{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:29:03Z","timestamp":1791253743484,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Peptides"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.regpep.2012.06.003","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T18:45:50Z","timestamp":1340909150000},"page":"21-28","source":"Crossref","is-referenced-by-count":46,"title":["Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice"],"prefix":"10.1016","volume":"178","author":[{"given":"Masako","family":"Sugiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Inomata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Minamitake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Ohsuye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kangawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.regpep.2012.06.003_bb0005","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.pharmthera.2008.09.009","article-title":"Cardiac cachexia: a systematic over view","volume":"121","author":"von Haehling","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.regpep.2012.06.003_bb0010","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.clnu.2008.06.013","article-title":"Cachexia: a new definition","volume":"27","author":"Evans","year":"2008","journal-title":"Clin Nutr"},{"key":"10.1016\/j.regpep.2012.06.003_bb0015","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1161\/hc4201.097836","article-title":"Elevated circulating level of ghrelin in cachexia associated with chronic heart failure","volume":"104","author":"Nagaya","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.regpep.2012.06.003_bb0020","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1210\/endo.142.4.8082","article-title":"Angiotensin II induced skeletal muscle wasting through enhanced protein degradation and down-regulates autocrine insulin-like growth factor I","volume":"142","author":"Brink","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2012.06.003_bb0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1172\/JCI22324","article-title":"Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting","volume":"115","author":"Song","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.regpep.2012.06.003_bb0030","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1097-2765(04)00211-4","article-title":"The IGF-1\/PI3K\/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors","volume":"14","author":"Stitt","year":"2004","journal-title":"Mol Cell"},{"key":"10.1016\/j.regpep.2012.06.003_bb0035","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.regpep.2012.06.003_bb0040","doi-asserted-by":"crossref","first-page":"H1565","DOI":"10.1152\/ajpheart.00146.2010","article-title":"IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression","volume":"298","author":"Yoshida","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.regpep.2012.06.003_bb0045","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1681\/ASN.2008060628","article-title":"IL-6 and serum amyloid a synergy mediates angiotensin II-induced muscle wasting","volume":"20","author":"Zhang","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.regpep.2012.06.003_bb0050","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/sj.bjc.6602725","article-title":"Angiotensin II directly induces muscle protein catabolism through the ubiquitin\u2013proteasome proteolytic pathway and may play a role in cancer cachexia","volume":"93","author":"Sanders","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.regpep.2012.06.003_bb0055","doi-asserted-by":"crossref","first-page":"1128S","DOI":"10.3945\/ajcn.2010.28608B","article-title":"Review of muscle wasting associated with chronic kidney disease","volume":"91","author":"Workeneh","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.regpep.2012.06.003_bb0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000093656","article-title":"Sarcopenia\u2014a potential target for Angiotensin-converting enzyme inhibition?","volume":"52","author":"Sumukadas","year":"2006","journal-title":"Gerontology"},{"key":"10.1016\/j.regpep.2012.06.003_bb0065","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2012.06.003_bb0070","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2012.06.003_bb0075","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tsch\u00f6p","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2012.06.003_bb0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-3940(03)00789-4","article-title":"Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats","volume":"349","author":"Yasuda","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.regpep.2012.06.003_bb0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1172\/JCI200421134","article-title":"Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells","volume":"114","author":"Dixit","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.regpep.2012.06.003_bb0090","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1210\/en.2007-0016","article-title":"Ghrelin treatment caused increased food intake and retention of lean body mass in a rat model of cancer cachexia","volume":"148","author":"DeBoer","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2012.06.003_bb0095","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/en.2007-1046","article-title":"Ghrelin treatment of chronic kidney disease: improvement in lean body mass and cytokine profile","volume":"149","author":"DeBoer","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2012.06.003_bb0100","doi-asserted-by":"crossref","first-page":"R893","DOI":"10.1152\/ajpregu.00015.2008","article-title":"Ghrelin inhibits skeletal muscle protein breakdown in rats with thermal injury through normalizing elevated expression of E3 ubiquitin ligases MuRF1 and MAFbx","volume":"296","author":"Balasubramaniam","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.regpep.2012.06.003_bb0105","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/270725a0","article-title":"Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle","volume":"270","author":"Yafee","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.regpep.2012.06.003_bb0110","doi-asserted-by":"crossref","first-page":"C1795","DOI":"10.1152\/ajpcell.1994.266.6.C1795","article-title":"C2C12 cells: biophysical, biochemical, and immunocytochemical properties","volume":"266","author":"McMahon","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.regpep.2012.06.003_bb0115","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/bip.20342","article-title":"Semisynthesis of human ghrelin: condensation of a Boc-protected recombinant peptide with a synthetic O-acylated fragment","volume":"79","author":"Makino","year":"2005","journal-title":"Biopolymers"},{"key":"10.1016\/j.regpep.2012.06.003_bb0120","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1210\/en.2006-0539","article-title":"Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy","volume":"148","author":"Gilson","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2012.06.003_bb0125","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1096\/fj.04-3144fje","article-title":"Effects of \u03b1-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle","volume":"19","author":"Jorgensen","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.regpep.2012.06.003_bb0130","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1378\/chest.128.3.1187","article-title":"Treatment of cachexia with ghrelin in patients with COPD","volume":"128","author":"Nagaya","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.regpep.2012.06.003_bb0135","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/00005344-200206000-00001","article-title":"Vasodilatory effect of ghrelin, an endogenous peptide from the stomach","volume":"39","author":"Okumura","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.regpep.2012.06.003_bb0140","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/01.HYP.34.5.1053","article-title":"Angiotensin II stimulates gene expression of cardiac insulin-like growth factor I and its receptor through effects on blood pressure and food intake","volume":"34","author":"Brink","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.regpep.2012.06.003_bb0145","doi-asserted-by":"crossref","first-page":"H426","DOI":"10.1152\/ajpheart.00643.2007","article-title":"Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction","volume":"294","author":"Soeki","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.regpep.2012.06.003_bb0150","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1038\/oby.2007.313","article-title":"Ghrelin enhances in vivo skeletal muscle but not liver AKT signaling in rats","volume":"15","author":"Barazzoni","year":"2007","journal-title":"Obesity"},{"key":"10.1016\/j.regpep.2012.06.003_bb0155","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1073\/pnas.96.13.7324","article-title":"Normal growth and development in the absence of hepatic insulin-like growth factor I","volume":"96","author":"Yakar","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.regpep.2012.06.003_bb0160","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.exger.2005.06.003","article-title":"Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO","volume":"40","author":"Masternak","year":"2005","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.regpep.2012.06.003_bb0165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ki.2009.411","article-title":"Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease","volume":"77","author":"Barazzoni","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.regpep.2012.06.003_bb0170","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.lfs.2007.11.019","article-title":"GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, atrogin-1 and MuRF1","volume":"82","author":"Yamamoto","year":"2007","journal-title":"Life Sci"}],"container-title":["Regulatory Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011512001887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011512001887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T07:05:21Z","timestamp":1561878321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167011512001887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":34,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0167011512001887"],"URL":"https:\/\/doi.org\/10.1016\/j.regpep.2012.06.003","relation":{},"ISSN":["0167-0115"],"issn-type":[{"value":"0167-0115","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}