{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:35:28Z","timestamp":1792931728869,"version":"4.5.0"},"reference-count":172,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2023ZD0503000"],"award-info":[{"award-number":["2023ZD0503000"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2023ZD0503004"],"award-info":[{"award-number":["2023ZD0503004"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012842","name":"Nuclear Power Institute of China","doi-asserted-by":"publisher","award":["HG2024220"],"award-info":[{"award-number":["HG2024220"]}],"id":[{"id":"10.13039\/100012842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYYC23006"],"award-info":[{"award-number":["ZYYC23006"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403204"],"award-info":[{"award-number":["2023YFC3403204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403200"],"award-info":[{"award-number":["2023YFC3403200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["JH2023082"],"award-info":[{"award-number":["JH2023082"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","award":["2024-YF06-00011-HZ"],"award-info":[{"award-number":["2024-YF06-00011-HZ"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022-GH03-00004-HZ"],"award-info":[{"award-number":["2022-GH03-00004-HZ"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2025YFHZ0087"],"award-info":[{"award-number":["2025YFHZ0087"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.redox.2026.104426","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:54:33Z","timestamp":1791215673000},"page":"104426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["State-matched redox nanomedicine for cell fate control and multicompartment therapeutic windows"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8028-6945","authenticated-orcid":false,"given":"Jiacheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2026.104426_bib1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s43018-024-00738-9","article-title":"The pleiotropic functions of reactive oxygen species in cancer","volume":"5","author":"Wu","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.redox.2026.104426_bib2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41580-024-00730-2","article-title":"Fundamentals of redox regulation in biology","volume":"25","author":"Sies","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2026.104426_bib3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41573-024-00979-4","article-title":"Targeting ROS in cancer: rationale and strategies","volume":"23","author":"Glorieux","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.redox.2026.104426_bib4","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.7150\/thno.112649","article-title":"Reduction-responsive RNAi nanoplatform for enhanced cancer sonoimmunotherapy via dual inhibition of mitophagy and Nrf2 pathways","volume":"15","author":"Fang","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.redox.2026.104426_bib5","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41467-025-55905-y","article-title":"Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104426_bib6","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1021\/acsnano.1c08464","article-title":"Self-adaptive single-atom catalyst boosting selective ferroptosis in tumor cells","volume":"16","author":"Cao","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib7","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1021\/acs.nanolett.5c01444","article-title":"Activatable chemodynamic theranostics through molecular imaging-energized companion diagnostics","volume":"25","author":"Meng","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.redox.2026.104426_bib8","article-title":"Interpretable radiomics model predicts nanomedicine tumor accumulation using routine medical imaging","volume":"37","author":"Tang","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.redox.2026.104426_bib9","article-title":"Nanosensors monitor intracellular GSH depletion: GSH triggers Cu(II) for tumor imaging and inhibition","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.redox.2026.104426_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41467-023-44429-y","article-title":"A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement","volume":"15","author":"Ge","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104426_bib11","article-title":"Specific and long-term luminescent monitoring of hydrogen peroxide in tumor metastasis","volume":"35","author":"Wang","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.redox.2026.104426_bib12","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1021\/acsnano.3c00940","article-title":"A multiple stimuli-responsive NanoCRISPR overcomes tumor redox heterogeneity to augment photodynamic therapy","volume":"17","author":"Jin","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib13","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1021\/acsnano.2c09502","article-title":"Personalized oncology by in vivo chemical imaging: photoacoustic mapping of tumor oxygen predicts radiotherapy efficacy","volume":"17","author":"Janggun","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202202551","article-title":"NIR-II ratiometric chemiluminescent\/fluorescent reporters for real-time monitoring and evaluating cancer photodynamic therapy efficacy","volume":"18","author":"Su","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.redox.2026.104426_bib15","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/jacs.1c09986","article-title":"Ultrasmall magneto-chiral cobalt hydroxide nanoparticles enable dynamic detection of reactive oxygen species in vivo","volume":"144","author":"Chen","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.redox.2026.104426_bib16","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1039\/D4CS00404C","article-title":"Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy","volume":"53","author":"Jia","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.redox.2026.104426_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103515","article-title":"Applications and enhancement strategies of ROS-based non-invasive therapies in cancer treatment","volume":"80","author":"Guo","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104426_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103686","article-title":"Targeting oxidative stress-mediated regulated cell death as a vulnerability in cancer","volume":"84","author":"Chen","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104426_bib19","article-title":"Nanomaterials-induced redox imbalance: challenged and opportunities for nanomaterials in cancer therapy","volume":"11","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.redox.2026.104426_bib20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41568-025-00847-2","article-title":"Advancing engineering design strategies for targeted cancer nanomedicine","volume":"25","author":"Gomerdinger Victoria","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.redox.2026.104426_bib21","doi-asserted-by":"crossref","first-page":"19810","DOI":"10.1021\/acsnano.3c04037","article-title":"Meta-analysis of nanoparticle distribution in tumors and major organs in tumor-bearing mice","volume":"17","author":"Chen","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib22","doi-asserted-by":"crossref","first-page":"9348","DOI":"10.1039\/D4NR01311E","article-title":"Controlling nanoparticle-induced endothelial leakiness with the protein corona","volume":"16","author":"Aparna","year":"2024","journal-title":"Nanoscale"},{"key":"10.1016\/j.redox.2026.104426_bib23","article-title":"Nanomedicine tumor targeting","volume":"36","author":"Twan","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.redox.2026.104426_bib24","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1038\/s41467-024-52416-0","article-title":"Transvascular transport of nanocarriers for tumor delivery","volume":"15","author":"Xin","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104426_bib25","article-title":"Engineering the protein corona: strategies, effects, and future directions in nanoparticle therapeutics","volume":"175","author":"Tianyu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.redox.2026.104426_bib26","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1186\/s12951-024-02954-y","article-title":"The role of patient-specific variables in protein corona formation and therapeutic efficacy in nanomedicine","volume":"22","author":"Cisneros Ethan","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.redox.2026.104426_bib27","doi-asserted-by":"crossref","first-page":"10920","DOI":"10.1021\/acs.chemrev.3c00062","article-title":"Tumor abnormality-oriented nanomedicine design","volume":"123","author":"Zhou","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.redox.2026.104426_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216166","article-title":"Barrier permeation and improved nanomedicine delivery in tumor microenvironments","volume":"562","author":"Liu","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.redox.2026.104426_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115051","article-title":"Progress on the pathological tissue microenvironment barrier-modulated nanomedicine","volume":"200","author":"Han","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.redox.2026.104426_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2023.05.043","article-title":"Overcoming tumor microenvironment obstacles: current approaches for boosting nanodrug delivery","volume":"166","author":"Wang","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.redox.2026.104426_bib31","article-title":"Meta-analysis of material properties influencing nanoparticle plasma pharmacokinetics","volume":"639","author":"Briana","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.redox.2026.104426_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2147\/IJN.S494970","article-title":"Mitochondria-targeting Type-I photodynamic therapy based on phenothiazine for realizing enhanced immunogenic cancer cell death via mitochondrial oxidative stress","volume":"20","author":"Duan","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.redox.2026.104426_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.137680","article-title":"Molecular engineering strategies for fabricating type-I mitochondria-targeted aggregation-induced emission photosensitizers for apoptosis-ferroptosis synergistically boosting photodynamic therapy","volume":"694","author":"Wang","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.redox.2026.104426_bib34","article-title":"An on-Demand oxygen nano-vehicle sensitizing protein and nucleic acid drug augment immunotherapy","volume":"37","author":"Zhang","year":"2025","journal-title":"Adv. Mater. (Deerfield Beach, Fla.)"},{"key":"10.1016\/j.redox.2026.104426_bib35","article-title":"Hypoxia-responsive albumin nanoparticles co-delivering banoxantrone and STING agonist enhance immunotherapy of high-intensity focused ultrasound","volume":"383","author":"Xinchang","year":"2025","journal-title":"J. Contr. Release : Off. J. Control. Release"},{"key":"10.1016\/j.redox.2026.104426_bib36","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1186\/s12951-025-03524-6","article-title":"An oxygen-generating nanoplatform remodels the immunosuppressive tumor microenvironment via synergistic lactate depletion and sonodynamic therapy","volume":"23","author":"Tang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.redox.2026.104426_bib37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","article-title":"Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2026.104426_bib38","article-title":"Breaking the siege of hypoxia and lactate: carrier-free flexible dual-enzyme protein vesicle to ignite photodynamic-immune storm in head and neck squamous cell carcinoma","volume":"33","author":"Yan","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.redox.2026.104426_bib39","doi-asserted-by":"crossref","first-page":"39228","DOI":"10.1021\/acsnano.5c12847","article-title":"A tumor microenvironment-responsive self-oxygenating nanoplatform for dual-enhanced cuproptosis and sonodynamic synergistic immunotherapy","volume":"19","author":"Tang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib40","article-title":"Self-delivery photodynamic-hypoxia alleviating nanomedicine synergizes with anti-PD-L1 for cancer immunotherapy","volume":"639","author":"Xianquan","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.redox.2026.104426_bib41","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.actbio.2026.04.062","article-title":"Endoplasmic reticulum-targeted photodynamic therapy synergizes with rapamycin to induce autophagic cancer cell death","volume":"217","author":"Zheng","year":"2026","journal-title":"Acta Biomater."},{"key":"10.1016\/j.redox.2026.104426_bib42","article-title":"In situ transformable nanoparticle effectively suppresses bladder cancer by damaging mitochondria and blocking mitochondrial autophagy flux","volume":"12","author":"Lv","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.redox.2026.104426_bib43","doi-asserted-by":"crossref","first-page":"34568","DOI":"10.1021\/jacs.4c12264","article-title":"Lysosome-mitochondria Cascade targeting nanoparticle drives robust pyroptosis for cancer immunotherapy","volume":"146","author":"Liu","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.redox.2026.104426_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122914","article-title":"Albumins constrainting the conformation of mitochondria-targeted photosensitizers for tumor-specific photodynamic therapy","volume":"315","author":"Fang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121854","article-title":"A mitochondria-targeted supramolecular nanoplatform for peroxynitrite-potentiated oxidative therapy of orthotopic hepatoma","volume":"290","author":"Dai","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib46","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104426_bib47","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molcel.2023.11.040","article-title":"The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death","volume":"84","author":"Ai","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.redox.2026.104426_bib48","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-025-00837-0","article-title":"Mechanistic insights into gasdermin-mediated pyroptosis","volume":"26","author":"Bai","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2026.104426_bib49","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1038\/s41556-024-01360-8","article-title":"A guideline on the molecular ecosystem regulating ferroptosis","volume":"26","author":"Dai","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2026.104426_bib50","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.actbio.2026.05.046","article-title":"A Metabolic NanoLock strategy enhances cuproptosis in hypoxic tumors by enforcing mitochondrial respiration and suppressing glycolysis","volume":"218","author":"Qin","year":"2026","journal-title":"Acta Biomater."},{"key":"10.1016\/j.redox.2026.104426_bib51","article-title":"Light-triggered carbon monoxide-induced activation of enhanced ferritinophagy-mediated ferroptosis for bone metastases therapy","volume":"35","author":"Liu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.redox.2026.104426_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2026.124196","article-title":"Self-amplifying nanomedicine reprograms redox metabolism to trigger immunogenic ferroptosis in colon cancer: multiomics identifies AMPD3 as a novel regulator","volume":"333","author":"Huang","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib53","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.actbio.2026.05.045","article-title":"A catalytic redox-cycling nanoreactor enables robust oxidative stress amplification for synergistic tumor apoptosis and ferroptosis","volume":"218","author":"Shao","year":"2026","journal-title":"Acta Biomater."},{"key":"10.1016\/j.redox.2026.104426_bib54","article-title":"Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer","volume":"31","author":"Zheng","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.redox.2026.104426_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.137820","article-title":"A locally-adapted nanoreactor for autophagy inhibition-enhanced cascade starvation-chemodynamic therapy","volume":"695","author":"Wang","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.redox.2026.104426_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114968","article-title":"Boosting ferroptosis therapy by sorafenib and ML385 loaded CuFe2O4 nanozymes","volume":"255","author":"Yin","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.redox.2026.104426_bib57","article-title":"Nickel atom-clusters nanozyme for boosting ferroptosis tumor therapy","volume":"27","author":"Liu","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.redox.2026.104426_bib58","doi-asserted-by":"crossref","first-page":"34656","DOI":"10.1021\/acsnano.4c09982","article-title":"Nanozyme as tumor energy homeostasis disruptor to augment Cascade catalytic therapy","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib59","article-title":"Zinc-based ROS amplifiers trigger cancer chemodynamic\/ion interference therapy through self-cascade catalysis","volume":"20","author":"Sun","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.redox.2026.104426_bib60","doi-asserted-by":"crossref","first-page":"44098","DOI":"10.1021\/acsami.2c11091","article-title":"Boosting chemodynamic therapy by tumor-targeting and cellular redox homeostasis-disrupting nanoparticles","volume":"14","author":"Lu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.redox.2026.104426_bib61","article-title":"Bacteria-mediated tumor-targeting delivery of multienzyme-mimicking covalent organic frameworks promoting pyroptosis for combinatorial sono-catalytic immunotherapy","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.redox.2026.104426_bib62","doi-asserted-by":"crossref","first-page":"21941","DOI":"10.1021\/acsami.3c02361","article-title":"Mitochondria-targeted nanosystem enhances radio-radiodynamic-chemodynamic therapy on triple negative breast cancer","volume":"15","author":"Li","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.redox.2026.104426_bib63","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.actbio.2023.01.022","article-title":"Radiotherapy-mediated redox homeostasis-controllable nanomedicine for enhanced ferroptosis sensitivity in tumor therapy","volume":"159","author":"Lin","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.redox.2026.104426_bib64","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12951-022-01455-0","article-title":"A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin","volume":"20","author":"Yang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.redox.2026.104426_bib65","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.actbio.2025.07.035","article-title":"Mitochondria-targeting pseudo-stealthy nanophotosensitizer as a potent immunogenic cell death inducer to unleash the cancer-immunity cycle for melanoma therapy","volume":"203","author":"Shi","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.redox.2026.104426_bib66","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1021\/acsbiomaterials.4c00376","article-title":"Biomimetic cancer-targeting nanoplatform boosting AIEgens-Based photodynamic therapy and ferroptosis by disrupting redox-homeostasis","volume":"10","author":"Wan","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.redox.2026.104426_bib67","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202201233","article-title":"Immunomodulatory-photodynamic nanostimulators for invoking pyroptosis to augment tumor immunotherapy","volume":"11","author":"Qiu","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.redox.2026.104426_bib68","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1021\/acs.nanolett.2c03784","article-title":"ROS-responsive nanoparticle delivery of mRNA and photosensitizer for combinatorial cancer therapy","volume":"23","author":"Zhou","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.redox.2026.104426_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122497","article-title":"Glutaminolysis inhibition boosts photodynamic therapy to eliminate cancer stem cells","volume":"306","author":"Wang","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib70","article-title":"Cascade-penetrating domino-ferroptosis nano inducer synergizes with sonodynamic therapy for anaplastic thyroid cancer","volume":"34","author":"Dong","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.redox.2026.104426_bib71","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2217\/nnm-2023-0218","article-title":"Multifunctional nanoparticles for enhanced sonodynamic-chemodynamic immunotherapy with glutathione depletion","volume":"19","author":"Song","year":"2024","journal-title":"Nanomedicine (London, England)"},{"key":"10.1016\/j.redox.2026.104426_bib72","article-title":"Carrier-free self-assembly nano-sonosensitizers for sonodynamic-amplified cuproptosis-ferroptosis in glioblastoma therapy","volume":"11","author":"Zhu","year":"2024","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.redox.2026.104426_bib73","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202303365","article-title":"PtMo-Au metalloenzymes regulated tumor microenvironment for enhanced sonodynamic\/chemodynamic\/starvation synergistic therapy","volume":"19","author":"Zhu","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.redox.2026.104426_bib74","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202210174","article-title":"Self-assembled aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy","volume":"61","author":"You","year":"2022","journal-title":"Angew. Chem."},{"key":"10.1016\/j.redox.2026.104426_bib75","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12951-025-03879-w","article-title":"Active-targeting biomimetic nanosystem for prostate cancer enhances radiotherapy efficacy by inducing ferroptosis","volume":"24","author":"Hu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.redox.2026.104426_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123437","article-title":"Dual inhibition of oxidative phosphorylation and glycolysis using a hyaluronic acid nanoparticle NOX inhibitor enhanced response to radiotherapy in colorectal cancer","volume":"323","author":"Zhang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114137","article-title":"Mitochondria-targeting nanozyme for catalytical therapy and radiotherapy with activation of cGAS-STING","volume":"244","author":"Liu","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.redox.2026.104426_bib78","doi-asserted-by":"crossref","first-page":"31055","DOI":"10.1021\/acsnano.4c07676","article-title":"Nanocarriers targeting circular RNA ADARB1 boost radiosensitivity of nasopharyngeal carcinoma through synergically promoting ferroptosis","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib79","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.redox.2026.104426_bib80","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.redox.2026.104426_bib81","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.redox.2026.104426_bib82","article-title":"Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy","volume":"14","author":"Xiaopeng","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.redox.2026.104426_bib83","article-title":"Oxidative stress amplifiers as immunogenic cell death nanoinducers disrupting mitochondrial redox homeostasis for cancer immunotherapy","volume":"12","author":"Jia","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.redox.2026.104426_bib84","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41590-024-02047-w","article-title":"The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity","volume":"26","author":"Xiang","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.redox.2026.104426_bib85","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41581-023-00689-x","article-title":"Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney","volume":"19","author":"Bay\u0131r","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.redox.2026.104426_bib86","article-title":"A mitochondria-targeted nanozyme platform for multi-pathway tumor therapy via ferroptosis and cuproptosis regulation","volume":"12","author":"Liu","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.redox.2026.104426_bib87","first-page":"2466","article-title":"Photo-activated autophagy-associated tumour cell death by lysosome impairment based on manganese-doped graphene quantum dots","volume":"B 11","author":"Liang","year":"2023","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.redox.2026.104426_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2026.104426_bib168","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1186\/s12951-024-02828-3","article-title":"Apoptosis and cuproptosis Co-activated Copper-based metal-organic frameworks for cancer therapy","volume":"22","author":"Li","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.redox.2026.104426_bib92","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-65056-9","article-title":"Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma","volume":"16","author":"Tang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104426_bib94","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41571-024-00876-0","article-title":"Targeting cuproplasia and cuproptosis in cancer","volume":"21","author":"Tang","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.redox.2026.104426_bib95","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.redox.2026.104426_bib100","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000337","article-title":"Consensus guidelines for the definition, detection and interpretation of immunogenic cell death","volume":"8","author":"Galluzzi","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.redox.2026.104426_bib97","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202501346","article-title":"NIR-II type I photosensitizer for efficient cancer therapy through synergistic ferroptosis\/pyroptosis induction and mitophagy inhibition","volume":"14","author":"Zhuang","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.redox.2026.104426_bib99","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.1112","article-title":"Defining PANoptosis: biochemical and mechanistic evaluation of innate immune cell death activation","volume":"4","author":"Tweedell","year":"2024","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.redox.2026.104426_bib89","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202402367","article-title":"Autophagy blockage enhancing photothermal and chemodynamic synergistic therapy based on HCQ\/CuS nanoplatform","volume":"13","author":"Wei","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.redox.2026.104426_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121796","article-title":"Engineering mitochondrial uncoupler synergistic photodynamic nanoplatform to harness immunostimulatory pro-death autophagy\/mitophagy","volume":"289","author":"Sun","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib91","doi-asserted-by":"crossref","first-page":"17267","DOI":"10.1021\/acsnano.4c04901","article-title":"Lipid nanoparticular codelivery system for enhanced antitumor effects by ferroptosis-apoptosis synergistic with programmed cell death-ligand 1 downregulation","volume":"18","author":"Cao","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib93","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300699","article-title":"A photo-activated thermoelectric catalyst for Ferroptosis-\/Pyroptosis-Boosted tumor nanotherapy","volume":"12","author":"Jiang","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.redox.2026.104426_bib96","article-title":"Nanoparticles synergize ferroptosis and cuproptosis to potentiate cancer immunotherapy","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.redox.2026.104426_bib98","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202409618","article-title":"Ultrasmall enzyodynamic PANoptosis nano-inducers for ultrasound-amplified hepatocellular carcinoma therapy and lung metastasis inhibition","volume":"36","author":"Wei","year":"2024","journal-title":"Adv. Mater. (Deerfield Beach, Fla.)"},{"key":"10.1016\/j.redox.2026.104426_bib101","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.actbio.2023.02.011","article-title":"Mitochondria-associated ER stress evokes immunogenic cell death through the ROS-PERK-eIF2\u03b1 pathway under PTT\/CDT combined therapy","volume":"160","author":"Feng","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.redox.2026.104426_bib102","article-title":"Synergistic STING activation and oxidative cascades-induced ferroptosis drive tumor microenvironment remodeling by engineered manganese nanoreactors","volume":"89","author":"Wa","year":"2026","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104426_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155747","article-title":"The role of ROS in tumor infiltrating immune cells and cancer immunotherapy","volume":"151","author":"Shah","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.redox.2026.104426_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122064","article-title":"Self-immolative polymer-based immunogenic cell death inducer for regulation of redox homeostasis","volume":"295","author":"Jeon","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib105","article-title":"Multimodal cascade-amplified phototheranostics for enhanced anti-tumor immunity","volume":"325","author":"Liang","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib106","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41467-024-55658-0","article-title":"Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species","volume":"16","author":"Zou","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104426_bib107","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12943-025-02242-9","article-title":"Multimodal lung cancer theranostics via manganese phosphate\/quercetin particle","volume":"24","author":"Qiu","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.redox.2026.104426_bib108","article-title":"One-step symbiosis of bimetallic peroxides nanoparticles to induce ferroptosis\/cuproptosis and activate cGAS-STING pathway for enhanced tumor immunotherapy","volume":"37","author":"Liu","year":"2025","journal-title":"Adv. Mater. (Deerfield Beach, Fla.)"},{"key":"10.1016\/j.redox.2026.104426_bib109","article-title":"Oxygen-vacancy MoO3-x nanodots induce immunogenic cell death and STING activation for synergistic cancer immunotherapy","volume":"388","author":"Lifeng","year":"2025","journal-title":"J. Contr. Release : Off. J. Control. Release"},{"key":"10.1016\/j.redox.2026.104426_bib110","article-title":"NO-Enhanced sonodynamic nanovesicles with Co-Stimulatory molecule self-presentation for multidimensional tumor immunotherapy","volume":"64","author":"Zhang","year":"2025","journal-title":"Angew. Chem."},{"key":"10.1016\/j.redox.2026.104426_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202501457","article-title":"A biomimetic nanomedicine for remodeling the immune microenvironment to potentiating anti-tumor therapy","volume":"14","author":"Ning","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.redox.2026.104426_bib112","article-title":"PhotoPyro-Induced cGAS-STING pathway activation enhanced anti-melanoma immunotherapy via a manganese-coordinated nanomedicine","volume":"13","author":"Yuzhao","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.redox.2026.104426_bib113","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.actbio.2024.04.032","article-title":"Ultra-small Janus nanoparticle-induced activation of ferroptosis for synergistic tumor immunotherapy","volume":"181","author":"Wang","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.redox.2026.104426_bib114","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jconrel.2024.05.001","article-title":"An ultrasound-activated nanoplatform remodels tumor microenvironment through diverse cell death induction for improved immunotherapy","volume":"370","author":"Ma","year":"2024","journal-title":"J. Contr. Release : Off. J. Control. Release"},{"key":"10.1016\/j.redox.2026.104426_bib115","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1186\/s12951-024-02909-3","article-title":"Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy","volume":"22","author":"Yue","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.redox.2026.104426_bib116","doi-asserted-by":"crossref","first-page":"31401","DOI":"10.1021\/acsnano.4c11278","article-title":"Targeted positron emission tomography-tracked biomimetic codelivery synergistically amplifies ferroptosis and pyroptosis for inducing lung cancer regression and Anti-PD-L1 immunotherapy efficacy","volume":"18","author":"Zhu","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib117","doi-asserted-by":"crossref","first-page":"10350","DOI":"10.1021\/acs.nanolett.3c02941","article-title":"Manganese-enriched zinc peroxide functional nanoparticles for potentiating cancer immunotherapy","volume":"23","author":"Zhou","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.redox.2026.104426_bib118","article-title":"Laser-activated nanoparticles rewire tumor microenvironment enhancing PD-1 blockade and T cell response in cholangiocarcinoma","author":"Mirko","year":"2025","journal-title":"Hepatology"},{"key":"10.1016\/j.redox.2026.104426_bib119","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/j.immuni.2025.09.003","article-title":"Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4","volume":"58","author":"Alicea","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2026.104426_bib120","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/s41556-025-01673-2","article-title":"Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8+ T cells","volume":"27","author":"Wan","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2026.104426_bib121","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.immuni.2024.08.003","article-title":"PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis","volume":"57","author":"Yu","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.redox.2026.104426_bib122","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.7150\/thno.129765","article-title":"Bioinspired nanoplatform potentiates sonodynamic immunotherapy by remodeling the antioxidant tumor microenvironment and activating STING pathway","volume":"16","author":"Zhang","year":"2026","journal-title":"Theranostics"},{"key":"10.1016\/j.redox.2026.104426_bib123","article-title":"Natural killer cell nano-engagers drive ferroptosis-immunomodulation synergy via inhibition of the Interleukin-6-JAK2-STAT3 Axis","volume":"390","author":"Xue","year":"2026","journal-title":"J. Contr. Release : Off. J. Control. Release"},{"key":"10.1016\/j.redox.2026.104426_bib124","doi-asserted-by":"crossref","first-page":"735","DOI":"10.34133\/research.0735","article-title":"A multifunctional Fe-EGCG@RSL3 nanomedicine synergizes ferroptosis induction and tumor microenvironment remodeling for enhanced bladder cancer immunotherapy","volume":"8","author":"Zhang","year":"2025","journal-title":"Research"},{"key":"10.1016\/j.redox.2026.104426_bib125","article-title":"Dual STING activation and CD47\/SIRP\u03b1 blockade via chitooligosaccharide-based nanoparticles to amplify antitumor immunity","volume":"387","author":"Shaohui","year":"2025","journal-title":"J. Contr. Release : Off. J. Control. Release"},{"key":"10.1016\/j.redox.2026.104426_bib126","article-title":"Novel Photo-STING agonists delivered by erythrocyte efferocytosis-mimicking pattern to repolarize tumor-associated macrophages for boosting anticancer immunotherapy","volume":"36","author":"Zhiyan","year":"2024","journal-title":"Adv. Mater. (Deerfield Beach, Fla.)"},{"key":"10.1016\/j.redox.2026.104426_bib127","article-title":"Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy","volume":"19","author":"Ju","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.redox.2026.104426_bib128","article-title":"ROS scavenging nanozyme modulates immunosuppression for sensitized cancer immunotherapy","volume":"12","author":"Wenjing","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.redox.2026.104426_bib129","article-title":"Chirality-dependent reprogramming of macrophages by chiral nanozymes","volume":"62","author":"Zhang","year":"2023","journal-title":"Angew. Chem."},{"key":"10.1016\/j.redox.2026.104426_bib130","doi-asserted-by":"crossref","first-page":"14424","DOI":"10.1021\/acsnano.2c12498","article-title":"Multifunctional redox-responsive nanoplatform with dual activation of macrophages and T cells for antitumor immunotherapy","volume":"17","author":"Zhang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122386","article-title":"Biomimetic inducer enabled dual ferroptosis of tumor and M2-type macrophages for enhanced tumor immunotherapy","volume":"303","author":"Chen","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib132","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12964-024-01523-y","article-title":"Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages","volume":"22","author":"Stoyan","year":"2024","journal-title":"Cell Commun. Signal. : CCS"},{"key":"10.1016\/j.redox.2026.104426_bib133","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202507665","article-title":"Reactive oxygen species-responsive biomimetic nanoplatelets for thrombus-mediated photothermal immunotherapy of tumor","volume":"64","author":"Ma","year":"2025","journal-title":"Angew. Chem."},{"key":"10.1016\/j.redox.2026.104426_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113606","article-title":"Stimuli-responsive polymer-dasatinib prodrug to reprogram cancer-associated fibroblasts for boosted immunotherapy","volume":"381","author":"Zhang","year":"2025","journal-title":"J. Contr. Release : Off. J. Control. Release"},{"key":"10.1016\/j.redox.2026.104426_bib135","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.1038\/s41467-025-63081-2","article-title":"Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy","volume":"16","author":"Rongrong","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104426_bib136","article-title":"Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment","volume":"6","author":"Hui","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.redox.2026.104426_bib137","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jconrel.2023.03.015","article-title":"Modulating tumor-stromal crosstalk via a redox-responsive nanomedicine for combination tumor therapy","volume":"356","author":"Zhang","year":"2023","journal-title":"J. Contr. Release : Off. J. Control. Release"},{"key":"10.1016\/j.redox.2026.104426_bib138","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/cac2.12608","article-title":"Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction","volume":"44","author":"Liu","year":"2024","journal-title":"Cancer Commun."},{"key":"10.1016\/j.redox.2026.104426_bib139","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.7150\/thno.89805","article-title":"Cancer-associated fibroblasts reprogram cysteine metabolism to increase tumor resistance to ferroptosis in pancreatic cancer","volume":"14","author":"Zhu","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.redox.2026.104426_bib140","article-title":"Nano-armed Limosilactobacillus reuteri for enhanced photo-immunotherapy and microbiota tryptophan metabolism against colorectal cancer","volume":"12","author":"Haiting","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.redox.2026.104426_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113797","article-title":"Multilayer cascade-response nanoplatforms as metabolic symbiotic disruptors to reprogram the immunosuppressive microenvironment","volume":"383","author":"Liu","year":"2025","journal-title":"J. Contr. Release : Off. J. Control. Release"},{"key":"10.1016\/j.redox.2026.104426_bib142","doi-asserted-by":"crossref","first-page":"10053","DOI":"10.1021\/acs.nanolett.5c01811","article-title":"Oxamate nanoparticles for enhanced tumor immunotherapy through blocking glycolysis metabolism and inducing pyroptosis","volume":"25","author":"Kuo","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.redox.2026.104426_bib143","doi-asserted-by":"crossref","first-page":"24034","DOI":"10.1021\/acsnano.5c06592","article-title":"Multienzymatic hybrid metalloenzymes triggering Cascade reactions-regulated tumor redox homeostasis and immunosuppressive microenvironment for catalytic immunotherapy","volume":"19","author":"Sun","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib144","article-title":"Lactate-modulating nanoreactors facilitate self-amplifying pyroptosis and the cGAS-STING Cascade for potentiated catalytic-immunotherapy","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.redox.2026.104426_bib145","article-title":"Tumor microenvironment-responsive metal-natural polyphenol nanozyme for radiosensitization by interfering glucose metabolism and redox homeostasis","volume":"388","author":"Jiongyu","year":"2025","journal-title":"J. Contr. Release : Off. J. Control. Release"},{"key":"10.1016\/j.redox.2026.104426_bib146","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1186\/s12951-025-03856-3","article-title":"Mesoporous multimetallic PdPtBi nanozymes target redox imbalance and glutamine deprivation for immuno-chemodynamic therapy","volume":"23","author":"Guanhua","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.redox.2026.104426_bib147","article-title":"Necroptosis-mediated synergistic photodynamic and glutamine-metabolic therapy enabled by a biomimetic targeting nanosystem for cholangiocarcinoma","volume":"11","author":"Qichang","year":"2024","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.redox.2026.104426_bib148","doi-asserted-by":"crossref","first-page":"16132","DOI":"10.1021\/acs.nanolett.4c04938","article-title":"Lactate\/cysteine dual-consuming probiotic-nanomedicine biohybrid system for enhanced cancer chemo-immunotherapy","volume":"24","author":"Tian-Qiu","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.redox.2026.104426_bib149","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.ccell.2024.10.010","article-title":"Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance","volume":"42","author":"Lin","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2026.104426_bib150","article-title":"Tumor microenvironment-initiated lipid redox cycling for efficient triple-negative breast cancer therapy","volume":"300","author":"Tian-Jiao","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.redox.2026.104426_bib151","doi-asserted-by":"crossref","first-page":"9652","DOI":"10.1039\/D3NR00107E","article-title":"Reactive oxygen species nanoamplifiers with multi-enzymatic activities for enhanced tumor therapy","volume":"15","author":"Zhao","year":"2023","journal-title":"Nanoscale"},{"key":"10.1016\/j.redox.2026.104426_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2026.115892","article-title":"Redox responsive nanosystems for medicine: from reactive species mapping to precision treatment","volume":"235","author":"Sang","year":"2026","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.redox.2026.104426_bib153","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1158\/1078-0432.CCR-16-1297","article-title":"First-in-Human study testing a new radioenhancer using nanoparticles (NBTXR3) activated by radiation therapy in patients with locally advanced soft tissue sarcomas","volume":"23","author":"Sylvie","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.redox.2026.104426_bib154","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejca.2021.01.007","article-title":"Phase I dose-escalation study of NBTXR3 activated by intensity-modulated radiation therapy in elderly patients with locally advanced squamous cell carcinoma of the oral cavity or oropharynx","volume":"146","author":"Caroline","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.redox.2026.104426_bib155","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S1470-2045(19)30326-2","article-title":"NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2-3, randomised, controlled trial","volume":"20","author":"Sylvie","year":"2019","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.redox.2026.104426_bib156","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ijrobp.2022.07.001","article-title":"Final safety and health-related quality of LIfe results of the phase 2\/3 Act.In.Sarc study with preoperative NBTXR3 plus radiation therapy versus radiation therapy in locally advanced soft-tissue sarcoma","volume":"114","author":"Sylvie","year":"2022","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.redox.2026.104426_bib157","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2217\/nnm-2022-0186","article-title":"A phase Ib\/II trial of PEP503 (NBTXR3, radioenhancer) with radiotherapy and chemotherapy in patients with rectal cancer","volume":"18","author":"Huang","year":"2023","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.redox.2026.104426_bib158","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/17435889.2025.2487411","article-title":"Results of phase Ib\/II trial of PEP503 (NBTXR3, radioenhancer) with chemoradiotherapy in patients with rectal cancer","volume":"20","author":"Huang","year":"2025","journal-title":"Nanomedicine"},{"key":"10.1016\/j.redox.2026.104426_bib159","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.radonc.2021.04.021","article-title":"Theranostic AGuIX nanoparticles as radiosensitizer: a phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial)","volume":"160","author":"Camille","year":"2021","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.redox.2026.104426_bib160","article-title":"Clinical transfer of AGuIX\u00ae-based radiation treatments for locally advanced cervical cancer: MR quantification and in vitro insights in the NANOCOL clinical trial framework","volume":"50","author":"Pauline","year":"2023","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.redox.2026.104426_bib161","doi-asserted-by":"crossref","first-page":"16516","DOI":"10.1021\/acsnano.3c12537","article-title":"Theragnostic gadolinium-based nanoparticles safely augment X-ray radiation effects in patients with cervical cancer","volume":"18","author":"Cyrus","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.redox.2026.104426_bib162","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s11307-024-01933-x","article-title":"A phase 2 multicenter clinical trial of intraoperative molecular imaging of lung cancer with a pH-Activatable nanoprobe","volume":"26","author":"Kennedy","year":"2024","journal-title":"Mol. Imag. Biol."},{"key":"10.1016\/j.redox.2026.104426_bib163","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s11307-023-01853-2","article-title":"A pH-Activatable nanoprobe labels diverse histologic subtypes of human lung cancer during resection","volume":"25","author":"Kennedy","year":"2023","journal-title":"Mol. Imag. Biol."},{"key":"10.1016\/j.redox.2026.104426_bib164","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1245\/s10434-024-15165-4","article-title":"Detection of residual peritoneal metastases following cytoreductive surgery using pegsitacianine, a pH-Sensitive imaging agent: final results from a phase II study","volume":"31","author":"Wagner","year":"2024","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.redox.2026.104426_bib169","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1080\/14796694.2025.2496131","article-title":"Nanoray-312: phase III study of NBTXR3 + radiotherapy \u00b1 cetuximab in elderly, platinum-ineligible locally advanced HNSCC","volume":"21","author":"Tourneau Christophe","year":"2025","journal-title":"Future Oncol."},{"key":"10.1016\/j.redox.2026.104426_bib170","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1038\/s41467-020-16814-4","article-title":"Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery","volume":"11","author":"Voskuil","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104426_bib171","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1186\/s12885-026-16216-7","article-title":"First-in-human evidence of multidrug resistance reversal in solid tumors: a cohort analysis of carbon nanoparticles-Fe(II) complex trials","volume":"26","author":"Xie","year":"2026","journal-title":"BMC Cancer"},{"key":"10.1016\/j.redox.2026.104426_bib172","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/bjc.2014.95","article-title":"Phase I\/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer","volume":"110","author":"Huggett","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.redox.2026.104426_bib165","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/s41565-024-01754-7","article-title":"A translational framework to DELIVER nanomedicines to the clinic","volume":"19","author":"Joyce","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.redox.2026.104426_bib166","article-title":"Clinical cancer nanomedicines","volume":"385","author":"Pallares Roger","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.redox.2026.104426_bib167","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.medj.2022.12.001","article-title":"Cancer nanomedicine toward clinical translation: obstacles, opportunities, and future prospects","volume":"4","author":"Zhang","year":"2023","journal-title":"Med"}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726004258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726004258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:21:47Z","timestamp":1792930907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726004258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":172,"alternative-id":["S2213231726004258"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104426","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"State-matched redox nanomedicine for cell fate control and multicompartment therapeutic windows","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104426","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104426"}}