{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T06:16:01Z","timestamp":1680329761018},"reference-count":47,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Peptides"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.regpep.2004.05.001","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T14:23:17Z","timestamp":1087914197000},"page":"155-162","source":"Crossref","is-referenced-by-count":6,"title":["CART peptide: central mediator of leptin-induced adipose tissue apoptosis?"],"prefix":"10.1016","volume":"121","author":[{"given":"Yang-Ho","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Anne","family":"Della-Fera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChangLong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane L","family":"Hartzell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne E","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Kuhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifton A","family":"Baile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.regpep.2004.05.001_BIB1","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.1073\/pnas.93.16.8733","article-title":"Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction","volume":"93","author":"Gautvik","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.regpep.2004.05.001_BIB2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/(SICI)1096-9861(20000117)416:3<291::AID-CNE2>3.0.CO;2-E","article-title":"CART peptide immunoreactivity in the hypothalamus and pituitary in monkeys: analysis of ultrastructural features and synaptic connections in the paraventricular nucleus","volume":"416","author":"Dall Vechia","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/(SICI)1096-9861(19980202)391:1<115::AID-CNE10>3.0.CO;2-X","article-title":"Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain","volume":"391","author":"Koylu","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1046\/j.1365-2826.1997.00651.x","article-title":"Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland","volume":"9","author":"Koylu","year":"1997","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0006-8993(98)01349-3","article-title":"Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour","volume":"818","author":"Vrang","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.regpep.2004.05.001_BIB6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/29993","article-title":"Hypothalamic CART is a new anorectic peptide regulated by leptin","volume":"393","author":"Kristensen","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2004.05.001_BIB7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1098-2396(199808)29:4<293::AID-SYN1>3.0.CO;2-0","article-title":"CART peptides in the central control of feeding and interactions with neuropeptide Y","volume":"29","author":"Lambert","year":"1998","journal-title":"Synapse"},{"key":"10.1016\/j.regpep.2004.05.001_BIB8","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/oby.2000.76","article-title":"Chronic intracerebroventricular administration of recombinant CART(42-89) peptide inhibits and causes weight loss in lean and obese Zucker (fa\/fa) rats","volume":"8","author":"Larsen","year":"2000","journal-title":"Obes. Res."},{"key":"10.1016\/j.regpep.2004.05.001_BIB9","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0896-6273(00)80656-X","article-title":"Leptin activates hypothalamic CART neurons projecting to the spinal cord","volume":"21","author":"Elias","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.regpep.2004.05.001_BIB10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1172\/JCI119532","article-title":"Receptor-mediated regional sympathetic nerve activation by leptin","volume":"100","author":"Haynes","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.regpep.2004.05.001_BIB11","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1097\/00001756-200009280-00040","article-title":"Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression","volume":"11","author":"Wang","year":"2000","journal-title":"NeuroReport"},{"key":"10.1016\/j.regpep.2004.05.001_BIB12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0031-9384(02)00652-2","article-title":"Energy metabolism and expression of uncoupling proteins 1, 2 and 3 after twenty-one days of recovery from mouse leptin ICV in rats","volume":"75","author":"Gullicksen","year":"2002","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.regpep.2004.05.001_BIB13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/sj.ijo.0802205","article-title":"Adipose tissue cellularity and apoptosis after intracerebroventricular injections of leptin and 21 days of recovery in rats","volume":"27","author":"Gullicksen","year":"2003","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.regpep.2004.05.001_BIB14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1463-1326.2001.00112.x","article-title":"Adipocyte apoptosis in the regulation of body fat mass by leptin","volume":"3","author":"Della-Fera","year":"2001","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.regpep.2004.05.001_BIB15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0031-9384(03)00205-1","article-title":"Melanocortin receptors mediate leptin effects on feeding and body weight, but not adipose apoptosis","volume":"79","author":"Choi","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.regpep.2004.05.001_BIB16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-022X(03)00151-9","article-title":"Detection of DNA fragmentation and apoptotic proteins, and quantification of uncoupling protein expression by real-time RT-PCR in adipose tissue","volume":"58","author":"Gullicksen","year":"2004","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10.1016\/j.regpep.2004.05.001_BIB17","doi-asserted-by":"crossref","first-page":"R1862","DOI":"10.1152\/ajpregu.2001.281.6.R1862","article-title":"Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site","volume":"281","author":"Aja","year":"2001","journal-title":"Am. J. Physiol., Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0006-8993(00)02386-6","article-title":"Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3-receptor","volume":"869","author":"Abbott","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.regpep.2004.05.001_BIB19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(03)01368-2","article-title":"Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents","volume":"464","author":"Chaki","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB20","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1210\/en.139.2.791","article-title":"Brain administration of leptin causes deletion of adipocytes by apoptosis","volume":"139","author":"Qian","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2004.05.001_BIB21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.domaniend.2003.08.004","article-title":"Beta-adrenergic receptor agonists increase apoptosis of adipose tissue in mice","volume":"26","author":"Page","year":"2004","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB22","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.2337\/diabetes.50.9.2157","article-title":"Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family","volume":"50","author":"del Giudice","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.regpep.2004.05.001_BIB23","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/sj.ijo.0801848","article-title":"Sequencing of the putative promoter region of the cocaine- and amphetamine-regulated-transcript gene and identification of polymorphic sites associated with obesity","volume":"26","author":"Yamada","year":"2002","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.regpep.2004.05.001_BIB24","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1210\/en.142.10.4394","article-title":"Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet","volume":"142","author":"Asnicar","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2004.05.001_BIB25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0006-8993(99)01977-0","article-title":"Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin\/hypocretin and neuropeptide Y","volume":"848","author":"Broberger","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.regpep.2004.05.001_BIB26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/cne.1162","article-title":"CART peptide-immunoreactive projection from the nucleus accumbens targets substantia nigra pars reticulata neurons in the rat","volume":"434","author":"Dallvechia-Adams","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/cne.10268","article-title":"Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons","volume":"448","author":"Dallvechia-Adams","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1046\/j.1365-2982.2003.00437.x","article-title":"Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract","volume":"15","author":"Ekblad","year":"2003","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.regpep.2004.05.001_BIB29","doi-asserted-by":"crossref","first-page":"E967","DOI":"10.1152\/ajpendo.00292.2001","article-title":"Hyperleptinemia in A(y)\/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression","volume":"282","author":"Tsuruta","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.regpep.2004.05.001_BIB30","doi-asserted-by":"crossref","first-page":"10373","DOI":"10.1073\/pnas.96.18.10373","article-title":"Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia","volume":"96","author":"Wang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.regpep.2004.05.001_BIB31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0006-8993(99)01907-1","article-title":"CART: from gene to function","volume":"848","author":"Adams","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.regpep.2004.05.001_BIB32","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1096\/fj.02-0805fje","article-title":"A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation","volume":"17","author":"Kong","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.regpep.2004.05.001_BIB33","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1210\/en.142.8.3457","article-title":"Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei","volume":"142","author":"Abbott","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2004.05.001_BIB34","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1037\/0735-7044.116.5.918","article-title":"Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats","volume":"116","author":"Aja","year":"2002","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.regpep.2004.05.001_BIB35","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2337\/diabetes.45.4.531","article-title":"Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob\/ob mice","volume":"45","author":"Schwartz","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.regpep.2004.05.001_BIB36","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2337\/diabetes.46.12.2119","article-title":"Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus","volume":"46","author":"Schwartz","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.regpep.2004.05.001_BIB37","first-page":"219","article-title":"Central thermoregulatory effects of neuropeptide Y and orexin A in rats","volume":"86","author":"Balasko","year":"1999","journal-title":"Acta Physiol. Hung."},{"key":"10.1016\/j.regpep.2004.05.001_BIB38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2170\/jjphysiol.32.677","article-title":"Effect of intraventricular administration of vasoactive intestinal polypeptide on body temperature in the rat","volume":"32","author":"Itoh","year":"1982","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2170\/jjphysiol.45.37","article-title":"Effects of neuromedins and related peptides on the body temperature of rats","volume":"45","author":"Itoh","year":"1995","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.regpep.2004.05.001_BIB40","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0006-8993(77)90173-1","article-title":"Neurotensin: central nervous system effects of a hypothalamic peptide","volume":"128","author":"Nemeroff","year":"1977","journal-title":"Brain Res."},{"key":"10.1016\/j.regpep.2004.05.001_BIB41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0006-8993(03)02281-9","article-title":"Pharmacological characteristics of bombesin receptor mediating hypothermia in the central nervous system of rats","volume":"969","author":"Tsushima","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.regpep.2004.05.001_BIB42","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0028-3908(82)90122-8","article-title":"The effects of injections of bombesin into the cerebral ventricles on food intake and body temperature in food-deprived rats","volume":"21","author":"Avery","year":"1982","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.regpep.2004.05.001_BIB43","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0196-9781(90)90017-Y","article-title":"Centrally administered neuropeptide Y enhances the hypothermia induced by peripheral administration of adrenoceptor antagonists","volume":"11","author":"Ruiz de Elvira","year":"1990","journal-title":"Peptides"},{"key":"10.1016\/j.regpep.2004.05.001_BIB44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0361-9230(94)00177-3","article-title":"Effects of NPY and NPY2-36 on body temperature and food intake following administration into hypothalamic nuclei","volume":"36","author":"Bouali","year":"1995","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.regpep.2004.05.001_BIB45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0361-9230(91)90237-E","article-title":"Neurobehavioral profile of neuropeptide Y","volume":"26","author":"Jolicoeur","year":"1991","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.regpep.2004.05.001_BIB46","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0196-9781(94)90032-9","article-title":"In vivo central actions of NPY(1-30), an N-terminal fragment of neuropeptide Y","volume":"15","author":"Bouali","year":"1994","journal-title":"Peptides"},{"key":"10.1016\/j.regpep.2004.05.001_BIB47","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1046\/j.1365-2826.2002.00832.x","article-title":"Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine- and amphetamine-regulated transcript and alpha-melanocyte-stimulating hormone in vitro in male rats","volume":"14","author":"Dhillo","year":"2002","journal-title":"J. Neuroendocrinol."}],"container-title":["Regulatory Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011504001338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011504001338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T19:50:46Z","timestamp":1549482646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167011504001338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":47,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0167011504001338"],"URL":"https:\/\/doi.org\/10.1016\/j.regpep.2004.05.001","relation":{},"ISSN":["0167-0115"],"issn-type":[{"value":"0167-0115","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}