms: streptococcus sanguinis and Streptococcus gordonii interference with Streptococcus mutans","volume":"190","author":"Kreth","year":"2008","journal-title":"J. Bacteriol."},{"issue":"13","key":"10.1016\/j.redox.2026.104194_bib8","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1128\/AEM.00309-11","article-title":"Environmental influences on competitive hydrogen peroxide production in Streptococcus gordonii","volume":"77","author":"Zheng","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"issue":"6","key":"10.1016\/j.redox.2026.104194_bib9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1099\/00222615-39-6-434","article-title":"Evaluation of the capacity of oral streptococci to produce hydrogen peroxide","volume":"39","author":"Garc\u00eda-Mendoza","year":"1993","journal-title":"J. Med. Microbiol."},{"issue":"4","key":"10.1016\/j.redox.2026.104194_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034769","article-title":"Complete genome and transcriptomes of Streptococcus parasanguinis FW213: phylogenic relations and potential virulence mechanisms","volume":"7","author":"Geng","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.redox.2026.104194_bib11","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1111\/1462-2920.13425","article-title":"Fine-tuned production of hydrogen peroxide promotes biofilm formation of Streptococcus parasanguinis by a pathogenic cohabitant Aggregatibacter actinomycetemcomitans","volume":"18","author":"Duan","year":"2016","journal-title":"Environ. Microbiol."},{"issue":"9","key":"10.1016\/j.redox.2026.104194_bib12","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1177\/0022034519855348","article-title":"Dietary nitrite drives disease outcomes in oral polymicrobial infections","volume":"98","author":"Scoffield","year":"2019","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.redox.2026.104194_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1128\/IAI.02396-14","article-title":"Oral streptococci and nitrite-mediated interference of Pseudomonas aeruginosa","volume":"83","author":"Scoffield","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.redox.2026.104194_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.817336","article-title":"A commensal streptococcus dysregulates the Pseudomonas aeruginosa nitrosative stress response","volume":"12","author":"Baty","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"6","key":"10.1016\/j.redox.2026.104194_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02198-23","article-title":"An oral commensal attenuates pseudomonas aeruginosa-induced airway inflammation and modulates nitrite flux in respiratory epithelium","volume":"11","author":"Baty","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"5","key":"10.1016\/j.redox.2026.104194_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1600-0722.2004.00153.x","article-title":"Protective effect of salivary nitrate and microbial nitrate reductase activity against caries","volume":"112","author":"Doel","year":"2004","journal-title":"Eur. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.redox.2026.104194_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/odi.12157","article-title":"The oral microbiome and nitric oxide homoeostasis","volume":"21","author":"Hezel","year":"2015","journal-title":"Oral Dis."},{"issue":"3","key":"10.1016\/j.redox.2026.104194_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088645","article-title":"Metagenomic analysis of nitrate-reducing bacteria in the oral cavity: implications for nitric oxide homeostasis","volume":"9","author":"Hyde","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2026.104194_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.niox.2016.08.006","article-title":"Sustaining elevated levels of nitrite in the oral cavity through consumption of nitrate-rich beetroot juice in young healthy adults reduces salivary pH","volume":"60","author":"Hohensinn","year":"2016","journal-title":"Nitric Oxide"},{"issue":"1","key":"10.1016\/j.redox.2026.104194_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69931-x","article-title":"Nitrate as a potential prebiotic for the oral microbiome","volume":"10","author":"Rosier","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.redox.2026.104194_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76744-5","article-title":"Disruption of Streptococcus mutans and Candida albicans synergy by a commensal streptococcus","volume":"10","author":"Huffines","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2026.104194_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.833339","article-title":"Nitrite triggers reprogramming of the oral polymicrobial metabolome by a commensal streptococcus","volume":"12","author":"Huffines","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"Pt 1","key":"10.1016\/j.redox.2026.104194_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1099\/mic.0.039669-0","article-title":"Identification of hydrogen peroxide production-related genes in Streptococcus sanguinis and their functional relationship with pyruvate oxidase","volume":"157","author":"Chen","year":"2011","journal-title":"Microbiology (Read.)"},{"issue":"47","key":"10.1016\/j.redox.2026.104194_bib24","doi-asserted-by":"crossref","DOI":"10.3791\/2437","article-title":"Microtiter dish biofilm formation assay","author":"O'Toole","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"7","key":"10.1016\/j.redox.2026.104194_bib25","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/s41396-022-01221-y","article-title":"Pseudomonas aeruginosa polysaccharide Psl supports airway microbial community development","volume":"16","author":"Stoner","year":"2022","journal-title":"ISME J."},{"issue":"10","key":"10.1016\/j.redox.2026.104194_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005951","article-title":"Pyruvate oxidase as a critical link between metabolism and capsule biosynthesis in Streptococcus pneumoniae","volume":"12","author":"Echlin","year":"2016","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.redox.2026.104194_bib27","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1099\/mic.0.000226","article-title":"Nitrite reductase is critical for Pseudomonas aeruginosa survival during co-infection with the oral commensal Streptococcus parasanguinis","volume":"162","author":"Scoffield","year":"2016","journal-title":"Microbiology (Read.)"},{"issue":"Pt 1","key":"10.1016\/j.redox.2026.104194_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/BST0330159","article-title":"Nitrate and nitrite transport in Escherichia coli","volume":"33","author":"Jia","year":"2005","journal-title":"Biochem. Soc. Trans."},{"issue":"5","key":"10.1016\/j.redox.2026.104194_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00295-23","article-title":"Catalase produced by Candida albicans protects Streptococcus mutans from H(2)O(2) stress-one more piece in the cross-kingdom synergism puzzle","volume":"8","author":"Katrak","year":"2023","journal-title":"mSphere"},{"issue":"4","key":"10.1016\/j.redox.2026.104194_bib30","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1128\/JB.01517-07","article-title":"Influence of the spxB gene on competence in Streptococcus pneumoniae","volume":"190","author":"B\u00e4ttig","year":"2008","journal-title":"J. Bacteriol."},{"issue":"7","key":"10.1016\/j.redox.2026.104194_bib31","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1128\/IAI.00026-12","article-title":"The Spx regulator modulates stress responses and virulence in Enterococcus faecalis","volume":"80","author":"Kajfasz","year":"2012","journal-title":"Infect. Immun."},{"issue":"10","key":"10.1016\/j.redox.2026.104194_bib32","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1128\/JB.00028-10","article-title":"Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans","volume":"192","author":"Kajfasz","year":"2010","journal-title":"J. Bacteriol."},{"issue":"4","key":"10.1016\/j.redox.2026.104194_bib33","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1046\/j.1365-2958.1996.425954.x","article-title":"Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae","volume":"19","author":"Spellerberg","year":"1996","journal-title":"Mol. Microbiol."},{"issue":"18","key":"10.1016\/j.redox.2026.104194_bib34","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1128\/JB.00813-07","article-title":"SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model","volume":"189","author":"Regev-Yochay","year":"2007","journal-title":"J. Bacteriol."},{"issue":"24","key":"10.1016\/j.redox.2026.104194_bib35","doi-asserted-by":"crossref","first-page":"8164","DOI":"10.1128\/JB.186.24.8164-8171.2004","article-title":"Pyruvate oxidase is a determinant of Avery's rough morphology","volume":"186","author":"Belanger","year":"2004","journal-title":"J. Bacteriol."},{"issue":"8","key":"10.1016\/j.redox.2026.104194_bib36","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1128\/IAI.00029-11","article-title":"New cell surface protein involved in biofilm formation by Streptococcus parasanguinis","volume":"79","author":"Liang","year":"2011","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.redox.2026.104194_bib37","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1128\/JB.00836-06","article-title":"Two gene determinants are differentially involved in the biogenesis of Fap1 precursors in Streptococcus parasanguis","volume":"189","author":"Wu","year":"2007","journal-title":"J. Bacteriol."},{"issue":"5","key":"10.1016\/j.redox.2026.104194_bib38","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1128\/IAI.01544-06","article-title":"The glycan moieties and the N-terminal polypeptide backbone of a fimbria-associated adhesin, Fap1, play distinct roles in the biofilm development of Streptococcus parasanguinis","volume":"75","author":"Wu","year":"2007","journal-title":"Infect. Immun."},{"issue":"20","key":"10.1016\/j.redox.2026.104194_bib39","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1128\/JB.00906-09","article-title":"Characterization of hydrogen peroxide-induced DNA release by Streptococcus sanguinis and Streptococcus gordonii","volume":"191","author":"Kreth","year":"2009","journal-title":"J. Bacteriol."},{"issue":"4","key":"10.1016\/j.redox.2026.104194_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00878-20","article-title":"The nitrite transporter facilitates biofilm Formation via suppression of nitrite reductase and is a new antibiofilm target in Pseudomonas aeruginosa","volume":"11","author":"Park","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.redox.2026.104194_bib41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fmicb.2020.00026","article-title":"Nitrate metabolism modulates biosynthesis of biofilm components in uropathogenic Escherichia coli and acts as a fitness factor during experimental urinary tract infection","volume":"11","author":"Mart\u00edn-Rodr\u00edguez","year":"2020","journal-title":"Front. Microbiol."},{"issue":"17","key":"10.1016\/j.redox.2026.104194_bib42","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/1873-3468.14859","article-title":"Do oral and gut microbiota communicate through redox pathways? A novel asset of the nitrate-nitrite-NO pathway","volume":"598","author":"Paiva","year":"2024","journal-title":"FEBS Lett."},{"issue":"8","key":"10.1016\/j.redox.2026.104194_bib43","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1128\/IAI.00201-07","article-title":"Nitrate sensing and metabolism modulate motility, biofilm formation, and virulence in Pseudomonas aeruginosa","volume":"75","author":"Van Alst","year":"2007","journal-title":"Infect. Immun."},{"issue":"50","key":"10.1016\/j.redox.2026.104194_bib44","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112986118","article-title":"Molecular mechanism of glycolytic flux control intrinsic to human phosphoglycerate kinase","volume":"118","author":"Yagi","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2026.104194_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1200923","article-title":"Staphylococcus epidermidis biofilms undergo metabolic and matrix remodeling under nitrosative stress","volume":"13","author":"Oliveira","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"Pt 5","key":"10.1016\/j.redox.2026.104194_bib46","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1099\/mic.0.26888-0","article-title":"Proteome analysis of Streptococcus mutans metabolic phenotype during acid tolerance","volume":"150","author":"Len","year":"2004","journal-title":"Microbiology (Read.)"},{"issue":"15","key":"10.1016\/j.redox.2026.104194_bib47","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1128\/AEM.01160-15","article-title":"Genetics and physiology of acetate metabolism by the pta-ack pathway of Streptococcus mutans","volume":"81","author":"Kim","year":"2015","journal-title":"Appl. Environ. Microbiol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726001928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726001928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:26:41Z","timestamp":1783092401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726001928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":47,"alternative-id":["S2213231726001928"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104194","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redox signaling modulates nitrite transport in a commensal Streptococcus","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104194","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104194"}}