{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:05:57Z","timestamp":1791273957409,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":537,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior)"},{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)"},{"name":"FAPERJ (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Peptides"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.regpep.2011.11.002","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T01:48:01Z","timestamp":1322617681000},"page":"6-11","source":"Crossref","is-referenced-by-count":10,"title":["Early life overfeeding decreases acylated ghrelin circulating levels and upregulates GHSR1a signaling pathway in white adipose tissue of obese young mice"],"prefix":"10.1016","volume":"174","author":[{"given":"Vivian M.","family":"Soares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica P.","family":"Garcia-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauciane","family":"Lacerda-Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anibal S.","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.regpep.2011.11.002_bb0005","series-title":"Obesity and overweight","author":"WHO","year":"2011"},{"key":"10.1016\/j.regpep.2011.11.002_bb0010","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1210\/er.2006-0032","article-title":"Understanding and addressing the epidemic of obesity: an energy balance perspective","volume":"27","author":"Hill","year":"2006","journal-title":"Endocr Rev"},{"key":"10.1016\/j.regpep.2011.11.002_bb0015","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1210\/me.2003-0459","article-title":"The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes","volume":"18","author":"Kim","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.regpep.2011.11.002_bb0020","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1210\/endo.141.11.7873","article-title":"The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion","volume":"141","author":"Wren","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2011.11.002_bb0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.regpep.2005.11.001","article-title":"Ghrelin stimulates insulin-induced glucose uptake in adipocytes","volume":"134","author":"Patel","year":"2006","journal-title":"Regul Pept"},{"key":"10.1016\/j.regpep.2011.11.002_bb0030","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jnutbio.2008.05.002","article-title":"Long-term effects of overfeeding during lactation on insulin secretion\u2014the role of GLUT-2","volume":"20","author":"Cunha","year":"2009","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.regpep.2011.11.002_bb0035","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1677\/JOE-07-0046","article-title":"Low expression of insulin signaling molecules impairs glucose uptake in adipocytes after early overnutrition","volume":"195","author":"Rodrigues","year":"2007","journal-title":"J Endocrinol"},{"key":"10.1016\/j.regpep.2011.11.002_bb0040","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0006-8993(99)01662-5","article-title":"Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats","volume":"836","author":"Plagemann","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.regpep.2011.11.002_bb0045","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1136\/bmj.2.5701.74","article-title":"Follow-up study of physical growth of children who had excessive weight gain in the first six months of life","volume":"2","author":"Eid","year":"1970","journal-title":"Br Med J"},{"key":"10.1016\/j.regpep.2011.11.002_bb0050","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1677\/JOE-08-0057","article-title":"Early overnutrition impairs insulin signaling in the heart of adult Swiss mice","volume":"198","author":"Martins","year":"2008","journal-title":"J Endocrinol"},{"key":"10.1016\/j.regpep.2011.11.002_bb0055","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1046\/j.1365-2826.1999.00357.x","article-title":"Observations on the orexigenic hypothalamic neuropeptide Y-system in neonatally overfed weanling rats","volume":"11","author":"Plagemann","year":"1999","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.regpep.2011.11.002_bb0060","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.physbeh.2005.08.065","article-title":"Perinatal programming and functional teratogenesis: impact on body weight regulation and obesity","volume":"86","author":"Plagemann","year":"2005","journal-title":"Physiol Behav"},{"key":"10.1016\/j.regpep.2011.11.002_bb0065","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1210\/me.2008-0432","article-title":"Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention","volume":"23","author":"Davies","year":"2009","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.regpep.2011.11.002_bb0070","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tschop","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2011.11.002_bb0075","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1172\/JCI25811","article-title":"Ghrelin action in the brain controls adipocyte metabolism","volume":"116","author":"Theander-Carrillo","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.regpep.2011.11.002_bb0080","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1172\/JCI26002","article-title":"Mice lacking ghrelin receptors resist the development of diet-induced obesity","volume":"115","author":"Zigman","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.regpep.2011.11.002_bb0085","first-page":"549","article-title":"The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin\/GHSR1a system","volume":"12","author":"Lodeiro","year":"2011","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.regpep.2011.11.002_bb0090","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1055\/s-0029-1211159","article-title":"Obesity and enhanced diabetes and cardiovascular risk in adult rats due to early postnatal overfeeding","volume":"99","author":"Plagemann","year":"1992","journal-title":"Exp Clin Endocrinol"},{"key":"10.1016\/j.regpep.2011.11.002_bb0095","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/jn\/128.3.661","article-title":"Issues of design and analysis relating to the use of multiparous species in developmental nutritional studies","volume":"128","author":"Wainwright","year":"1998","journal-title":"J Nutr"},{"issue":"199","key":"10.1016\/j.regpep.2011.11.002_bb0100","first-page":"208","article-title":"Revised Guide for the Care and Use of Laboratory Animals available. American Physiological Society","volume":"39","author":"Bayne","year":"1996","journal-title":"Physiologist"},{"key":"10.1016\/j.regpep.2011.11.002_bb0105","series-title":"Practical methods for biological morphometry","article-title":"Stereological methods","author":"Weibel","year":"1979"},{"key":"10.1016\/j.regpep.2011.11.002_bb0110","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2011.11.002_bb0115","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.numecd.2009.01.008","article-title":"Left ventricular hypertrophy induced by overnutrition early in life","volume":"19","author":"Moreira","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.regpep.2011.11.002_bb0120","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2337\/diabetes.50.4.707","article-title":"Circulating ghrelin levels are decreased in human obesity","volume":"50","author":"Tschop","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.regpep.2011.11.002_bb0125","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.mce.2011.02.011","article-title":"Ghrelin in obesity and endocrine diseases","volume":"340","author":"Scerif","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.regpep.2011.11.002_bb0130","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/BF03349188","article-title":"Overfeeding-induced weight gain suppresses plasma ghrelin levels in rats","volume":"29","author":"Williams","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.regpep.2011.11.002_bb0135","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1210\/en.2010-0439","article-title":"Basal plasma levels of insulin, leptin, ghrelin, and amylin do not signal adiposity in rats recovering from forced overweight","volume":"151","author":"Gloy","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2011.11.002_bb0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yfrne.2004.03.002","article-title":"Ghrelin\u2014a hormone with multiple functions","volume":"25","author":"Korbonits","year":"2004","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.regpep.2011.11.002_bb0145","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1474-9726.2011.00740.x","article-title":"Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues","volume":"10","author":"Lin","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.regpep.2011.11.002_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030048","article-title":"Roles of 5\u2032-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis","volume":"375","author":"Rutter","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.regpep.2011.11.002_bb0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.2006.111484","article-title":"Functions of AMP-activated protein kinase in adipose tissue","volume":"574","author":"Daval","year":"2006","journal-title":"J Physiol"},{"key":"10.1016\/j.regpep.2011.11.002_bb0160","doi-asserted-by":"crossref","first-page":"E228","DOI":"10.1152\/ajpendo.00115.2004","article-title":"Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle","volume":"288","author":"Barazzoni","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.regpep.2011.11.002_bb0165","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1210\/en.2002-220783","article-title":"The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis","volume":"144","author":"Choi","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2011.11.002_bb0170","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)81654-2","article-title":"PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function","volume":"99","author":"Lowell","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.regpep.2011.11.002_bb0175","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1006\/bbrc.2001.5484","article-title":"The effects of AICAR on adipocyte differentiation of 3T3-L1 cells","volume":"286","author":"Habinowski","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.regpep.2011.11.002_bb0180","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbrc.2005.11.159","article-title":"AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes","volume":"340","author":"Dagon","year":"2006","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Regulatory Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011511001856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011511001856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T03:48:05Z","timestamp":1561002485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167011511001856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":36,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0167011511001856"],"URL":"https:\/\/doi.org\/10.1016\/j.regpep.2011.11.002","relation":{},"ISSN":["0167-0115"],"issn-type":[{"value":"0167-0115","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}