{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:49:19Z","timestamp":1784260159827,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.repbio.2013.03.001","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T02:46:21Z","timestamp":1363747581000},"page":"113-121","source":"Crossref","is-referenced-by-count":18,"title":["Constitutive activity of Erk1\/2 and NF-\u03baB protects human endometrial stromal cells from death receptor-mediated apoptosis"],"prefix":"10.1016","volume":"13","author":[{"given":"Herbert","family":"Fluhr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Spratte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marike","family":"Bredow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Heidrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Zygmunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2013.03.001_bib0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/humupd\/dmh007","article-title":"Apoptosis in human endometrium and endometriosis","volume":"10","author":"Harada","year":"2004","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.repbio.2013.03.001_bib0010","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/01.RES.0000261352.81736.37","article-title":"Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death","volume":"100","author":"Keogh","year":"2007","journal-title":"Circulation Research"},{"key":"10.1016\/j.repbio.2013.03.001_bib0015","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1053\/plac.2001.0703","article-title":"Death-inducing tumour necrosis factor (TNF) superfamily ligands and receptors are transcribed in human placentae, cytotrophoblasts, placental macrophages and placental cell lines","volume":"22","author":"Phillips","year":"2001","journal-title":"Placenta"},{"key":"10.1016\/j.repbio.2013.03.001_bib0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/molehr\/gah006","article-title":"First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis","volume":"10","author":"Abrahams","year":"2004","journal-title":"Molecular Human Reproduction"},{"key":"10.1016\/j.repbio.2013.03.001_bib0025","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/molehr\/3.8.655","article-title":"Trophoblasts express Fas ligand: a proposed mechanism for immune privilege in placenta and maternal invasion","volume":"3","author":"Uckan","year":"1997","journal-title":"Molecular Human Reproduction"},{"key":"10.1016\/j.repbio.2013.03.001_bib0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.placenta.2008.10.012","article-title":"Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium","volume":"30","author":"Haider","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.repbio.2013.03.001_bib0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","article-title":"Tumor necrosis factor signaling","volume":"10","author":"Wajant","year":"2003","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.repbio.2013.03.001_bib0040","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","article-title":"Apoptosis by death factor","volume":"88","author":"Nagata","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.repbio.2013.03.001_bib0045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1359-6101(02)00072-2","article-title":"Non-apoptotic Fas signaling","volume":"14","author":"Wajant","year":"2003","journal-title":"Cytokine and Growth Factor Reviews"},{"key":"10.1016\/j.repbio.2013.03.001_bib0050","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.biocel.2007.02.007","article-title":"TRAIL signalling: decisions between life and death","volume":"39","author":"Falschlehner","year":"2007","journal-title":"International Journal of Biochemistry and Cellular Biology"},{"key":"10.1016\/j.repbio.2013.03.001_bib0055","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc776","article-title":"Death and anti-death: tumour resistance to apoptosis","volume":"2","author":"Igney","year":"2002","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/j.repbio.2013.03.001_bib0060","first-page":"3947","article-title":"Metabolic inhibitors sensitize for CD95 (APO-1\/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression","volume":"60","author":"Fulda","year":"2000","journal-title":"Cancer Research"},{"key":"10.1016\/j.repbio.2013.03.001_bib0065","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0898-6568(03)00093-7","article-title":"Live and let die: regulatory mechanisms in Fas-mediated apoptosis","volume":"15","author":"Curtin","year":"2003","journal-title":"Cellular Signalling"},{"key":"10.1016\/j.repbio.2013.03.001_bib0070","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1242\/jcs.009761","article-title":"Interferon-gamma and tumor necrosis factor-alpha sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis","volume":"120","author":"Fluhr","year":"2007","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.repbio.2013.03.001_bib0075","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.fertnstert.2009.04.017","volume":"92","author":"Fluhr","year":"2009","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.repbio.2013.03.001_bib0080","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/molehr\/gaq082","article-title":"Non-apoptotic Fas-induced regulation of cytokines in undifferentiated and decidualized human endometrial stromal cells depends on caspase-activity","volume":"17","author":"Fluhr","year":"2011","journal-title":"Molecular Human Reproduction"},{"key":"10.1016\/j.repbio.2013.03.001_bib0085","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1016\/j.fertnstert.2009.10.025","article-title":"Heparin and low-molecular-weight heparins modulate the decidualization of human endometrial stromal cells","volume":"93","author":"Fluhr","year":"2010","journal-title":"Fertility and Sterility"},{"key":"10.1016\/j.repbio.2013.03.001_bib0090","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(91)90198-O","article-title":"A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry","volume":"139","author":"Nicoletti","year":"1991","journal-title":"Journal of Immunological Methods"},{"key":"10.1016\/j.repbio.2013.03.001_bib0095","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.4049\/jimmunol.145.6.1859","article-title":"Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis","volume":"145","author":"Martin","year":"1990","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.repbio.2013.03.001_bib0100","first-page":"1157","article-title":"Resistance to Fas-mediated apoptosis in human hepatoma cells","volume":"11","author":"Natoli","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.repbio.2013.03.001_bib0105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0027-5107(00)00132-9","article-title":"Intravenous injection of cycloheximide induces apoptosis and up-regulates p53 and Fas receptor expression in the rat liver in vivo","volume":"457","author":"Higami","year":"2000","journal-title":"Mutation Research"},{"key":"10.1016\/j.repbio.2013.03.001_bib0110","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.yexcr.2007.11.003","article-title":"Conversion of CD95 (Fas) type II into type I signaling by sub-lethal doses of cycloheximide","volume":"314","author":"Brumatti","year":"2008","journal-title":"Experimental Cell Research"},{"key":"10.1016\/j.repbio.2013.03.001_bib0115","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tcb.2004.03.002","article-title":"Death without caspases, caspases without death","volume":"14","author":"Abraham","year":"2004","journal-title":"Trends in Cellular Biology"},{"key":"10.1016\/j.repbio.2013.03.001_bib0120","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm1263","article-title":"Caspase-independent cell death","volume":"11","author":"Kroemer","year":"2005","journal-title":"Nature Medicine"},{"key":"10.1016\/j.repbio.2013.03.001_bib0125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tcb.2007.01.001","article-title":"Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination","volume":"17","author":"Kuranaga","year":"2007","journal-title":"Trends in Cellular Biology"},{"key":"10.1016\/j.repbio.2013.03.001_bib0130","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/molehr\/gah260","article-title":"Caspase cascade of Fas-mediated apoptosis in human normal endometrium and endometrial carcinoma cells","volume":"12","author":"Abe","year":"2006","journal-title":"Molecular Human Reproduction"},{"key":"10.1016\/j.repbio.2013.03.001_bib0135","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/humrep\/deh824","article-title":"Menstrual-like breakdown and apoptosis in human endometrial explants","volume":"20","author":"Li","year":"2005","journal-title":"Human Reproduction"},{"key":"10.1016\/j.repbio.2013.03.001_bib0140","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1093\/humrep\/16.10.2103","article-title":"Effects of the levonorgestrel-releasing intrauterine system on proliferation and apoptosis in the endometrium","volume":"16","author":"Maruo","year":"2001","journal-title":"Human Reproduction"},{"key":"10.1016\/j.repbio.2013.03.001_bib0145","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1477-7827-8-126","article-title":"Apoptosis is increased and cell proliferation is decreased in out-of-phase endometria from infertile and recurrent abortion patients","volume":"8","author":"Meresman","year":"2010","journal-title":"Reproductive Biology and Endocrinology"},{"key":"10.1016\/j.repbio.2013.03.001_bib0150","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1210\/en.2005-1577","article-title":"Human chorionic gonadotropin and decidualization in vitro inhibits cytochalasin-D-induced apoptosis in cultured endometrial stromal fibroblasts","volume":"147","author":"Jasinska","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.repbio.2013.03.001_bib0155","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1210\/jc.2004-2130","article-title":"Prevention of endometrial apoptosis: randomized prospective comparison of human chorionic gonadotropin versus progesterone treatment in the luteal phase","volume":"90","author":"Lovely","year":"2005","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.repbio.2013.03.001_bib0160","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1128\/MCB.19.9.5991","article-title":"Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis","volume":"19","author":"Holmstrom","year":"1999","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.repbio.2013.03.001_bib0165","doi-asserted-by":"crossref","first-page":"19532","DOI":"10.1074\/jbc.274.28.19532","article-title":"Selective sensitization to tumor necrosis factor-alpha-induced apoptosis by blockade of NF-kappaB in primary glomerular mesangial cells","volume":"274","author":"Sugiyama","year":"1999","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.repbio.2013.03.001_bib0170","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/sj.jid.5701141","article-title":"NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2","volume":"128","author":"Diessenbacher","year":"2008","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.repbio.2013.03.001_bib0175","doi-asserted-by":"crossref","first-page":"G1357","DOI":"10.1152\/ajpgi.2001.281.6.G1357","article-title":"Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation","volume":"281","author":"Hatano","year":"2001","journal-title":"American Journal of Physiology and Gastrointestinal Liver Physiology"},{"key":"10.1016\/j.repbio.2013.03.001_bib0180","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1095\/biolreprod.109.078972","article-title":"AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression","volume":"82","author":"Straszewski-Chavez","year":"2010","journal-title":"Biology of Reproduction"},{"key":"10.1016\/j.repbio.2013.03.001_bib0185","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/0264-6021:3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"Davies","year":"2000","journal-title":"Biochemistry Journal"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X13002180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X13002180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T17:50:25Z","timestamp":1715104225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X13002180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S1642431X13002180"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2013.03.001","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}