{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:24:55Z","timestamp":1791271495822,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Peptides"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.regpep.2003.12.001","type":"journal-article","created":{"date-parts":[[2004,2,28]],"date-time":"2004-02-28T05:31:43Z","timestamp":1077946303000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"title":["Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice"],"prefix":"10.1016","volume":"118","author":[{"given":"Albert","family":"Salehi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotta","family":"Dornonville de la Cour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"H\u00e5kanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingmar","family":"Lundquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.regpep.2003.12.001_BIB1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0016-5085(72)80078-7","article-title":"Gastric operations and glucose homeostasis","volume":"62","author":"Breuer","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2003.12.001_BIB2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0002-9610(82)90576-1","article-title":"Pancreatic endocrine function after total gastrectomy and truncal vagotomy","volume":"144","author":"Sudo","year":"1982","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.regpep.2003.12.001_BIB3","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1469-7793.1999.579ae.x","article-title":"Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice","volume":"514","author":"Salehi","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.regpep.2003.12.001_BIB4","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2003.12.001_BIB5","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1210\/endo.141.11.7757","article-title":"Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans","volume":"141","author":"Date","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2003.12.001_BIB6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0167-0115(01)00243-9","article-title":"A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control","volume":"99","author":"Dornonville de la Cour","year":"2001","journal-title":"Regul. Pept."},{"key":"10.1016\/j.regpep.2003.12.001_BIB7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00418-002-0415-1","article-title":"Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues","volume":"117","author":"Rindi","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.regpep.2003.12.001_BIB8","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tschop","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2003.12.001_BIB9","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1006\/bbrc.2001.4518","article-title":"Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration","volume":"281","author":"Toshinai","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.regpep.2003.12.001_BIB10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2337\/diabetes.51.1.124","article-title":"Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion","volume":"51","author":"Date","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.regpep.2003.12.001_BIB11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1210\/endo.143.1.8602","article-title":"Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations","volume":"143","author":"Lee","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2003.12.001_BIB12","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1210\/jcem.86.10.8098","article-title":"Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans","volume":"86","author":"Broglio","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.regpep.2003.12.001_BIB13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/eje.0.1460241","article-title":"Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion","volume":"146","author":"Egido","year":"2002","journal-title":"Eur J. Endocrinol."},{"key":"10.1016\/j.regpep.2003.12.001_BIB14","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1210\/en.2002-220819","article-title":"Dose-dependent inhibition by ghrelin of insulin secretion in the mouse","volume":"144","author":"Kvist Reimer","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2003.12.001_BIB15","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.2337\/diabetes.51.10.2911","article-title":"Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia","volume":"51","author":"Lucidi","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.regpep.2003.12.001_BIB16","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1677\/joe.0.175r007","article-title":"Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents","volume":"175","author":"McCowen","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.regpep.2003.12.001_BIB17","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1210\/jcem.87.8.8879","article-title":"Insulin regulates plasma ghrelin concentration","volume":"87","author":"Saad","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.regpep.2003.12.001_BIB18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1210\/jcem.87.1.8129","article-title":"Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion","volume":"87","author":"Shiiya","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.regpep.2003.12.001_BIB19","doi-asserted-by":"crossref","first-page":"E313","DOI":"10.1152\/ajpendo.00569.2001","article-title":"The influence of insulin on circulating ghrelin","volume":"284","author":"Flanagan","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.regpep.2003.12.001_BIB20","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1210\/jcem.87.4.8538","article-title":"Insulin, unlike food intake, does not suppress ghrelin in human subjects","volume":"87","author":"Caixas","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.regpep.2003.12.001_BIB21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00007890-198510000-00018","article-title":"An improved method for isolation of mouse pancreatic islets","volume":"40","author":"Gotoh","year":"1985","journal-title":"Transplantation"},{"key":"10.1016\/j.regpep.2003.12.001_BIB22","series-title":"Labelled Proteins in Tracer Studies","first-page":"345","article-title":"A simplified insulin radioimmunoassay method","author":"Heding","year":"1966"},{"key":"10.1016\/j.regpep.2003.12.001_BIB23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/BF00281302","article-title":"Glucagon immunoreactivity in plasma from normal and dystrophic mice","volume":"22","author":"Ahr\u00e9n","year":"1982","journal-title":"Diabetologia"},{"key":"10.1016\/j.regpep.2003.12.001_BIB24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0168-8227(92)90142-E","article-title":"Homologous islet amyloid polypeptide: effects on plasma levels of glucagon, insulin and glucose in the mouse","volume":"18","author":"Panagiotidis","year":"1992","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.regpep.2003.12.001_BIB25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0003-2697(78)90514-6","article-title":"Enzymatic microdetermination of glycogen","volume":"84","author":"Bruss","year":"1978","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.regpep.2003.12.001_BIB26","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1210\/endo.137.4.8625892","article-title":"Islet acid glucan-1,4-alpha-glucosidase: a putative key enzyme in nutrient-stimulated insulin secretion","volume":"137","author":"Lundquist","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2003.12.001_BIB27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00006676-199205000-00013","article-title":"The relationship of islet amyloglucosidase activity and glucose-induced insulin secretion","volume":"7","author":"Lundquist","year":"1992","journal-title":"Pancreas"},{"key":"10.1016\/j.regpep.2003.12.001_BIB28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1385\/ENDO:11:1:99","article-title":"Nitric oxide and hydroperoxide affect islet hormone release and Ca2+ efflux","volume":"11","author":"\u00c5kesson","year":"1999","journal-title":"Endocrine"},{"key":"10.1016\/j.regpep.2003.12.001_BIB29","series-title":"The Stomach as an Endocrine Organ","first-page":"9","article-title":"Gastric endocrine cell typing at the light microscopic level","author":"Sundler","year":"1991"},{"key":"10.1016\/j.regpep.2003.12.001_BIB30","series-title":"Physiology of the Gastrointestinal Tract","first-page":"1171","article-title":"The ECL cells","author":"H\u00e5kanson","year":"1994"},{"key":"10.1016\/j.regpep.2003.12.001_BIB31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0303-7207(90)90152-X","article-title":"Control of insulin secretion: a model involving Ca2+, cAMP and diacylglycerol","volume":"70","author":"Zawalich","year":"1990","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.regpep.2003.12.001_BIB32","first-page":"362","article-title":"Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure","volume":"83","author":"Svensson","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.regpep.2003.12.001_BIB33","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.1074\/jbc.M103898200","article-title":"Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells","volume":"277","author":"Murata","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.regpep.2003.12.001_BIB34","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1006\/bbrc.2002.6737","article-title":"Ghrelin, macronutrient intake and dietary preferences in Long\u2013Evans rats","volume":"292","author":"Beck","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.regpep.2003.12.001_BIB35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1677\/joe.0.1740283","article-title":"Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats","volume":"174","author":"Murakami","year":"2002","journal-title":"J. Endocrinol."}],"container-title":["Regulatory Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011503003070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011503003070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:15:46Z","timestamp":1759072546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167011503003070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0167011503003070"],"URL":"https:\/\/doi.org\/10.1016\/j.regpep.2003.12.001","relation":{},"ISSN":["0167-0115"],"issn-type":[{"value":"0167-0115","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice","name":"articletitle","label":"Article Title"},{"value":"Regulatory Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.regpep.2003.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}