{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:35:17Z","timestamp":1792931717818,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["202610449"],"award-info":[{"award-number":["202610449"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20232ACB216009"],"award-info":[{"award-number":["20232ACB216009"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20253BDH410005"],"award-info":[{"award-number":["20253BDH410005"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20252BAC240546"],"award-info":[{"award-number":["20252BAC240546"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB20377"],"award-info":[{"award-number":["20242BAB20377"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20232ACB206019"],"award-info":[{"award-number":["20232ACB206019"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260388"],"award-info":[{"award-number":["82260388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260378"],"award-info":[{"award-number":["82260378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.redox.2026.104416","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:37:52Z","timestamp":1790689072000},"page":"104416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["USP18\/DDX5 axis ameliorates mitochondrial morphofunctional damage via OPA1 to inhibit neuronal apoptosis after traumatic brain injury"],"prefix":"10.1016","volume":"97","author":[{"given":"Yangyang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raorao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2026.104416_bib1","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.apmr.2010.05.017","article-title":"Position statement: definition of traumatic brain injury","volume":"91","author":"Menon","year":"2010","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.redox.2026.104416_bib2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S1474-4422(20)30182-4","article-title":"Clinical characteristics and outcomes in patients with traumatic brain injury in China: a prospective, multicentre, longitudinal, observational study","volume":"19","author":"Gao","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.redox.2026.104416_bib3","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic brain injury: progress and challenges in prevention, clinical care, and research","volume":"21","author":"Maas","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.redox.2026.104416_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107389","article-title":"The bioenergetics of traumatic brain injury and its long-term impact for brain plasticity and function","volume":"208","author":"Thapak","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.redox.2026.104416_bib5","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41418-024-01408-0","article-title":"Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury","volume":"32","author":"Weng","year":"2025","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104416_bib6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2026.104416_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.cellbio.22.010305.104638","article-title":"Mitochondrial fusion and fission in mammals","volume":"22","author":"Chan","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.redox.2026.104416_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/acel.70416","article-title":"Dynamin-related protein 1-Dependent disruption of mitochondrial homeostasis drives blue light-induced epithelial-mesenchymal transition in retinal aging","volume":"25","author":"Li","year":"2026","journal-title":"Aging Cell"},{"key":"10.1016\/j.redox.2026.104416_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/biom15030433","article-title":"The balance of MFN2 and OPA1 in mitochondrial dynamics, cellular homeostasis, and disease","volume":"15","author":"Zanfardino","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.redox.2026.104416_bib10","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1038\/s42255-023-00924-6","article-title":"Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice","volume":"5","author":"Dong","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.redox.2026.104416_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41419-024-06748-w","article-title":"FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control","volume":"15","author":"Ge","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104416_bib12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.freeradbiomed.2025.12.005","article-title":"Decreased OPA1 expression increases neuronal vulnerability to ischaemic stroke during ageing: role of Timm8b as a therapeutic target","volume":"244","author":"Li","year":"2026","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.redox.2026.104416_bib13","doi-asserted-by":"crossref","first-page":"8795","DOI":"10.1038\/s41467-025-63856-7","article-title":"Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus","volume":"16","author":"Freimann","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104416_bib14","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1084\/jem.20122327","article-title":"USP18 inhibits NF-\u03baB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1\u2013TAB1 complex","volume":"210","author":"Liu","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.redox.2026.104416_bib15","first-page":"380","volume":"vol. 7","author":"Wang","year":"2024"},{"key":"10.1016\/j.redox.2026.104416_bib16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13046-023-02787-x","article-title":"Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA repair, immune suppression, cancer metabolic control, virus infection promotion, and human microbiome (microbiota) negative influence","volume":"42","author":"Li","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.redox.2026.104416_bib17","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/1878-0261.13431","article-title":"Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation","volume":"17","author":"Leszczynska","year":"2023","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.redox.2026.104416_bib18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1161\/CIRCULATIONAHA.123.064774","article-title":"RNA helicase DDX5 maintains cardiac function by regulating CamkII\u03b4 alternative splicing","volume":"150","author":"Jia","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.redox.2026.104416_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112787","article-title":"Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties","volume":"43","author":"Harel","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104416_bib20","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.celrep.2014.05.019","article-title":"Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5","volume":"7","author":"Mazurek","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104416_bib21","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1074\/jbc.RA120.012600","article-title":"The RNA helicase DDX5 supports mitochondrial function in small cell lung cancer","volume":"295","author":"Xing","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2026.104416_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25073693","article-title":"FL118 is a potent therapeutic agent against chronic myeloid leukemia resistant to BCR-ABL inhibitors through targeting RNA helicase DDX5","volume":"25","author":"Takeda","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2026.104416_bib23","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31126","article-title":"Neuropathological and transcriptomic characteristics of the aged brain","volume":"6","author":"Miller","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.redox.2026.104416_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.624696","article-title":"The delayed neuropathological consequences of traumatic brain injury in a community-based sample","volume":"12","author":"Postupna","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.redox.2026.104416_bib25","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104416_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103156","article-title":"Atox1 protects hippocampal neurons after traumatic brain injury via DJ-1 mediated anti-oxidative stress and mitophagy","volume":"72","author":"Zhao","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104416_bib27","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.neuron.2014.07.027","article-title":"TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord","volume":"83","author":"Kroner","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.redox.2026.104416_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.reprotox.2014.11.004","article-title":"Application of sholl analysis to quantify changes in growth and development in rat mammary gland whole mounts","volume":"54","author":"Stanko","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.redox.2026.104416_bib30","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S1474-4422(25)00154-1","article-title":"A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI classification and nomenclature initiative","volume":"24","author":"Manley","year":"2025","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.redox.2026.104416_bib31","article-title":"Single-nucleus RNA sequencing reveals that Gabra6(+) neurons in prefrontal cortex promote the progression of PTSD after shockwave-induced TBI","volume":"12","author":"Fei","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.redox.2026.104416_bib32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s13311-012-0107-z","article-title":"Genetic manipulation of cell death and neuroplasticity pathways in traumatic brain injury","volume":"9","author":"Schoch","year":"2012","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.redox.2026.104416_bib33","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12974-022-02602-y","article-title":"Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis","volume":"19","author":"Hu","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.redox.2026.104416_bib34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/cc2950","article-title":"Bench-to-bedside review: apoptosis\/programmed cell death triggered by traumatic brain injury","volume":"9","author":"Zhang","year":"2005","journal-title":"Crit. Care"},{"key":"10.1016\/j.redox.2026.104416_bib35","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.nbd.2012.03.018","article-title":"Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury","volume":"46","author":"Piao","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.redox.2026.104416_bib36","doi-asserted-by":"crossref","DOI":"10.1227\/NEU.0000000000000577","article-title":"Enhancement of neurogenesis and memory by a neurotrophic peptide in mild to moderate traumatic brain injury","volume":"76","author":"Chohan","year":"2015","journal-title":"Neurosurgery"},{"key":"10.1016\/j.redox.2026.104416_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022200","article-title":"USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon \u03b1 response","volume":"6","author":"Fran\u00e7ois-Newton","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2026.104416_bib38","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/emboj\/19.1.94","article-title":"Recognition of the polyubiquitin proteolytic signal","volume":"19","author":"Thrower","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2026.104416_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbamcr.2004.09.019","article-title":"Ubiquitin: structures, functions, mechanisms","volume":"1695","author":"Pickart","year":"2004","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.redox.2026.104416_bib40","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1073\/pnas.1412881112","article-title":"Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance","volume":"112","author":"Ketscher","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2026.104416_bib41","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1002\/hep.29375","article-title":"USP18 protects against hepatic steatosis and insulin resistance through its deubiquitinating activity","volume":"66","author":"An","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2026.104416_bib42","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1074\/mcp.M112.017905","article-title":"Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues","volume":"11","author":"Wagner","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.redox.2026.104416_bib43","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.013284","article-title":"A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles","volume":"10","author":"Wagner","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.redox.2026.104416_bib44","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2522583123","article-title":"Human lncRNA RMRP interacts with DEAD-box helicases and modulates mitochondrial function","volume":"123","author":"Pereira","year":"2026","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2026.104416_bib45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bbrc.2023.05.069","article-title":"USP30 impairs mitochondrial quality control and aggravates oxidative damage after traumatic brain injury","volume":"671","author":"Wu","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.redox.2026.104416_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41418-026-01749-y","article-title":"USP4 modulates ZBP1 ubiquitination to regulate microglial PANoptosis and functional outcomes following traumatic brain injury","author":"shuang","year":"2026","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104416_bib47","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1080\/15548627.2025.2471633","article-title":"Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury","volume":"21","author":"Xu","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2026.104416_bib48","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.15252\/embj.201490791","article-title":"USP18 lack in microglia causes destructive interferonopathy of the mouse brain","volume":"34","author":"Goldmann","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.redox.2026.104416_bib49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s40478-019-0757-8","article-title":"Loss of USP18 in microglia induces white matter pathology","volume":"7","author":"Schwabenland","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.redox.2026.104416_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.326","article-title":"Multiple functions of USP18","volume":"7","author":"Honke","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104416_bib51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molcel.2021.10.027","article-title":"Deubiquitinases: from mechanisms to their inhibition by small molecules","volume":"82","author":"Lange","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2026.104416_bib52","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.tibs.2022.04.003","article-title":"Assembly and function of branched ubiquitin chains","volume":"47","author":"Kolla","year":"2022","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.redox.2026.104416_bib53","first-page":"5190","article-title":"Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5 a superior oncogenic biomarker and target for targeted cancer therapy","volume":"11","author":"Li","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.redox.2026.104416_bib54","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1093\/nar\/gkl460","article-title":"DExD\/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation","volume":"34","author":"Fuller-Pace","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2026.104416_bib55","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.gendis.2022.02.008","article-title":"DEAD-box RNA helicases with special reference to p68: unwinding their biology, versatility, and therapeutic opportunity in cancer","volume":"10","author":"Tabassum","year":"2023","journal-title":"Genes Dis."},{"key":"10.1016\/j.redox.2026.104416_bib56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","article-title":"OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion","volume":"126","author":"Frezza","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104416_bib57","article-title":"Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury","volume":"5","author":"Sridharan","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.redox.2026.104416_bib58","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ymthe.2022.08.005","article-title":"DDX5 mRNA-targeting antisense oligonucleotide as a new promising therapeutic in combating castration-resistant prostate cancer","volume":"31","author":"Le","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.redox.2026.104416_bib59","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1158\/0008-5472.CAN-22-2145","article-title":"CSN6 mediates nucleotide metabolism to promote tumor development and chemoresistance in colorectal cancer","volume":"83","author":"Zou","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.redox.2026.104416_bib60","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/s41419-023-06115-1","article-title":"AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer","volume":"14","author":"Tian","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104416_bib62","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12974-016-0738-9","article-title":"Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation","volume":"13","author":"Corrigan","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.redox.2026.104416_bib63","article-title":"Glutamate excitotoxicity: a key secondary injury mechanism of traumatic brain injury and spinal cord injury","volume":"30","author":"Hou","year":"2025","journal-title":"Front. Biosci. (Landmark Ed.)"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726004155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726004155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:18:00Z","timestamp":1792930680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726004155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":61,"alternative-id":["S2213231726004155"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104416","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"USP18\/DDX5 axis ameliorates mitochondrial morphofunctional damage via OPA1 to inhibit neuronal apoptosis after traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104416"}}