{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:02:34Z","timestamp":1773864154701,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Peptides"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.regpep.2007.09.009","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T14:34:59Z","timestamp":1190126099000},"page":"197-203","source":"Crossref","is-referenced-by-count":21,"title":["Effects of pinealectomy and exogenous melatonin on ghrelin and peptide YY in gastrointestinal system and neuropeptide Y in hypothalamic arcuate nucleus: Immunohistochemical studies in male rats"],"prefix":"10.1016","volume":"146","author":[{"given":"Mehmet","family":"Aydin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"Canpolat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuncay","family":"Kulo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Yasar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neriman","family":"Colakoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haluk","family":"Kelestimur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.regpep.2007.09.009_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-2999(01)01230-4","article-title":"Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat","volume":"428","author":"Canpolat","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.regpep.2007.09.009_bib2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.33549\/physiolres.930478","article-title":"Pinealectomy increases and exogenous melatonin decreases leptin production in rat anterior pituitary cells: an immunohistochemical study","volume":"53","author":"Kus","year":"2004","journal-title":"Physiol Res"},{"key":"10.1016\/j.regpep.2007.09.009_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S1043-2760(00)00362-3","article-title":"Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor","volume":"12","author":"Kojima","year":"2001","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.regpep.2007.09.009_bib4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1210\/er.2002-0029","article-title":"Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin","volume":"25","author":"van der Lely","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.regpep.2007.09.009_bib5","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tschop","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2007.09.009_bib6","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1210\/en.2004-1622","article-title":"Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat","volume":"146","author":"Fernandez-Fernandez R Navarro","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2007.09.009_bib7","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1210\/jc.86.10.4753","article-title":"Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelinlike immunoreactivity levels in humans","volume":"86","author":"Ariyasu","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.regpep.2007.09.009_bib8","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1210\/en.141.11.4255","article-title":"Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans","volume":"141","author":"Date","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2007.09.009_bib9","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.mad.2004.06.011","article-title":"Alterations in stomach ghrelin production and in ghrelin-induced growth hormone secretion in the aged rat","volume":"125","author":"Englander","year":"2004","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.regpep.2007.09.009_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.regpep.2004.08.038","article-title":"Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus","volume":"126","author":"Mondal","year":"2005","journal-title":"Regul Pept"},{"key":"10.1016\/j.regpep.2007.09.009_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1385\/ENDO:16:1:43","article-title":"Preliminary evidence that pharmacologic melatonin treatment decreases rat ghrelin levels","volume":"16","author":"Mustonen","year":"2001","journal-title":"Endocrine"},{"key":"10.1016\/j.regpep.2007.09.009_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neulet.2006.09.071","article-title":"Effects of pinealectomy and exogenous melatonin on immunohistochemical ghrelin staining of arcuate nucleus and serum ghrelin leves in the rat","volume":"410","author":"Canpolat","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.regpep.2007.09.009_bib13","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/0016-5085(85)90211-2","article-title":"Human distribution and release of a putative new gut hormone, peptide YY","volume":"89","author":"Adrian","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2007.09.009_bib14","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0016-5085(85)90144-1","article-title":"Distribution and release of peptide YY in dog measured by specific radioimmunoassay","volume":"88","author":"Taylor","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2007.09.009_bib15","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0196-9781(94)90035-3","article-title":"Characterization of two forms of peptide YY, PYY(1\u201336) and PYY(3\u2013 36), in the rabbit","volume":"15","author":"Grandt","year":"1994","journal-title":"Peptides"},{"key":"10.1016\/j.regpep.2007.09.009_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0167-0115(94)90204-6","article-title":"Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY(1\u201336) and PYY(3\u201336)","volume":"51","author":"Grandt","year":"1994","journal-title":"Regul Pept"},{"key":"10.1016\/j.regpep.2007.09.009_bib17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/153537020322800301","article-title":"Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes","volume":"228","author":"Berglund","year":"2003","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.regpep.2007.09.009_bib18","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1210\/jc.2004-1251","article-title":"Ghrelin, peptide YY, glucose-dependent \u0131nsulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents","volume":"90","author":"Stock","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.regpep.2007.09.009_bib19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1210\/en.2004-1138","article-title":"Intravenous \u0131nfusion of peptide YY(3\u201336) potently \u0131nhibits food \u0131ntake in rats","volume":"146","author":"Chelikani","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2007.09.009_bib20","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1210\/en.2004-1266","article-title":"The role of the vagal nerve in peripheral PYY3\u201336-\u0131nduced feeding reduction in rats","volume":"146","author":"Koda","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2007.09.009_bib21","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/oby.2004.244","article-title":"Regulation of peptide YY levels by age. Hormonal, and nutritional status","volume":"12","author":"Tovar","year":"2004","journal-title":"Obes Res"},{"key":"10.1016\/j.regpep.2007.09.009_bib22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/296659a0","article-title":"Neuropeptide Y\u2014a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide","volume":"296","author":"Tatemoto","year":"1982","journal-title":"Nature."},{"key":"10.1016\/j.regpep.2007.09.009_bib23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s000180300029","article-title":"Neuropeptide Y: the universal soldier","volume":"60","author":"Pedrazzini","year":"2003","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.regpep.2007.09.009_bib24","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0306-4522(85)90260-X","article-title":"The anatomy of neuropeptide-y-containing neurons in rat brain","volume":"15","author":"Chronwall","year":"1985","journal-title":"Neuroscience"},{"key":"10.1016\/j.regpep.2007.09.009_bib25","doi-asserted-by":"crossref","first-page":"948","DOI":"10.2337\/diabetes.52.4.948","article-title":"Ghrelin directly interacts With Neuropeptide-Y-containing neurons in the rat arcuate nucleus Ca2 signaling via protein kinase A and N-Type channel-dependent mechanisms and cross-talk with leptin and orexin","volume":"52","author":"Kohno","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.regpep.2007.09.009_bib26","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1210\/en.140.11.5382","article-title":"Morphological evidence for direct interaction between arcuate nucleus neuropeptide Y (NPY) neurons and gonadotropin-releasing hormone neurons and the possible involvement of NPY Y1 receptors","volume":"140","author":"Li","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2007.09.009_bib27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.pain.2005.08.023","article-title":"Involvement of neuropeptide Y and Y1 receptor in antinociception in the arcuate nucleus of hypothalamus, an immunohistochemical and pharmacological study in intact rats and rats with inflammation","volume":"118","author":"Li","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.regpep.2007.09.009_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0304-3940(00)01425-7","article-title":"Prenatal melatonin exposure affects luteinizing hormone and hypothalamic and striatal neuropeptide Y in the male rat offspring","volume":"292","author":"Diaz","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.regpep.2007.09.009_bib29","doi-asserted-by":"crossref","first-page":"10510","DOI":"10.1523\/JNEUROSCI.2552-05.2005","article-title":"Peptide YY(3\u201336) inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons: implications for hypothalamic regulation of energy homeostasis","volume":"25","author":"Acuna-Goycolea","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.regpep.2007.09.009_bib30","first-page":"3","article-title":"Relationship between the pineal gland and the mitotic activity of some tissues","volume":"55","author":"Bindoni","year":"1971","journal-title":"Arch Sci Biol"},{"key":"10.1016\/j.regpep.2007.09.009_bib31","first-page":"317","article-title":"The opposing effect of high and low doses of melatonin upon mitotic activity of the mouse intestinal epithelium","volume":"38","author":"Zerek-Melen","year":"1987","journal-title":"Endokrynol Pol"},{"key":"10.1016\/j.regpep.2007.09.009_bib32","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1210\/endo.140.11.7093","article-title":"Morphological evidence for direct interaction between arcuate nucleus neuropeptide Y (NPY) neurons and gonadotropin-releasing hormone neurons and the possible involvement of NPY YI receptors","volume":"140","author":"Li","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2007.09.009_bib33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/09513599009009804","article-title":"The role of neuropeptide Y (NPY) in control of gonadotropin and prolactin release in the rat","volume":"4","author":"Rettori","year":"1990","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.regpep.2007.09.009_bib34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/1082","article-title":"Co-expression of AgRP and NPY in fasting-activated hypothalamic neurons","volume":"1","author":"Hahn","year":"1998","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.regpep.2007.09.009_bib35","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0896-6273(03)00063-1","article-title":"The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis","volume":"37","author":"Cowley","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.regpep.2007.09.009_bib36","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1365-2826.2004.01213.x","article-title":"Role of leptin in orexigenic neuropeptide expression during lactation in rats","volume":"16","author":"Crowley","year":"2004","journal-title":"J Neuroendocrinol"}],"container-title":["Regulatory Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011507001826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011507001826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T05:20:36Z","timestamp":1684041636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167011507001826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":36,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0167011507001826"],"URL":"https:\/\/doi.org\/10.1016\/j.regpep.2007.09.009","relation":{},"ISSN":["0167-0115"],"issn-type":[{"value":"0167-0115","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}