{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T20:59:27Z","timestamp":1747169967934,"version":"3.40.5"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Norwegian University of Science and Technology (NTNU)"},{"name":"St. Olav's Hospital"},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"crossref","award":["266408"],"award-info":[{"award-number":["266408"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Peptides"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.regpep.2014.08.002","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T04:52:07Z","timestamp":1409115127000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors"],"prefix":"10.1016","volume":"192-193","author":[{"given":"Chun-Mei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnar","family":"Flatberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-1665","authenticated-orcid":false,"given":"Vidar","family":"Beisvag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e5rd","family":"Kulseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne K.","family":"Sandvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens F.","family":"Rehfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.regpep.2014.08.002_bb0005","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.00015.2012","article-title":"Gastric acid, calcium absorption, and their impact on bone health","volume":"93","author":"Kopic","year":"2013","journal-title":"Physiol Rev"},{"key":"10.1016\/j.regpep.2014.08.002_bb0010","doi-asserted-by":"crossref","first-page":"G7","DOI":"10.1152\/ajpgi.00448.2003","article-title":"Gastrointestinal satiety signals I. An overview of gastrointestinal signals that influence food intake","volume":"286","author":"Woods","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0015","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2174\/092986712803414060","article-title":"The ECL cell: relay station for gastric integrity","volume":"19","author":"Zhao","year":"2012","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.regpep.2014.08.002_bb0020","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2174\/138161210790945904","article-title":"Complexity of gastric acid secretion revealed by targeted gene disruption in mice","volume":"16","author":"Chen","year":"2010","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.regpep.2014.08.002_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.00176.2006","article-title":"Transcriptional profiling of gastrin-regulated genes in mouse stomach","volume":"29","author":"Jain","year":"2007","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.regpep.2014.08.002_bb0030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1152\/physiolgenomics.00133.2005","article-title":"Gene expression profiling of gastrin target genes in parietal cells","volume":"24","author":"Jain","year":"2006","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.regpep.2014.08.002_bb0035","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1053\/j.gastro.2003.11.012","article-title":"Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice","volume":"126","author":"Chen","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2014.08.002_bb0040","doi-asserted-by":"crossref","first-page":"G607","DOI":"10.1152\/ajpgi.1998.274.4.G607","article-title":"I. CCK receptors: an exemplary family","volume":"274","author":"Wank","year":"1998","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0045","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nm.1963","article-title":"Impaired gastric acidification negatively affects calcium homeostasis and bone mass","volume":"15","author":"Schinke","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.regpep.2014.08.002_bb0050","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1073\/pnas.0934373100","article-title":"Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss","volume":"100","author":"Fitzpatrick","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.regpep.2014.08.002_bb0055","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.2174\/138161211796196972","article-title":"The possible existence of a gut\u2013bone axis suggested by studies of genetically manipulated mouse models?","volume":"17","author":"Chen","year":"2011","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.regpep.2014.08.002_bb0060","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cellsig.2009.02.012","article-title":"PTH and PTHrP signaling in osteoblasts","volume":"21","author":"Datta","year":"2009","journal-title":"Cell Signal"},{"key":"10.1016\/j.regpep.2014.08.002_bb0065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/00365521.1973.12096677","article-title":"Determination of gastrin in serum. An evaluation of the reliability of a radioimmunoassay","volume":"8","author":"Stadil","year":"1973","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0070","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.regpep.2012.05.087","article-title":"Beginnings: a reflection on the history of gastrointestinal endocrinology","volume":"177","author":"Rehfeld","year":"2012","journal-title":"Regul Pept"},{"key":"10.1016\/j.regpep.2014.08.002_bb0075","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0003-2697(88)90580-5","article-title":"Processing-independent radioimmunoanalysis: a general analytical principle applied to progastrin and its products","volume":"175","author":"Bardram","year":"1988","journal-title":"Anal Biochem"},{"key":"10.1016\/j.regpep.2014.08.002_bb0080","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0003-2697(86)90129-6","article-title":"Measurement of precursors for alpha-amidated hormones by radioimmunoassay of glycine-extended peptides after trypsin-carboxypeptidase B cleavage","volume":"152","author":"Hilsted","year":"1986","journal-title":"Anal Biochem"},{"key":"10.1016\/j.regpep.2014.08.002_bb0085","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/clinchem\/44.5.991","article-title":"Accurate measurement of cholecystokinin in plasma","volume":"44","author":"Rehfeld","year":"1998","journal-title":"Clin Chem"},{"key":"10.1016\/j.regpep.2014.08.002_bb0090","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s004410050707","article-title":"Effect of alpha-fluoromethylhistidine-evoked histamine depletion on ultrastructure of endocrine cells in acid-producing mucosa of stomach in mouse, rat and hamster","volume":"286","author":"Andersson","year":"1996","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.regpep.2014.08.002_bb0095","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.regpep.2014.08.002_bb0100","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1113\/jphysiol.1980.sp013355","article-title":"Mechanisms of gastric acid secretion after pylorus and oesophagus ligation in the rat","volume":"305","author":"H\u00e5kanson","year":"1980","journal-title":"J Physiol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/00365529609031623","article-title":"Rat stomach enterochromaffin-like cells are not stimulated by pylorus ligation. A biochemical and ultrastructural study","volume":"31","author":"Zhao","year":"1996","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0110","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/gast.2002.34746","article-title":"Differentiation of gastric ECL cells is altered in CCK(2) receptor-deficient mice","volume":"123","author":"Chen","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2014.08.002_bb0115","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12576-008-0001-y","article-title":"Gastric acid secretion in cholecystokinin-1 receptor, -2 receptor, and -1, -2 receptor gene knockout mice","volume":"59","author":"Kanai","year":"2009","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.regpep.2014.08.002_bb0120","doi-asserted-by":"crossref","first-page":"G539","DOI":"10.1152\/ajpgi.00178.2006","article-title":"Differentiation of the gastric mucosa. I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes","volume":"291","author":"Chen","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0125","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1210\/en.2007-0238","article-title":"Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine\/paracrine to neurocrine pathways","volume":"149","author":"Zhao","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.regpep.2014.08.002_bb0130","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00535-010-0269-6","article-title":"Comparison of the actions of acylated and desacylated ghrelin on acid secretion in the rat stomach","volume":"45","author":"Sakurada","year":"2010","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0135","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/MOG.0b013e328358e5cc","article-title":"Gastric secretion","volume":"28","author":"Chu","year":"2012","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0140","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0167-0115(01)00243-9","article-title":"A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control","volume":"99","author":"Dornonville de la Cour","year":"2001","journal-title":"Regul Pept"},{"key":"10.1016\/j.regpep.2014.08.002_bb0145","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbrc.2005.05.004","article-title":"A gene expression fingerprint of mouse stomach ECL cells","volume":"332","author":"Andersson","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.regpep.2014.08.002_bb0150","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10620-010-1375-2","article-title":"The expression of PTHLH in human gastric mucosa enterochromaffin-like cells","volume":"56","author":"Liu","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.regpep.2014.08.002_bb0155","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1053\/gast.2000.16480","article-title":"Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice","volume":"119","author":"Chen","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2014.08.002_bb0160","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/apha.12208","article-title":"The regulation of gastric acid secretion \u2014 clinical perspectives","volume":"210","author":"Waldum","year":"2014","journal-title":"Acta Physiol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0165","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1095-6433(00)00331-7","article-title":"Control of gastric acid secretion: the gastrin-ECL cell-parietal cell axis","volume":"128","author":"Lindstrom","year":"2001","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0170","first-page":"258","article-title":"Proceedings: mode of action of cholestyramine in enteral hyperoxaluria","volume":"14","author":"Caspary","year":"1976","journal-title":"Z Gastroenterol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s12031-010-9440-z","article-title":"PAC1 deficiency in a murine model induces gastric mucosa hypertrophy and higher basal gastric acid output","volume":"43","author":"Lu","year":"2011","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.regpep.2014.08.002_bb0180","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1469-7793.2001.00663.x","article-title":"Gastrin and the neuropeptide PACAP evoke secretion from rat stomach histamine-containing (ECL) cells by stimulating influx of Ca2+ through different Ca2+ channels","volume":"535","author":"Lindstrom","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0185","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1385\/JMN:26:1:085","article-title":"PACAP regulation of secretion and proliferation of pure populations of gastric ECL cells","volume":"26","author":"Oh","year":"2005","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.regpep.2014.08.002_bb0190","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0167-0115(01)00314-7","article-title":"PACAP mediates the neural proliferative pathway of Mastomys enterochromaffin-like cell transformation","volume":"102","author":"Lauffer","year":"2001","journal-title":"Regul Pept"},{"key":"10.1016\/j.regpep.2014.08.002_bb0195","doi-asserted-by":"crossref","first-page":"G51","DOI":"10.1152\/ajpgi.00169.2002","article-title":"PACAP and gastrin regulate the histidine decarboxylase promoter via distinct mechanisms","volume":"286","author":"McLaughlin","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.regpep.2014.08.002_bb0200","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-0115(97)01018-5","article-title":"Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells","volume":"71","author":"Lindstrom","year":"1997","journal-title":"Regul Pept"},{"key":"10.1016\/j.regpep.2014.08.002_bb0205","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nm0609-610","article-title":"Stomaching calcium for bone health","volume":"15","author":"Boyce","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.regpep.2014.08.002_bb0210","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cmet.2009.06.004","article-title":"The gutsy side of bone","volume":"10","author":"Ferron","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.regpep.2014.08.002_bb0240","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/jpet.103.052019","article-title":"Crucial role of histamine for regulation of gastric acid secretion ascertained by histidine decarboxylase-knockout mice","volume":"307","author":"Furutani","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.regpep.2014.08.002_bb0245","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0167-0115(90)90068-8","article-title":"Evidence that gastrin enhances 45Ca uptake into bone through release of a gastric hormone","volume":"28","author":"H\u00e5kanson","year":"1990","journal-title":"Regul Pept"},{"key":"10.1016\/j.regpep.2014.08.002_bb0250","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1073\/pnas.86.8.2834","article-title":"Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach","volume":"86","author":"Persson","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.regpep.2014.08.002_bb0260","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1053\/j.gastro.2006.04.031","article-title":"Gastric inflammation, metaplasia, and tumor development in gastrin-deficient mice","volume":"131","author":"Friis-Hansen","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.regpep.2014.08.002_bb0265","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/gut.2006.117382","article-title":"Gut, inflammation and osteoporosis: basic and clinical concepts","volume":"57","author":"Tilg","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.regpep.2014.08.002_bb0270","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0083-6729(06)77010-8","article-title":"Ghrelin and bone","volume":"77","author":"van der Velde","year":"2008","journal-title":"Vitam Horm"},{"key":"10.1016\/j.regpep.2014.08.002_bb0275","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.1128\/MCB.23.22.7973-7981.2003","article-title":"Deletion of ghrelin impairs neither growth nor appetite","volume":"23","author":"Sun","year":"2003","journal-title":"Mol Cell Biol"}],"container-title":["Regulatory Peptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011514000627?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167011514000627?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T17:19:19Z","timestamp":1650043159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167011514000627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":49,"alternative-id":["S0167011514000627"],"URL":"https:\/\/doi.org\/10.1016\/j.regpep.2014.08.002","relation":{},"ISSN":["0167-0115"],"issn-type":[{"type":"print","value":"0167-0115"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors","name":"articletitle","label":"Article Title"},{"value":"Regulatory Peptides","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.regpep.2014.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}