{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:15:04Z","timestamp":1777580104239,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Revista Espa\u00f1ola de Medicina Nuclear e Imagen Molecular"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.remn.2012.11.005","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T00:03:05Z","timestamp":1358380985000},"page":"92-97","source":"Crossref","is-referenced-by-count":3,"title":["Radiomarcaje y estudios de biodistribuci\u00f3n de nanopart\u00edculas polim\u00e9ricas como adyuvantes para la vacunaci\u00f3n oft\u00e1lmica frente a la brucelosis"],"prefix":"10.1016","volume":"32","author":[{"given":"M.","family":"S\u00e1nchez-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"da Costa Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Quincoces","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gamazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Caicedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Irache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Pe\u00f1uelas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.remn.2012.11.005_bib0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S1369-5274(00)00165-X","article-title":"Brucellosis: a worldwide zoonosis","volume":"4","author":"Boschiroli","year":"2001","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.remn.2012.11.005_bib0010","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/j.1365-2672.2005.02622.x","article-title":"Brucellosis\u2014new aspects of an old disease","volume":"98","author":"Cutler","year":"2005","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.remn.2012.11.005_bib0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3201\/eid1403.070829","article-title":"Marine mammal Brucella genotype associated with zoonotic infection","volume":"14","author":"Whatmore","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.remn.2012.11.005_bib0020","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/clinids\/21.2.283","article-title":"An overview of human brucellosis","volume":"21","author":"Young","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.remn.2012.11.005_bib0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0167-5877(96)01110-5","article-title":"A review of the use of B. melitensis Rev 1 vaccine in adult sheep and goats","volume":"31","author":"Blasco","year":"1997","journal-title":"Prev Vet Med"},{"key":"10.1016\/j.remn.2012.11.005_bib0030","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0140-6736(93)91571-3","article-title":"Brucella melitensis Rev-1 vaccine as a cause of human brucellosis","volume":"342","author":"Blasco","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.remn.2012.11.005_bib0035","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0378-1135(02)00255-9","article-title":"Brucellosis vaccines: past, present and future","volume":"90","author":"Schurig","year":"2002","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.remn.2012.11.005_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1051\/vetres:2003037","article-title":"Rough vaccines in animal brucellosis: structural and genetic basis and present status","volume":"35","author":"Moriy\u00f3n","year":"2004","journal-title":"Vet Res"},{"key":"10.1016\/j.remn.2012.11.005_bib0045","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0165-2427(93)90198-D","article-title":"Evaluation of whole cell and subcellular vaccines against Brucella ovis in rams","volume":"37","author":"Blasco","year":"1993","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.remn.2012.11.005_bib0050","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1128\/IAI.57.5.1419-1426.1989","article-title":"Comparative analyses of proteins extracted by hot saline or released spontaneously into outer membrane blebs from field strains of Brucella ovis and Brucella melitensis","volume":"57","author":"Gamazo","year":"1989","journal-title":"Infect Immun"},{"key":"10.1016\/j.remn.2012.11.005_bib0055","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3109\/10611869609015965","article-title":"Nasal delivery of vaccines","volume":"3","author":"Almeida","year":"1996","journal-title":"J Drug Target"},{"key":"10.1016\/j.remn.2012.11.005_bib0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0168-3659(03)00066-X","article-title":"Influence of the surface characteristics of PVM\/MA nanoparticles on their bioadhesive properties","volume":"89","author":"Arb\u00f3s","year":"2003","journal-title":"J Control Release"},{"key":"10.1016\/j.remn.2012.11.005_bib0065","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1016\/j.vaccine.2007.05.020","article-title":"Gantrez AN nanoparticles as an adjuvant for oral immunotherapy with allergens","volume":"25","author":"G\u00f3mez","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.remn.2012.11.005_bib0070","first-page":"513","article-title":"Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimisation and in vitro characterisation","volume":"68","author":"Motwani","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.remn.2012.11.005_bib0075","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1002\/eji.1830270941","article-title":"The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells","volume":"27","author":"Engering","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.remn.2012.11.005_bib0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/08982100600992302","article-title":"Mannosylated niosomes as adjuvant-carrier system for oral mucosal immunization","volume":"16","author":"Jain","year":"2006","journal-title":"J Liposome Res"},{"key":"10.1016\/j.remn.2012.11.005_bib0085","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0168-3659(02)00015-9","article-title":"Gantrez AN as a new polymer for the preparation of ligand\u2013nanoparticle conjugates","volume":"83","author":"Arb\u00f3s","year":"2002","journal-title":"J Control Release"},{"key":"10.1016\/j.remn.2012.11.005_bib0090","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1166\/jnn.2006.445","article-title":"Bioadhesive mannosylated nanoparticles for oral drug delivery","volume":"6","author":"Salman","year":"2006","journal-title":"J Nanosci Nanotechnol"},{"key":"10.1016\/j.remn.2012.11.005_bib0095","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ejps.2009.05.002","article-title":"Design and influence of gamma-irradiation on the biopharmaceutical properties of nanoparticles containing an antigenic complex from Brucella ovis","volume":"37","author":"Da Costa Martins","year":"2009","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.remn.2012.11.005_bib0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejps.2009.02.010","article-title":"Bioadhesive properties and biodistribution of cyclodextrin\u2013poly(anhydride) nanoparticles","volume":"37","author":"Ag\u00fceros","year":"2009","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.remn.2012.11.005_bib0105","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s11307-010-0456-0","article-title":"Molecular imaging techniques to study the biodistribution of orally administered (99m)Tc-labelled naive and ligand-tagged nanoparticles","volume":"13","author":"Areses","year":"2011","journal-title":"Mol Imaging Biol"},{"key":"10.1016\/j.remn.2012.11.005_bib0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/10915810490275044","article-title":"Evidence for competitive inhibition of iodide uptake by perchlorate and translocation of perchlorate into the thyroid","volume":"23","author":"Clewell","year":"2004","journal-title":"Int J Toxicol"},{"key":"10.1016\/j.remn.2012.11.005_bib0115","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0169-409X(98)00040-4","article-title":"Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract","volume":"34","author":"Ponchel","year":"1998","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.remn.2012.11.005_bib0120","doi-asserted-by":"crossref","first-page":"876","DOI":"10.2741\/s108","article-title":"Poly(anhydride) nanoparticles as adjuvants for mucosal vaccination","volume":"2","author":"Irache","year":"2010","journal-title":"Front Biosci (Schol Ed)"},{"key":"10.1016\/j.remn.2012.11.005_bib0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0169-409X(95)00010-5","article-title":"Ocular absorption following topical delivery","volume":"16","author":"J\u00e4rvinen","year":"1995","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.remn.2012.11.005_bib0130","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.addr.2009.11.026","article-title":"Chitosan-based nanostructures: a delivery platform for ocular therapeutics","volume":"62","author":"De la Fuente","year":"2010","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.remn.2012.11.005_bib0135","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1016\/j.vaccine.2009.10.073","article-title":"Evaluation of particulate acellular vaccines against Brucella ovis infection in rams","volume":"28","author":"Da Costa Martins","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.remn.2012.11.005_bib0140","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jconrel.2012.07.030","article-title":"Conjunctival vaccination against Brucella ovis in mice with mannosylated nanoparticles","volume":"162","author":"Da Costa Martins","year":"2012","journal-title":"J Control Release"}],"container-title":["Revista Espa\u00f1ola de Medicina Nuclear e Imagen Molecular"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2253654X12002430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2253654X12002430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T14:34:39Z","timestamp":1595255679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2253654X12002430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S2253654X12002430"],"URL":"https:\/\/doi.org\/10.1016\/j.remn.2012.11.005","relation":{},"ISSN":["2253-654X"],"issn-type":[{"value":"2253-654X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}