{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:02:56Z","timestamp":1785225776987,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070462"],"award-info":[{"award-number":["82070462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300327"],"award-info":[{"award-number":["82300327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203172"],"award-info":[{"award-number":["82203172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.redox.2026.104250","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:41:22Z","timestamp":1780728082000},"page":"104250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fenofibrate attenuates hyperhomocysteinemia-potentiated thrombosis by restoring platelet fatty acid \u03b2-oxidation"],"prefix":"10.1016","volume":"95","author":[{"given":"Lulu","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"47\u201348","key":"10.1016\/j.redox.2026.104250_bib1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.4414\/smw.2006.11283","article-title":"Homocysteine as a risk factor for cardiovascular disease: should we (still) worry about?","volume":"136","author":"Faeh","year":"2006","journal-title":"Swiss Med. Wkly."},{"issue":"13","key":"10.1016\/j.redox.2026.104250_bib2","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jama.2015.2274","article-title":"Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial","volume":"313","author":"Huo","year":"2015","journal-title":"JAMA"},{"issue":"19","key":"10.1016\/j.redox.2026.104250_bib3","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1016\/j.jacc.2018.02.072","article-title":"Platelet count affects efficacy of folic acid in preventing first stroke","volume":"71","author":"Kong","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.redox.2026.104250_bib4","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/bph.13988","article-title":"Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets","volume":"175","author":"Fu","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.redox.2026.104250_bib5","first-page":"585","article-title":"Immunoregulatory effects of homocysteine on cardiovascular diseases","volume":"59","author":"Dai","year":"2007","journal-title":"Sheng Li Xue Bao : Acta Physiol. Sin."},{"key":"10.1016\/j.redox.2026.104250_bib6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-14-6","article-title":"Role of homocysteine in the development of cardiovascular disease","volume":"14","author":"Ganguly","year":"2015","journal-title":"Nutr. J."},{"issue":"1","key":"10.1016\/j.redox.2026.104250_bib7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41392-024-01817-0","article-title":"Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention","volume":"9","author":"Shi","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"5","key":"10.1016\/j.redox.2026.104250_bib8","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/01.ATV.20.5.1203","article-title":"Simultaneously increased TxA(2) activity in isolated arterioles and platelets of rats with hyperhomocysteinemia","volume":"20","author":"Ungvari","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.redox.2026.104250_bib9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.numecd.2019.09.018","article-title":"Homocysteine levels and platelet reactivity in coronary artery disease patients treated with ticagrelor","volume":"30","author":"Verdoia","year":"2020","journal-title":"Nutr. Metabol. Cardiovasc. Dis. : Nutr. Metabol. Cardiovasc. Dis."},{"issue":"5b","key":"10.1016\/j.redox.2026.104250_bib10","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1111\/j.1582-4934.2008.00200.x","article-title":"Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus","volume":"12","author":"Alexandru","year":"2008","journal-title":"J. Cell Mol. Med."},{"issue":"10","key":"10.1016\/j.redox.2026.104250_bib11","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/hc3501.095287","article-title":"Oxidative stress and platelet activation in homozygous homocystinuria","volume":"104","author":"Dav\u00ec","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.redox.2026.104250_bib12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1182\/bloodadvances.2021004572","article-title":"The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans","volume":"6","author":"Han","year":"2022","journal-title":"Blood Adv."},{"issue":"20","key":"10.1016\/j.redox.2026.104250_bib13","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1182\/blood.2024025593","article-title":"N-homocysteinylation of \u03b2-arrestins biases GPCR signaling and promotes platelet activation","volume":"145","author":"Zhang","year":"2025","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.redox.2026.104250_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/MOH.0000000000000820","article-title":"Platelet lipidomics and de novo lipogenesis: impact on health and disease","volume":"31","author":"Pirotton","year":"2024","journal-title":"Curr. Opin. Hematol."},{"issue":"5","key":"10.1016\/j.redox.2026.104250_bib15","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.cmet.2016.04.001","article-title":"Mapping the human platelet lipidome reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics during activation","volume":"23","author":"Slatter","year":"2016","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.redox.2026.104250_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123597","article-title":"Metabolic plasticity in resting and thrombin activated platelets","volume":"10","author":"Ravi","year":"2015","journal-title":"PLoS One"},{"issue":"210","key":"10.1016\/j.redox.2026.104250_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-29423-5_1","article-title":"Platelets: production, morphology and ultrastructure","author":"Thon","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"issue":"1","key":"10.1016\/j.redox.2026.104250_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.blre.2005.12.003","article-title":"The gray platelet syndrome: clinical spectrum of the disease","volume":"21","author":"Nurden","year":"2007","journal-title":"Blood Rev."},{"issue":"6","key":"10.1016\/j.redox.2026.104250_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061126","article-title":"The peroxisome-mitochondria connection: how and why?","volume":"18","author":"Fransen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.redox.2026.104250_bib20","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.tcb.2021.02.005","article-title":"Peroxisomes as cellular adaptors to metabolic and environmental stress","volume":"31","author":"He","year":"2021","journal-title":"Trends Cell Biol."},{"issue":"2","key":"10.1016\/j.redox.2026.104250_bib21","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqz046","article-title":"CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential","volume":"161","author":"Schlaepfer","year":"2020","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.redox.2026.104250_bib22","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrendo.2015.129","article-title":"Acylcarnitines--old actors auditioning for new roles in metabolic physiology","volume":"11","author":"McCoin","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"issue":"22","key":"10.1016\/j.redox.2026.104250_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213933","article-title":"Mitochondrial fatty acid \u03b2-Oxidation disorders: from disease to lipidomic Studies-A critical review","volume":"23","author":"Guerra","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.redox.2026.104250_bib24","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1182\/bloodadvances.2021006687","article-title":"CPT2 K79 acetylation regulates platelet life span","volume":"6","author":"Fan","year":"2022","journal-title":"Blood Adv."},{"issue":"14","key":"10.1016\/j.redox.2026.104250_bib25","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.2165\/11208090-000000000-00000","article-title":"Fenofibrate: a review of its use in dyslipidaemia","volume":"71","author":"McKeage","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.redox.2026.104250_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103994","article-title":"Fenofibrate attenuates the adverse effects of radiation on endothelial cells through modulation of ROS-NO signalling and inflammation","volume":"89","author":"Elsaeed","year":"2026","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.redox.2026.104250_bib27","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/s41588-025-02077-6","article-title":"Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma","volume":"57","author":"Liang","year":"2025","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.redox.2026.104250_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4049\/jimmunol.1600613","article-title":"Homocysteine activates B cells via regulating PKM2-Dependent metabolic reprogramming","volume":"198","author":"Deng","year":"2017","journal-title":"J. Immunol. (Baltimore, Md : 1950)"},{"issue":"6","key":"10.1016\/j.redox.2026.104250_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00109-018-1645-6","article-title":"PKM2-dependent metabolic reprogramming in CD4(+) T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis","volume":"96","author":"L\u00fc","year":"2018","journal-title":"J. Mol. Med. (Berlin, Germany)"},{"key":"10.1016\/j.redox.2026.104250_bib30","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.redox.2018.04.021","article-title":"GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation","volume":"17","author":"Li","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104250_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102257","article-title":"T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2","volume":"50","author":"Dang","year":"2022","journal-title":"Redox Biol."},{"issue":"11","key":"10.1016\/j.redox.2026.104250_bib32","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1093\/cvr\/cvz288","article-title":"B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinaemia-aggravated abdominal aortic aneurysm","volume":"116","author":"Shao","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.redox.2026.104250_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101742","article-title":"Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1\u03b1-ERO1\u03b1-dependent oxidative stress manner","volume":"37","author":"Yan","year":"2020","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.redox.2026.104250_bib34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/hep.28518","article-title":"Hyperhomocysteinemia activates the aryl hydrocarbon receptor\/CD36 pathway to promote hepatic steatosis in mice","volume":"64","author":"Yao","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2026.104250_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103892","article-title":"Beyond energy: mitochondrial control of platelet lifecycle through redox, calcium, and dynamics","volume":"87","author":"Wang","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104250_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2025.120555","article-title":"Not all fibrates are made equal: learning from biology and clinical trials","volume":"411","author":"Zambon","year":"2025","journal-title":"Atherosclerosis"},{"issue":"18","key":"10.1016\/j.redox.2026.104250_bib37","doi-asserted-by":"crossref","first-page":"4522","DOI":"10.1182\/bloodadvances.2020002493","article-title":"Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPAR\u03b1-dependent manner","volume":"4","author":"Yeung","year":"2020","journal-title":"Blood Adv."},{"issue":"9729","key":"10.1016\/j.redox.2026.104250_bib38","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/S0140-6736(10)60656-3","article-title":"Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis","volume":"375","author":"Jun","year":"2010","journal-title":"Lancet (London, England)"},{"issue":"3","key":"10.1016\/j.redox.2026.104250_bib39","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.cmet.2024.01.014","article-title":"Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin \u03b12\u03b21","volume":"36","author":"Huang","year":"2024","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.redox.2026.104250_bib40","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003620","article-title":"Serum acylcarnitines and risk of cardiovascular death and acute myocardial infarction in patients with stable angina pectoris","volume":"6","author":"Strand","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"21","key":"10.1016\/j.redox.2026.104250_bib41","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1161\/CIRCULATIONAHA.123.065409","article-title":"Scherer PE ceramides and atherosclerotic cardiovascular disease: a current perspective","volume":"149","author":"Zhu","year":"2024","journal-title":"Circulation"},{"issue":"8062","key":"10.1016\/j.redox.2026.104250_bib42","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41586-025-08792-8","article-title":"Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis","volume":"641","author":"Zhang","year":"2025","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.redox.2026.104250_bib43","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/s44161-023-00364-1","article-title":"Alkaline ceramidase 1-mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation","volume":"2","author":"Zhang","year":"2023","journal-title":"Nat. Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.redox.2026.104250_bib44","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.jtha.2025.01.020","article-title":"Platelet lipidomics indicates enhanced thrombocyte activation in patients with antiphospholipid syndrome in vivo","volume":"23","author":"Heimerl","year":"2025","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.redox.2026.104250_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2024.118569","article-title":"Phospholipid-derived lysophospholipids in (patho)physiology","volume":"398","author":"Prabutzki","year":"2024","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.redox.2026.104250_bib46","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/ehjcvp\/pvad090","article-title":"Associations of omega-3 fatty acids vs. fenofibrate with adverse cardiovascular outcomes in people with metabolic syndrome: propensity matched cohort study","volume":"10","author":"Kim","year":"2024","journal-title":"Eur. Heart J. Cardiovasc. Pharmacother."},{"issue":"1","key":"10.1016\/j.redox.2026.104250_bib47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12933-024-02353-5","article-title":"Fenofibrate's impact on cardiovascular risk in patients with diabetes: a nationwide propensity-score matched cohort study","volume":"23","author":"Hong","year":"2024","journal-title":"Cardiovasc. Diabetol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172600248X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221323172600248X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:48:03Z","timestamp":1785224883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221323172600248X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"alternative-id":["S221323172600248X"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104250","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fenofibrate attenuates hyperhomocysteinemia-potentiated thrombosis by restoring platelet fatty acid \u03b2-oxidation","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104250","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104250"}}