{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:18:26Z","timestamp":1788985106220,"version":"build-2803163510"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.redox.2026.104340","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:46:39Z","timestamp":1785912399000},"page":"104340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["S-Nitrosothiols modulate Porphyromonas gingivalis virulence"],"prefix":"10.1016","volume":"96","author":[{"given":"Tsian D.","family":"Ramrattan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan R.","family":"Stair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Dandu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Robert L.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quincy K.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-0658","authenticated-orcid":false,"given":"Mark H.","family":"Schoenfisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.redox.2026.104340_bib2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4103\/0972-124X.106878","article-title":"Periodontitis and systemic diseases: a literature review","volume":"16","author":"Arigbede","year":"2012","journal-title":"J. Indian Soc. Periodontol."},{"key":"10.1016\/j.redox.2026.104340_bib3","series-title":"Prevention in Clinical Oral Health Care","first-page":"213","article-title":"Prevention strategies for periodontal diseases","author":"Eden","year":"2008"},{"key":"10.1016\/j.redox.2026.104340_bib4","first-page":"1","article-title":"Global prevalence of periodontal disease and lack of its surveillance","volume":"2020","author":"Nazir","year":"2020","journal-title":"Sci. World J."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2016-000260","article-title":"Systemic inflammatory responses in patients with type 2 diabetes with chronic periodontitis","volume":"4","author":"Mesia","year":"2016","journal-title":"BMJ Open Diab Res Care"},{"key":"10.1016\/j.redox.2026.104340_bib6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ibneur.2024.12.004","article-title":"Association between Periodontitis and alzheimer's disease: a narrative review","volume":"18","author":"Seyedmoalemi","year":"2025","journal-title":"IBRO Neuroscience Reports"},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/milmed\/166.1.85","article-title":"Periodontal disease and its Association with systemic disease","volume":"166","author":"Fowler","year":"2001","journal-title":"Mil. Med."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1902\/annals.2001.6.1.9","article-title":"The Association between periodontal diseases and cardiovascular diseases: a state-of-the-science review","volume":"6","author":"Beck","year":"2001","journal-title":"Ann. Periodontol."},{"issue":"3","key":"10.1016\/j.redox.2026.104340_bib9","first-page":"101","article-title":"The periodontal infection-systemic disease link: a review of the truth or myth","volume":"4","author":"Paquette","year":"2002","journal-title":"J. Int. Acad. Periodontol."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41514-025-00319-9","article-title":"Taxonomic and functional signatures of smoking and periodontitis severity in the subgingival microbiome of older adults","volume":"12","author":"Moradi","year":"2025","journal-title":"npj Aging"},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/prd.12296","article-title":"The role of the microbiota in periodontal disease","volume":"83","author":"Curtis","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.redox.2026.104340_bib12","article-title":"Systemic, lifestyle and environmental modifying factors in the pathogenesis of periodontitis","author":"Sabine Elisabeth","year":"2025","journal-title":"J. Periodontal. Res."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/prd.12105","article-title":"Activation and resolution of periodontal inflammation and its systemic impact","volume":"69","author":"Hasturk","year":"2000","journal-title":"Periodontology"},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib14","doi-asserted-by":"crossref","first-page":"6222","DOI":"10.1038\/s41598-024-56849-x","article-title":"Defining Porphyromonas Gingivalis strains associated with periodontal disease","volume":"14","author":"Murugaiyan","year":"2024","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.redox.2026.104340_bib15","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3390\/pathogens11101173","article-title":"Porphyromonas Gingivalis virulence factors and clinical significance in periodontal disease and coronary artery diseases","volume":"11","author":"Aleksijevi\u0107","year":"2022","journal-title":"Pathogens"},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32603-y","article-title":"Impact of Porphyromonas Gingivalis peptidylarginine deiminase on bacterial biofilm Formation, epithelial cell invasion, and epithelial cell transcriptional landscape","volume":"8","author":"Aliko","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2026.104340_bib17","volume":"vol. 29","year":"2021"},{"issue":"5","key":"10.1016\/j.redox.2026.104340_bib18","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1128\/IAI.69.5.3048-3056.2001","article-title":"Porphyromonas Gingivalis gingipains and adhesion to epithelial cells","volume":"69","author":"Chen","year":"2001","journal-title":"Infect. Immun."},{"issue":"9","key":"10.1016\/j.redox.2026.104340_bib19","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3390\/microorganisms8091432","article-title":"Oral pathogen Porphyromonas Gingivalis can escape phagocytosis of Mammalian macrophages","volume":"8","author":"Werheim","year":"2020","journal-title":"Microorganisms"},{"issue":"5","key":"10.1016\/j.redox.2026.104340_bib20","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1128\/iai.65.5.1980-1984.1997","article-title":"A role for fimbriae in Porphyromonas Gingivalis invasion of oral epithelial cells","volume":"65","author":"Njoroge","year":"1997","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1128\/IAI.70.1.257-267.2002","article-title":"Fimbria-Dependent activation of cell adhesion molecule expression in Porphyromonas Gingivalis -Infected endothelial cells","volume":"70","author":"Khlgatian","year":"2002","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1556\/EuJMI.1.2011.1.7","article-title":"Gingipains from Porphyromonas Gingivalis \u2014 complex domain structures confer diverse functions","volume":"1","author":"Li","year":"2011","journal-title":"Eur. J. Microbiol. Immunol."},{"issue":"3","key":"10.1016\/j.redox.2026.104340_bib23","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1128\/IAI.73.3.1543-1552.2005","article-title":"Gingipains from Porphyromonas Gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells","volume":"73","author":"Sheets","year":"2005","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/0976-9668.82317","article-title":"Biofilm: a dental microbial infection","volume":"2","author":"Saini","year":"2011","journal-title":"J. Nat. Sci. Biol. Med."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4103\/jnsbm.JNSBM_88_17","article-title":"Periodontal flap surgery along with vestibular deepening with diode laser to increase attached Gingiva in lower anterior teeth: a prospective clinical Study","volume":"9","author":"Bhardwaj","year":"2018","journal-title":"J. Nat. Sci. Biol. Med."},{"issue":"suppl 2","key":"10.1016\/j.redox.2026.104340_bib26","first-page":"4","article-title":"Microbes, inflammation, scaling and root planing, and the periodontal condition","volume":"82","author":"Cobb","year":"2008","journal-title":"J. Dent. Hyg."},{"issue":"5","key":"10.1016\/j.redox.2026.104340_bib27","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s13238-018-0548-1","article-title":"Oral microbiomes: more and more importance in oral cavity and whole body","volume":"9","author":"Gao","year":"2018","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41368-022-00163-7","article-title":"Oral Microbiota in human systematic diseases","volume":"14","author":"Peng","year":"2022","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.redox.2026.104340_bib29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fcimb.2019.00074","article-title":"Recent advances in anti-virulence therapeutic strategies with a focus on dismantling bacterial membrane microdomains, toxin neutralization, quorum-sensing interference and biofilm inhibition","volume":"9","author":"Fleitas Mart\u00ednez","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"5","key":"10.1016\/j.redox.2026.104340_bib30","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/micr.20168","article-title":"Nitric oxide in wound-healing","volume":"25","author":"Isenberg","year":"2005","journal-title":"Microsurgery"},{"issue":"30","key":"10.1016\/j.redox.2026.104340_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202303259","article-title":"Nitric oxide: physiological functions, delivery, and biomedical applications","volume":"10","author":"Andrabi","year":"2023","journal-title":"Adv. Sci."},{"issue":"9","key":"10.1016\/j.redox.2026.104340_bib32","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41577-022-00694-4","article-title":"Immunomodulation by endothelial cells \u2014 partnering up with the immune System?","volume":"22","author":"Amersfoort","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.redox.2026.104340_bib33","first-page":"469","article-title":"Nitric oxide and superoxide in inflammation and immune regulation","volume":"54","author":"Guzik","year":"2003","journal-title":"J. Physiol. Pharmacol."},{"issue":"3","key":"10.1016\/j.redox.2026.104340_bib34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/07853899509002589","article-title":"Nitric oxide in inflammation and immune response","volume":"27","author":"Moilanen","year":"1995","journal-title":"Ann. Med."},{"issue":"3","key":"10.1016\/j.redox.2026.104340_bib35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/10715762.2015.1118473","article-title":"Mechanisms of nitric oxide crosstalk with reactive oxygen species scavenging enzymes during abiotic stress tolerance in plants","volume":"50","author":"Arora","year":"2016","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1021\/acsbiomaterials.9b01384","article-title":"Mode of nitric oxide delivery affects antibacterial action","volume":"6","author":"Hall","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"23","key":"10.1016\/j.redox.2026.104340_bib37","doi-asserted-by":"crossref","first-page":"7333","DOI":"10.1128\/JB.00975-09","article-title":"Nitric oxide signaling in Pseudomonas Aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic Di-GMP levels, and enhanced dispersal","volume":"191","author":"Barraud","year":"2009","journal-title":"J. Bacteriol."},{"issue":"21","key":"10.1016\/j.redox.2026.104340_bib38","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1128\/JB.00779-06","article-title":"Involvement of nitric oxide in biofilm dispersal of Pseudomonas Aeruginosa","volume":"188","author":"Barraud","year":"2006","journal-title":"J. Bacteriol."},{"issue":"5","key":"10.1016\/j.redox.2026.104340_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2024.107339","article-title":"Impact of nitric oxide donors on capsule, biofilm and resistance profiles of Klebsiella Pneumoniae","volume":"64","author":"Nguyen","year":"2024","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"3","key":"10.1016\/j.redox.2026.104340_bib40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.niox.2012.02.002","article-title":"Examination of bacterial resistance to exogenous nitric oxide","volume":"26","author":"Privett","year":"2012","journal-title":"Nitric Oxide"},{"issue":"9","key":"10.1016\/j.redox.2026.104340_bib41","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1021\/acs.molpharmaceut.9b00671","article-title":"In vivo antibacterial efficacy of nitric oxide-releasing hyperbranched polymers against Porphyromonas Gingivalis","volume":"16","author":"Yang","year":"2019","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.redox.2026.104340_bib42","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.dental.2020.03.012","article-title":"Antibacterial action of nitric oxide-releasing hyperbranched polymers against Ex vivo dental biofilms","volume":"36","author":"Yang","year":"2020","journal-title":"Dent. Mater."},{"issue":"4","key":"10.1016\/j.redox.2026.104340_bib43","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1021\/acsabm.8b00304","article-title":"Nitric oxide-releasing hyperbranched polyaminoglycosides for antibacterial therapy","volume":"1","author":"Yang","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"issue":"28","key":"10.1016\/j.redox.2026.104340_bib44","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1016\/j.biomaterials.2013.05.063","article-title":"Long-Term nitric oxide release and elevated temperature stability with S-Nitroso-N-Acetylpenicillamine (SNAP)-Doped Elast-Eon E2As polymer","volume":"34","author":"Brisbois","year":"2013","journal-title":"Biomaterials"},{"issue":"27","key":"10.1016\/j.redox.2026.104340_bib45","doi-asserted-by":"crossref","first-page":"30595","DOI":"10.1021\/acsami.2c06712","article-title":"Long-Term storage stability and nitric oxide release behavior of (N -Acetyl- S -Nitrosopenicillaminyl)- S -Nitrosopenicillamine-Incorporated silicone rubber coatings","volume":"14","author":"Kumar","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.redox.2026.104340_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01327-23","article-title":"Nitric oxide-releasing prodrug for the treatment of complex Mycobacterium Abscessus infections","volume":"68","author":"McDonald","year":"2024","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.redox.2026.104340_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101447","article-title":"NIR responsive nitric oxide nanogenerator for enhanced biofilm eradication and inflammation immunotherapy against periodontal diseases","volume":"43","author":"Qi","year":"2022","journal-title":"Nano Today"},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74977-y","article-title":"Quercetin inhibits virulence properties of porphyromas gingivalis in periodontal disease","volume":"10","author":"He","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.redox.2026.104340_bib49","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1128\/JB.06457-11","article-title":"Nitric oxide stress resistance in Porphyromonas Gingivalis is mediated by a putative hydroxylamine reductase","volume":"194","author":"Boutrin","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.redox.2026.104340_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.redox.2018.04.003","article-title":"The phosphorylated redox proteome of Chlamydomonas Reinhardtii: revealing novel means for regulation of protein structure and function","volume":"17","author":"McConnell","year":"2018","journal-title":"Redox Biol."},{"issue":"11","key":"10.1016\/j.redox.2026.104340_bib51","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmeth1113","article-title":"Semi-Supervised learning for peptide identification from shotgun proteomics datasets","volume":"4","author":"K\u00e4ll","year":"2007","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib52","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Stat. Soc. B Stat. Methodol."},{"issue":"10","key":"10.1016\/j.redox.2026.104340_bib53","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1128\/iai.63.10.3878-3885.1995","article-title":"Porphyromonas Gingivalis invasion of gingival epithelial cells","volume":"63","author":"Lamont","year":"1995","journal-title":"Infect. Immun."},{"issue":"31","key":"10.1016\/j.redox.2026.104340_bib54","doi-asserted-by":"crossref","first-page":"18596","DOI":"10.1074\/jbc.271.31.18596","article-title":"Mechanism of nitric oxide release from S-Nitrosothiols","volume":"271","author":"Singh","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.redox.2026.104340_bib55","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00319-19","article-title":"The distinct immune-stimulatory capacities of Porphyromonas Gingivalis strains 381 and ATCC 33277 are determined by the fimB allele and gingipain activity","volume":"87","author":"Coats","year":"2019","journal-title":"Infect. Immun."},{"key":"10.1016\/j.redox.2026.104340_bib56","series-title":"Site-Specific Protein Labeling","first-page":"29","article-title":"Getting across the cell membrane: an overview for small molecules, peptides, and proteins","volume":"1266","author":"Yang","year":"2015"},{"issue":"5","key":"10.1016\/j.redox.2026.104340_bib57","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1177\/1753425912440598","article-title":"Regulatory role of periodontal ligament fibroblasts for innate immune cell function and differentiation","volume":"18","author":"Konermann","year":"2012","journal-title":"Innate Immun."},{"key":"10.1016\/j.redox.2026.104340_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.763334","article-title":"Polarized macrophages in periodontitis: characteristics, function, and molecular signaling","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.redox.2026.104340_bib59","series-title":"Oral Mucosal Immunity and Microbiome","first-page":"55","article-title":"Gingival epithelial cell recognition of lipopolysaccharide","volume":"1197","author":"Kantrong","year":"2019"},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib60","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2172-3-3","article-title":"Auto-Protective Redox buffering systems in stimulated macrophages","volume":"3","author":"Ferret","year":"2002","journal-title":"BMC Immunol."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib61","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2017.1300366","article-title":"New approaches to combat Porphyromonas Gingivalis biofilms","volume":"9","author":"Gerits","year":"2017","journal-title":"J. Oral Microbiol."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib62","doi-asserted-by":"crossref","DOI":"10.5041\/RMMJ.10428","volume":"12","author":"Rath","year":"2021","journal-title":"Rambam Maimonides Med J"},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib63","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2022.2055523","article-title":"Anti-Biofilm activities of coumarin as quorum sensing inhibitor for Porphyromonas Gingivalis","volume":"14","author":"He","year":"2022","journal-title":"J. Oral Microbiol."},{"issue":"2","key":"10.1016\/j.redox.2026.104340_bib64","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-0765.2004.00719.x","article-title":"Variations of Porphyromonas Gingivalis fimbriae in relation to microbial pathogenesis","volume":"39","author":"Amano","year":"2004","journal-title":"J. Periodontal. Res."},{"issue":"9","key":"10.1016\/j.redox.2026.104340_bib65","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1034\/j.1600-051X.2003.00375.x","article-title":"Locally delivered minocycline microspheres for the treatment of periodontitis in smokers","volume":"30","author":"Paquette","year":"2003","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib66","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0757.1996.tb00072.x","article-title":"Local delivery of antimicrobial agents in the periodontal pocket","volume":"10","author":"Rams","year":"2000","journal-title":"Periodontology"},{"issue":"6","key":"10.1016\/j.redox.2026.104340_bib67","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.2041-1014.2011.00626.x","article-title":"Differential expression and adherence of Porphyromonas Gingivalis FimA genotypes","volume":"26","author":"Zheng","year":"2011","journal-title":"Molecular Oral Microbiology"},{"key":"10.1016\/j.redox.2026.104340_bib68","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fcimb.2017.00215","article-title":"The type IX secretion System (T9SS): highlights and recent insights into its structure and function","volume":"7","author":"Lasica","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"37","key":"10.1016\/j.redox.2026.104340_bib69","doi-asserted-by":"crossref","first-page":"43332","DOI":"10.1021\/acsami.3c07160","article-title":"Chemical modification of tiopronin for dual management of Cystinuria and associated bacterial infections","volume":"15","author":"Kumar","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"7","key":"10.1016\/j.redox.2026.104340_bib70","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/antiox10071111","article-title":"Biological mechanisms of S-Nitrosothiol Formation and degradation: how is specificity of S-Nitrosylation achieved?","volume":"10","author":"Massa","year":"2021","journal-title":"Antioxidants"},{"issue":"3","key":"10.1016\/j.redox.2026.104340_bib71","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.molcel.2017.12.019","article-title":"Evidence against stable protein S-Nitrosylation as a widespread mechanism of post-translational regulation","volume":"69","author":"Wolhuter","year":"2018","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.redox.2026.104340_bib72","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1042\/BST20120105","article-title":"Microscale gradients and their role in electron-transfer mechanisms in biofilms","volume":"40","author":"Beyenal","year":"2012","journal-title":"Biochem. Soc. Trans."},{"issue":"6","key":"10.1016\/j.redox.2026.104340_bib73","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2174\/1389203033487036","article-title":"The Major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes","volume":"4","author":"Potempa","year":"2003","journal-title":"CPPS"},{"issue":"4","key":"10.1016\/j.redox.2026.104340_bib74","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00572-18","article-title":"The Porphyromonas Gingivalis hybrid cluster protein Hcp is required for growth with nitrite and survival with host cells","volume":"87","author":"Belvin","year":"2019","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.redox.2026.104340_bib75","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/10454411010120020101","article-title":"Molecular strategies for fimbrial expression and assembly","volume":"12","author":"Wu","year":"2001","journal-title":"Crit. Rev. Oral Biol. Med."},{"issue":"9","key":"10.1016\/j.redox.2026.104340_bib76","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s00784-025-06472-5","article-title":"Gingipain inhibitors as an innovative therapy for periodontal and associated-systemic diseases: a systematic review","volume":"29","author":"Pedrosa","year":"2025","journal-title":"Clin. Oral Invest."},{"issue":"12","key":"10.1016\/j.redox.2026.104340_bib77","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1515\/hsz-2018-0215","article-title":"Host cell-surface proteins as substrates of gingipains, the main proteases of Porphyromonas Gingivalis","volume":"399","author":"Ho\u010devar","year":"2018","journal-title":"Biol. Chem."},{"issue":"2","key":"10.1016\/j.redox.2026.104340_bib78","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1128\/IAI.73.2.883-893.2005","article-title":"A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systems","volume":"73","author":"Takii","year":"2005","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.redox.2026.104340_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autrev.2015.08.009","article-title":"The critical role of toll-like receptors \u2014 from microbial recognition to autoimmunity: a comprehensive review","volume":"15","author":"Jim\u00e9nez-Dalmaroni","year":"2016","journal-title":"Autoimmun. Rev."},{"issue":"D1","key":"10.1016\/j.redox.2026.104340_bib80","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for Mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726003393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726003393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:03:51Z","timestamp":1788984231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726003393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":79,"alternative-id":["S2213231726003393"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104340","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S-Nitrosothiols modulate Porphyromonas gingivalis virulence","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104340","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104340"}}