{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:08:43Z","timestamp":1789679323664,"version":"4.0.1"},"reference-count":60,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Peptides"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.regpep.2013.11.002","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T08:34:14Z","timestamp":1385454854000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Octreotide modulates the effects on fibrosis of TNF-\u03b1, TGF-\u03b2 and PDGF in activated rat hepatic stellate cells"],"prefix":"10.1016","volume":"188","author":[{"given":"Stefanos","family":"Klironomos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Notas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ourania","family":"Sfakianaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Kiagiadaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costas","family":"Xidakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Kouroumalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.regpep.2013.11.002_bb0005","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.1074\/jbc.M010303200","article-title":"Signal transduction by the chemokine receptor CXCR3: activation of Ras\/ERK, Src, and phosphatidylinositol 3-kinase\/Akt controls cell migration and proliferation in human vascular pericytes","volume":"276","author":"Bonacchi","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.regpep.2013.11.002_bb0010","first-page":"361","article-title":"Molecular pathogenesis of liver fibrosis","volume":"120","author":"Brenner","year":"2009","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"10.1016\/j.regpep.2013.11.002_bb0015","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/gast.2002.33666","article-title":"Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro","volume":"122","author":"Galli","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0020","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1053\/jhep.2000.20243","article-title":"Mechanisms and therapy of hepatic fibrosis: report of the AASLD single topic basic research conference","volume":"32","author":"Friedman","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0025","first-page":"193","article-title":"Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture","volume":"24","author":"Rockey","year":"1992","journal-title":"J Submicrosc Cytol Pathol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0030","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/s-2001-17551","article-title":"Hepatic blood flow regulation by stellate cells in normal and injured liver","volume":"21","author":"Rockey","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.regpep.2013.11.002_bb0035","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hep.510290107","article-title":"Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells","volume":"29","author":"Marra","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0040","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/labinvest.3780073","article-title":"PDGF-mediated chemoattraction of hepatic stellate cells by bile duct segments in cholestatic liver injury","volume":"80","author":"Kinnman","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.regpep.2013.11.002_bb0045","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1089-3261(05)70113-6","article-title":"The cell and molecular biology of hepatic fibrogenesis. Clinical and therapeutic implications","volume":"4","author":"Rockey","year":"2000","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.regpep.2013.11.002_bb0050","doi-asserted-by":"crossref","first-page":"G245","DOI":"10.1152\/ajpgi.2000.279.2.G245","article-title":"Metalloproteinases and their inhibitors in liver fibrosis","volume":"279","author":"Arthur","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0055","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/hep.1840210328","article-title":"Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats","volume":"21","author":"Takahara","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0060","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1053\/gast.1996.v110.pm8608892","article-title":"Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver","volume":"110","author":"Benyon","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0065","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-8278(99)80010-5","article-title":"The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo","volume":"30","author":"Hellerbrand","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0070","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1172\/JCI114363","article-title":"Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells","volume":"84","author":"Pinzani","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.regpep.2013.11.002_bb0075","doi-asserted-by":"crossref","first-page":"d1720","DOI":"10.2741\/pinzani","article-title":"PDGF and signal transduction in hepatic stellate cells","volume":"7","author":"Pinzani","year":"2002","journal-title":"Front Biosci"},{"key":"10.1016\/j.regpep.2013.11.002_bb0080","doi-asserted-by":"crossref","first-page":"23183","DOI":"10.1074\/jbc.273.36.23183","article-title":"Role of NF-kappaB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-alpha in human hepatic stellate cells. Involvement of cyclooxygenase-2","volume":"273","author":"Gallois","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.regpep.2013.11.002_bb0085","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/hep.510300144","article-title":"Transforming growth factor beta and tumor necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cells","volume":"30","author":"Saile","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2172-10-15","article-title":"Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1","volume":"10","author":"Zhou","year":"2009","journal-title":"BMC Immunol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0095","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1053\/gast.1997.v113.pm9247485","article-title":"Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein","volume":"113","author":"Hernandez-Munoz","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0100","first-page":"G840","article-title":"TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region","volume":"274","author":"Houglum","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0105","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1053\/j.gastro.2008.03.001","article-title":"Diagnosis and quantitation of fibrosis","volume":"134","author":"Manning","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0110","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.regpep.2013.11.002_bb0120","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.regpep.2013.11.002_bb0125","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.regpep.2013.11.002_bb0130","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/labinvest.3700116","article-title":"IGF-I induces DNA synthesis and apoptosis in rat liver hepatic stellate cells (HSC) but DNA synthesis and proliferation in rat liver myofibroblasts (rMF)","volume":"84","author":"Saile","year":"2004","journal-title":"Lab Invest"},{"key":"10.1016\/j.regpep.2013.11.002_bb0135","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0014-5793(92)81122-3","article-title":"Cloning and expression of a novel mouse somatostatin receptor (SSTR2B)","volume":"311","author":"Vanetti","year":"1992","journal-title":"FEBS Lett"},{"key":"10.1016\/j.regpep.2013.11.002_bb0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0006-8993(98)00361-8","article-title":"Identification of somatostatin sst2(a) receptor expressing neurones in central regions involved in nociception","volume":"798","author":"Schindler","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.regpep.2013.11.002_bb0145","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/frne.1999.0183","article-title":"Somatostatin and its receptor family","volume":"20","author":"Patel","year":"1999","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0150","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/BF03350317","article-title":"Molecular pharmacology of somatostatin receptor subtypes","volume":"20","author":"Patel","year":"1997","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.regpep.2013.11.002_bb0155","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.regpep.2004.03.009","article-title":"Secretion of inflammatory mediators by isolated rat Kupffer cells: the effect of octreotide","volume":"120","author":"Valatas","year":"2004","journal-title":"Regul Pept"},{"key":"10.1016\/j.regpep.2013.11.002_bb0160","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s10620-005-2668-8","article-title":"Production of pro- and anti-fibrotic agents by rat Kupffer cells; the effect of octreotide","volume":"50","author":"Xidakis","year":"2005","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.regpep.2013.11.002_bb0165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1065-6995(02)00249-4","article-title":"Isolation of rat Kupffer cells: a combined methodology for highly purified primary cultures","volume":"27","author":"Valatas","year":"2003","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.regpep.2013.11.002_bb0170","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal Biochem"},{"key":"10.1016\/j.regpep.2013.11.002_bb0175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.regpep.2013.11.002_bb0180","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0928-4257(00)00212-6","article-title":"Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies","volume":"94","author":"Schulz","year":"2000","journal-title":"J Physiol Paris"},{"key":"10.1016\/j.regpep.2013.11.002_bb0185","first-page":"2047","article-title":"Immunocytochemical detection of somatostatin receptors sst1, sst2A, sst2B, and sst3 in paraffin-embedded breast cancer tissue using subtype-specific antibodies","volume":"4","author":"Schulz","year":"1998","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.regpep.2013.11.002_bb0190","first-page":"1665","article-title":"Relationship between somatostatin receptors and activation of hepatic stellate cells","volume":"117","author":"Pan","year":"2004","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.regpep.2013.11.002_bb0195","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1053\/gast.2001.27971","article-title":"Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1","volume":"121","author":"Reynaert","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0200","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.3748\/wjg.v10.i11.1663","article-title":"Expression of subtypes of somatostatin receptors in hepatic stellate cells","volume":"10","author":"Song","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0205","first-page":"551","article-title":"The effect of somatostatin analogue on expression of connective tissue growth factor gene of rat hepatic stellate cells","volume":"42","author":"Song","year":"2004","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"10.1016\/j.regpep.2013.11.002_bb0210","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1478-3231.2005.01057.x","article-title":"Somatostatin inhibits pro-inflammatory cytokine secretion from rat hepatic stellate cells","volume":"25","author":"Lang","year":"2005","journal-title":"Liver Int"},{"key":"10.1016\/j.regpep.2013.11.002_bb0215","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.bjp.0706298","article-title":"Somatostatin at nanomolar concentration reduces collagen I and III synthesis by, but not proliferation of activated rat hepatic stellate cells","volume":"146","author":"Reynaert","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0220","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/thx.2007.078006","article-title":"Activation of somatostatin receptors attenuates pulmonary fibrosis","volume":"63","author":"Borie","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.regpep.2013.11.002_bb0225","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3748\/wjg.v10.i7.1015","article-title":"Antiproliferative and proapoptotic effects of somatostatin on activated hepatic stellate cells","volume":"10","author":"Pan","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0230","first-page":"785","article-title":"Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis","volume":"148","author":"Pinzani","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0235","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1172\/JCI117497","article-title":"Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture","volume":"94","author":"Wong","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.regpep.2013.11.002_bb0240","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/labinvest.3780384","article-title":"Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury","volume":"81","author":"Kinnman","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.regpep.2013.11.002_bb0245","first-page":"680","article-title":"Octreotide inhibits hepatic fibrosis, bile duct proliferation and bacterial translocation in obstructive jaundice","volume":"50","author":"Turkcapar","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0250","first-page":"1574","article-title":"Somatostatin analogue (octreotide) inhibits bile duct epithelial cell proliferation and fibrosis after extrahepatic biliary obstruction","volume":"143","author":"Tracy","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1016\/j.regpep.2013.11.002_bb0255","first-page":"408","article-title":"Therapeutic effects of octreotide on hepatofibrosis-induced with carbon tetrachloride in rats","volume":"11","author":"Wang","year":"2003","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"10.1016\/j.regpep.2013.11.002_bb0260","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/hep.510280612","article-title":"Antifibrotic and hemodynamic effects of the early and chronic administration of octreotide in two models of liver fibrosis in rats","volume":"28","author":"Fort","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0265","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1053\/j.gastro.2007.02.033","article-title":"Gene expression profiles during hepatic stellate cell activation in culture and in vivo","volume":"132","author":"De Minicis","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2013.11.002_bb0270","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1432-1033.1992.tb17138.x","article-title":"Stimulation of a membrane tyrosine phosphatase activity by somatostatin analogues in rat pancreatic acinar cells","volume":"207","author":"Colas","year":"1992","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.regpep.2013.11.002_bb0275","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0026-0495(96)90071-2","article-title":"Molecular mechanisms of antiproliferative effect of somatostatin: involvement of a tyrosine phosphatase","volume":"45","author":"Lopez","year":"1996","journal-title":"Metabolism"},{"key":"10.1016\/j.regpep.2013.11.002_bb0280","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1073\/pnas.92.5.1580","article-title":"Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms","volume":"92","author":"Buscail","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.regpep.2013.11.002_bb0285","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1091\/mbc.E03-02-0069","article-title":"Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation","volume":"14","author":"Ferjoux","year":"2003","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.regpep.2013.11.002_bb0290","doi-asserted-by":"crossref","first-page":"e14230","DOI":"10.1371\/journal.pone.0014230","article-title":"Activation of protein serine\/threonine phosphatase PP2Calpha efficiently prevents liver fibrosis","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.regpep.2013.11.002_bb0295","first-page":"935","article-title":"Phosphatase activity in the arterial wall after balloon injury: effect of somatostatin analog octreotide","volume":"79","author":"Yamashita","year":"1999","journal-title":"Lab Invest"},{"key":"10.1016\/j.regpep.2013.11.002_bb0300","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0928-4257(00)00214-X","article-title":"Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2","volume":"94","author":"Florio","year":"2000","journal-title":"J Physiol Paris"}],"container-title":["Regulatory Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011513001651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011513001651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T02:54:30Z","timestamp":1564887270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167011513001651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":60,"alternative-id":["S0167011513001651"],"URL":"https:\/\/doi.org\/10.1016\/j.regpep.2013.11.002","relation":{},"ISSN":["0167-0115"],"issn-type":[{"value":"0167-0115","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Octreotide modulates the effects on fibrosis of TNF-\u03b1, TGF-\u03b2 and PDGF in activated rat hepatic stellate cells","name":"articletitle","label":"Article Title"},{"value":"Regulatory Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.regpep.2013.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}