{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:35:26Z","timestamp":1792931726440,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ50584"],"award-info":[{"award-number":["2025JJ50584"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2026ZZTS0517"],"award-info":[{"award-number":["2026ZZTS0517"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270590"],"award-info":[{"award-number":["82270590"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.redox.2026.104403","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:05:02Z","timestamp":1789398302000},"page":"104403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["IL1B-high macrophages promote ferroptosis-like lipid peroxidation injury in Crohn's disease intestinal epithelium"],"prefix":"10.1016","volume":"97","author":[{"given":"Qi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganglei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4089-770X","authenticated-orcid":false,"given":"Mengyao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5089-5066","authenticated-orcid":false,"given":"Lianwen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2026.104403_bib1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn's disease","volume":"6","author":"Roda","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.redox.2026.104403_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5582\/irdr.2025.01046","article-title":"Towards an Asian paradigm of inflammatory bowel disease management: a comparative review of China and Japan","volume":"14","author":"Sun","year":"2025","journal-title":"Intractable Rare Dis Res"},{"key":"10.1016\/j.redox.2026.104403_bib3","first-page":"573","article-title":"The intestinal barrier: a pivotal role in health, inflammation, and cancer","volume":"10","author":"Neurath","year":"2025"},{"key":"10.1016\/j.redox.2026.104403_bib4","first-page":"27","article-title":"The inflammation-aging axis: shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging","volume":"20","author":"Yang","year":"2026"},{"key":"10.1016\/j.redox.2026.104403_bib5","first-page":"700","article-title":"TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity","volume":"14","author":"Kang","year":"2023"},{"key":"10.1016\/j.redox.2026.104403_bib6","article-title":"The role and intrinsic connection of cellular senescence and cell death in inflammatory bowel disease","volume":"13","author":"Yang","year":"2025"},{"key":"10.1016\/j.redox.2026.104403_bib7","first-page":"2152","article-title":"A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease","volume":"25","author":"Thomas","year":"2024"},{"key":"10.1016\/j.redox.2026.104403_bib8","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.cell.2019.08.008","article-title":"Single-cell analysis of crohn's disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy","volume":"178","author":"Martin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104403_bib9","first-page":"1970","article-title":"IL-1-driven stromal\u2013neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies","volume":"27","author":"Friedrich","year":"2021"},{"key":"10.1016\/j.redox.2026.104403_bib10","first-page":"538","article-title":"Macrophages in intestinal homeostasis and inflammatory bowel disease","volume":"20","author":"Hegarty","year":"2023"},{"key":"10.1016\/j.redox.2026.104403_bib11","first-page":"1345","article-title":"IL-1 family cytokines in inflammation and immunity","volume":"22","author":"Garlanda","year":"2025"},{"key":"10.1016\/j.redox.2026.104403_bib12","first-page":"1335","article-title":"Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications","volume":"74","author":"Gudi\u00f1o","year":"2025"},{"key":"10.1016\/j.redox.2026.104403_bib13","first-page":"1060","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012"},{"key":"10.1016\/j.redox.2026.104403_bib14","first-page":"1775","article-title":"Dietary lipids fuel GPX4-restricted enteritis resembling crohn's disease","volume":"11","author":"Mayr","year":"2020"},{"key":"10.1016\/j.redox.2026.104403_bib15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1053\/j.gastro.2024.01.051","article-title":"Ferroptosis: biology and role in gastrointestinal disease","volume":"167","author":"Escuder-Rodr\u00edguez","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2026.104403_bib16","first-page":"963","article-title":"Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1\u03b2-producing macrophages","volume":"38","author":"Wu","year":"2026"},{"key":"10.1016\/j.redox.2026.104403_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2026.04.012","article-title":"Microbial phosphoketolase promotes histone lactylation to improve anti-TNF therapy efficacy in inflammatory bowel disease","author":"Jiang","year":"2026","journal-title":"Cell Metab."},{"key":"10.1016\/j.redox.2026.104403_bib18","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.immuni.2023.01.002","article-title":"The landscape of immune dysregulation in crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon","volume":"56","author":"Kong","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2026.104403_bib19","first-page":"699","article-title":"Single-cell integration reveals metaplasia in inflammatory gut diseases","volume":"635","author":"Oliver","year":"2024"},{"key":"10.1016\/j.redox.2026.104403_bib20","first-page":"4506","article-title":"Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease","volume":"14","author":"Garrido-Trigo","year":"2023"},{"key":"10.1016\/j.redox.2026.104403_bib21","first-page":"447","article-title":"A disease-associated gene desert directs macrophage inflammation through ETS2","volume":"630","author":"Stankey","year":"2024"},{"key":"10.1016\/j.redox.2026.104403_bib22","first-page":"1","article-title":"Cell-type-resolved genetic variation shapes inflammatory bowel disease risk","author":"Alegbe","year":"2026"},{"key":"10.1016\/j.redox.2026.104403_bib23","article-title":"IL-1\u03b2 and the intestinal epithelial tight junction barrier","volume":"12","author":"Kaminsky","year":"2021"},{"key":"10.1016\/j.redox.2026.104403_bib24","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1053\/j.gastro.2020.06.038","article-title":"IL1B increases intestinal tight junction permeability by up-regulation of MIR200C-3p, which degrades occludin mRNA","volume":"159","author":"Rawat","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.redox.2026.104403_bib25","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.2353\/ajpath.2010.100371","article-title":"IL-1\u03b2-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-\u03baB pathway","volume":"177","author":"Al-Sadi","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.redox.2026.104403_bib26","article-title":"NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis","volume":"135","author":"Liang","year":"2025"},{"key":"10.1016\/j.redox.2026.104403_bib27","first-page":"5142","article-title":"A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis","volume":"22","author":"Yang","year":"2026"},{"key":"10.1016\/j.redox.2026.104403_bib28","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0140-6736(23)02586-2","article-title":"Crohn's disease","volume":"403","author":"Dolinger","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.redox.2026.104403_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250248","article-title":"Human intestinal organoids: modeling gastrointestinal physiology and immunopathology - current applications and limitations","volume":"54","author":"Flood","year":"2024","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.redox.2026.104403_bib30","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41591-024-03489-3","article-title":"Clinical applications of human organoids","volume":"31","author":"Verstegen","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.redox.2026.104403_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.amsu.2016.07.019","article-title":"The TNBS-induced colitis animal model: an overview","volume":"11","author":"Antoniou","year":"2016","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.redox.2026.104403_bib32","first-page":"1295","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017"},{"key":"10.1016\/j.redox.2026.104403_bib33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev-biodatasci-102523-103801","article-title":"Harnessing artificial intelligence in multimodal omics data integration: paving the path for the next frontier in precision medicine","volume":"7","author":"Nam","year":"2024","journal-title":"Annu Rev Biomed Data Sci. Annual Reviews"},{"key":"10.1016\/j.redox.2026.104403_bib34","article-title":"Integrating inflammatory and coagulation biomarkers for surgical risk stratification and treatment benefit assessment in crohn's disease","volume":"17","author":"Xie","year":"2026"},{"key":"10.1016\/j.redox.2026.104403_bib35","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/ueg2.12720","article-title":"Multi-omics biomarkers for predicting efficacy of biologic and small-molecule therapies in adults with inflammatory bowel disease: a systematic review","volume":"13","author":"Chen","year":"2025","journal-title":"United Eur. Gastroenterol. J."},{"key":"10.1016\/j.redox.2026.104403_bib36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.5582\/bst.2024.01342","article-title":"Applications of and issues with machine learning in medicine: bridging the gap with explainable AI","volume":"18","author":"Karako","year":"2024","journal-title":"BioSci Trends"},{"key":"10.1016\/j.redox.2026.104403_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142113","article-title":"Integrated analysis of multiple programmed cell death-related prognostic genes and functional validation of apoptosis-related genes in osteosarcoma","volume":"307","author":"Tang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.redox.2026.104403_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104920","article-title":"Analysis of multiple programmed cell death-related prognostic genes and functional validations of necroptosis-associated genes in oesophageal squamous cell carcinoma","volume":"99","author":"Cao","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.redox.2026.104403_bib39","article-title":"Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery","volume":"107","year":"2022","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.redox.2026.104403_bib40","first-page":"381","article-title":"Cell death, therapeutics, and the immune response in cancer","volume":"9","author":"H\u00e4nggi","year":"2023"},{"key":"10.1016\/j.redox.2026.104403_bib41","article-title":"Development and validation of immunogenic cell death-related signature for predicting the prognosis and immune landscape of uveal melanoma","volume":"13","author":"Hu","year":"2022"},{"key":"10.1016\/j.redox.2026.104403_bib42","article-title":"Identification and validation of a prognostic signature of autophagy, apoptosis and pyroptosis-related genes for head and neck squamous cell carcinoma: to imply therapeutic choices of HPV negative patients","volume":"13","author":"Nan","year":"2023"},{"key":"10.1016\/j.redox.2026.104403_bib43","article-title":"Multi-omics features of immunogenic cell death in gastric cancer identified by combining single-cell sequencing analysis and machine learning","volume":"14","author":"Dai","year":"2024"},{"key":"10.1016\/j.redox.2026.104403_bib44","article-title":"Comprehensive evaluation of disulfidptosis in intestinal immunity and biologic therapy response in ulcerative colitis","volume":"10","author":"Yang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.redox.2026.104403_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169127","article-title":"Chronic experimental model of TNBS-induced colitis to study inflammatory bowel disease","volume":"23","author":"Silva","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2026.104403_bib46","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/ecco-jcc\/jjac084","article-title":"CD147 targeting by AC-73 induces autophagy and reduces intestinal fibrosis associated with TNBS chronic colitis","volume":"16","author":"Butera","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.redox.2026.104403_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106426","article-title":"Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis","volume":"83","author":"Gao","year":"2020","journal-title":"Int. Immunopharmacol."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726004027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726004027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:13:01Z","timestamp":1792930381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726004027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":47,"alternative-id":["S2213231726004027"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104403","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL1B-high macrophages promote ferroptosis-like lipid peroxidation injury in Crohn's disease intestinal epithelium","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104403","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104403"}}