{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:14:26Z","timestamp":1768295666014,"version":"3.49.0"},"reference-count":93,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.repbio.2020.100468","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T06:59:48Z","timestamp":1607842788000},"page":"100468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Review: Preimplantation genetic diagnosis (PGD) as a reproductive option in patients with neurodegenerative disorders"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-8823","authenticated-orcid":false,"given":"Romualdo","family":"Sciorio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Aiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso Maria","family":"Irollo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2020.100468_bib0005","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pneurobio.2013.07.001","article-title":"Ethics in prion disease","volume":"110","author":"Bechtel","year":"2013","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.repbio.2020.100468_bib0010","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nrneurol.2013.129","article-title":"New treatments for mitochondrial disease\u2014no time to drop our standards","volume":"9","author":"Pfeffer","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.repbio.2020.100468_bib0015","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/sj.ejhg.5200865","article-title":"Preimplantation genetic diagnosis for Huntington\u2019s disease with exclusion testing","volume":"10","author":"Sermon","year":"2002","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.repbio.2020.100468_bib0020","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/344768a0","article-title":"Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification","volume":"344","author":"Handyside","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.repbio.2020.100468_bib0025","unstructured":"ESHG: European Society for Human Genetics (2017). https:\/\/www.eshg.org (Accessed 14 Sep 2017)."},{"key":"10.1016\/j.repbio.2020.100468_bib0030","unstructured":"ESHRE: European Society for Human Reproduction and Embryology (2017). https:\/\/www.eshre.eu (Accessed 14 Sep2017)."},{"key":"10.1016\/j.repbio.2020.100468_bib0035","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/sj.ejhg.5201598","article-title":"The interface between assisted reproductive technologies and genetics: technical, social, ethical and legal issues","volume":"14","author":"Soini","year":"2006","journal-title":"Eur J Hum Genet"},{"issue":"21","key":"10.1016\/j.repbio.2020.100468_bib0040","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/ejhg.2013.219","article-title":"Current issues in medically assisted reproduction and genetics in Europe: research, clinical practice, ethics, legal issues and policyeuropean society of human genetics and european society of human reproduction and embryology","author":"Harper","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.repbio.2020.100468_bib0045","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.rbmo.2010.07.007","article-title":"Preimplantation genetic diagnosis after 20 years","volume":"21","author":"Handyside","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.repbio.2020.100468_bib0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00439-011-1056-z","article-title":"Preimplantation genetic diagnosis: state of the art 2011","volume":"131","author":"Harper","year":"2012","journal-title":"Hum Genet"},{"issue":"23(2)","key":"10.1016\/j.repbio.2020.100468_bib0055","first-page":"99","article-title":"Preimplantation genetic testing for monogenic diseases: a Brazilian IVF centre experience","volume":"30","author":"Zanetti","year":"2019","journal-title":"JBRA Assist Reprod Apr"},{"issue":"10 October","key":"10.1016\/j.repbio.2020.100468_bib0060","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/humrep\/dex265","article-title":"ESHRE PGD Consortium data collection XIV-XV: cycles from January 2011 to December 2012 with pregnancy follow-up to October 2013","volume":"32","author":"De Rycke","year":"2017","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0065","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1001\/jama.287.8.1018","article-title":"Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation","volume":"287","author":"Verlinsky","year":"2002","journal-title":"JAMA"},{"issue":"April 4","key":"10.1016\/j.repbio.2020.100468_bib0070","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1001\/jamaneurol.2013.5884","article-title":"Preimplanation genetic diagnosis (PGD) for genetic prion disorder due to F198S mutation in the PRNP gene","volume":"71","author":"Uflacker","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.repbio.2020.100468_bib0075","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/humrep\/deq229","article-title":"ESHRE PGD consortium best practice guidelines for organization of a PGD centre for PGD\/preimplantation genetic screening","volume":"26","author":"Harton","year":"2011","journal-title":"Hum Reprod"},{"issue":"October 10","key":"10.1016\/j.repbio.2020.100468_bib0080","first-page":"1957","article-title":"Assisted reproductive technology in Europe, 2013: results generated from European registers by ESHRE","volume":"32","author":"Calhaz-Jorge","year":"2017","journal-title":"European IVF-monitoring Consortium (EIM); European Society of Human Reproduction and Embryology (ESHRE), Hum Reprod"},{"issue":"7\u20138","key":"10.1016\/j.repbio.2020.100468_bib0085","first-page":"385","article-title":"Views of preimplantation genetic diagnosis among psychiatrists and neurologists","volume":"59","author":"Klitzman","year":"2014","journal-title":"J Reprod Med"},{"key":"10.1016\/j.repbio.2020.100468_bib0090","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.fertnstert.2003.09.082","article-title":"Over a decade of experience with preimplantation genetic diagnosis: a multicenter report","volume":"82","author":"Verlinsky","year":"2004","journal-title":"Fertil Steril"},{"issue":"30","key":"10.1016\/j.repbio.2020.100468_bib0095","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/pd.2552","article-title":"Preimplantation genetic diagnosis at 20 years","volume":"2010","author":"Simpson","year":"2010","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.repbio.2020.100468_bib0100","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1093\/oxfordjournals.humrep.a138001","article-title":"Diagnosis of major chromosome aneuploidies in human preimplantation embryos","volume":"8","author":"Munn\u00e8","year":"1993","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0105","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/molehr\/gaw034","article-title":"The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists","volume":"22","author":"Sermon","year":"2016","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0110","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.fertnstert.2012.11.007","article-title":"Four-hour quantitative real-time polymerase chain reaction-based comprehensive chromosome screening and accumulating evidence of accuracy, safety, predictive value, and clinical efficacy","volume":"99","author":"Treff","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0115","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.fertnstert.2013.04.039","article-title":"Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial","volume":"100","author":"Scott","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0120","doi-asserted-by":"crossref","DOI":"10.1017\/S0967199400003920","article-title":"Laser blastocyst biopsy for preimplantation genetic diagnosis in the human","volume":"5","author":"Veiga","year":"1997","journal-title":"Zygote"},{"issue":"10","key":"10.1016\/j.repbio.2020.100468_bib0125","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1093\/humrep\/13.10.2880","article-title":"Effect of Ca2+\/Mg2+-free medium on the biopsy procedure for preimplantation genetic diagnosis and further development of human embryos","volume":"13","author":"Dumoulin","year":"1998","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1016\/j.repbio.2020.100468_bib0130","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/humrep\/del506","article-title":"Blastocyst biopsy versus cleavage stage biopsy and blastocyst transfer for preimplantation genetic diagnosis of beta-thalassaemia: a pilot study","volume":"22","author":"Kokkali","year":"2007","journal-title":"Hum Reprod May"},{"key":"10.1016\/j.repbio.2020.100468_bib0135","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/oxfordjournals.humrep.a137191","article-title":"Trophectoderm biopsy in human blastocysts","volume":"5","author":"Dokras","year":"1990","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.fertnstert.2014.03.019","article-title":"Preterm births, multiples, and fertility treatment: recommendations for changes to policy and clinical practices","volume":"102","author":"Johnston","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0145","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/humrep\/deu012","article-title":"ESHRE PGD Consortium data collection XII: cycles from January to December 2009 with pregnancy follow-up to October 2010","volume":"29","author":"Moutou","year":"2014","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.repbio.2020.100468_bib0150","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1098-2795(199809)51:1<53::AID-MRD6>3.0.CO;2-V","article-title":"Open pulled Straw (OPS) vitrification: a new way to reduce cryoinjuries of bovine ova and embryos","volume":"51","author":"Vajta","year":"1998","journal-title":"Mol Reprod Dev Sep"},{"issue":"92","key":"10.1016\/j.repbio.2020.100468_bib0155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cryobiol.2019.11.041","article-title":"Clinical utility of freeze-all approach in ART treatment: a mini-review","volume":"1","author":"Sciorio","year":"2020","journal-title":"Cryobiology Feb"},{"issue":"October","key":"10.1016\/j.repbio.2020.100468_bib0160","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cryobiol.2018.08.004","article-title":"Single blastocyst transfer (SET) and pregnancy outcome of day 5 and day 6 human blastocysts vitrified using a closed device","volume":"84","author":"Sciorio","year":"2018","journal-title":"Cryobiology"},{"issue":"5","key":"10.1016\/j.repbio.2020.100468_bib0165","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1017\/S0967199419000273","article-title":"Increased pregnancy outcome after day 5 versus day 6 transfers of human vitrified-warmed blastocysts","volume":"27","author":"Sciorio","year":"2019","journal-title":"Zygote Oct"},{"key":"10.1016\/j.repbio.2020.100468_bib0170","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/humrep\/dev294","article-title":"Consistent and reproducible outcomes of blastocyst biopsy and aneuploidy screening across different biopsy practitioners: a multicentre study involving 2586 embryo biopsies","volume":"31","author":"Capalbo","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0175","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1055\/s-0032-1313910","article-title":"Clinical management of in vitro fertilization with preimplantation genetic diagnosis","volume":"30","author":"Tur-Kaspa","year":"2012","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.repbio.2020.100468_bib0180","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1471-0528.2006.01143.x","article-title":"Three hundred and thirty cycles of preimplantation genetic diagnosis for serious genetic disease: clinical considerations affecting outcome","volume":"113","author":"Grace","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.repbio.2020.100468_bib0185","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.fertnstert.2007.08.002","article-title":"Substandard application of preimplantation genetic screening may interfere with its clinical success","volume":"88","author":"Munne","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0190","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.fertnstert.2006.12.012","article-title":"Ten-year experience with preimplantation genetic diagnosis (PGD) at the New York University School of Medicine Fertility Centre","volume":"88","author":"Grifo","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0195","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1093\/humrep\/dep272","article-title":"Cumulative reproductive outcome after preimplantation genetic diagnosis: a report on 1498 couples","volume":"24","author":"Verpoest","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0200","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/humupd\/dmu016","article-title":"The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans","volume":"20","author":"Taylor","year":"2014","journal-title":"Hum Reprod Update"},{"issue":"November 21","key":"10.1016\/j.repbio.2020.100468_bib0205","article-title":"Healthy babies after intrauterine transfer of mosaic aneuploid blastocysts","volume":"373","author":"Greco","year":"2015","journal-title":"N Engl J Med"},{"issue":"April 3","key":"10.1016\/j.repbio.2020.100468_bib0210","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/humupd\/dmz050","article-title":"Chromosomal mosaicism in human blastocysts: the ultimate diagnostic dilemma","volume":"26","author":"Popovic","year":"2020","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.repbio.2020.100468_bib0215","doi-asserted-by":"crossref","first-page":"11165","DOI":"10.1038\/ncomms11165","article-title":"Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal development potential","volume":"7","author":"Bolton","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.repbio.2020.100468_bib0220","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/molehr\/gaq062","article-title":"Comprehensive analysis of karyotypic mosaicism between trophectoderm and inner cell mass","volume":"16","author":"Johnson","year":"2010","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0225","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1093\/humrep\/det073","article-title":"The effect of preimplantation genetic screening on neurological, cognitive and behavioural development in 4-year-old children: follow-up of a RCT","volume":"28","author":"Schendelaar","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0230","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.fertnstert.2016.07.1092","article-title":"Preimplantation genetic diagnosis: a national multicenter obstetric and neonatal follow-up study","volume":"106","author":"Bay","year":"2016","journal-title":"Fertil Steril"},{"issue":"1","key":"10.1016\/j.repbio.2020.100468_bib0235","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.fertnstert.2016.03.010","article-title":"Obstetric and neonatal outcomes in blastocyst-stage biopsy with frozen embryo transfer and cleavage-stage biopsy with fresh embryo transfer after preimplantation genetic diagnosis\/screening","volume":"106","author":"Shuang","year":"2016","journal-title":"Fertil Steril Jul"},{"issue":"1","key":"10.1016\/j.repbio.2020.100468_bib0240","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/uog.18942","article-title":"Influence of cryopreservation on perinatal outcome after blastocyst- vs cleavage-stage embryo transfer: systematic review and meta-analysis","volume":"51","author":"Alviggi","year":"2018","journal-title":"Ultrasound Obstet Gynecol Jan"},{"key":"10.1016\/j.repbio.2020.100468_bib0245","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/humrep\/dep428","article-title":"Children born after preimplantation genetic diagnosis show no increase in congenital anomalies","volume":"25","author":"Simpson","year":"2010","journal-title":"Hum Reprod"},{"issue":"November 11","key":"10.1016\/j.repbio.2020.100468_bib0250","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s10815-018-1286-2","article-title":"Perinatal follow-up of children born after preimplantation genetic diagnosis between 1995 and 2014","volume":"35","author":"Heijligers","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.repbio.2020.100468_bib0255","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/humrep\/der360","article-title":"Neonatal follow-up of 995 consecutively born children after embryo biopsy for PGD","volume":"27","author":"Desmyttere","year":"2012","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.repbio.2020.100468_bib0260","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/humrep\/dew317","article-title":"Pre-term birth and low birth weight following preimplantation genetic diagnosis: analysis of 88 010 singleton live births following PGD and IVF cycles","volume":"32","author":"Sunkara","year":"2017","journal-title":"Hum Reprod Feb"},{"key":"10.1016\/j.repbio.2020.100468_bib0265","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1471-0528.2006.01143.x","article-title":"Three hundred and thirty cycles of preimplantation genetic diagnosis for serious genetic disease: clinical considerations affecting outcome","volume":"113","author":"Grace","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.repbio.2020.100468_bib0270","first-page":"6","article-title":"PGT-A preimplantation genetic testing for aneuploidies and embryo selection in routine ART cycles: time to step back?","author":"Sciorio","year":"2020","journal-title":"Clin Genet Mar"},{"key":"10.1016\/j.repbio.2020.100468_bib0275","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/humu.20324","article-title":"Optimization and evaluation of single-cell whole genome multiple displacement amplification","volume":"27","author":"Spits","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.repbio.2020.100468_bib0280","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1093\/nar\/27.4.1214","article-title":"Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation","volume":"27","author":"Wells","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.repbio.2020.100468_bib0285","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/molehr\/gan062","article-title":"Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH","volume":"14","author":"Wells","year":"2008","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0290","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.fertnstert.2010.04.064","article-title":"The use of arrays in preimplantation genetic diagnosis and screening","volume":"94","author":"Harper","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0295","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.fertnstert.2012.01.115","article-title":"Development and validation of an accurate quantitative real-time polymerase chain reaction-based assay for human blastocyst comprehensive chromosomal aneuploidy screening","volume":"97","author":"Treff","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0300","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1093\/humrep\/deu277","article-title":"Application of next-generation sequencing technology for comprehensive aneuploidy screening of blastocysts in clinical preimplantation genetic screening cycles","volume":"29","author":"Fiorentino","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0305","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/humupd\/dmr052","article-title":"The ESHRE PGD Consortium: 10 years of data collection","volume":"18","author":"Harper","year":"2012","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.repbio.2020.100468_bib0310","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/humupd\/dms058","article-title":"Reproductive options for prospective parents in families with Huntington\u2019s disease: clinical, psychological and ethical reflections","volume":"19","author":"de Die-Smulders","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.repbio.2020.100468_bib0315","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.fertnstert.2006.12.033","article-title":"Preimplantation genetic screening as an alternative to prenatal testing for Down syndrome: preferences of women undergoing in vitro fertilization\/intracytoplasmic sperm injection treatment","volume":"88","author":"Twisk","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0320","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.fertnstert.2009.08.025","article-title":"Perspectives of couples with high risk of transmitting genetic disorders","volume":"94","author":"Musters","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0325","doi-asserted-by":"crossref","unstructured":"Offit K., Sagi M., Hurley K. (2206) Preimplantation genetic diagnosis for cancer syndromes: a new challenge for preventive medicine. JAMA 296, 2727-2730.","DOI":"10.1001\/jama.296.22.2727"},{"key":"10.1016\/j.repbio.2020.100468_bib0330","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.rbmo.2011.05.016","article-title":"Seven years of experience of preimplantation HLA typing: a clinical overview of 327 cycles","volume":"23","author":"Kahraman","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.repbio.2020.100468_bib0335","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.1016\/j.fertnstert.2008.08.062","article-title":"Preimplantation genetic testing: a Practice Committee opinion","volume":"90","author":"Practice Committee of Society for Assisted Reproductive Technology & Practice Committee of American Society for Reproductive Medicine","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0340","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.fertnstert.2013.02.043","article-title":"Use of preimplantation genetic diagnosis for serious adult onset conditions: a committee opinion","volume":"100","author":"Ethics Committee of American Society for Reproductive Medicine","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0345","series-title":"PGD conditions licensed by the HFEA","author":"Human Fertilisation and Embryology Authority","year":"2020"},{"issue":"October 10","key":"10.1016\/j.repbio.2020.100468_bib0350","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/ejhg.2017.113","article-title":"Acceptable applications of preimplantation genetic diagnosis (PGD) among Israeli PGD users","volume":"25","author":"Zuckerman","year":"2017","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.repbio.2020.100468_bib0355","first-page":"10","article-title":"The role of prenatal diagnosis following preimplantation genetic testing for single-gene conditions: a historical overview of evolving technologies and clinical practice","author":"Hardy","year":"2020","journal-title":"Prenat Diagn Feb"},{"key":"10.1016\/j.repbio.2020.100468_bib0360","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-4939-8889-1_2","article-title":"Overview of preimplantation genetic diagnosis (PGD): historical perspective and future direction","volume":"1885","author":"Simpson","year":"2019","journal-title":"Methods Mol Biol"},{"issue":"January 1","key":"10.1016\/j.repbio.2020.100468_bib0365","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s disease: a clinical review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.repbio.2020.100468_bib0370","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"HDCRG: a novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.repbio.2020.100468_bib0375","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable in Huntington\u2019s disease chromosomes","volume":"72","author":"Huntington\u2019s Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.repbio.2020.100468_bib0380","series-title":"GeneReviews\u00ae [internet]. Seattle (WA)","first-page":"1993","article-title":"Huntington disease","author":"Caron","year":"1998"},{"issue":"3\u20134","key":"10.1016\/j.repbio.2020.100468_bib0385","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000369343","article-title":"Prevalence of muscular dystrophies: a systematic literature review","volume":"43","author":"Theadom","year":"2014","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.repbio.2020.100468_bib0390","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/jnnp.2008.158261","article-title":"The myotonic dystrophies: diagnosis and management: review","volume":"81","author":"Turner","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"February 8","key":"10.1016\/j.repbio.2020.100468_bib0395","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1001\/jama.287.8.1018","article-title":"Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation","volume":"287","author":"Verlinsky","year":"2002","journal-title":"JAMA"},{"issue":"June 6534","key":"10.1016\/j.repbio.2020.100468_bib0400","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer\u2019s disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"issue":"August 5226","key":"10.1016\/j.repbio.2020.100468_bib0405","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer\u2019s disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"issue":"February 6311","key":"10.1016\/j.repbio.2020.100468_bib0410","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer\u2019s disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.repbio.2020.100468_bib0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2009.05.007","article-title":"Singleton birth after preimplantation genetic diagnosis for Huntington disease using whole genome amplification","volume":"92","author":"Chow","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0420","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.fertnstert.2009.01.120","article-title":"One-step multiplex polymerase chain reaction for preimplantation genetic diagnosis of Huntington disease","volume":"93","author":"Peci\u00f1a","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.repbio.2020.100468_bib0425","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/ejhg.2012.122","article-title":"Preimplantation genetic diagnosis (PGD) for Huntington\u2019s disease: the experience of three European centres","volume":"20","author":"Van Rij","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.repbio.2020.100468_bib0430","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/pd.1909","article-title":"Birth after pre-implantation genetic diagnosis (PGD) of spinocerebellar ataxia 2 (Sca2)","volume":"28","author":"Moutou","year":"2008","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.repbio.2020.100468_bib0435","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/molehr\/gah008","article-title":"Preimplantation genetic diagnosis of spinocerebellar ataxia 3 by (CAG)n repeat detection","volume":"10","author":"Dr\u00fcsedau","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0440","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/molehr\/gag054","article-title":"Preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1A","volume":"9","author":"Sermon","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0445","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5653\/cerm.2013.40.4.163","article-title":"Preimplantation genetic diagnosis for Charcot-Marie-Tooth disease","volume":"40","author":"Lee","year":"2013","journal-title":"Clin Exp Reprod Med"},{"key":"10.1016\/j.repbio.2020.100468_bib0450","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/pd.250","article-title":"Preimplantation genetic diagnosis for familial amyloidotic polyneuropathy (FAP)","volume":"21","author":"Carvalho","year":"2001","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.repbio.2020.100468_bib0455","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1093\/molehr\/7.10.995","article-title":"Six unaffected livebirths following preimplantation diagnosis for spinal muscular atrophy","volume":"7","author":"Pettigrew","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.repbio.2020.100468_bib0460","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1212\/WNL.53.5.1087","article-title":"Preimplantation genetic diagnosis for spinal muscular atrophy type I","volume":"53","author":"Fallon","year":"1999","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.repbio.2020.100468_bib0465","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.fertnstert.2014.09.011","article-title":"Clinically recognizable error rate after the transfer of comprehensive chromosomal screened euploid embryos is low","volume":"102","author":"Werner","year":"2014","journal-title":"Fertil Steril"}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X20302989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X20302989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:22:12Z","timestamp":1761646932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X20302989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":93,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1642431X20302989"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2020.100468","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Review: Preimplantation genetic diagnosis (PGD) as a reproductive option in patients with neurodegenerative disorders","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2020.100468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100468"}}