{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:35:26Z","timestamp":1792931726225,"version":"4.5.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"US Department of War","doi-asserted-by":"publisher","award":["HT94252310443"],"award-info":[{"award-number":["HT94252310443"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG077396"],"award-info":[{"award-number":["R01AG077396"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS133688"],"award-info":[{"award-number":["R01NS133688"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS101967"],"award-info":[{"award-number":["R01NS101967"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.redox.2026.104378","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:33:41Z","timestamp":1788305621000},"page":"104378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["TLDc proteins: Stress-responsive nexus regulators of redox signaling, V-ATPase dynamics, and organellar crosstalk in neurodegeneration"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-5185","authenticated-orcid":false,"given":"Mohammad Sajid","family":"Ghufran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-3899","authenticated-orcid":false,"given":"Priyanka","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-9726","authenticated-orcid":false,"given":"Bobby","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41580-025-00873-w","article-title":"Lysosomal membrane homeostasis and its importance in physiology and disease","volume":"27","author":"Radulovic","year":"2026","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2026.104378_bib2","article-title":"Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivatives","volume":"13","author":"Zhang","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.redox.2026.104378_bib3","first-page":"2495","article-title":"Mitochondrial dysfunction in aging and age-related disorders","volume":"16","author":"Adlimoghaddam","year":"2025","journal-title":"Aging Dis"},{"issue":"3","key":"10.1016\/j.redox.2026.104378_bib4","first-page":"R203","article-title":"Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis","volume":"241","author":"Mink","year":"1981","journal-title":"Am. J. Physiol."},{"issue":"9\u201310","key":"10.1016\/j.redox.2026.104378_bib5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00335-017-9706-7","article-title":"TLDc proteins: new players in the oxidative stress response and neurological disease","volume":"28","author":"Finelli","year":"2017","journal-title":"Mamm. Genome"},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111515","article-title":"TBC1D24 interacts with the v-ATPase and regulates intraorganellar pH in neurons","volume":"28","author":"Pepe","year":"2025","journal-title":"iScience"},{"issue":"26","key":"10.1016\/j.redox.2026.104378_bib7","doi-asserted-by":"crossref","first-page":"14530","DOI":"10.1073\/pnas.260495897","article-title":"Functional genomics reveals a family of eukaryotic oxidation protection genes","volume":"97","author":"Volkert","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2026.104378_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.611904","article-title":"Preventing neurodegeneration by controlling oxidative stress: the role of OXR1","volume":"14","author":"Volkert","year":"2020","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.redox.2026.104378_bib9","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1074\/jbc.M115.685222","article-title":"The evolutionarily conserved Tre2\/Bub2\/Cdc16 (TBC), Lysin Motif (LysM), domain catalytic (TLDc) domain is neuroprotective against oxidative stress","volume":"291","author":"Finelli","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib10","article-title":"The evolutionary conserved TLDc domain defines a new class of (H(+))V-ATPase interacting proteins","volume":"11","author":"Eaton","year":"2021","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.redox.2026.104378_bib11","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.ajhg.2019.11.002","article-title":"Loss of oxidation resistance 1, OXR1, is associated with an autosomal-recessive neurological disease with cerebellar atrophy and lysosomal dysfunction","volume":"105","author":"Wang","year":"2019","journal-title":"Am. J. Hum. Genet."},{"issue":"10","key":"10.1016\/j.redox.2026.104378_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002338","article-title":"Oxr1 is essential for protection against oxidative stress-induced neurodegeneration","volume":"7","author":"Oliver","year":"2011","journal-title":"PLoS Genet."},{"issue":"6","key":"10.1016\/j.redox.2026.104378_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13060685","article-title":"Neuroinflammation and lysosomal abnormalities characterise the essential role for oxidation resistance 1 in the developing and adult cerebellum","volume":"13","author":"Bucknor","year":"2024","journal-title":"Antioxidants"},{"issue":"Pt 5","key":"10.1016\/j.redox.2026.104378_bib14","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/brain\/awv039","article-title":"Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis","volume":"138","author":"Liu","year":"2015","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.redox.2026.104378_bib15","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1007\/s00018-020-03721-6","article-title":"The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour","volume":"78","author":"Castroflorio","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"48","key":"10.1016\/j.redox.2026.104378_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adz3192","article-title":"Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans","volume":"11","author":"Zhai","year":"2025","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.redox.2026.104378_bib17","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201527","article-title":"CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7","volume":"5","author":"Tan","year":"2022","journal-title":"Life Sci. Alliance"},{"issue":"7","key":"10.1016\/j.redox.2026.104378_bib18","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.str.2024.03.009","article-title":"Human V-ATPase function is positively and negatively regulated by TLDc proteins","volume":"32","author":"Oot","year":"2024","journal-title":"Structure"},{"issue":"3","key":"10.1016\/j.redox.2026.104378_bib19","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021109360","article-title":"Oxidative stress protein Oxr1 promotes V-ATPase holoenzyme disassembly in catalytic activity-independent manner","volume":"41","author":"Khan","year":"2022","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.redox.2026.104378_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.tibs.2019.12.007","article-title":"Structure and roles of V-type ATPases","volume":"45","author":"Vasanthakumar","year":"2020","journal-title":"Trends Biochem. Sci."},{"issue":"7","key":"10.1016\/j.redox.2026.104378_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202200251","article-title":"Tender love and disassembly: how a TLDc domain protein breaks the V-ATPase","volume":"45","author":"Wilkens","year":"2023","journal-title":"Bioessays"},{"issue":"5","key":"10.1016\/j.redox.2026.104378_bib22","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1038\/s44319-024-00126-5","article-title":"Molecular mechanism of Oxr1p mediated disassembly of yeast V-ATPase","volume":"25","author":"Khan","year":"2024","journal-title":"EMBO Rep."},{"issue":"22","key":"10.1016\/j.redox.2026.104378_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2505975122","article-title":"Oxr1 and Ncoa7 regulate V-ATPase to achieve optimal pH for glycosylation within the Golgi apparatus and trans-Golgi network","volume":"122","author":"Yoshimura","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.redox.2026.104378_bib24","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/hmg\/ddy370","article-title":"The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons","volume":"28","author":"Finelli","year":"2019","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.redox.2026.104378_bib25","doi-asserted-by":"crossref","first-page":"F890","DOI":"10.1152\/ajprenal.00363.2024","article-title":"Knockout of the V-ATPase interacting protein Tldc2 in B-type kidney intercalated cells impairs urine alkalinization","volume":"328","author":"Eaton","year":"2025","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib94","doi-asserted-by":"crossref","first-page":"F173","DOI":"10.1152\/ajprenal.00407.2017","article-title":"Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice","volume":"315","author":"Merkulova","year":"2018","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.redox.2026.104378_bib71","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3389\/fneur.2020.00767","article-title":"Clinicopathological relationships in an aged case of DOORS syndrome with a p.Arg506X mutation in the ATP6V1B2 gene","volume":"11","author":"Zadori","year":"2020","journal-title":"Front. Neurol."},{"issue":"2","key":"10.1016\/j.redox.2026.104378_bib72","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1387\/ijdb.240060jd","article-title":"TBC1D24 is likely to regulate vesicle trafficking in glia-like non-sensory epithelial cells of the cochlea","volume":"68","author":"Defourny","year":"2024","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.redox.2026.104378_bib73","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/epi.70013","article-title":"Clinical trajectories and medication response in TBC1D24-related epilepsies","volume":"67","author":"Mondragon","year":"2026","journal-title":"Epilepsia"},{"issue":"9","key":"10.1016\/j.redox.2026.104378_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107725","article-title":"Interaction between the TBC1D24 TLDc domain and the KIBRA C2 domain is disrupted by two epilepsy-associated TBC1D24 missense variants","volume":"300","author":"Tona","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"18","key":"10.1016\/j.redox.2026.104378_bib27","doi-asserted-by":"crossref","first-page":"7137","DOI":"10.1074\/jbc.TM118.001189","article-title":"Friend or foe-post-translational modifications as regulators of phase separation and RNP granule dynamics","volume":"294","author":"Hofweber","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.redox.2026.104378_bib28","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1038\/s41418-019-0313-x","article-title":"TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons","volume":"26","author":"Aprile","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104378_bib29","article-title":"The role of mitochondria-associated ER membranes in disease pathology: protein complex and therapeutic targets","volume":"13","author":"Zhang","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.redox.2026.104378_bib30","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.redox.2026.104378_bib31","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1080\/15548627.2022.2125629","article-title":"The acid gate in the lysosome","volume":"19","author":"Hu","year":"2023","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.redox.2026.104378_bib32","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2503909123","article-title":"Proton-selective conductance and gating of the lysosomal cation channel TMEM175","volume":"123","author":"Schulze","year":"2026","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib33","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202501145","article-title":"TMEM175 does not function as a proton-selective ion channel to prevent lysosomal over-acidification","volume":"225","author":"Riederer","year":"2026","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.redox.2026.104378_bib34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.cell.2015.08.002","article-title":"TMEM175 is an Organelle K(+) channel regulating lysosomal function","volume":"162","author":"Cang","year":"2015","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.redox.2026.104378_bib35","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.cell.2022.05.021","article-title":"Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes","volume":"185","author":"Hu","year":"2022","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.redox.2026.104378_bib36","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.molcel.2023.06.004","article-title":"Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel","volume":"83","author":"Zhang","year":"2023","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.redox.2026.104378_bib37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/15548627.2023.2274253","article-title":"Ups and downs of lysosomal pH: conflicting roles of LAMP proteins?","volume":"20","author":"Handy","year":"2024","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.redox.2026.104378_bib38","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s42255-025-01352-4","article-title":"BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states","volume":"7","author":"Rizzollo","year":"2025","journal-title":"Nat. Metab."},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib39","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41467-023-44343-3","article-title":"OXR1 maintains the retromer to delay brain aging under dietary restriction","volume":"15","author":"Wilson","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40035-023-00362-0","article-title":"Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases","volume":"12","author":"Lo","year":"2023","journal-title":"Transl. Neurodegener."},{"issue":"Suppl 6","key":"10.1016\/j.redox.2026.104378_bib41","doi-asserted-by":"crossref","first-page":"1559S","DOI":"10.3945\/ajcn.117.155804","article-title":"Current understanding of iron homeostasis","volume":"106","author":"Anderson","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.redox.2026.104378_bib42","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/cyto.b.21633","article-title":"Labile iron pool as a parameter to monitor iron overload and oxidative stress status in beta-thalassemic erythrocytes","volume":"94","author":"Chutvanichkul","year":"2018","journal-title":"Cytometry B Clin Cytom"},{"issue":"2","key":"10.1016\/j.redox.2026.104378_bib43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1091\/mbc.E20-02-0129","article-title":"Unconventional endocytosis and trafficking of transferrin receptor induced by iron","volume":"32","author":"Gammella","year":"2021","journal-title":"Mol. Biol. Cell"},{"issue":"22","key":"10.1016\/j.redox.2026.104378_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/cells12222641","article-title":"Examining the role of a functional deficiency of iron in lysosomal storage disorders with translational relevance to Alzheimer's Disease","volume":"12","author":"LeVine","year":"2023","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.redox.2026.104378_bib45","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1016\/j.jmb.2020.02.033","article-title":"Impairment of lysosome function and autophagy in rare neurodegenerative diseases","volume":"432","author":"Darios","year":"2020","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.redox.2026.104378_bib46","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1182\/bloodadvances.2021005609","article-title":"Lysosomal iron recycling in mouse macrophages is dependent upon both LcytB and Steap3 reductases","volume":"6","author":"Meng","year":"2022","journal-title":"Blood Adv."},{"issue":"11","key":"10.1016\/j.redox.2026.104378_bib47","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/s12276-025-01579-x","article-title":"Failure of lysosomal acidification and endomembrane network in neurodegeneration","volume":"57","author":"Kim","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib48","doi-asserted-by":"crossref","first-page":"6617","DOI":"10.1038\/s41467-025-61894-9","article-title":"Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis","volume":"16","author":"Loo","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104378_bib49","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51031","article-title":"Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo","volume":"8","author":"Yambire","year":"2019","journal-title":"eLife"},{"issue":"3","key":"10.1016\/j.redox.2026.104378_bib50","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molcel.2020.01.003","article-title":"Maintaining Iron homeostasis is the key role of lysosomal acidity for cell proliferation","volume":"77","author":"Weber","year":"2020","journal-title":"Mol. Cell"},{"issue":"12","key":"10.1016\/j.redox.2026.104378_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/cells11121977","article-title":"Age-Related lysosomal dysfunctions","volume":"11","author":"Guerrero-Navarro","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.redox.2026.104378_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1390798","article-title":"A critical appraisal of ferroptosis in Alzheimer's and Parkinson's disease: new insights into emerging mechanisms and therapeutic targets","volume":"15","author":"Soni","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.redox.2026.104378_bib53","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.freeradbiomed.2024.10.311","article-title":"The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death","volume":"225","author":"Baldensperger","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"8067","key":"10.1016\/j.redox.2026.104378_bib54","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41586-025-08974-4","article-title":"Activation of lysosomal iron triggers ferroptosis in cancer","volume":"642","author":"Caneque","year":"2025","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.redox.2026.104378_bib55","first-page":"60","article-title":"[Experience in controlling hypodermyiasis in reindeer]","volume":"45","author":"Nepoklonov","year":"1968","journal-title":"Veterinar"},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib56","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1038\/s41467-025-58909-w","article-title":"Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization","volume":"16","author":"Saimoto","year":"2025","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.redox.2026.104378_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/cells11132049","article-title":"The impact of mitochondrial dysfunction in amyotrophic lateral sclerosis","volume":"11","author":"Zhao","year":"2022","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.redox.2026.104378_bib58","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.4103\/1673-5374.324847","article-title":"Iron, the endolysosomal system and neuroinflammation: a matter of balance","volume":"17","author":"Borquez","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"2","key":"10.1016\/j.redox.2026.104378_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13020240","article-title":"Mitochondria dysfunction and neuroinflammation in neurodegeneration: who comes first?","volume":"13","author":"Peggion","year":"2024","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.redox.2026.104378_bib60","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.4103\/NRR.NRR-D-24-01382","article-title":"The critical role of iron homeostasis in neurodegenerative diseases","volume":"21","author":"Liang","year":"2026","journal-title":"Neural Regen. Res."},{"issue":"3","key":"10.1016\/j.redox.2026.104378_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00586","article-title":"Nrf 2\/Bach 1 signaling axis: a promising multifaceted therapeutic strategy for Alzheimer's disease","volume":"22","author":"Soni","year":"2025","journal-title":"Neurotherapeutics"},{"issue":"9","key":"10.1016\/j.redox.2026.104378_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092198","article-title":"Down the iron path: mitochondrial iron homeostasis and beyond","volume":"10","author":"Dietz","year":"2021","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.redox.2026.104378_bib63","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.redox.2026.104378_bib64","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fnins.2019.00180","article-title":"Iron in neurodegeneration - cause or consequence?","volume":"13","author":"Ndayisaba","year":"2019","journal-title":"Front. Neurosci."},{"issue":"8","key":"10.1016\/j.redox.2026.104378_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084269","article-title":"The irony of iron: the element with diverse influence on neurodegenerative diseases","volume":"25","author":"Lee","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.redox.2026.104378_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/cells13161376","article-title":"Iron dyshomeostasis in neurodegeneration with brain iron accumulation (NBIA): is it the cause or the effect?","volume":"13","author":"Agostini","year":"2024","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.redox.2026.104378_bib67","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1093\/brain\/awaf398","article-title":"Iron on trial: recasting the role of iron in neurodegeneration","volume":"148","author":"Ayton","year":"2025","journal-title":"Brain"},{"issue":"17","key":"10.1016\/j.redox.2026.104378_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/cells13171441","article-title":"V-ATPase dysfunction in the brain: genetic insights and therapeutic opportunities","volume":"13","author":"Falace","year":"2024","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.redox.2026.104378_bib69","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14487","article-title":"V-ATPase disassembly at the yeast lysosome-like vacuole is a phenotypic driver of lysosome dysfunction in replicative aging","volume":"24","author":"Hashmi","year":"2025","journal-title":"Aging Cell"},{"issue":"30","key":"10.1016\/j.redox.2026.104378_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg1925","article-title":"Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP betaCTF","volume":"9","author":"Im","year":"2023","journal-title":"Sci. Adv."},{"issue":"16","key":"10.1016\/j.redox.2026.104378_bib74","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1073\/pnas.82.16.5305","article-title":"Inducible transcription of the unrearranged kappa constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis","volume":"82","author":"Nelson","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib75","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13059-023-03037-1","article-title":"A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment","volume":"24","author":"Lin","year":"2023","journal-title":"Genome Biol."},{"issue":"12","key":"10.1016\/j.redox.2026.104378_bib76","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/s41564-018-0273-9","article-title":"The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry","volume":"3","author":"Doyle","year":"2018","journal-title":"Nat. Microbiol."},{"issue":"21","key":"10.1016\/j.redox.2026.104378_bib77","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1093\/hmg\/ddz190","article-title":"Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo","volume":"28","author":"Williamson","year":"2019","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.redox.2026.104378_bib78","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0161-5890(88)90099-5","article-title":"Alteration of the conformation of human IgG subclasses by reduction of the Hinge S-S bonds","volume":"25","author":"Michaelsen","year":"1988","journal-title":"Mol. Immunol."},{"issue":"11","key":"10.1016\/j.redox.2026.104378_bib79","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.4103\/1673-5374.371346","article-title":"Enhancement of lysosome biogenesis as a potential therapeutic approach for neurodegenerative diseases","volume":"18","author":"Xue","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.redox.2026.104378_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1627921","article-title":"Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases","volume":"17","author":"Jaganathan","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.redox.2026.104378_bib81","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.arr.2016.05.004","article-title":"Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease","volume":"32","author":"Colacurcio","year":"2016","journal-title":"Ageing Res. Rev."},{"issue":"11","key":"10.1016\/j.redox.2026.104378_bib82","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1097\/MS9.0000000000002611","article-title":"Neurological manifestations of lysosomal storage diseases","volume":"86","author":"Elendu","year":"2024","journal-title":"Ann. Med. Surg."},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib83","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13024-025-00822-3","article-title":"Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease","volume":"20","author":"Franzmeier","year":"2025","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib84","article-title":"The role of autophagy in synucleinopathy: clearance versus spread of alpha-synuclein","volume":"4","author":"Birnbaum","year":"2025","journal-title":"Autophagy Rep"},{"issue":"5","key":"10.1016\/j.redox.2026.104378_bib85","doi-asserted-by":"crossref","DOI":"10.3390\/cells7050037","article-title":"Autophagy in age-associated neurodegeneration","volume":"7","author":"Metaxakis","year":"2018","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2023.10.002","article-title":"Mitochondrial dysfunction in neurodegenerative disorders","volume":"21","author":"Klemmensen","year":"2024","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.redox.2026.104378_bib87","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00401-024-02799-7","article-title":"Autophagy-lysosomal-associated neuronal death in neurodegenerative disease","volume":"148","author":"Nixon","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.redox.2026.104378_bib88","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuro.2021.11.003","article-title":"Mitochondrial iron metabolism and neurodegenerative diseases","volume":"88","author":"Cheng","year":"2022","journal-title":"Neurotoxicology"},{"issue":"4","key":"10.1016\/j.redox.2026.104378_bib89","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and metabolic dysfunction in ageing and age-related diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"issue":"9","key":"10.1016\/j.redox.2026.104378_bib90","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/cns.12861","article-title":"The effect of V-ATPase function defects in pathogenesis of Alzheimer's disease","volume":"24","author":"Zhao","year":"2018","journal-title":"CNS Neurosci. Ther."},{"issue":"4","key":"10.1016\/j.redox.2026.104378_bib91","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13584","article-title":"Acidic nanoparticles protect against alpha-synuclein-induced neurodegeneration through the restoration of lysosomal function","volume":"21","author":"Arotcarena","year":"2022","journal-title":"Aging Cell"},{"issue":"22","key":"10.1016\/j.redox.2026.104378_bib92","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202502906","article-title":"Lysosome-Acidifying nanoparticles rescue A30P alpha-Synuclein induced neuronal death in cellular and drosophila models of Parkinson's Disease","volume":"15","author":"Lo","year":"2026","journal-title":"Adv. Healthcare Mater."},{"issue":"6","key":"10.1016\/j.redox.2026.104378_bib93","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259875","article-title":"The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system","volume":"136","author":"Somogyi","year":"2023","journal-title":"J. Cell Sci."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726003770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726003770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:15:18Z","timestamp":1792930518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726003770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":94,"alternative-id":["S2213231726003770"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104378","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLDc proteins: Stress-responsive nexus regulators of redox signaling, V-ATPase dynamics, and organellar crosstalk in neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104378"}}