{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:24:35Z","timestamp":1793870675617,"version":"4.6.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023650","name":"NCCR Catalysis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023650","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["205601"],"award-info":[{"award-number":["205601"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Redox Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.redox.2026.104439","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:33:31Z","timestamp":1791934411000},"page":"104439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Stress-induced vtRNA1-1 modulates redox homeostasis and ferroptosis susceptibility in hepatocellular carcinoma cells"],"prefix":"10.1016","volume":"98","author":[{"given":"EunBin","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sanchez-Taltavull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Oliveira-Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiia","family":"Suspitsyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Stroka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5317-3990","authenticated-orcid":false,"given":"Norbert","family":"Polacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.redox.2026.104439_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-cellbio-100616-060748","article-title":"Unconventional ways to live and die: cell death and survival in development, homeostasis, and disease","volume":"34","author":"Gudipaty","year":"2018","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.redox.2026.104439_bib2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41392-022-01110-y","article-title":"Regulated cell death (RCD) in cancer: key pathways and targeted therapies","volume":"7","author":"Peng","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2026.104439_bib3","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104439_bib4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.redox.2026.104439_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2026.104439_bib6","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41556-020-0565-1","article-title":"Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture","volume":"22","author":"Riegman","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2026.104439_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2026.104439_bib8","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2026.104439_bib9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104439_bib10","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.redox.2026.104439_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2025.104924","article-title":"Crosstalk between ROS and ferroptosis, cuproptosis, and PANoptosis in liver cancer: mechanisms and therapeutic strategies","volume":"215","author":"Chen","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.redox.2026.104439_bib12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104439_bib13","first-page":"143","article-title":"Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis","volume":"403","author":"Imai","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.redox.2026.104439_bib14","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.redox.2026.104439_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.redox.2026.104439_bib16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41576-023-00662-1","article-title":"Non-coding RNAs in disease: from mechanisms to therapeutics","volume":"25","author":"Nemeth","year":"2024","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.redox.2026.104439_bib17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12672-025-01957-x","article-title":"YRNAs: biosynthesis, structure, functions and involvment in cancer development","volume":"16","author":"Campo","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.redox.2026.104439_bib18","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1101\/gad.1837609","article-title":"A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)","volume":"23","author":"Lee","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.redox.2026.104439_bib19","article-title":"Distinct stress-dependent signatures of cellular and extracellular tRNA-Derived small RNAs","volume":"9","author":"Li","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.redox.2026.104439_bib20","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/wrna.85","article-title":"Emerging roles for the Ro 60-kDa autoantigen in noncoding RNA metabolism","volume":"2","author":"Sim","year":"2011","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.redox.2026.104439_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113112","article-title":"A ribosome-bound tRNA half stimulates mitochondrial translation during stress recovery in Trypanosoma brucei","volume":"42","author":"Brogli","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104439_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkag832","article-title":"hY3 RNA binds and inhibits ribosomes and modulates the starvation-induced integrated stress response","volume":"54","author":"Pecoraro","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2026.104439_bib23","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/s41418-022-00998-x","article-title":"Non-coding RNAs and ferroptosis: potential implications for cancer therapy","volume":"29","author":"Balihodzic","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104439_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713336","article-title":"The regulation of ferroptosis by noncoding RNAs","volume":"24","author":"Zheng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.redox.2026.104439_bib25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.omtn.2019.11.007","article-title":"Nuclear factor kappaB signaling and its related non-coding RNAs in cancer therapy","volume":"19","author":"Liu","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.redox.2026.104439_bib26","article-title":"Epigenetic therapeutics targeting NRF2\/KEAP1 signaling in cancer oxidative stress","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.redox.2026.104439_bib27","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1038\/s41418-022-00970-9","article-title":"Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p\/MIOX axis as a ceRNA","volume":"29","author":"Zhang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104439_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12943-024-02224-3","article-title":"CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p\/SLC7A11 axis","volume":"24","author":"Zhang","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.redox.2026.104439_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1115996","article-title":"Emerging role of miRNAs in the regulation of ferroptosis","volume":"10","author":"Mahmoudi-Lamouki","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.redox.2026.104439_bib30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.thbio.2005.01.002","article-title":"Evolutionary patterns of non-coding RNAs","volume":"123","author":"Bompfunewerer","year":"2005","journal-title":"Theory Biosci"},{"key":"10.1016\/j.redox.2026.104439_bib31","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1083\/jcb.103.3.699","article-title":"Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA","volume":"103","author":"Kedersha","year":"1986","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.redox.2026.104439_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14112787","article-title":"Small but powerful: the human vault RNAs as multifaceted modulators of pro-survival characteristics and tumorigenesis","volume":"14","author":"Gallo","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.redox.2026.104439_bib33","doi-asserted-by":"crossref","first-page":"7030","DOI":"10.1038\/ncomms8030","article-title":"Expression of the vault RNA protects cells from undergoing apoptosis","volume":"6","author":"Amort","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104439_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/biom10040614","article-title":"Human vtRNA1-1 levels modulate signaling pathways and regulate apoptosis in human cancer cells","volume":"10","author":"Bracher","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.redox.2026.104439_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011614","article-title":"TRIM21 modulates stability of pro-survival non-coding RNA vtRNA1-1 in human hepatocellular carcinoma cells","volume":"21","author":"Kong","year":"2025","journal-title":"PLoS Genet."},{"key":"10.1016\/j.redox.2026.104439_bib36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/15548627.2021.1922983","article-title":"The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome in hepatocellular carcinoma","volume":"18","author":"Ferro","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.redox.2026.104439_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/narcan\/zcaf028","article-title":"Regulation of angiogenesis and cancer cell proliferation by human vault RNA1-2","volume":"7","author":"Gallo","year":"2025","journal-title":"NAR Cancer"},{"key":"10.1016\/j.redox.2026.104439_bib38","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.3748\/wjg.v20.i25.8082","article-title":"Oxidative stress as a crucial factor in liver diseases","volume":"20","author":"Cichoz-Lach","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.redox.2026.104439_bib39","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41416-022-01998-x","article-title":"Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy","volume":"128","author":"Ajoolabady","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.redox.2026.104439_bib40","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41420-024-01863-1","article-title":"Ferroptosis: a new hunter of hepatocellular carcinoma","volume":"10","author":"Jiang","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.redox.2026.104439_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103815","article-title":"Cathepsin S regulates ferroptosis sensitivity in hepatocellular carcinoma through the KEAP1-NRF2 signaling pathway","volume":"86","author":"Xu","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104439_bib42","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1038\/s41418-020-0519-y","article-title":"Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15","volume":"27","author":"Kong","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.redox.2026.104439_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/260909","article-title":"tRNA-derived fragments target the ribosome and function as regulatory non-coding RNA in Haloferax volcanii","volume":"2012","author":"Gebetsberger","year":"2012","journal-title":"Archaea"},{"key":"10.1016\/j.redox.2026.104439_bib44","doi-asserted-by":"crossref","first-page":"D572","DOI":"10.1093\/nar\/gkaf1119","article-title":"FerrDb V3: expanding the manually curated resource for regulators and disease associations from ferroptosis to regulated cell death","volume":"54","author":"Zhou","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.redox.2026.104439_bib45","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.redox.2026.104439_bib46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.redox.2026.104439_bib47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.celrep.2013.06.029","article-title":"NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs","volume":"4","author":"Hussain","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104439_bib48","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1038\/s41467-019-10020-7","article-title":"Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation","volume":"10","author":"Sajini","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.redox.2026.104439_bib49","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302054","article-title":"Small vault RNA1-2 modulates expression of cell membrane proteins through nascent RNA silencing","volume":"6","author":"Alagia","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.redox.2026.104439_bib50","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/ncb1972","article-title":"The non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs","volume":"11","author":"Persson","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.redox.2026.104439_bib51","article-title":"Characteristics and biomarkers of ferroptosis","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.redox.2026.104439_bib52","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41416-019-0660-x","article-title":"Activation of the reverse transsulfuration pathway through NRF2\/CBS confers erastin-induced ferroptosis resistance","volume":"122","author":"Liu","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.redox.2026.104439_bib53","first-page":"2826","article-title":"Erastin induces apoptotic and ferroptotic cell death by inducing ROS accumulation by causing mitochondrial dysfunction in gastric cancer cell HGC-27","volume":"22","author":"Sun","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.redox.2026.104439_bib54","first-page":"853","article-title":"Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells","volume":"55","author":"Hou","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.redox.2026.104439_bib55","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41419-024-06866-5","article-title":"RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB\/Bcl-2 signaling pathway","volume":"15","author":"Liu","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104439_bib56","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-kappaB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.redox.2026.104439_bib57","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.omtn.2020.08.014","article-title":"ROS\/NF-kappaB signaling pathway-mediated transcriptional activation of TRIM37 promotes HBV-associated hepatic fibrosis","volume":"22","author":"Xie","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.redox.2026.104439_bib58","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","article-title":"NF-kappaB\/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.redox.2026.104439_bib59","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3390\/cancers2020483","article-title":"Nrf2 and NF-kappaB and their concerted modulation in cancer pathogenesis and progression","volume":"2","author":"Bellezza","year":"2010","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.redox.2026.104439_bib60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.molcel.2016.03.015","article-title":"TRIM21 ubiquitylates SQSTM1\/p62 and suppresses protein sequestration to regulate redox homeostasis","volume":"62","author":"Pan","year":"2016","journal-title":"Mol Cell"},{"key":"10.1016\/j.redox.2026.104439_bib61","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00642-17","article-title":"Negative regulation of the Keap1-Nrf2 pathway by a p62\/Sqstm1 splicing variant","volume":"38","author":"Kageyama","year":"2018","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.redox.2026.104439_bib62","article-title":"Identification of ferroptosis-related genes for overall survival prediction in hepatocellular carcinoma","volume":"12","author":"Luo","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.redox.2026.104439_bib63","article-title":"A novel ferroptosis-related signature for predicting prognosis, immune characteristics, and treatment prediction in hepatocellular carcinoma","volume":"20","author":"Wu","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.redox.2026.104439_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.210","article-title":"Regulatory non-coding RNA: new instruments in the orchestration of cell death","volume":"7","author":"Su","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.redox.2026.104439_bib65","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2019.01.030","article-title":"The small non-coding vault RNA1-1 acts as a riboregulator of autophagy","volume":"176","author":"Horos","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.redox.2026.104439_bib66","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jmb.2009.03.031","article-title":"Epstein-barr virus-induced expression of a novel human vault RNA","volume":"388","author":"Nandy","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.redox.2026.104439_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10020174","article-title":"Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy","volume":"10","author":"Arroyave-Ospina","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2026.104439_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12091653","article-title":"Oxidative stress in liver pathophysiology and disease","volume":"12","author":"Allameh","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2026.104439_bib69","doi-asserted-by":"crossref","DOI":"10.20517\/2394-5079.2018.29","article-title":"Oxidative stress and hepatocarcinogenesis","volume":"4","author":"Fu","year":"2018","journal-title":"Hepatoma Res"},{"key":"10.1016\/j.redox.2026.104439_bib70","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: pivotal roles in inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.redox.2026.104439_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11122345","article-title":"Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease","volume":"11","author":"Ngo","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.redox.2026.104439_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.11.017","article-title":"NRF2 and NF-\u049bB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches","volume":"21","author":"Sivandzade","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.redox.2026.104439_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101480","article-title":"An Nrf2-NF-kappaB crosstalk controls hepatocyte proliferation in the normal and injured liver","volume":"19","author":"Kuklin","year":"2025","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2026.104439_bib74","doi-asserted-by":"crossref","first-page":"41282","DOI":"10.1074\/jbc.M206980200","article-title":"The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein","volume":"277","author":"Kickhoefer","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.redox.2026.104439_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2024.101410","article-title":"Noncoding vault RNA1-1 impairs intestinal epithelial renewal and barrier function by interacting with CUG-binding protein 1","volume":"19","author":"Sharma","year":"2025","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.redox.2026.104439_bib76","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201911078","article-title":"Small noncoding vault RNA modulates synapse formation by amplifying MAPK signaling","volume":"220","author":"Wakatsuki","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.redox.2026.104439_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115823","article-title":"Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1","volume":"44","author":"Stok","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.redox.2026.104439_bib78","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1038\/s12276-025-01569-z","article-title":"RNA-binding protein HnRNPU regulates proliferation and ferroptosis in colon adenocarcinoma by stabilizing the mRNA of system xc","volume":"57","author":"Zhang","year":"2025","journal-title":"Exp. Mol. Med."}],"container-title":["Redox Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726004386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213231726004386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:25:50Z","timestamp":1793867150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231726004386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":78,"alternative-id":["S2213231726004386"],"URL":"https:\/\/doi.org\/10.1016\/j.redox.2026.104439","relation":{},"ISSN":["2213-2317"],"issn-type":[{"value":"2213-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stress-induced vtRNA1-1 modulates redox homeostasis and ferroptosis susceptibility in hepatocellular carcinoma cells","name":"articletitle","label":"Article Title"},{"value":"Redox Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.redox.2026.104439","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104439"}}