{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:42:31Z","timestamp":1793817751817,"version":"4.6.1"},"reference-count":198,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015624","name":"Leidos Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["ZIABC010300-27"],"award-info":[{"award-number":["ZIABC010300-27"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["ZIABC010899-17"],"award-info":[{"award-number":["ZIABC010899-17"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHS 75N91019D00024"],"award-info":[{"award-number":["HHS 75N91019D00024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031022","name":"Center for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.redox.2026.104245","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:42:39Z","timestamp":1780443759000},"page":"104245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Nitric oxide-driven Warburg reprogramming at the NOS2-COX2 axis: An integrative engine of cancer hallmarks"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0989-6144","authenticated-orcid":false,"given":"Leandro L.","family":"Coutinho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika M.","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Ridnour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Y.S.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen K.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Billiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Lockett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Cristina","family":"Rangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas D.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-5111","authenticated-orcid":false,"given":"Daniel W.","family":"McVicar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-7480","authenticated-orcid":false,"given":"David A.","family":"Wink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2026.104245_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/HP.S93413","article-title":"The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy","volume":"3","author":"Muz","year":"2015","journal-title":"Hypoxia"},{"issue":"12","key":"10.1016\/j.redox.2026.104245_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122598","article-title":"Hypoxia dictates metabolic rewiring of tumors: implications for chemoresistance","volume":"9","author":"Belisario","year":"2020","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202300551","article-title":"Hypoxia: intriguing feature in cancer cell biology","volume":"19","author":"Chowdhury","year":"2024","journal-title":"ChemMedChem"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13045-025-01684-4","article-title":"Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance","volume":"18","author":"Shang","year":"2025","journal-title":"J. Hematol. Oncol."},{"issue":"4","key":"10.1016\/j.redox.2026.104245_bib5","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/0006-291X(80)91341-8","article-title":"Interdependence of glucose and arginine catabolism in Streptococcus faecalis R. ATCC 8043","volume":"96","author":"Pandey","year":"1980","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib6","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.pharmthera.2012.11.003","article-title":"The Warburg effect: insights from the past decade","volume":"137","author":"Upadhyay","year":"2013","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib7","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1042\/BST20160094","article-title":"The Warburg effect: 80 years on","volume":"44","author":"Potter","year":"2016","journal-title":"Biochem. Soc. Trans."},{"issue":"24","key":"10.1016\/j.redox.2026.104245_bib8","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1007\/s00018-008-8224-x","article-title":"Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer","volume":"65","author":"Yeung","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.redox.2026.104245_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1101\/sqb.2011.76.010975","article-title":"Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases","volume":"76","author":"Kaelin","year":"2011","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"7","key":"10.1016\/j.redox.2026.104245_bib10","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/09553002.2019.1589653","article-title":"The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression","volume":"95","author":"Vaupel","year":"2019","journal-title":"Int. J. Radiat. Biol."},{"issue":"6","key":"10.1016\/j.redox.2026.104245_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.264","article-title":"Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells","volume":"5","author":"Caneba","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104245_bib12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.freeradbiomed.2014.11.012","article-title":"Cancer cell metabolism and the modulating effects of nitric oxide","volume":"79","author":"Chang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.redox.2026.104245_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25116103","article-title":"NOS2 and COX-2 Co-Expression promotes cancer progression: a potential target for developing agents to prevent or treat highly aggressive breast cancer","volume":"25","author":"Coutinho","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"49","key":"10.1016\/j.redox.2026.104245_bib14","doi-asserted-by":"crossref","first-page":"13030","DOI":"10.1073\/pnas.1709119114","article-title":"Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer","volume":"114","author":"Basudhar","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"2 Pt A","key":"10.1016\/j.redox.2026.104245_bib16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2014.04.001","article-title":"The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism","volume":"356","author":"Lu","year":"2015","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2008.03.020","article-title":"The chemical biology of nitric oxide: implications in cellular signaling","volume":"45","author":"Thomas","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2026.104245_bib18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2015.06.002","article-title":"Signaling and stress: the redox landscape in NOS2 biology","volume":"87","author":"Thomas","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"4 Pt 1","key":"10.1016\/j.redox.2026.104245_bib19","doi-asserted-by":"crossref","first-page":"C1077","DOI":"10.1152\/ajpcell.1992.262.4.C1077","article-title":"Association between synthesis and release of cGMP and nitric oxide biosynthesis by hepatocytes","volume":"262","author":"Billiar","year":"1992","journal-title":"Am. J. Physiol."},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.trecan.2017.07.005","article-title":"Nitric oxide: the forgotten child of tumor metabolism","volume":"3","author":"Salimian","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.redox.2026.104245_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113769","article-title":"Nitric oxide and tumor metabolic reprogramming","volume":"176","author":"Lopez-Sanchez","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib22","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1172\/JCI112642","article-title":"Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible","volume":"78","author":"Drapier","year":"1986","journal-title":"J. Clin. Investig."},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib23","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1084\/jem.169.5.1543","article-title":"Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells","volume":"169","author":"Stuehr","year":"1989","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib24","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1172\/JCI115666","article-title":"Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy","volume":"89","author":"Hibbs","year":"1992","journal-title":"J. Clin. Investig."},{"issue":"22","key":"10.1016\/j.redox.2026.104245_bib25","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1073\/pnas.82.22.7738","article-title":"Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide","volume":"82","author":"Stuehr","year":"1985","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"18","key":"10.1016\/j.redox.2026.104245_bib26","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1073\/pnas.84.18.6369","article-title":"Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst","volume":"84","author":"Iyengar","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.redox.2026.104245_bib27","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/carcin\/8.7.955","article-title":"Nitrosation of amines by stimulated macrophages","volume":"8","author":"Miwa","year":"1987","journal-title":"Carcinogenesis"},{"issue":"21","key":"10.1016\/j.redox.2026.104245_bib28","first-page":"5590","article-title":"Synthesis of nitrite and nitrate in murine macrophage cell lines","volume":"47","author":"Stuehr","year":"1987","journal-title":"Cancer Res."},{"issue":"13","key":"10.1016\/j.redox.2026.104245_bib29","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1084\/jem.20413fta","article-title":"Macrophages and nitric oxide: a deadly combination","volume":"204","author":"Ruttimann","year":"2007","journal-title":"J. Exp. Med."},{"issue":"17","key":"10.1016\/j.redox.2026.104245_bib30","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.1073\/pnas.1401799111","article-title":"Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression","volume":"111","author":"Heinecke","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"20","key":"10.1016\/j.redox.2026.104245_bib31","doi-asserted-by":"crossref","first-page":"33047","DOI":"10.18632\/oncotarget.16523","article-title":"iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.redox.2026.104245_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1165326","article-title":"Uncoupled nitric oxide synthase activity promotes colorectal cancer progression","volume":"13","author":"Alam","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.redox.2026.104245_bib33","article-title":"Ferroptosis regulator NOS2 is closely associated with the prognosis and cell malignant behaviors of hepatoblastoma: a bioinformatic and in vitro study","volume":"13","author":"Zhang","year":"2023","journal-title":"Front. Oncol."},{"issue":"16","key":"10.1016\/j.redox.2026.104245_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.193091","article-title":"Elevated tumor NOS2\/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER- breast cancer","volume":"10","author":"Ridnour","year":"2025","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.redox.2026.104245_bib35","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1089\/ars.2018.7527","article-title":"Molecular mechanisms of nitric oxide in cancer progression, signal transduction, and metabolism","volume":"30","author":"Somasundaram","year":"2019","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41419-023-05834-9","article-title":"Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome","volume":"14","author":"Cheng","year":"2023","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.redox.2026.104245_bib37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1089\/ars.2000.2.4-673","article-title":"Nitric oxide induces a decrease in the mitochondrial membrane potential of peripheral blood lymphocytes, especially in natural killer cells","volume":"2","author":"Takabayashi","year":"2000","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib38","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.1038\/s41467-023-40738-4","article-title":"Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming","volume":"14","author":"Palmieri","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104245_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113885","article-title":"Mitophagy contributes to alpha-tocopheryl succinate toxicity in GSNOR-deficient hepatocellular carcinoma","volume":"176","author":"Rizza","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"22","key":"10.1016\/j.redox.2026.104245_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225774","article-title":"Pyruvate dehydrogenase and tricarboxylic acid cycle enzymes are sensitive targets of traumatic brain injury induced metabolic derangement","volume":"20","author":"Lazzarino","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib41","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41467-020-14433-7","article-title":"Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase","volume":"11","author":"Palmieri","year":"2020","journal-title":"Nat. Commun."},{"issue":"Pt 3","key":"10.1016\/j.redox.2026.104245_bib42","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1042\/BJ20051435","article-title":"Direct evidence for S-nitrosation of mitochondrial complex I","volume":"394","author":"Burwell","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.redox.2026.104245_bib43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.redox.2016.09.005","article-title":"Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production","volume":"10","author":"Baseler","year":"2016","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib44","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.bbabio.2010.01.033","article-title":"Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells","volume":"1797","author":"Aguirre","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26052050","article-title":"Nitroxidative stress, cell-signaling pathways, and manganese porphyrins: therapeutic potential in neuropathic pain","volume":"26","author":"Silva","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib46","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1089\/152308603322110878","article-title":"Interactions of mitochondrial thiols with nitric oxide","volume":"5","author":"Costa","year":"2003","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib47","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1423-0127-16-70","article-title":"Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release","volume":"16","author":"Borutaite","year":"2009","journal-title":"J. Biomed. Sci."},{"issue":"18","key":"10.1016\/j.redox.2026.104245_bib48","doi-asserted-by":"crossref","first-page":"11098","DOI":"10.1016\/S0021-9258(17)44390-0","article-title":"The role of iron in the activation-inactivation of aconitase","volume":"258","author":"Kennedy","year":"1983","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib49","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.celrep.2019.06.018","article-title":"Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation","volume":"28","author":"Bailey","year":"2019","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.redox.2026.104245_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10110429","article-title":"Nitric oxide in macrophage immunometabolism: hiding in Plain sight","volume":"10","author":"Palmieri","year":"2020","journal-title":"Metabolites"},{"issue":"16","key":"10.1016\/j.redox.2026.104245_bib51","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1073\/pnas.1430507100","article-title":"A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system","volume":"100","author":"Miranda","year":"2003","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.redox.2026.104245_bib52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.abb.2016.08.014","article-title":"The chemical biology of HNO signaling","volume":"617","author":"Bianco","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"issue":"16","key":"10.1016\/j.redox.2026.104245_bib53","doi-asserted-by":"crossref","first-page":"8971","DOI":"10.1016\/S0021-9258(19)38795-2","article-title":"Structure-function relationships in dihydrolipoamide acyltransferases","volume":"265","author":"Reed","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","article-title":"Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase","volume":"7","author":"Selak","year":"2005","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib55","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1128\/MCB.01927-06","article-title":"Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells","volume":"27","author":"MacKenzie","year":"2007","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib56","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/BJ20111275","article-title":"The mitochondrial citrate carrier: a new player in inflammation","volume":"438","author":"Infantino","year":"2011","journal-title":"Biochem. J."},{"issue":"7444","key":"10.1016\/j.redox.2026.104245_bib57","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.redox.2026.104245_bib58","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ni.2833","article-title":"TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation","volume":"15","author":"Everts","year":"2014","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib59","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ni.3796","article-title":"alpha-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","volume":"18","author":"Liu","year":"2017","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib60","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0014-5793(94)00424-2","article-title":"Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases","volume":"345","author":"Cleeter","year":"1994","journal-title":"FEBS Lett."},{"issue":"2\u20133","key":"10.1016\/j.redox.2026.104245_bib61","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-5793(94)01290-3","article-title":"Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase","volume":"356","author":"Brown","year":"1994","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib62","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/bbrc.1994.2441","article-title":"Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension","volume":"204","author":"Schweizer","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib63","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/abbi.1994.1013","article-title":"Inhibition of mitochondrial electron transport by peroxynitrite","volume":"308","author":"Radi","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"issue":"31","key":"10.1016\/j.redox.2026.104245_bib64","doi-asserted-by":"crossref","first-page":"28799","DOI":"10.1074\/jbc.M102341200","article-title":"Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo","volume":"276","author":"Jourd'heuil","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"36","key":"10.1016\/j.redox.2026.104245_bib65","doi-asserted-by":"crossref","first-page":"25984","DOI":"10.1074\/jbc.M602242200","article-title":"Superoxide fluxes limit nitric oxide-induced signaling","volume":"281","author":"Thomas","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.redox.2026.104245_bib66","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1089\/ars.2013.5305","article-title":"MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx","volume":"20","author":"Candas","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.redox.2026.104245_bib67","first-page":"1022","article-title":"Impact of superoxide dismutase on nitric oxide and peroxynitrite levels in the microcirculation--a computational model","volume":"2007","author":"Chavez","year":"2007","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"issue":"10","key":"10.1016\/j.redox.2026.104245_bib68","doi-asserted-by":"crossref","first-page":"7114","DOI":"10.3390\/ijms12107114","article-title":"Manganese superoxide dismutase: guardian of the powerhouse","volume":"12","author":"Holley","year":"2011","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.redox.2026.104245_bib69","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ncb2114","article-title":"GAPDH mediates nitrosylation of nuclear proteins","volume":"12","author":"Kornberg","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"26","key":"10.1016\/j.redox.2026.104245_bib70","doi-asserted-by":"crossref","first-page":"15294","DOI":"10.1073\/pnas.261560998","article-title":"Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection","volume":"98","author":"Almeida","year":"2001","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"23","key":"10.1016\/j.redox.2026.104245_bib71","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1182\/blood-2009-10-249540","article-title":"Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation","volume":"115","author":"Krawczyk","year":"2010","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.redox.2026.104245_bib72","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1182\/blood-2012-03-419747","article-title":"Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells","volume":"120","author":"Everts","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.redox.2026.104245_bib73","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.canlet.2017.10.032","article-title":"The role of nitric oxide in metabolic regulation of dendritic cell immune function","volume":"412","author":"Thwe","year":"2018","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib74","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1109\/TBME.2016.2607183","article-title":"Stem cell plasticity and niche dynamics in cancer progression","volume":"64","author":"Picco","year":"2017","journal-title":"IEEE Trans. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib75","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2337\/diabetes.50.1.123","article-title":"Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats","volume":"50","author":"Dobbins","year":"2001","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib76","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/cdd.2012.34","article-title":"Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation","volume":"19","author":"Boren","year":"2012","journal-title":"Cell Death Differ."},{"issue":"25","key":"10.1016\/j.redox.2026.104245_bib77","doi-asserted-by":"crossref","first-page":"10258","DOI":"10.1073\/pnas.1222404110","article-title":"MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells","volume":"110","author":"Zirath","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.redox.2026.104245_bib78","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fimmu.2020.00131","article-title":"Classical Activation of Macrophages Leads to Lipid Droplet Formation Without de novo Fatty Acid Synthesis","volume":"11","author":"Rosas-Ballina","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.redox.2026.104245_bib79","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1194\/jlr.M065805","article-title":"S-nitrosylation of fatty acid synthase regulates its activity through dimerization","volume":"57","author":"Choi","year":"2016","journal-title":"J. Lipid Res."},{"issue":"8","key":"10.1016\/j.redox.2026.104245_bib80","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1091\/mbc.e02-12-0791","article-title":"Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases","volume":"14","author":"Metzen","year":"2003","journal-title":"Mol. Biol. Cell"},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib81","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s00424-024-02953-w","article-title":"Hypoxia-inducible factor-driven glycolytic adaptations in host-microbe interactions","volume":"476","author":"DeMichele","year":"2024","journal-title":"Pflugers Arch."},{"issue":"16","key":"10.1016\/j.redox.2026.104245_bib82","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.7150\/ijbs.75434","article-title":"Lactylation of PKM2 suppresses inflammatory metabolic adaptation in pro-inflammatory macrophages","volume":"18","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib83","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4161\/jkst.20662","article-title":"PKM2, STAT3 and HIF-1alpha: the Warburg's vicious circle","volume":"1","author":"Demaria","year":"2012","journal-title":"JAK-STAT"},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib84","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1158\/1541-7786.MCR-12-0124","article-title":"S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer","volume":"10","author":"Switzer","year":"2012","journal-title":"Mol. Cancer Res."},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib85","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2337\/db06-0900","article-title":"The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic","volume":"56","author":"Thong","year":"2007","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib86","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.semcancer.2008.11.010","article-title":"Is Akt the \"Warburg kinase\"?-Akt-energy metabolism interactions and oncogenesis","volume":"19","author":"Robey","year":"2009","journal-title":"Semin. Cancer Biol."},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib87","doi-asserted-by":"crossref","DOI":"10.1186\/bcr3319","article-title":"Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer","volume":"14","author":"Switzer","year":"2012","journal-title":"Breast Cancer Res."},{"issue":"12","key":"10.1016\/j.redox.2026.104245_bib88","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/ncb2629","article-title":"ERK1\/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect","volume":"14","author":"Yang","year":"2012","journal-title":"Nat. Cell Biol."},{"issue":"13","key":"10.1016\/j.redox.2026.104245_bib89","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/s41388-018-0582-8","article-title":"The ERK and JNK pathways in the regulation of metabolic reprogramming","volume":"38","author":"Papa","year":"2019","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.redox.2026.104245_bib90","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.exphem.2015.03.005","article-title":"Negative regulation of the LKB1\/AMPK pathway by ERK in human acute myeloid leukemia cells","volume":"43","author":"Kawashima","year":"2015","journal-title":"Exp. Hematol."},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib91","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41419-017-0250-x","article-title":"ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells","volume":"9","author":"Chang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib92","first-page":"2142","article-title":"Regulation of transforming growth factor beta1 by nitric oxide","volume":"59","author":"Vodovotz","year":"1999","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.redox.2026.104245_bib93","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s00018-019-03398-6","article-title":"TGFbeta-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer","volume":"77","author":"Hua","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib94","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s13046-021-02188-y","article-title":"HIF-1alpha switches the functionality of TGF-beta signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer","volume":"40","author":"Huang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13030401","article-title":"TGF-beta in cancer: Metabolic driver of the tolerogenic crosstalk in the tumor microenvironment","volume":"13","author":"Angioni","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.redox.2026.104245_bib96","article-title":"The interplay between TGF-beta signaling and cell metabolism","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib97","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2006.05.036","article-title":"TIGAR, a p53-inducible regulator of glycolysis and apoptosis","volume":"126","author":"Bensaad","year":"2006","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.redox.2026.104245_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10060189","article-title":"The roles of p53 in mitochondrial dynamics and cancer metabolism: the pendulum between survival and death in breast cancer?","volume":"10","author":"Moulder","year":"2018","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib99","doi-asserted-by":"crossref","first-page":"705","DOI":"10.18632\/oncotarget.974","article-title":"P53 mutations in advanced cancers: clinical characteristics, outcomes, and correlation between progression-free survival and bevacizumab-containing therapy","volume":"4","author":"Said","year":"2013","journal-title":"Oncotarget"},{"issue":"Pt 1","key":"10.1016\/j.redox.2026.104245_bib100","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1042\/bj3190299","article-title":"Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways","volume":"319","author":"Messmer","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.redox.2026.104245_bib101","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fimmu.2014.00532","article-title":"Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages","volume":"5","author":"Rath","year":"2014","journal-title":"Front. Immunol."},{"issue":"15","key":"10.1016\/j.redox.2026.104245_bib102","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1523\/JNEUROSCI.4668-14.2015","article-title":"Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease","volume":"35","author":"Kan","year":"2015","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib103","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1006\/bbrc.2000.3169","article-title":"Regulation of nitric oxide production by arginine metabolic enzymes","volume":"275","author":"Mori","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Pt 1","key":"10.1016\/j.redox.2026.104245_bib104","first-page":"1","article-title":"Arginine metabolism: nitric oxide and beyond","volume":"336","author":"Wu","year":"1998","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.redox.2026.104245_bib105","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1084\/jem.193.6.777","article-title":"The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages","volume":"193","author":"Iniesta","year":"2001","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.redox.2026.104245_bib106","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/labinvest.2016.62","article-title":"Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation","volume":"96","author":"Lasch","year":"2016","journal-title":"Lab. Invest."},{"issue":"10","key":"10.1016\/j.redox.2026.104245_bib107","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1158\/2767-9764.CRC-24-0235","article-title":"Tumor NOS2 and COX2 spatial juxtaposition with CD8+ T cells promote metastatic and cancer stem cell niches that lead to poor outcome in ER- breast cancer","volume":"4","author":"Ridnour","year":"2024","journal-title":"Cancer Res. Commun."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib108","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-03446-1","article-title":"Metabolomic reprogramming of the tumor microenvironment by dual arginase inhibitor OATD-02 boosts anticancer immunity","volume":"15","author":"Grzybowski","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib109","article-title":"Role of polyamines in immune cell functions","volume":"6","author":"Hesterberg","year":"2018","journal-title":"Med. Sci."},{"key":"10.1016\/j.redox.2026.104245_bib110","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3389\/fonc.2018.00549","article-title":"Iron in the tumor microenvironment-connecting the dots","volume":"8","author":"Pfeifhofer-Obermair","year":"2018","journal-title":"Front. Oncol."},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib111","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1021\/acs.accounts.9b00150","article-title":"Aconitases: Non-redox iron-sulfur proteins sensitive to reactive species","volume":"52","author":"Castro","year":"2019","journal-title":"Acc. Chem. Res."},{"issue":"43","key":"10.1016\/j.redox.2026.104245_bib112","doi-asserted-by":"crossref","first-page":"28926","DOI":"10.1074\/jbc.M707862200","article-title":"Nitric oxide-induced conversion of cellular chelatable iron into macromolecule-bound paramagnetic dinitrosyliron complexes","volume":"283","author":"Toledo","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.redox.2026.104245_bib113","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.freeradbiomed.2011.06.030","article-title":"Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance","volume":"51","author":"Hickok","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.redox.2026.104245_bib114","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1089\/ars.2012.4543","article-title":"Is S-nitrosocysteine a true surrogate for nitric oxide?","volume":"17","author":"Hickok","year":"2012","journal-title":"Antioxid Redox Signal"},{"issue":"182","key":"10.1016\/j.redox.2026.104245_bib115","doi-asserted-by":"crossref","DOI":"10.1126\/stke.2003.182.pe17","article-title":"Iron regulatory proteins as NO signal transducers","volume":"2003","author":"Bouton","year":"2003","journal-title":"Sci. STKE"},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib116","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","article-title":"Regulators of iron homeostasis: new players in metabolism, cell death, and disease","volume":"41","author":"Bogdan","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib117","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.molcel.2023.12.033","article-title":"Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide","volume":"84","author":"Russo","year":"2024","journal-title":"Mol Cell"},{"issue":"22","key":"10.1016\/j.redox.2026.104245_bib118","doi-asserted-by":"crossref","first-page":"16004","DOI":"10.1074\/jbc.M112.432294","article-title":"Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases","volume":"288","author":"Hickok","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib119","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1038\/s41467-025-56928-1","article-title":"Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome","volume":"16","author":"Palczewski","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104245_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102928","article-title":"Nitric oxide inhibits FTO demethylase activity to regulate N(6)-methyladenosine mRNA methylation","volume":"67","author":"Kuschman","year":"2023","journal-title":"Redox Biol."},{"issue":"24","key":"10.1016\/j.redox.2026.104245_bib121","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1158\/0008-5472.CAN-15-1582","article-title":"Nitric oxide regulates gene expression in cancers by controlling histone posttranslational modifications","volume":"75","author":"Vasudevan","year":"2015","journal-title":"Cancer Res."},{"issue":"24","key":"10.1016\/j.redox.2026.104245_bib122","doi-asserted-by":"crossref","first-page":"8894","DOI":"10.1073\/pnas.0400453101","article-title":"Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide","volume":"101","author":"Thomas","year":"2004","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"48","key":"10.1016\/j.redox.2026.104245_bib123","doi-asserted-by":"crossref","first-page":"41413","DOI":"10.1074\/jbc.M111.287052","article-title":"Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron","volume":"286","author":"Hickok","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib124","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1074\/jbc.M115.689653","article-title":"The metastasis suppressor, N-MYC downstream-regulated Gene-1 (NDRG1), down-regulates the ErbB family of receptors to inhibit downstream oncogenic signaling pathways","volume":"291","author":"Kovacevic","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib125","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/carcin\/bgr046","article-title":"The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms","volume":"32","author":"Kovacevic","year":"2011","journal-title":"Carcinogenesis"},{"issue":"7","key":"10.1016\/j.redox.2026.104245_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110230","article-title":"NDRG1 and its family members: more than just metastasis suppressor proteins and targets of thiosemicarbazones","volume":"301","author":"Azad","year":"2025","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib127","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/ars.2016.6693","article-title":"Structure and activation of soluble guanylyl cyclase, the nitric oxide sensor","volume":"26","author":"Montfort","year":"2017","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib128","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1038\/s41467-021-25617-0","article-title":"Activation mechanism of human soluble guanylate cyclase by stimulators and activators","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"issue":"29","key":"10.1016\/j.redox.2026.104245_bib129","doi-asserted-by":"crossref","first-page":"9892","DOI":"10.1073\/pnas.0804257105","article-title":"Interaction of nitric oxide with a functional model of cytochrome c oxidase","volume":"105","author":"Collman","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"25","key":"10.1016\/j.redox.2026.104245_bib130","doi-asserted-by":"crossref","first-page":"8524","DOI":"10.1074\/jbc.RA119.011988","article-title":"Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants","volume":"295","author":"Kalous","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2026.104245_bib131","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.763417","article-title":"Sirtuin oxidative post-translational modifications","volume":"12","author":"Kalous","year":"2021","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib132","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1104\/pp.16.01734","article-title":"Nitric oxide modulates histone acetylation at stress genes by inhibition of histone deacetylases","volume":"173","author":"Mengel","year":"2017","journal-title":"Plant Physiol."},{"issue":"12","key":"10.1016\/j.redox.2026.104245_bib133","doi-asserted-by":"crossref","DOI":"10.3390\/life11121424","article-title":"Pillars and gaps of S-Nitrosylation-Dependent epigenetic regulation in physiology and cancer","volume":"11","author":"Salvatori","year":"2021","journal-title":"Life"},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib134","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12030771","article-title":"Nutriepigenomics in environmental-associated oxidative stress","volume":"12","author":"Rubio","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2026.104245_bib135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.niox.2018.03.003","article-title":"Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes","volume":"76","author":"Sahni","year":"2018","journal-title":"Nitric Oxide"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib136","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.redox.2012.11.002","article-title":"Oxygen dependence of nitric oxide-mediated signaling","volume":"1","author":"Hickok","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104245_bib137","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.redox.2015.05.002","article-title":"Breathing new life into nitric oxide signaling: a brief overview of the interplay between oxygen and nitric oxide","volume":"5","author":"Thomas","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104245_bib138","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101354","article-title":"Inducible nitric oxide synthase-derived extracellular nitric oxide flux regulates proinflammatory responses at the single cell level","volume":"28","author":"Somasundaram","year":"2020","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.redox.2026.104245_bib139","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.4049\/jimmunol.1301758","article-title":"Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses","volume":"192","author":"Gross","year":"2014","journal-title":"J. Immunol."},{"issue":"5\u20136","key":"10.1016\/j.redox.2026.104245_bib140","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1089\/ars.2006.8.893","article-title":"Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background","volume":"8","author":"Vitek","year":"2006","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib141","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0022-3565(25)12266-0","article-title":"Determination of Km for oxygen of nitric oxide synthase isoforms","volume":"276","author":"Rengasamy","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"issue":"23","key":"10.1016\/j.redox.2026.104245_bib142","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1021\/bi010066m","article-title":"Regulation of inducible nitric oxide synthase by self-generated NO","volume":"40","author":"Abu-Soud","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.redox.2026.104245_bib143","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1750-1326-9-50","article-title":"The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment","volume":"9","author":"Hoos","year":"2014","journal-title":"Mol. Neurodegener."},{"issue":"47","key":"10.1016\/j.redox.2026.104245_bib144","doi-asserted-by":"crossref","first-page":"30114","DOI":"10.1074\/jbc.271.47.30114","article-title":"Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes. Requirement of NF-kappaB activation after stimulation with bacterial cell wall products and phorbol esters","volume":"271","author":"Diaz-Guerra","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"15","key":"10.1016\/j.redox.2026.104245_bib145","doi-asserted-by":"crossref","first-page":"8638","DOI":"10.1073\/pnas.151239498","article-title":"Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B","volume":"98","author":"Ganster","year":"2001","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib146","doi-asserted-by":"crossref","first-page":"L137","DOI":"10.1152\/ajplung.00441.2002","article-title":"STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation","volume":"285","author":"Xu","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib147","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.immuni.2010.07.001","article-title":"Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression","volume":"33","author":"Farlik","year":"2010","journal-title":"Immunity"},{"issue":"21","key":"10.1016\/j.redox.2026.104245_bib148","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1158\/0008-5472.CAN-13-1620","article-title":"Nitric oxide production upregulates Wnt\/beta-catenin signaling by inhibiting Dickkopf-1","volume":"73","author":"Du","year":"2013","journal-title":"Cancer Res."},{"issue":"14","key":"10.1016\/j.redox.2026.104245_bib149","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1158\/0008-5472.CAN-05-4110","article-title":"Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling","volume":"66","author":"Du","year":"2006","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gde.2008.01.020","article-title":"NF-kappaB and cancer-identifying targets and mechanisms","volume":"18","author":"Naugler","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib151","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s42003-021-01954-0","article-title":"An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients","volume":"4","author":"Gilmore","year":"2021","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib152","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.celrep.2016.12.037","article-title":"The anti-warburg effect elicited by the cAMP-PGC1alpha pathway drives differentiation of glioblastoma cells into astrocytes","volume":"18","author":"Xing","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104245_bib153","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fcell.2017.00043","article-title":"Metabolic reprogramming in Glioma","volume":"5","author":"Strickland","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib154","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020473","article-title":"Regulation of mitochondrial homeostasis by sAC-Derived cAMP pool: basic and translational aspects","volume":"10","author":"Aslam","year":"2021","journal-title":"Cells"},{"issue":"21","key":"10.1016\/j.redox.2026.104245_bib155","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.1158\/0008-5472.CAN-11-1011","article-title":"PGC1alpha promotes tumor growth by inducing gene expression programs supporting lipogenesis","volume":"71","author":"Bhalla","year":"2011","journal-title":"Cancer Res."},{"issue":"22","key":"10.1016\/j.redox.2026.104245_bib156","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1111\/bph.13331","article-title":"Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?","volume":"172","author":"O'Callaghan","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib157","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.apsb.2023.12.003","article-title":"Targeting the Warburg effect: a revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer","volume":"14","author":"Liao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib158","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13045-024-01524-x","article-title":"cAMP-PKA\/EPAC signaling and cancer: the interplay in tumor microenvironment","volume":"17","author":"Zhang","year":"2024","journal-title":"J. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib159","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12307-011-0063-x","article-title":"Nitric Oxide (NO) and Cyclooxygenase-2 (COX-2) cross-talk in Co-Cultures of tumor spheroids with normal cells","volume":"4","author":"Paduch","year":"2011","journal-title":"Cancer Microenviron"},{"issue":"4","key":"10.1016\/j.redox.2026.104245_bib160","doi-asserted-by":"crossref","DOI":"10.3945\/ajcn.110.001917","article-title":"Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis","volume":"93","author":"Fernandez-Marcos","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbabio.2022.148931","article-title":"The Warburg effect and mitochondrial oxidative phosphorylation: friends or foes?","volume":"1864","author":"Martins Pinto","year":"2023","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib162","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1053\/j.seminoncol.2017.10.004","article-title":"Metabolic coupling and the Reverse Warburg Effect in cancer: implications for novel biomarker and anticancer agent development","volume":"44","author":"Wilde","year":"2017","journal-title":"Semin. Oncol."},{"issue":"6","key":"10.1016\/j.redox.2026.104245_bib163","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2022.5357","article-title":"'Reverse Warburg effect' of cancer-associated fibroblasts","volume":"60","author":"Liang","year":"2022","journal-title":"Int. J. Oncol."},{"issue":"11","key":"10.1016\/j.redox.2026.104245_bib164","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1089\/ars.2011.4243","article-title":"Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis","volume":"16","author":"Pavlides","year":"2012","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib165","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3892\/ijo.2015.3225","article-title":"Interleukin-6 stimulates aerobic glycolysis by regulating PFKFB3 at early stage of colorectal cancer","volume":"48","author":"Han","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.redox.2026.104245_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107692","article-title":"Interleukin-8: a chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression","volume":"219","author":"Fousek","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.redox.2026.104245_bib167","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/cac2.12549","article-title":"The regulatory roles and clinical significance of glycolysis in tumor","volume":"44","author":"Qiao","year":"2024","journal-title":"Cancer Commun."},{"issue":"4","key":"10.1016\/j.redox.2026.104245_bib168","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.pan.2017.04.013","article-title":"Tumour-associated macrophages activate migration and STAT3 in pancreatic ductal adenocarcinoma cells in co-cultures","volume":"17","author":"Salmiheimo","year":"2017","journal-title":"Pancreatology"},{"key":"10.1016\/j.redox.2026.104245_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216784","article-title":"Tumor-associated macrophages drive glycolysis through the IL-8\/STAT3\/GLUT3 signaling pathway in pancreatic cancer progression","volume":"588","author":"Zhong","year":"2024","journal-title":"Cancer Lett."},{"issue":"24","key":"10.1016\/j.redox.2026.104245_bib170","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.4161\/cc.10.24.18487","article-title":"Energy transfer in \"parasitic\" cancer metabolism: mitochondria are the powerhouse and Achilles' heel of tumor cells","volume":"10","author":"Martinez-Outschoorn","year":"2011","journal-title":"Cell Cycle"},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib171","first-page":"763","article-title":"Classifying the linkage between adipose tissue inflammation and tumor growth through cancer-associated adipocytes","volume":"43","author":"Song","year":"2020","journal-title":"Mol. Cells"},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib172","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/bjc.2013.748","article-title":"Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction","volume":"110","author":"Nagasaki","year":"2014","journal-title":"Br. J. Cancer"},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib173","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41419-023-06110-6","article-title":"Stromal cells in the tumor microenvironment: accomplices of tumor progression?","volume":"14","author":"Zhao","year":"2023","journal-title":"Cell Death Dis."},{"issue":"37","key":"10.1016\/j.redox.2026.104245_bib174","doi-asserted-by":"crossref","first-page":"13141","DOI":"10.1073\/pnas.0502977102","article-title":"Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner","volume":"102","author":"Isenberg","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"37","key":"10.1016\/j.redox.2026.104245_bib175","doi-asserted-by":"crossref","first-page":"13147","DOI":"10.1073\/pnas.0502979102","article-title":"Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1","volume":"102","author":"Ridnour","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2026.104245_bib176","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.matbio.2017.12.009","article-title":"Thrombospondin-1 regulation of latent TGF-beta activation: a therapeutic target for fibrotic disease","volume":"68\u201369","author":"Murphy-Ullrich","year":"2018","journal-title":"Matrix Biol."},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib177","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1470-2045(00)00256-4","article-title":"Role of nitric oxide in carcinogenesis and tumour progression","volume":"2","author":"Lala","year":"2001","journal-title":"Lancet Oncol."},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib178","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0002-9440(10)63699-1","article-title":"Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma","volume":"163","author":"Gallo","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.redox.2026.104245_bib179","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1073\/pnas.93.6.2442","article-title":"Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53","volume":"93","author":"Forrester","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.redox.2026.104245_bib180","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw292","article-title":"Role of RPL39 in metaplastic breast cancer","volume":"109","author":"Dave","year":"2017","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib181","doi-asserted-by":"crossref","DOI":"10.3390\/biom13020311","article-title":"Chronic exposure to nitric oxide induces P53 mutations and malignant-like features in human breast epithelial cells","volume":"13","author":"Cheng","year":"2023","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.redox.2026.104245_bib182","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.immuni.2025.02.008","article-title":"Lactate: a key regulator of the immune response","volume":"58","author":"Llibre","year":"2025","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib183","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1158\/0008-5472.CAN-14-1491","article-title":"l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells","volume":"75","author":"Fletcher","year":"2015","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.redox.2026.104245_bib184","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1172\/JCI131859","article-title":"Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells","volume":"130","author":"Oh","year":"2020","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib185","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s42255-020-00317-z","article-title":"Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism","volume":"3","author":"Elia","year":"2021","journal-title":"Nat. Metab."},{"issue":"4","key":"10.1016\/j.redox.2026.104245_bib186","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s10555-021-10007-1","article-title":"Extracellular citrate and metabolic adaptations of cancer cells","volume":"40","author":"Parkinson","year":"2021","journal-title":"Cancer Metastasis Rev."},{"issue":"9","key":"10.1016\/j.redox.2026.104245_bib187","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/aps.2010.151","article-title":"The role of p53 in cell metabolism","volume":"31","author":"Zhang","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.redox.2026.104245_bib188","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1096\/fasebj.11.6.9194524","article-title":"Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression","volume":"11","author":"Ambs","year":"1997","journal-title":"FASEB J."},{"issue":"21","key":"10.1016\/j.redox.2026.104245_bib189","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1158\/0008-5472.CAN-04-2212","article-title":"Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53","volume":"64","author":"Cook","year":"2004","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib190","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3390\/cancers2020274","article-title":"Oxidative and nitrosative stress in the metastatic microenvironment","volume":"2","author":"Ortega","year":"2010","journal-title":"Cancers (Basel)"},{"issue":"12","key":"10.1016\/j.redox.2026.104245_bib191","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/apm.13447","article-title":"Unraveling the intricacies of cancer-associated fibroblasts: a comprehensive review on metabolic reprogramming and tumor microenvironment crosstalk","volume":"132","author":"Ahuja","year":"2024","journal-title":"APMIS"},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib192","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41420-024-01872-0","article-title":"The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway","volume":"10","author":"Suman","year":"2024","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib193","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.redox.2026.104245_bib194","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10565-025-10025-7","article-title":"Lipotoxicity, lipid peroxidation and ferroptosis: a dilemma in cancer therapy","volume":"41","author":"Ma","year":"2025","journal-title":"Cell Biol. Toxicol."},{"issue":"12","key":"10.1016\/j.redox.2026.104245_bib195","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1101\/gad.191056.112","article-title":"Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors","volume":"26","author":"Xiao","year":"2012","journal-title":"Genes Dev."},{"issue":"11","key":"10.1016\/j.redox.2026.104245_bib196","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112960","article-title":"The metabolic control of Myeloid cells in the tumor microenvironment","volume":"10","author":"Ramel","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib197","first-page":"117","article-title":"S-Nitrosation mediates multiple pathways that lead to tumor progression in Estrogen receptor-negative breast cancer","volume":"3","author":"Switzer","year":"2012","journal-title":"For Immunopathol Dis Therap."},{"issue":"2","key":"10.1016\/j.redox.2026.104245_bib198","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.niox.2010.12.010","article-title":"Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease","volume":"25","author":"Olson","year":"2011","journal-title":"Nitric Oxide"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726002430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726002430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:50:39Z","timestamp":1785225039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726002430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":198,"alternative-id":["S2213231726002430"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104245","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide-driven Warburg reprogramming at the NOS2-COX2 axis: An integrative engine of cancer hallmarks","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104245"}}