{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:41:24Z","timestamp":1784860884554,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31802263"],"award-info":[{"award-number":["31802263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71473019"],"award-info":[{"award-number":["71473019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["KM201810020007"],"award-info":[{"award-number":["KM201810020007"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.repbio.2019.06.003","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T18:03:42Z","timestamp":1560189822000},"page":"204-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Exosome-derived uterine microRNAs isolated from cows with endometritis impede blastocyst development"],"prefix":"10.1016","volume":"19","author":[{"given":"Xiangguo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihui","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2019.06.003_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.repbio.2015.12.002","article-title":"Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility","volume":"16","author":"Carneiro","year":"2016","journal-title":"Reprod Biol"},{"key":"10.1016\/j.repbio.2019.06.003_bib0010","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3168\/jds.S0022-0302(02)74302-6","article-title":"Defining and diagnosing postpartum clinical endometritis and its impact on reproductive performance in dairy cows","volume":"85","author":"LeBlanc","year":"2002","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.repbio.2019.06.003_bib0015","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1095\/biolreprod.109.077370","article-title":"Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle","volume":"81","author":"Sheldon","year":"2009","journal-title":"Biol Reprod"},{"key":"10.1016\/j.repbio.2019.06.003_bib0020","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.4049\/jimmunol.168.7.3235","article-title":"TCR activation of human T cells induces the production of exosomes bearing the TCR\/CD3\/zeta complex","volume":"168","author":"Blanchard","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.repbio.2019.06.003_bib0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/gast.2001.26263","article-title":"Intestinal epithelial cells secrete exosome-like vesicles","volume":"121","author":"van Niel","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.repbio.2019.06.003_bib0030","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1083\/jcb.147.3.599","article-title":"Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73","volume":"147","author":"Thery","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/j.repbio.2019.06.003_bib0035","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1091\/mbc.8.12.2631","article-title":"Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation","volume":"8","author":"Raposo","year":"1997","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.repbio.2019.06.003_bib0040","doi-asserted-by":"crossref","first-page":"9143","DOI":"10.3168\/jds.2017-13261","article-title":"Effect of exosomes from plasma of dairy cows with or without an infected uterus on prostaglandin production by endometrial cell lines","volume":"100","author":"Almughlliq","year":"2017","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.repbio.2019.06.003_bib0045","article-title":"Endometrial exosomes\/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation","volume":"8","author":"Ng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.repbio.2019.06.003_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174535","article-title":"Effects of embryo-derived exosomes on the development of bovine cloned embryos","volume":"12","author":"Qu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.repbio.2019.06.003_bib0055","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1530\/REP-16-0384","article-title":"Effect of bovine oviductal extracellular vesicles on embryo development and quality in vitro","volume":"153","author":"Lopera-Vasquez","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.repbio.2019.06.003_bib0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.theriogenology.2018.03.027","article-title":"Bovine uterus-derived exosomes improve developmental competence of somatic cell nuclear transfer embryos","volume":"114","author":"Qiao","year":"2018","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2019.06.003_bib0065","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3892\/br.2016.824","article-title":"Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells","volume":"6","author":"Sato","year":"2017","journal-title":"Biomed Rep"},{"key":"10.1016\/j.repbio.2019.06.003_bib0070","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1186\/s12864-016-2962-1","article-title":"Comparative miRNAome analysis revealed different miRNA expression profiles in bovine sera and exosomes","volume":"17","author":"Zhao","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.repbio.2019.06.003_bib0075","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1073\/pnas.0813371106","article-title":"Circulating microRNAs, potential biomarkers for drug-induced liver injury","volume":"106","author":"Wang","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.repbio.2019.06.003_bib0080","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrg3198","article-title":"MicroRNA profiling: approaches and considerations","volume":"13","author":"Pritchard","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.repbio.2019.06.003_bib0085","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"10.1016\/j.repbio.2019.06.003_bib0090","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/nar\/gkg006","article-title":"Rfam: an RNA family database","volume":"31","author":"Griffiths-Jones","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.repbio.2019.06.003_bib0095","doi-asserted-by":"crossref","first-page":"D154","DOI":"10.1093\/nar\/gkm952","article-title":"miRBase: tools for microRNA genomics","volume":"36","author":"Griffiths-Jones","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.repbio.2019.06.003_bib0100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/nar\/gkr688","article-title":"miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades","volume":"40","author":"Friedlander","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.repbio.2019.06.003_bib0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1479-7364-5-1-56","article-title":"A survey of statistical software for analysing RNA-seq data","volume":"5","author":"Gao","year":"2010","journal-title":"Hum Genomics"},{"key":"10.1016\/j.repbio.2019.06.003_bib0110","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/1471-2105-10-310","article-title":"Basic properties and information theory of Audic-Claverie statistic for analyzing cDNA arrays","volume":"10","author":"Tino","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.repbio.2019.06.003_bib0115","article-title":"Using RepeatMasker to identify repetitive elements in genomic sequences","volume":"10","author":"Chen","year":"2004","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1016\/j.repbio.2019.06.003_bib0120","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"miRBase: microRNA sequences, targets and gene nomenclature","volume":"34","author":"Griffiths-Jones","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.repbio.2019.06.003_bib0125","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vetimm.2012.09.042","article-title":"Endometrial epithelial cells are potent producers of tracheal antimicrobial peptide and serum amyloid A3 gene expression in response to E. Coli stimulation","volume":"151","author":"Chapwanya","year":"2013","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.repbio.2019.06.003_bib0130","first-page":"1","article-title":"Downregulation of exosome-encapsulated miR-548c-5p is associated with poor prognosis in colorectal cancer","author":"Peng","year":"2018","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.repbio.2019.06.003_bib0135","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41392-018-0006-9","article-title":"miRNAs reshape immunity and inflammatory responses in bacterial infection","volume":"3","author":"Zhou","year":"2018","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.repbio.2019.06.003_bib0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19072120","article-title":"Non-coding RNAs in endometrial physiopathology","volume":"19","author":"Ferlita","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2019.06.003_bib0145","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12864-016-2513-9","article-title":"Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile","volume":"17","author":"Salilew-Wondim","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.repbio.2019.06.003_bib0150","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12858","article-title":"MiR-27a-3p and miR-124-3p, upregulated in endometrium and serum from women affected by Chronic Endometritis, are new potential molecular markers of endometrial receptivity","author":"Di Pietro","year":"2018","journal-title":"Am J Reprod Immunol."},{"key":"10.1016\/j.repbio.2019.06.003_bib0155","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4971261","article-title":"Exosomes derived from miR-214-Enriched bone marrow-derived mesenchymal stem cells regulate oxidative damage in cardiac stem cells by targeting CaMKII","volume":"2018","author":"Wang","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.repbio.2019.06.003_bib0160","doi-asserted-by":"crossref","first-page":"12974","DOI":"10.1038\/s41598-018-31108-y","article-title":"Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients","volume":"8","author":"Ni","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2019.06.003_bib0165","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12967-018-1470-2","article-title":"Urinary miR-196a predicts disease progression in patients with chronic kidney disease","volume":"16","author":"Zhang","year":"2018","journal-title":"J Transl Med"},{"key":"10.1016\/j.repbio.2019.06.003_bib0170","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1038\/s41598-017-04996-9","article-title":"Circulating miR-323-3p is a biomarker for cardiomyopathy and an indicator of phenotypic variability in Friedreich\u2019s ataxia patients","volume":"7","author":"Seco-Cervera","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.repbio.2019.06.003_bib0175","first-page":"5495","article-title":"Expression profile of microRNAs following bone marrow-derived mesenchymal stem cell treatment in lipopolysaccharide-induced acute lung injury","volume":"15","author":"Park","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.repbio.2019.06.003_bib0180","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1002\/jcb.26854","article-title":"The anti-inflammatory effect of microRNA-383-3p interacting with IL1R2 against homocysteine-induced endothelial injury in rat coronary arteries","volume":"119","author":"Lian","year":"2018","journal-title":"J Cell Biochem"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X19300580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X19300580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:39:19Z","timestamp":1778621959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X19300580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S1642431X19300580"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2019.06.003","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosome-derived uterine microRNAs isolated from cows with endometritis impede blastocyst development","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2019.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}