{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:01:19Z","timestamp":1790524879850,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"am","delay-in-days":253,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100016307","name":"APIS-GENE","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016307","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Reproductive Biology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.repbio.2021.100512","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T12:30:38Z","timestamp":1620822638000},"page":"100512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Metabolomic analysis of oviduct fluid on day 3 post-estrus in Holstein heifers"],"prefix":"10.1016","volume":"21","author":[{"given":"Coline","family":"Mah\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6073-2436","authenticated-orcid":false,"given":"Julie","family":"Gatien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Desnoes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Le Bourhis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Mermillod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4534-9949","authenticated-orcid":false,"given":"Pascal","family":"Salvetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Saint-Dizier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.repbio.2021.100512_bib0005","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1017\/S1751731119002775","article-title":"Review: recent advances in bovine in vitro embryo production: reproductive biotechnology history and methods","volume":"14","author":"Ferre","year":"2020","journal-title":"Animal"},{"key":"10.1016\/j.repbio.2021.100512_bib0010","doi-asserted-by":"crossref","first-page":"s103","DOI":"10.1017\/S175173111900315X","article-title":"Review: Environmental impact on early embryonic development in the bovine species","volume":"14","author":"Besenfelder","year":"2020","journal-title":"Animal"},{"key":"10.1016\/j.repbio.2021.100512_bib0015","first-page":"194","article-title":"Development of the egg of the cow up to the stage of blastocyst formation","volume":"80","author":"Hamilton","year":"1946","journal-title":"J Anat"},{"key":"10.1016\/j.repbio.2021.100512_bib0020","doi-asserted-by":"crossref","DOI":"10.1590\/1984-3143-ar2020-0015","article-title":"Erasing gametes to write blastocysts: metabolism as the new player in epigenetic reprogramming","volume":"17","author":"Milazzotto","year":"2020","journal-title":"Anim Reprod"},{"key":"10.1016\/j.repbio.2021.100512_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010223","article-title":"Composing the early embryonic microenvironment: physiology and regulation of oviductal secretions","volume":"21","author":"Saint-Dizier","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2021.100512_bib0030","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1071\/RD17389","article-title":"Metabolomic profiling of bovine oviductal fluid across the oestrous cycle using proton nuclear magnetic resonance spectroscopy","volume":"30","author":"Lamy","year":"2018","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.repbio.2021.100512_bib0035","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.3168\/jds.2014-9185","article-title":"Short communication: comparison of estrus characteristics in Holstein heifers by 2 activity monitoring systems","volume":"98","author":"Silper","year":"2015","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.repbio.2021.100512_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10060233","article-title":"The bovine metabolome","volume":"10","author":"Foroutan","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.repbio.2021.100512_bib0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051681","article-title":"Spatial and pregnancy-related changes in the protein, amino acid, and carbohydrate composition of bovine oviduct fluid","volume":"21","author":"Rodriguez-Alonso","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.repbio.2021.100512_bib0050","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/mrd.20760","article-title":"Energy substrates in bovine oviduct and uterine fluid and blood plasma during the oestrous cycle","volume":"75","author":"Hugentobler","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.repbio.2021.100512_bib0055","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1071\/RD09129","article-title":"Effects of changes in the concentration of systemic progesterone on ions, amino acids and energy substrates in cattle oviduct and uterine fluid and blood","volume":"22","author":"Hugentobler","year":"2010","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.repbio.2021.100512_bib0060","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.theriogenology.2016.04.086","article-title":"Steroid hormones in bovine oviductal fluid during the estrous cycle","volume":"86","author":"Lamy","year":"2016","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2021.100512_bib0065","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0093-691X(98)00011-9","article-title":"Local distributions of oviductal estradiol, progesterone, prostaglandins, oxytocin and endothelin-1 in the cyclic cow","volume":"49","author":"Wijayagunawardane","year":"1998","journal-title":"Theriogenology"},{"key":"10.1016\/j.repbio.2021.100512_bib0070","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/mrd.20607","article-title":"Amino acids in oviduct and uterine fluid and blood plasma during the estrous cycle in the bovine","volume":"74","author":"Hugentobler","year":"2007","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.repbio.2021.100512_bib0075","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2754\/avb200574010037","article-title":"Stress response in dairy cows related to blood glucose","volume":"74","author":"Mudron","year":"2005","journal-title":"Acta Vet Brno."}],"container-title":["Reproductive Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X21000334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1642431X21000334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:21:39Z","timestamp":1761646899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1642431X21000334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1642431X21000334"],"URL":"https:\/\/doi.org\/10.1016\/j.repbio.2021.100512","relation":{},"ISSN":["1642-431X"],"issn-type":[{"value":"1642-431X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomic analysis of oviduct fluid on day 3 post-estrus in Holstein heifers","name":"articletitle","label":"Article Title"},{"value":"Reproductive Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.repbio.2021.100512","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100512"}}